Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243070                                                           18    1482
NP_001186551                                                           18    1935
NP_065734                                                              17    3301
NP_001075445                                                           17    3301
XP_005270547                                                           17    3301
XP_005270546                                                           17    3301
XP_005270543                                                           17    3301
XP_005270542                                                           17    3301
NP_001269335                                                           17    4312
NP_076419                                                              17    4312
NP_009049                                                              16    5631
NP_009184                                                              16    5631
NP_006707                                                              16    5631
XP_006719294                                                           16    5631
XP_005250179                                                           16    5631
XP_005250177                                                           16    5631
NP_001138947                                                           16    5631
NP_690850                                                              16    5631
NP_660187                                                              16    7355
NP_149163                                                              16    7355
NP_115972                                                              16    7355
NP_001248339                                                           16    7355
NP_003558                                                              16    7355
NP_001248337                                                           16    7355
NP_001248338                                                           16    7355
NP_055571                                                              16    7355
NP_001008938                                                           16    7355
NP_006304                                                              16    7355
NP_001239007                                                           16    7355
NP_001160006                                                           16    7355
NP_001160005                                                           16    7355
XP_005269318                                                           16    7355
XP_005269316                                                           16    7355
XP_005248604                                                           16    7355
XP_005248602                                                           16    7355
NP_001136021                                                           16    7355
NP_077726                                                              16    7355
NP_001171569                                                           15    9605
NP_001761                                                              15    9605
NP_001273433                                                           15    9605
NP_001273432                                                           15    9605
NP_006635                                                              15    9605
NP_001273434                                                           15    9605
NP_002145                                                              15    9605
NP_077307                                                              15    9605
NP_005480                                                              15    9605
NP_001034288                                                           15    9605
NP_001239263                                                           15    9605
NP_001248768                                                           15    9605
NP_001136004                                                           15    9605
NP_001136005                                                           15    9605
NP_733745                                                              15    9605
NP_001136003                                                           15    9605
NP_001136006                                                           15    9605
NP_775790                                                              15    9605
NP_055524                                                              15    9605
NP_000333                                                              15    9605
XP_005260606                                                           15    9605
XP_005257650                                                           15    9605
XP_005257649                                                           15    9605
XP_005255753                                                           15    9605
XP_006721167                                                           15    9605
XP_006719820                                                           15    9605
XP_005266293                                                           15    9605
XP_005251694                                                           15    9605
XP_005251696                                                           15    9605
XP_005251233                                                           15    9605
>NP_001243070
          Length = 299

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 1  IKPFVKIL 8
          +KP+VKIL
Sbjct: 22 VKPYVKIL 29
>NP_001186551
          Length = 219

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  KPFVKILT 9
          +PFVKI+T
Sbjct: 21 EPFVKIIT 28
>NP_065734
          Length = 347

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 329 LKPFSRVLT 337
>NP_001075445
          Length = 266

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 248 LKPFSRVLT 256
>XP_005270547
          Length = 178

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 160 LKPFSRVLT 168
>XP_005270546
          Length = 193

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 175 LKPFSRVLT 183
>XP_005270543
          Length = 215

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 197 LKPFSRVLT 205
>XP_005270542
          Length = 346

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KPF ++LT
Sbjct: 328 LKPFSRVLT 336
>NP_001269335
          Length = 225

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKPFVKIL 8
          IKP VK+L
Sbjct: 85 IKPLVKLL 92
>NP_076419
          Length = 255

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           IKP VK+L
Sbjct: 115 IKPLVKLL 122
>NP_009049
          Length = 3097

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           IKP +KIL
Sbjct: 138 IKPLLKIL 145
>NP_009184
          Length = 520

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IKPFVKILT 9
           +KP++KI +
Sbjct: 160 LKPYIKIFS 168
>NP_006707
          Length = 674

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 217 KPFVKV 222
>XP_006719294
          Length = 2348

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KPFVKIL 8
            KPF+K+L
Sbjct: 2263 KPFLKLL 2269
>XP_005250179
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 217 KPFVKV 222
>XP_005250177
          Length = 673

