Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              21     229
XP_006713721                                                           21     229
NP_703143                                                              17    2528
NP_001267474                                                           17    3301
NP_060732                                                              17    3301
NP_443715                                                              17    3301
NP_443716                                                              17    3301
NP_001267470                                                           17    3301
NP_443711                                                              17    3301
NP_001267475                                                           17    3301
NP_775919                                                              17    3301
XP_006713758                                                           17    3301
XP_006713757                                                           17    3301
XP_006713756                                                           17    3301
XP_005247668                                                           17    3301
XP_006713755                                                           17    3301
XP_005247667                                                           17    3301
XP_005247666                                                           17    3301
XP_005247665                                                           17    3301
XP_005247664                                                           17    3301
XP_006713754                                                           17    3301
XP_006713753                                                           17    3301
XP_005247661                                                           17    3301
XP_006713752                                                           17    3301
XP_005247660                                                           17    3301
XP_006712503                                                           17    3301
XP_006710324                                                           17    3301
NP_065961                                                              17    4312
NP_001158137                                                           17    4312
XP_006716134                                                           17    4312
NP_663314                                                              16    5631
NP_055271                                                              16    5631
NP_001186421                                                           16    5631
NP_036553                                                              16    5631
NP_077734                                                              16    5631
XP_006717830                                                           16    5631
XP_005269759                                                           16    5631
XP_005245325                                                           16    5631
XP_005245324                                                           16    5631
NP_055907                                                              16    7355
NP_443188                                                              16    7355
NP_006047                                                              16    7355
NP_002938                                                              16    7355
XP_003960419                                                           16    7355
XP_005255242                                                           16    7355
XP_005255241                                                           16    7355
XP_005255240                                                           16    7355
XP_005255239                                                           16    7355
XP_006721081                                                           16    7355
XP_005255143                                                           16    7355
XP_006721079                                                           16    7355
XP_005255141                                                           16    7355
XP_003846394                                                           16    7355
XP_006712259                                                           16    7355
XP_006712258                                                           16    7355
XP_003846733                                                           16    7355
NP_004611                                                              15    9605
NP_665802                                                              15    9605
NP_000043                                                              15    9605
NP_001269153                                                           15    9605
NP_003317                                                              15    9605
NP_001138462                                                           15    9605
NP_940862                                                              15    9605
NP_203124                                                              15    9605
NP_821158                                                              15    9605
NP_001361                                                              15    9605
NP_057438                                                              15    9605
NP_075048                                                              15    9605
XP_005260260                                                           15    9605
XP_005263286                                                           15    9605
XP_006712019                                                           15    9605
XP_006710456                                                           15    9605
>NP_006209
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILCATYVSV 9
           ILCATYV+V
Sbjct: 338 ILCATYVNV 346
>XP_006713721
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ILCATYVSV 9
           ILCATYV+V
Sbjct: 338 ILCATYVNV 346
>NP_703143
          Length = 337

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ILCATYVSV 9
           +LC TY+ V
Sbjct: 187 VLCCTYLKV 195
>NP_001267474
          Length = 1091

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 659 LLCATYL 665
>NP_060732
          Length = 1182

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 750 LLCATYL 756
>NP_443715
          Length = 1241

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 809 LLCATYL 815
>NP_443716
          Length = 1131

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 698 LLCATYL 704
>NP_001267470
          Length = 1234

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 801 LLCATYL 807
>NP_443711
          Length = 1292

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 860 LLCATYL 866
>NP_001267475
          Length = 1032

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 600 LLCATYL 606
>NP_775919
          Length = 1530

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LCATYVSV 9
            LC  YVSV
Sbjct: 1514 LCVVYVSV 1521
>XP_006713758
          Length = 877

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 809 LLCATYL 815
>XP_006713757
          Length = 1034

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 600 LLCATYL 606
>XP_006713756
          Length = 1093

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 659 LLCATYL 665
>XP_005247668
          Length = 1132

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 698 LLCATYL 704
>XP_006713755
          Length = 1165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 732 LLCATYL 738
>XP_005247667
          Length = 1183

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 750 LLCATYL 756
>XP_005247666
          Length = 1183

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 750 LLCATYL 756
>XP_005247665
          Length = 1184

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 750 LLCATYL 756
>XP_005247664
          Length = 1191

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 757 LLCATYL 763
>XP_006713754
          Length = 1224

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 791 LLCATYL 797
>XP_006713753
          Length = 1225

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 791 LLCATYL 797
>XP_005247661
          Length = 1242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 809 LLCATYL 815
>XP_006713752
          Length = 1242

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 809 LLCATYL 815
>XP_005247660
          Length = 1243

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LCATY+
Sbjct: 809 LLCATYL 815
>XP_006712503
          Length = 1470

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    LCATYVSV 9
            LC  YVSV
Sbjct: 1454 LCVVYVSV 1461
>XP_006710324
          Length = 943

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  LCATYVSV 9
          LCA+YV V
Sbjct: 16 LCASYVPV 23
>NP_065961
          Length = 1934

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILCATYVSV 9
           I  ATYVSV
Sbjct: 137 IFVATYVSV 145
>NP_001158137
          Length = 1950

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   ILCATYVSV 9
           I  ATYVSV
Sbjct: 137 IFVATYVSV 145
>XP_006716134
          Length = 1847

