Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

• Home Page
• Cancer-specific
• Epitope Search
• Data Retrieval
• Browse Gene
• Browse Tissue
• Sequence Similarity
• Partially Personalized
• Submit a Protein
• Vaccine Target
• Proteome Data
• NGS data
• BLAST & Predict
• Fully Personalized
• Proteins Pair
• Proteome Pair
• Advanced Tools
• Epitope Mapping
• Cross Reactivity
• Important Information
• Acknowledgement
• Algorithm
• Help
• Developers
• Contact

Blast-Search of mutated query peptide against human proteome

BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              19     665
XP_006718908                                                           19     665
XP_005271621                                                           19     665
XP_006718907                                                           19     665
XP_006718906                                                           19     665
XP_005271619                                                           19     665
XP_005271618                                                           19     665
NP_065717                                                              16    5631
XP_005266006                                                           16    5631
XP_005266005                                                           16    5631
XP_006714959                                                           16    5631
XP_006714958                                                           16    5631
XP_005266004                                                           16    5631
NP_065433                                                              16    7355
NP_004975                                                              16    7355
NP_004513                                                              16    7355
NP_004512                                                              16    7355
NP_005600                                                              15    9605
NP_002854                                                              15    9605
NP_002853                                                              15    9605
XP_006723664                                                           15    9605

>NP_000042
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 2260 ILARTFKNT 2268



>XP_006718908
          Length = 1708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   ILARTLKNT 9
           ILART KNT
Sbjct: 912 ILARTFKNT 920



>XP_005271621
          Length = 2708

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 1912 ILARTFKNT 1920



>XP_006718907
          Length = 3050

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 2254 ILARTFKNT 2262



>XP_006718906
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 2260 ILARTFKNT 2268



>XP_005271619
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 2260 ILARTFKNT 2268



>XP_005271618
          Length = 3056

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    ILARTLKNT 9
            ILART KNT
Sbjct: 2260 ILARTFKNT 2268



>NP_065717
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 312 RTLKNT 317



>XP_005266006
          Length = 301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 132 RTLKNT 137



>XP_005266005
          Length = 301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 132 RTLKNT 137



>XP_006714959
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 276 RTLKNT 281



>XP_006714958
          Length = 445

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 276 RTLKNT 281



>XP_005266004
          Length = 484

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RTLKNT 9
           RTLKNT
Sbjct: 315 RTLKNT 320



>NP_065433
          Length = 1091

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   LARTLKN 8
           LAR+LKN
Sbjct: 869 LARSLKN 875



>NP_004975
          Length = 1032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARTLKNT 9
           A+T+KNT
Sbjct: 324 AKTIKNT 330



>NP_004513
          Length = 957

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARTLKNT 9
           A+T+KNT
Sbjct: 324 AKTIKNT 330



>NP_004512
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   ARTLKNT 9
           A+T+KNT
Sbjct: 322 AKTIKNT 328



>NP_005600
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LARTLKNT 9
          + RTL+NT
Sbjct: 92 MGRTLQNT 99



>NP_002854
          Length = 847

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LARTLKNT 9
          + RTL+NT
Sbjct: 92 MGRTLQNT 99



>NP_002853
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LARTLKNT 9
          + RTL+NT
Sbjct: 92 MGRTLQNT 99



>XP_006723664
          Length = 843

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  LARTLKNT 9
          + RTL+NT
Sbjct: 92 MGRTLQNT 99



  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.131    0.324 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 333,073
Number of extensions: 477
Number of successful extensions: 21
Number of sequences better than 10000.0: 21
Number of HSP's gapped: 21
Number of HSP's successfully gapped: 21
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)