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 216 KPFVKV 221
>NP_001138947
          Length = 2351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KPFVKIL 8
            KPF+K+L
Sbjct: 2263 KPFLKLL 2269
>NP_690850
          Length = 1714

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  PFVKIL 8
          PFVKIL
Sbjct: 93 PFVKIL 98
>NP_660187
          Length = 1344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KPFVKIL 8
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_149163
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KPFVKIL 8
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_115972
          Length = 1382

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   KPFVKIL 8
           KPF KI+
Sbjct: 359 KPFAKII 365
>NP_001248339
          Length = 734

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF K+L
Sbjct: 593 LKPFSKLL 600
>NP_003558
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF K+L
Sbjct: 684 LKPFSKLL 691
>NP_001248337
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF K+L
Sbjct: 684 LKPFSKLL 691
>NP_001248338
          Length = 825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF K+L
Sbjct: 684 LKPFSKLL 691
>NP_055571
          Length = 1972

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KP +K+L
Sbjct: 162 LKPIIKVL 169
>NP_001008938
          Length = 2032

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KP +K+L
Sbjct: 162 LKPIIKVL 169
>NP_006304
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 754 KPFVKL 759
>NP_001239007
          Length = 981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 783 KPFVKL 788
>NP_001160006
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 505 QPLVKVLT 512
>NP_001160005
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 634 QPLVKVLT 641
>XP_005269318
          Length = 648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 450 KPFVKL 455
>XP_005269316
          Length = 860

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KPFVKI 7
           KPFVK+
Sbjct: 662 KPFVKL 667
>XP_005248604
          Length = 666

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 596 QPLVKVLT 603
>XP_005248602
          Length = 700

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 630 QPLVKVLT 637
>NP_001136021
          Length = 690

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 620 QPLVKVLT 627
>NP_077726
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KPFVKILT 9
           +P VK+LT
Sbjct: 654 QPLVKVLT 661
>NP_001171569
          Length = 557

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IKPFVKI 7
          +KPF+K+
Sbjct: 58 LKPFLKL 64
>NP_001761
          Length = 556

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IKPFVKI 7
          +KPF+K+
Sbjct: 58 LKPFLKL 64
>NP_001273433
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 429 PFSKVLT 435
>NP_001273432
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_006635
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_001273434
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 351 PFSKVLT 357
>NP_002145
          Length = 840

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 427 PFSKVLT 433
>NP_077307
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 239 IKPFLK 244
>NP_005480
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 565 LKPFLKSL 572
>NP_001034288
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 239 IKPFLK 244
>NP_001239263
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 654 LKPFLKSL 661
>NP_001248768
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 205 IKPFLK 210
>NP_001136004
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 368 LKPFLKSL 375
>NP_001136005
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 564 LKPFLKSL 571
>NP_733745
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 722 LKPFLKSL 729
>NP_001136003
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 368 LKPFLKSL 375
>NP_001136006
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 562 LKPFLKSL 569
>NP_775790
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 236 IKPFLK 241
>NP_055524
          Length = 3546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PFVKILT 9
            PF K+LT
Sbjct: 2602 PFFKLLT 2608
>NP_000333
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PFV ILT
Sbjct: 860 PFVLILT 866
>XP_005260606
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 239 IKPFLK 244
>XP_005257650
          Length = 846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PFV ILT
Sbjct: 795 PFVLILT 801
>XP_005257649
          Length = 911

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PFV ILT
Sbjct: 860 PFVLILT 866
>XP_005255753
          Length = 282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IKPFVKI 7
          +KPF+K+
Sbjct: 58 LKPFLKL 64
>XP_006721167
          Length = 319

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IKPFVKI 7
          +KPF+K+
Sbjct: 58 LKPFLKL 64
>XP_006719820
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 482 PFSKVLT 488
>XP_005266293
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PFVKILT 9
           PF K+LT
Sbjct: 429 PFSKVLT 435
>XP_005251694
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 684 LKPFLKSL 691
>XP_005251696
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKPFVKIL 8
           +KPF+K L
Sbjct: 368 LKPFLKSL 375
>XP_005251233
          Length = 354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IKPFVK 6
           IKPF+K
Sbjct: 236 IKPFLK 241
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.155    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 587,135
Number of extensions: 945
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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