Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001257436                                                           22     103
NP_001257437                                                           22     103
NP_006281                                                              22     103
XP_005267176                                                           22     103
NP_003238                                                              18    1482
NP_001239586                                                           17    4312
XP_006713051                                                           17    4312
NP_000589                                                              16    5631
NP_001128662                                                           16    5631
NP_056057                                                              16    5631
NP_001013416                                                           16    5631
NP_001035207                                                           16    5631
NP_061939                                                              16    5631
NP_055383                                                              16    5631
NP_006098                                                              16    5631
NP_057508                                                              16    5631
XP_006722006                                                           16    5631
XP_005257508                                                           16    5631
XP_005257507                                                           16    5631
XP_005257506                                                           16    5631
XP_005257505                                                           16    5631
NP_003237                                                              16    7355
NP_060893                                                              16    7355
NP_612372                                                              16    7355
NP_112598                                                              16    7355
NP_001258436                                                           16    7355
XP_005257839                                                           16    7355
XP_006722230                                                           16    7355
XP_006722229                                                           16    7355
XP_005257838                                                           16    7355
XP_005257837                                                           16    7355
XP_005257836                                                           16    7355
XP_005257835                                                           16    7355
XP_005257834                                                           16    7355
XP_005253474                                                           16    7355
XP_006714967                                                           16    7355
NP_001035203                                                           15    9605
NP_006260                                                              15    9605
NP_002465                                                              15    9605
NP_001182612                                                           15    9605
NP_003283                                                              15    9605
NP_003234                                                              15    9605
NP_878918                                                              15    9605
NP_001182613                                                           15    9605
NP_055995                                                              15    9605
NP_001263334                                                           15    9605
NP_001035364                                                           15    9605
NP_004720                                                              15    9605
NP_001164607                                                           15    9605
NP_001164606                                                           15    9605
NP_683692                                                              15    9605
NP_001009996                                                           15    9605
XP_006726560                                                           15    9605
XP_005267517                                                           15    9605
XP_005267516                                                           15    9605
XP_005267515                                                           15    9605
XP_005267514                                                           15    9605
XP_005267513                                                           15    9605
XP_005267512                                                           15    9605
XP_005267511                                                           15    9605
XP_005266384                                                           15    9605
XP_006719857                                                           15    9605
XP_006719856                                                           15    9605
XP_005266378                                                           15    9605
XP_005248208                                                           15    9605
XP_005248207                                                           15    9605
XP_006714021                                                           15    9605
XP_005265331                                                           15    9605
XP_005265329                                                           15    9605
XP_005265327                                                           15    9605
XP_005265326                                                           15    9605
XP_005265324                                                           15    9605
XP_005265323                                                           15    9605
XP_005245528                                                           15    9605
XP_006710931                                                           15    9605
XP_006710930                                                           15    9605
>NP_001257436
          Length = 790

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IKETDTRNF 9
           +KETDTRNF
Sbjct: 130 LKETDTRNF 138
>NP_001257437
          Length = 790

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IKETDTRNF 9
           +KETDTRNF
Sbjct: 130 LKETDTRNF 138
>NP_006281
          Length = 790

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IKETDTRNF 9
           +KETDTRNF
Sbjct: 130 LKETDTRNF 138
>XP_005267176
          Length = 790

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IKETDTRNF 9
           +KETDTRNF
Sbjct: 130 LKETDTRNF 138
>NP_003238
          Length = 1172

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   IKETDTRNF 9
           I ETD RNF
Sbjct: 954 ISETDFRNF 962
>NP_001239586
          Length = 630

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KETDTRNF 9
           KE+DT++F
Sbjct: 582 KESDTKSF 589
>XP_006713051
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KETDTRNF 9
           KE+DT++F
Sbjct: 582 KESDTKSF 589
>NP_000589
          Length = 291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KETDTRNF 9
           + TDT+NF
Sbjct: 193 QSTDTQNF 200
>NP_001128662
          Length = 1133

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKETDTRNF 9
           +KE D R+F
Sbjct: 245 VKEVDRRSF 253
>NP_056057
          Length = 1205

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKETDTRNF 9
           +KE D R+F
Sbjct: 245 VKEVDRRSF 253
>NP_001013416
          Length = 297

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   KETDTRNF 9
           + TDT+NF
Sbjct: 199 QSTDTQNF 206
>NP_001035207
          Length = 1450

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IKETDTRNF 9
           +KE D R+F
Sbjct: 490 VKEVDRRSF 498
>NP_061939
          Length = 1249

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IKETDTRN 8
            +KE DT+N
Sbjct: 1077 LKEIDTKN 1084
>NP_055383
          Length = 940

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IKETDT 6
           IKETDT
Sbjct: 659 IKETDT 664
>NP_006098
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>NP_057508
          Length = 432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>XP_006722006
          Length = 413

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 332 KESDTKN 338
>XP_005257508
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>XP_005257507
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>XP_005257506
          Length = 472

