Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     390
NP_671714                                                              20     390
XP_006715890                                                           20     390
XP_005250160                                                           20     390
XP_005250159                                                           20     390
NP_001092693                                                           18    1482
NP_001092692                                                           18    1482
NP_079379                                                              18    1482
NP_001093164                                                           17    3301
XP_006723084                                                           17    3301
XP_006723083                                                           17    3301
XP_006723082                                                           17    3301
XP_005258584                                                           17    3301
NP_001005376                                                           16    5631
NP_001005377                                                           16    5631
NP_002650                                                              16    5631
NP_001131140                                                           16    5631
NP_036247                                                              16    5631
NP_001131139                                                           16    5631
NP_005717                                                              16    5631
NP_001166167                                                           16    5631
XP_005259047                                                           16    5631
XP_005259046                                                           16    5631
XP_006723304                                                           16    5631
XP_005259045                                                           16    5631
NP_001104537                                                           16    7355
NP_001096                                                              16    7355
NP_001129243                                                           16    7355
NP_665804                                                              16    7355
NP_001092688                                                           16    7355
NP_115605                                                              16    7355
NP_002942                                                              16    7355
XP_006723915                                                           16    7355
XP_006723914                                                           16    7355
XP_005260548                                                           16    7355
XP_006723913                                                           16    7355
XP_006723912                                                           16    7355
XP_006723128                                                           16    7355
XP_006723127                                                           16    7355
XP_006712888                                                           16    7355
XP_005246996                                                           16    7355
XP_005246997                                                           16    7355
XP_005262682                                                           16    7355
NP_689816                                                              16    7355
NP_001177                                                              15    9605
NP_996749                                                              15    9605
NP_078966                                                              15    9605
NP_077008                                                              15    9605
NP_001166045                                                           15    9605
NP_078872                                                              15    9605
NP_872335                                                              15    9605
NP_002702                                                              15    9605
NP_056052                                                              15    9605
NP_001123947                                                           15    9605
NP_003096                                                              15    9605
XP_006724097                                                           15    9605
XP_005261071                                                           15    9605
XP_005261070                                                           15    9605
XP_005261069                                                           15    9605
XP_006723004                                                           15    9605
XP_006722947                                                           15    9605
XP_005266092                                                           15    9605
XP_005266091                                                           15    9605
XP_005250530                                                           15    9605
NP_002998                                                              15    9605
>NP_005742
          Length = 3907

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IHSQKTNLE 9
            IHSQ TNLE
Sbjct: 1307 IHSQMTNLE 1315
>NP_671714
          Length = 3899

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IHSQKTNLE 9
            IHSQ TNLE
Sbjct: 1307 IHSQMTNLE 1315
>XP_006715890
          Length = 3860

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IHSQKTNLE 9
            IHSQ TNLE
Sbjct: 1307 IHSQMTNLE 1315
>XP_005250160
          Length = 3939

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IHSQKTNLE 9
            IHSQ TNLE
Sbjct: 1307 IHSQMTNLE 1315
>XP_005250159
          Length = 3952

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IHSQKTNLE 9
            IHSQ TNLE
Sbjct: 1307 IHSQMTNLE 1315
>NP_001092693
          Length = 600

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           HSQ TNLE
Sbjct: 539 HSQLTNLE 546
>NP_001092692
          Length = 600

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           HSQ TNLE
Sbjct: 539 HSQLTNLE 546
>NP_079379
          Length = 600

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           HSQ TNLE
Sbjct: 539 HSQLTNLE 546
>NP_001093164
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IHSQKTNLE 9
           + SQK+NLE
Sbjct: 463 VFSQKSNLE 471
>XP_006723084
          Length = 562

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IHSQKTNLE 9
           + SQK+NLE
Sbjct: 435 VFSQKSNLE 443
>XP_006723083
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IHSQKTNLE 9
           + SQK+NLE
Sbjct: 463 VFSQKSNLE 471
>XP_006723082
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IHSQKTNLE 9
           + SQK+NLE
Sbjct: 463 VFSQKSNLE 471
>XP_005258584
          Length = 590

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IHSQKTNLE 9
           + SQK+NLE
Sbjct: 463 VFSQKSNLE 471
>NP_001005376
          Length = 281

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 69 HSEKTN 74
>NP_001005377
          Length = 290

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 69 HSEKTN 74
>NP_002650
          Length = 335

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 69 HSEKTN 74
>NP_001131140
          Length = 1982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HSQKTNLE 9
           H QKTN E
Sbjct: 496 HLQKTNKE 503
>NP_036247
          Length = 1982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HSQKTNLE 9
           H QKTN E
Sbjct: 496 HLQKTNKE 503
>NP_001131139
          Length = 1982