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  ILCATYVSV 9
          I  ATYVSV
Sbjct: 61 IFVATYVSV 69
>NP_663314
          Length = 458

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ILCATYV 7
           ILC TY+
Sbjct: 262 ILCNTYI 268
>NP_055271
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ILCATYV 7
           ILC TY+
Sbjct: 273 ILCNTYI 279
>NP_001186421
          Length = 455

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   ILCATYV 7
           ILC TY+
Sbjct: 259 ILCNTYI 265
>NP_036553
          Length = 1914

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ILCATYVS 8
           +LC TY++
Sbjct: 297 VLCTTYLT 304
>NP_077734
          Length = 749

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CATYVS 8
           CATYV+
Sbjct: 220 CATYVA 225
>XP_006717830
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ILCATYV 7
          ILC TY+
Sbjct: 87 ILCNTYI 93
>XP_005269759
          Length = 283

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ILCATYV 7
          ILC TY+
Sbjct: 87 ILCNTYI 93
>XP_005245325
          Length = 689

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CATYVS 8
           CATYV+
Sbjct: 160 CATYVA 165
>XP_005245324
          Length = 712

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   CATYVS 8
           CATYV+
Sbjct: 183 CATYVA 188
>NP_055907
          Length = 3661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   LCATY 6
           LCATY
Sbjct: 253 LCATY 257
>NP_443188
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ILCATY 6
           ++CATY
Sbjct: 374 LICATY 379
>NP_006047
          Length = 426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LCATYVSV 9
          +CATY+ +
Sbjct: 63 ICATYLLI 70
>NP_002938
          Length = 121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ILCATYV 7
          ILC +YV
Sbjct: 79 ILCTSYV 85
>XP_003960419
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ILCATYVS 8
           +LC  YVS
Sbjct: 111 LLCPVYVS 118
>XP_005255242
          Length = 3609

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   LCATY 6
           LCATY
Sbjct: 201 LCATY 205
>XP_005255241
          Length = 3637

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   LCATY 6
           LCATY
Sbjct: 201 LCATY 205
>XP_005255240
          Length = 3663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   LCATY 6
           LCATY
Sbjct: 227 LCATY 231
>XP_005255239
          Length = 3689

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 2   LCATY 6
           LCATY
Sbjct: 253 LCATY 257
>XP_006721081
          Length = 357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ILCATY 6
           ++CATY
Sbjct: 154 LICATY 159
>XP_005255143
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ILCATY 6
           ++CATY
Sbjct: 194 LICATY 199
>XP_006721079
          Length = 543

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ILCATY 6
           ++CATY
Sbjct: 374 LICATY 379
>XP_005255141
          Length = 577

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   ILCATY 6
           ++CATY
Sbjct: 374 LICATY 379
>XP_003846394
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ILCATYVS 8
           +LC  YVS
Sbjct: 111 LLCPVYVS 118
>XP_006712259
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LCATYVSV 9
          +CATY+ +
Sbjct: 63 ICATYLLI 70
>XP_006712258
          Length = 370

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  LCATYVSV 9
          +CATY+ +
Sbjct: 63 ICATYLLI 70
>XP_003846733
          Length = 209

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   ILCATYVS 8
           +LC  YVS
Sbjct: 111 LLCPVYVS 118
>NP_004611
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CATYVSV 9
           CA Y+S+
Sbjct: 403 CANYISL 409
>NP_665802
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   CATYVSV 9
           CA Y+S+
Sbjct: 403 CANYISL 409
>NP_000043
          Length = 1500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           ++CAT+V
Sbjct: 901 LICATHV 907
>NP_001269153
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           ++CAT+V
Sbjct: 823 LICATHV 829
>NP_003317
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  ILCATYV 7
          +LC TY+
Sbjct: 37 LLCFTYI 43
>NP_001138462
          Length = 1742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   LCATYVS 8
           LC TY S
Sbjct: 379 LCKTYAS 385
>NP_940862
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LC+T+V
Sbjct: 121 LLCSTFV 127
>NP_203124
          Length = 336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  LCATYVS 8
          +CA+YV+
Sbjct: 26 ICASYVT 32
>NP_821158
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LCATYVSV 9
           LC TY+++
Sbjct: 554 LCGTYLAL 561
>NP_001361
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    ILCATYV 7
            ILC T+V
Sbjct: 1988 ILCQTFV 1994
>NP_057438
          Length = 722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LCATYVS 8
           LC T+VS
Sbjct: 155 LCLTFVS 161
>NP_075048
          Length = 1088

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 2   LCATYVS 8
           LC  YVS
Sbjct: 841 LCGNYVS 847
>XP_005260260
          Length = 684

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   LCATYVS 8
           LC T+VS
Sbjct: 155 LCLTFVS 161
>XP_005263286
          Length = 869

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  ILCATYV 7
          +LC TYV
Sbjct: 12 MLCYTYV 18
>XP_006712019
          Length = 4158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    ILCATYV 7
            ILC T+V
Sbjct: 1988 ILCQTFV 1994
>XP_006710456
          Length = 633

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   ILCATYV 7
           +LC+T+V
Sbjct: 121 LLCSTFV 127
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.138    0.429 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 617,908
Number of extensions: 864
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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