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>XP_005257505
          Length = 489

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           KE+DT+N
Sbjct: 408 KESDTKN 414
>NP_003237
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IKETDTRNF 9
           I ETD R F
Sbjct: 952 ISETDFRRF 960
>NP_060893
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  IKETDTRNF 9
          +KET   NF
Sbjct: 87 LKETSVENF 95
>NP_612372
          Length = 821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 472 RETDVRQF 479
>NP_112598
          Length = 5088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IKETDTRN 8
            I+ET+T+N
Sbjct: 1835 IEETETQN 1842
>NP_001258436
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   KETDTRNF 9
           +ET+TR+F
Sbjct: 684 EETNTRSF 691
>XP_005257839
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 520 RETDVRQF 527
>XP_006722230
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 260 RETDVRQF 267
>XP_006722229
          Length = 610

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 260 RETDVRQF 267
>XP_005257838
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 308 RETDVRQF 315
>XP_005257837
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 308 RETDVRQF 315
>XP_005257836
          Length = 822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 472 RETDVRQF 479
>XP_005257835
          Length = 869

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 520 RETDVRQF 527
>XP_005257834
          Length = 870

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +ETD R F
Sbjct: 520 RETDVRQF 527
>XP_005253474
          Length = 422

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  IKETDTRNF 9
          +KET   NF
Sbjct: 87 LKETSVENF 95
>XP_006714967
          Length = 1327

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    IKETDTRNF 9
            +KE   RNF
Sbjct: 1314 VKENQLRNF 1322
>NP_001035203
          Length = 1979

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KETDTRN 8
            +ETDTR+
Sbjct: 1963 EETDTRD 1969
>NP_006260
          Length = 2156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2    KETDTRNF 9
            KE+D  NF
Sbjct: 1939 KESDIENF 1946
>NP_002465
          Length = 1972

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    KETDTRN 8
            +ETDTR+
Sbjct: 1956 EETDTRD 1962
>NP_001182612
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ET+ RNF
Sbjct: 147 ETEERNF 153
>NP_003283
          Length = 2363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KETDTRN 8
            KET+ RN
Sbjct: 1507 KETEARN 1513
>NP_003234
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ET+ RNF
Sbjct: 147 ETEERNF 153
>NP_878918
          Length = 6907

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>NP_001182613
          Length = 850

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ET+ RNF
Sbjct: 147 ETEERNF 153
>NP_055995
          Length = 6885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>NP_001263334
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>NP_001035364
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ETD+R F
Sbjct: 272 ETDSRRF 278
>NP_004720
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKETDTR 7
           IKETD++
Sbjct: 436 IKETDSK 442
>NP_001164607
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKETDTR 7
           IKETD++
Sbjct: 436 IKETDSK 442
>NP_001164606
          Length = 694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IKETDTR 7
           IKETD++
Sbjct: 436 IKETDSK 442
>NP_683692
          Length = 3051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           +ETDTR+
Sbjct: 669 EETDTRD 675
>NP_001009996
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_006726560
          Length = 197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  IKETDT 6
          +KETDT
Sbjct: 33 LKETDT 38
>XP_005267517
          Length = 6883

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 4979 LKETDT 4984
>XP_005267516
          Length = 6884

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005267515
          Length = 6899

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005267514
          Length = 6908

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005267513
          Length = 6921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005267512
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005267511
          Length = 6922

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    IKETDT 6
            +KETDT
Sbjct: 5018 LKETDT 5023
>XP_005266384
          Length = 171

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +E DTR F
Sbjct: 153 EEADTRGF 160
>XP_006719857
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +E DTR F
Sbjct: 275 EEADTRGF 282
>XP_006719856
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +E DTR F
Sbjct: 275 EEADTRGF 282
>XP_005266378
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   KETDTRNF 9
           +E DTR F
Sbjct: 275 EEADTRGF 282
>XP_005248208
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           +ETDTR+
Sbjct: 669 EETDTRD 675
>XP_005248207
          Length = 3098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           +ETDTR+
Sbjct: 669 EETDTRD 675
>XP_006714021
          Length = 3112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   KETDTRN 8
           +ETDTR+
Sbjct: 669 EETDTRD 675
>XP_005265331
          Length = 378

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005265329
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005265327
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005265326
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005265324
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005265323
          Length = 602

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IKETDTRN 8
          IKET TR+
Sbjct: 27 IKETRTRH 34
>XP_005245528
          Length = 2439

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    KETDTRN 8
            KET+ RN
Sbjct: 1583 KETEARN 1589
>XP_006710931
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ET+ RNF
Sbjct: 147 ETEERNF 153
>XP_006710930
          Length = 851

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETDTRNF 9
           ET+ RNF
Sbjct: 147 ETEERNF 153
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.132    0.359 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 585,346
Number of extensions: 1363
Number of successful extensions: 76
Number of sequences better than 10000.0: 76
Number of HSP's gapped: 76
Number of HSP's successfully gapped: 76
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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