Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              20     509
NP_005913                                                              20     509
XP_005267046                                                           20     509
XP_005267045                                                           20     509
NP_001095896                                                           17    4312
NP_001158152                                                           17    4312
NP_847898                                                              17    4312
XP_005263921                                                           17    4312
XP_005263920                                                           17    4312
XP_005263919                                                           17    4312
NP_001130                                                              16    5631
NP_006195                                                              16    5631
NP_067641                                                              16    7355
NP_001159432                                                           16    7355
NP_612486                                                              16    7355
NP_071735                                                              16    7355
NP_001132                                                              16    7355
XP_006725154                                                           16    7355
XP_006724202                                                           16    7355
XP_005256802                                                           16    7355
XP_005254235                                                           16    7355
XP_005254233                                                           16    7355
XP_005254234                                                           16    7355
XP_006716678                                                           16    7355
XP_005265443                                                           16    7355
XP_005265442                                                           16    7355
XP_005265441                                                           16    7355
XP_005265440                                                           16    7355
NP_689639                                                              16    7355
NP_001034219                                                           16    7355
NP_001034220                                                           16    7355
NP_001094348                                                           16    7355
NP_620581                                                              15    9605
NP_620583                                                              15    9605
NP_620582                                                              15    9605
NP_004657                                                              15    9605
NP_001243000                                                           15    9605
NP_005329                                                              15    9605
NP_009069                                                              15    9605
NP_976241                                                              15    9605
NP_998754                                                              15    9605
NP_001230127                                                           15    9605
NP_001229279                                                           15    9605
NP_511043                                                              15    9605
NP_068776                                                              15    9605
NP_004656                                                              15    9605
NP_004446                                                              15    9605
XP_005257603                                                           15    9605
XP_006722058                                                           15    9605
XP_005257602                                                           15    9605
XP_006719746                                                           15    9605
XP_005253685                                                           15    9605
XP_005253684                                                           15    9605
XP_006719126                                                           15    9605
XP_005253411                                                           15    9605
XP_005253410                                                           15    9605
XP_006719125                                                           15    9605
XP_005253409                                                           15    9605
XP_005250362                                                           15    9605
XP_005250361                                                           15    9605
XP_006715656                                                           15    9605
XP_006715061                                                           15    9605
XP_005246837                                                           15    9605
XP_005246836                                                           15    9605
XP_006712758                                                           15    9605
XP_005246834                                                           15    9605
XP_006710511                                                           15    9605
XP_006710510                                                           15    9605
XP_005245836                                                           15    9605
NP_003950                                                              15    9605
>NP_006715
          Length = 1558

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KLILRLHK 9
           KLILRLHK
Sbjct: 541 KLILRLHK 548
>NP_005913
          Length = 1608

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KLILRLHK 9
           KLILRLHK
Sbjct: 541 KLILRLHK 548
>XP_005267046
          Length = 1554

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KLILRLHK 9
           KLILRLHK
Sbjct: 541 KLILRLHK 548
>XP_005267045
          Length = 1604

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   KLILRLHK 9
           KLILRLHK
Sbjct: 541 KLILRLHK 548
>NP_001095896
          Length = 1140

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           IKL+ RLH
Sbjct: 917 IKLLYRLH 924
>NP_001158152
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IKLILRLHK 9
          I+++LR HK
Sbjct: 5  IRMLLRAHK 13
>NP_847898
          Length = 376

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IKLILRLHK 9
          I+++LR HK
Sbjct: 5  IRMLLRAHK 13
>XP_005263921
          Length = 1147

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           IKL+ RLH
Sbjct: 924 IKLLYRLH 931
>XP_005263920
          Length = 1155

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           IKL+ RLH
Sbjct: 932 IKLLYRLH 939
>XP_005263919
          Length = 1162

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           IKL+ RLH
Sbjct: 939 IKLLYRLH 946
>NP_001130
          Length = 701

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LILRLHK 9
          +I+RLHK
Sbjct: 65 IIIRLHK 71
>NP_006195
          Length = 858

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           + +ILRLH
Sbjct: 220 VSIILRLH 227
>NP_067641
          Length = 711

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LILRLHK 9
          L+LR+HK
Sbjct: 65 LLLRVHK 71
>NP_001159432
          Length = 843

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LR+HK
Sbjct: 197 LLLRVHK 203
>NP_612486
          Length = 1227

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LRLH+
Sbjct: 719 LLLRLHR 725
>NP_071735
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLILRLHK 9
           KLI+RL K
Sbjct: 123 KLIIRLEK 130
>NP_001132
          Length = 676

