Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001004432                                                           17    2528
NP_003652                                                              17    3301
NP_001130012                                                           17    3301
NP_663318                                                              17    3301
NP_001130013                                                           17    3301
NP_064450                                                              17    3301
XP_005261853                                                           17    3301
XP_005261852                                                           17    3301
XP_005273257                                                           17    3301
NP_003027                                                              16    5631
NP_872296                                                              16    5631
NP_054747                                                              16    5631
NP_001276098                                                           16    5631
NP_001276097                                                           16    5631
NP_001276096                                                           16    5631
NP_001276095                                                           16    5631
NP_060681                                                              16    5631
XP_006723433                                                           16    5631
XP_005259289                                                           16    5631
XP_006715527                                                           16    5631
XP_005244832                                                           16    5631
XP_006710801                                                           16    5631
NP_112235                                                              16    7355
NP_001188478                                                           16    7355
NP_001827                                                              16    7355
NP_001188476                                                           16    7355
NP_004687                                                              16    7355
NP_001051                                                              16    7355
NP_963998                                                              16    7355
NP_077283                                                              16    7355
XP_005259057                                                           16    7355
XP_005259056                                                           16    7355
XP_006723307                                                           16    7355
XP_005259055                                                           16    7355
XP_005271375                                                           16    7355
XP_005271374                                                           16    7355
NP_059128                                                              16    7355
NP_001933                                                              15    9605
NP_037434                                                              15    9605
NP_112092                                                              15    9605
NP_001230925                                                           15    9605
NP_001027                                                              15    9605
NP_612396                                                              15    9605
NP_663612                                                              15    9605
NP_056535                                                              15    9605
XP_005276554                                                           15    9605
XP_006724281                                                           15    9605
XP_006724280                                                           15    9605
>NP_001004432
          Length = 593

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IIAMGLLPF 9
           ++A+G LPF
Sbjct: 535 VLAVGFLPF 543
>NP_003652
          Length = 398

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 191 LVGMGLAPF 199
>NP_001130012
          Length = 398

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 191 LVGMGLAPF 199
>NP_663318
          Length = 414

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 207 LVGMGLAPF 215
>NP_001130013
          Length = 380

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 173 LVGMGLAPF 181
>NP_064450
          Length = 1722

 Score = 16.9 bits (32), Expect =  3301
 Identities = 9/10 (90%), Positives = 9/10 (90%), Gaps = 1/10 (10%)

Query: 1   IIAMG-LLPF 9
           IIAMG LLPF
Sbjct: 565 IIAMGLLLPF 574
>XP_005261853
          Length = 380

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 173 LVGMGLAPF 181
>XP_005261852
          Length = 396

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ MGL PF
Sbjct: 189 LVGMGLAPF 197
>XP_005273257
          Length = 1726

 Score = 16.9 bits (32), Expect =  3301
 Identities = 9/10 (90%), Positives = 9/10 (90%), Gaps = 1/10 (10%)

Query: 1   IIAMG-LLPF 9
           IIAMG LLPF
Sbjct: 565 IIAMGLLLPF 574
>NP_003027
          Length = 728

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MGLLPF 9
           MG+LPF
Sbjct: 164 MGILPF 169
>NP_872296
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 59 LVAVGHLPF 67
>NP_054747
          Length = 334

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IAMGLLPF 9
          +A+G LPF
Sbjct: 28 LALGALPF 35
>NP_001276098
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 8  LVAVGHLPF 16
>NP_001276097
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 8  LVAVGHLPF 16
>NP_001276096
          Length = 748

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 8  LVAVGHLPF 16
>NP_001276095
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 59 LVAVGHLPF 67
>NP_060681
          Length = 678

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MGLLPF 9
           MG+LPF
Sbjct: 472 MGMLPF 477
>XP_006723433
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 59 LVAVGHLPF 67
>XP_005259289
          Length = 799

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IIAMGLLPF 9
          ++A+G LPF
Sbjct: 59 LVAVGHLPF 67
>XP_006715527
          Length = 280

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  IAMGLLPF 9
          +A+G LPF
Sbjct: 28 LALGALPF 35
>XP_005244832
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MGLLPF 9
           MG+LPF
Sbjct: 164 MGILPF 169
>XP_006710801
          Length = 647

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MGLLPF 9
           MG+LPF
Sbjct: 441 MGMLPF 446
>NP_112235
          Length = 747

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 521 IFMGLIPY 528
>NP_001188478
          Length = 319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAMGLLP 8
           + MGLLP
Sbjct: 115 VTMGLLP 121
>NP_001827
          Length = 247

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           +A+G LPF
Sbjct: 124 LAVGTLPF 131
>NP_001188476
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IAMGLLP 8
          + MGLLP
Sbjct: 53 VTMGLLP 59
>NP_004687
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAMGLLP 8
           + MGLLP
Sbjct: 115 VTMGLLP 121
>NP_001051
          Length = 343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IAMGLLP 8
           +A+GLLP
Sbjct: 161 LALGLLP 167
>NP_963998
          Length = 407

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   IAMGLLP 8
           +A+GLLP
Sbjct: 161 LALGLLP 167
>NP_077283
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   MGLLPF 9
           +GLLPF
Sbjct: 213 LGLLPF 218
>XP_005259057
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 213 IFMGLIPY 220
>XP_005259056
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 213 IFMGLIPY 220
>XP_006723307
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 228 IFMGLIPY 235
>XP_005259055
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 228 IFMGLIPY 235
>XP_005271375
          Length = 257

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  IAMGLLP 8
          + MGLLP
Sbjct: 53 VTMGLLP 59
>XP_005271374
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   IAMGLLP 8
           + MGLLP
Sbjct: 115 VTMGLLP 121
>NP_059128
          Length = 416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           I MGL+P+
Sbjct: 213 IFMGLIPY 220
>NP_001933
          Length = 1049

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   IAMGLLPF 9
           + +GL+PF
Sbjct: 559 LVLGLVPF 566
>NP_037434
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AMGLLPF 9
           +MGL PF
Sbjct: 320 SMGLAPF 326
>NP_112092
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ +GL PF
Sbjct: 132 LLGLGLAPF 140
>NP_001230925
          Length = 4865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IAMGLLPF 9
            +AMG+L F
Sbjct: 1417 LAMGMLSF 1424
>NP_001027
          Length = 4870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    IAMGLLPF 9
            +AMG+L F
Sbjct: 1417 LAMGMLSF 1424
>NP_612396
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IIAMGLL 7
           ++AMGLL
Sbjct: 288 VLAMGLL 294
>NP_663612
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ +GL PF
Sbjct: 132 LLGLGLAPF 140
>NP_056535
          Length = 605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   IIAMGLL 7
           IIA+GLL
Sbjct: 515 IIALGLL 521
>XP_005276554
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   AMGLLPF 9
           +MGL PF
Sbjct: 320 SMGLAPF 326
>XP_006724281
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ +GL PF
Sbjct: 132 LLGLGLAPF 140
>XP_006724280
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IIAMGLLPF 9
           ++ +GL PF
Sbjct: 210 LLGLGLAPF 218
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.346    0.166    0.508 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 472,361
Number of extensions: 551
Number of successful extensions: 48
Number of sequences better than 10000.0: 48
Number of HSP's gapped: 48
Number of HSP's successfully gapped: 48
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.6 bits)
S2: 28 (15.4 bits)

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