Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_073713                                                              20     390
NP_001240842                                                           18    1482
NP_055988                                                              18    1482
NP_001240844                                                           18    1482
NP_001240843                                                           18    1482
XP_006714064                                                           18    1482
XP_005262708                                                           18    1482
XP_005262706                                                           18    1482
XP_006714063                                                           18    1482
XP_005262705                                                           18    1482
XP_006714062                                                           18    1482
XP_005262704                                                           18    1482
XP_005262703                                                           18    1482
NP_065108                                                              17    3301
XP_006719056                                                           17    3301
NP_055863                                                              16    5631
NP_783553                                                              16    5631
NP_001185556                                                           16    5631
NP_001185561                                                           16    5631
NP_004340                                                              16    5631
NP_001185560                                                           16    5631
NP_001185559                                                           16    5631
NP_001185557                                                           16    5631
NP_001185563                                                           16    5631
NP_783552                                                              16    5631
NP_001185558                                                           16    5631
NP_001185562                                                           16    5631
NP_783554                                                              16    5631
NP_001185554                                                           16    5631
NP_001185555                                                           16    5631
NP_001185608                                                           16    5631
NP_078788                                                              16    5631
XP_006719359                                                           16    5631
XP_006719358                                                           16    5631
XP_005253915                                                           16    5631
XP_006716739                                                           16    5631
XP_006713395                                                           16    5631
NP_001191121                                                           16    7355
NP_001119713                                                           16    7355
NP_001119712                                                           16    7355
NP_005418                                                              16    7355
NP_001191113                                                           16    7355
NP_055621                                                              16    7355
NP_001129471                                                           16    7355
NP_536724                                                              16    7355
NP_001257589                                                           16    7355
NP_001257590                                                           16    7355
NP_005876                                                              16    7355
XP_006716959                                                           16    7355
XP_006710322                                                           16    7355
NP_001036                                                              15    9605
NP_001009571                                                           15    9605
NP_060424                                                              15    9605
NP_001161412                                                           15    9605
NP_055699                                                              15    9605
NP_001017392                                                           15    9605
XP_005250765                                                           15    9605
XP_005250764                                                           15    9605
XP_005250763                                                           15    9605
XP_005250762                                                           15    9605
XP_005250761                                                           15    9605
XP_005250760                                                           15    9605
XP_005250759                                                           15    9605
XP_005250758                                                           15    9605
XP_005250757                                                           15    9605
XP_005250756                                                           15    9605
XP_005250755                                                           15    9605
XP_005250754                                                           15    9605
XP_005250753                                                           15    9605
XP_005250752                                                           15    9605
NP_703145                                                              15    9605
>NP_073713
          Length = 985

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IKSVTPNLG 9
           IKSV PNLG
Sbjct: 329 IKSVAPNLG 337
>NP_001240842
          Length = 265

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           IKS  PNLG
Sbjct: 123 IKSTLPNLG 131
>NP_055988
          Length = 1168

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1026 IKSTLPNLG 1034
>NP_001240844
          Length = 180

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1  IKSVTPNLG 9
          IKS  PNLG
Sbjct: 38 IKSTLPNLG 46
>NP_001240843
          Length = 265

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           IKS  PNLG
Sbjct: 123 IKSTLPNLG 131
>XP_006714064
          Length = 546

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           IKS  PNLG
Sbjct: 404 IKSTLPNLG 412
>XP_005262708
          Length = 1039

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           IKS  PNLG
Sbjct: 897 IKSTLPNLG 905
>XP_005262706
          Length = 1146

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1004 IKSTLPNLG 1012
>XP_006714063
          Length = 1168

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1026 IKSTLPNLG 1034
>XP_005262705
          Length = 1181

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1039 IKSTLPNLG 1047
>XP_006714062
          Length = 1262

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1120 IKSTLPNLG 1128
>XP_005262704
          Length = 1262

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1120 IKSTLPNLG 1128
>XP_005262703
          Length = 1275

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IKSVTPNLG 9
            IKS  PNLG
Sbjct: 1133 IKSTLPNLG 1141
>NP_065108
          Length = 270