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LILRLHK 9
          L+LR+HK
Sbjct: 65 LLLRVHK 71
>XP_006725154
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           + L+LRLH
Sbjct: 534 VPLLLRLH 541
>XP_006724202
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           ++LRLHK
Sbjct: 146 VLLRLHK 152
>XP_005256802
          Length = 867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LR+HK
Sbjct: 221 LLLRVHK 227
>XP_005254235
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LRLH+
Sbjct: 720 LLLRLHR 726
>XP_005254233
          Length = 1228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LRLH+
Sbjct: 720 LLLRLHR 726
>XP_005254234
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           L+LRLH+
Sbjct: 720 LLLRLHR 726
>XP_006716678
          Length = 585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           + L+LRLH
Sbjct: 534 VPLLLRLH 541
>XP_005265443
          Length = 695

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  KLILRLHK 9
          KLI+RL K
Sbjct: 34 KLIIRLEK 41
>XP_005265442
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLILRLHK 9
           KLI+RL K
Sbjct: 123 KLIIRLEK 130
>XP_005265441
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLILRLHK 9
           KLI+RL K
Sbjct: 123 KLIIRLEK 130
>XP_005265440
          Length = 784

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KLILRLHK 9
           KLI+RL K
Sbjct: 123 KLIIRLEK 130
>NP_689639
          Length = 386

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LILRLHK 9
           ++LRLHK
Sbjct: 146 VLLRLHK 152
>NP_001034219
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LILRLHK 9
          L+LR+HK
Sbjct: 65 LLLRVHK 71
>NP_001034220
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LILRLHK 9
          L+LR+HK
Sbjct: 65 LLLRVHK 71
>NP_001094348
          Length = 719

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           + L+LRLH
Sbjct: 533 VPLLLRLH 540
>NP_620581
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IKLILRL 7
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_620583
          Length = 307

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IKLILRL 7
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_620582
          Length = 297

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IKLILRL 7
           +KLILRL
Sbjct: 232 LKLILRL 238
>NP_004657
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KLILRLHK 9
           KL+ R HK
Sbjct: 171 KLVARYHK 178
>NP_001243000
          Length = 5207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ILRLHK 9
            +LRLHK
Sbjct: 5090 LLRLHK 5095
>NP_005329
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 240 VKLLFKLH 247
>NP_009069
          Length = 601

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   LILRLHK 9
           L+LR HK
Sbjct: 354 LVLRTHK 360
>NP_976241
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 322 KLVIRVH 328
>NP_998754
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 270 KLVIRVH 276
>NP_001230127
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 240 VKLLFKLH 247
>NP_001229279
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KLILRLHK 9
           KL+ R HK
Sbjct: 172 KLVARYHK 179
>NP_511043
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KLILRLHK 9
           KL+ R HK
Sbjct: 119 KLVARYHK 126
>NP_068776
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 349 LNFLLRMHK 357
>NP_004656
          Length = 520

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KLILRLHK 9
           KL+ R HK
Sbjct: 172 KLVARYHK 179
>NP_004446
          Length = 676

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LILRLH 8
           L+LRLH
Sbjct: 160 LVLRLH 165
>XP_005257603
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ILRLHK 9
            +LRLHK
Sbjct: 5139 LLRLHK 5144
>XP_006722058
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ILRLHK 9
            +LRLHK
Sbjct: 5139 LLRLHK 5144
>XP_005257602
          Length = 5256

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    ILRLHK 9
            +LRLHK
Sbjct: 5139 LLRLHK 5144
>XP_006719746
          Length = 603

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 219 VKLLFKLH 226
>XP_005253685
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 219 VKLLFKLH 226
>XP_005253684
          Length = 1073

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 231 VKLLFKLH 238
>XP_006719126
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 272 LNFLLRMHK 280
>XP_005253411
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 276 LNFLLRMHK 284
>XP_005253410
          Length = 686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 332 LNFLLRMHK 340
>XP_006719125
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 349 LNFLLRMHK 357
>XP_005253409
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IKLILRLHK 9
           +  +LR+HK
Sbjct: 349 LNFLLRMHK 357
>XP_005250362
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 206 VKLLFKLH 213
>XP_005250361
          Length = 1008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 211 VKLLFKLH 218
>XP_006715656
          Length = 467

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KLILRLHK 9
           KL+ R HK
Sbjct: 119 KLVARYHK 126
>XP_006715061
          Length = 283

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IKLILRL 7
           +KLILRL
Sbjct: 155 LKLILRL 161
>XP_005246837
          Length = 1277

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 297 KLVIRVH 303
>XP_005246836
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 322 KLVIRVH 328
>XP_006712758
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 322 KLVIRVH 328
>XP_005246834
          Length = 1302

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLILRLH 8
           KL++R+H
Sbjct: 322 KLVIRVH 328
>XP_006710511
          Length = 484

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LILRLH 8
           L+LRLH
Sbjct: 160 LVLRLH 165
>XP_006710510
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LILRLH 8
           L+LRLH
Sbjct: 160 LVLRLH 165
>XP_005245836
          Length = 640

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   LILRLH 8
           L+LRLH
Sbjct: 160 LVLRLH 165
>NP_003950
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IKLILRLH 8
           +KL+ +LH
Sbjct: 231 VKLLFKLH 238
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.345    0.161    0.441 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 547,249
Number of extensions: 1278
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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