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           + SVTPN G
Sbjct: 226 LMSVTPNTG 234
>XP_006719056
          Length = 244

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           + SVTPN G
Sbjct: 200 LMSVTPNTG 208
>NP_055863
          Length = 1923

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 242 SVTPNSG 248
>NP_783553
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 532 SVTPNSG 538
>NP_001185556
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185561
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 542 SVTPNSG 548
>NP_004340
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 542 SVTPNSG 548
>NP_001185560
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185559
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185557
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185563
          Length = 615

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 580 SVTPNSG 586
>NP_783552
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185558
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185562
          Length = 584

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 549 SVTPNSG 555
>NP_783554
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 532 SVTPNSG 538
>NP_001185554
          Length = 577

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 542 SVTPNSG 548
>NP_001185555
          Length = 604

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 569 SVTPNSG 575
>NP_001185608
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 628 SVTPNSG 634
>NP_078788
          Length = 371

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           +KS+ P LG
Sbjct: 179 LKSIPPELG 187
>XP_006719359
          Length = 1966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 242 SVTPNSG 248
>XP_006719358
          Length = 1966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 242 SVTPNSG 248
>XP_005253915
          Length = 1966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 242 SVTPNSG 248
>XP_006716739
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           SVTPN G
Sbjct: 532 SVTPNSG 538
>XP_006713395
          Length = 219

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           +KS+ P LG
Sbjct: 179 LKSIPPELG 187
>NP_001191121
          Length = 565

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           + TPNLG
Sbjct: 369 AATPNLG 375
>NP_001119713
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           + TPNLG
Sbjct: 391 AATPNLG 397
>NP_001119712
          Length = 587

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           + TPNLG
Sbjct: 391 AATPNLG 397
>NP_005418
          Length = 636

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           + TPNLG
Sbjct: 440 AATPNLG 446
>NP_001191113
          Length = 499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   SVTPNLG 9
           + TPNLG
Sbjct: 440 AATPNLG 446
>NP_055621
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SVTPNLG 9
            SV+PN+G
Sbjct: 1027 SVSPNVG 1033
>NP_001129471
          Length = 1516

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    SVTPNLG 9
            SV+PN+G
Sbjct: 1027 SVSPNVG 1033
>NP_536724
          Length = 435

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           +  +TPN+G
Sbjct: 264 VPDLTPNIG 272
>NP_001257589
          Length = 862

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           IKSV PN
Sbjct: 454 IKSVLPN 460
>NP_001257590
          Length = 805

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           IKSV PN
Sbjct: 397 IKSVLPN 403
>NP_005876
          Length = 910

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           IKSV PN
Sbjct: 502 IKSVLPN 508
>XP_006716959
          Length = 638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   SVTPNLG 9
           SV+PN+G
Sbjct: 149 SVSPNVG 155
>XP_006710322
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IKSVTPNLG 9
           I  VTP+LG
Sbjct: 634 ILGVTPSLG 642
>NP_001036
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKSVTP 6
           IKS+TP
Sbjct: 609 IKSITP 614
>NP_001009571
          Length = 1255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>NP_060424
          Length = 1296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>NP_001161412
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>NP_055699
          Length = 1082

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKSVTPNL 8
           +KSVTP L
Sbjct: 437 LKSVTPLL 444
>NP_001017392
          Length = 1082

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKSVTPNL 8
           +KSVTP L
Sbjct: 437 LKSVTPLL 444
>XP_005250765
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250764
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250763
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250762
          Length = 1260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250761
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250760
          Length = 1268

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250759
          Length = 1293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250758
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250757
          Length = 1300

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250756
          Length = 1301

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250755
          Length = 1303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250754
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250753
          Length = 1305

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>XP_005250752
          Length = 1308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IKSVTPN 7
           +KSV PN
Sbjct: 377 LKSVAPN 383
>NP_703145
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  SVTPNL 8
          SVTPN+
Sbjct: 72 SVTPNM 77
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.308    0.133    0.367 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 651,715
Number of extensions: 728
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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