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   HSQKTNLE 9
           H QKTN E
Sbjct: 496 HLQKTNKE 503
>NP_005717
          Length = 325

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QKTNLE 9
           QKTNLE
Sbjct: 245 QKTNLE 250
>NP_001166167
          Length = 346

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   QKTNLE 9
           QKTNLE
Sbjct: 266 QKTNLE 271
>XP_005259047
          Length = 279

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 69 HSEKTN 74
>XP_005259046
          Length = 286

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 69 HSEKTN 74
>XP_006723304
          Length = 310

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 44 HSEKTN 49
>XP_005259045
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  HSQKTN 7
          HS+KTN
Sbjct: 64 HSEKTN 69
>NP_001104537
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +HSQ TN
Sbjct: 360 MHSQSTN 366
>NP_001096
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +HSQ TN
Sbjct: 360 MHSQSTN 366
>NP_001129243
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 406 LHNQKTGQE 414
>NP_665804
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           HS KT+L+
Sbjct: 261 HSDKTSLQ 268
>NP_001092688
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +HSQ  N+E
Sbjct: 758 MHSQDLNME 766
>NP_115605
          Length = 841

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           IH Q+ N+E
Sbjct: 345 IHCQERNIE 353
>NP_002942
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 438 LHNQKTGQE 446
>XP_006723915
          Length = 615

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 454 LHNQKTGQE 462
>XP_006723914
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 454 LHNQKTGQE 462
>XP_005260548
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 438 LHNQKTGQE 446
>XP_006723913
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 454 LHNQKTGQE 462
>XP_006723912
          Length = 663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +H+QKT  E
Sbjct: 454 LHNQKTGQE 462
>XP_006723128
          Length = 623

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQKTNL 8
           SQKTNL
Sbjct: 515 SQKTNL 520
>XP_006723127
          Length = 647

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQKTNL 8
           SQKTNL
Sbjct: 515 SQKTNL 520
>XP_006712888
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +HSQ TN
Sbjct: 360 MHSQSTN 366
>XP_005246996
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +HSQ TN
Sbjct: 360 MHSQSTN 366
>XP_005246997
          Length = 509

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +HSQ TN
Sbjct: 360 MHSQSTN 366
>XP_005262682
          Length = 1150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +HSQ  N+E
Sbjct: 749 MHSQDLNME 757
>NP_689816
          Length = 616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   SQKTNL 8
           SQKTNL
Sbjct: 484 SQKTNL 489
>NP_001177
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>NP_996749
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>NP_078966
          Length = 14507

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HSQKTNL 8
            HS+ TNL
Sbjct: 9699 HSEMTNL 9705
>NP_077008
          Length = 468

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +H+ KTN
Sbjct: 215 VHASKTN 221
>NP_001166045
          Length = 610

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +  QKTNL+
Sbjct: 138 LQRQKTNLD 146
>NP_078872
          Length = 835

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +  QKTNL+
Sbjct: 138 LQRQKTNLD 146
>NP_872335
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  SQKTNLE 9
          SQK NLE
Sbjct: 58 SQKKNLE 64
>NP_002702
          Length = 1122

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSQKTNL 8
           HS +TNL
Sbjct: 583 HSPRTNL 589
>NP_056052
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IHSQKTNL 8
           IH Q TN+
Sbjct: 366 IHEQDTNV 373
>NP_001123947
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   SQKTNLE 9
           SQK NLE
Sbjct: 100 SQKKNLE 106
>NP_003096
          Length = 2214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2    HSQKTN 7
            HS KTN
Sbjct: 1606 HSNKTN 1611
>XP_006724097
          Length = 623

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>XP_005261071
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>XP_005261070
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>XP_005261069
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   HSQKTNLE 9
           H QKT+L+
Sbjct: 149 HCQKTDLK 156
>XP_006723004
          Length = 6443

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    HSQKTNL 8
            HS+ TNL
Sbjct: 1613 HSEMTNL 1619
>XP_006722947
          Length = 412

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IHSQKTN 7
           +H+ KTN
Sbjct: 215 VHASKTN 221
>XP_005266092
          Length = 480

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +  QKTNL+
Sbjct: 138 LQRQKTNLD 146
>XP_005266091
          Length = 865

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IHSQKTNLE 9
           +  QKTNL+
Sbjct: 138 LQRQKTNLD 146
>XP_005250530
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   HSQKTNL 8
           HS +TNL
Sbjct: 382 HSPRTNL 388
>NP_002998
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 2   HSQKTN 7
           HSQK N
Sbjct: 339 HSQKAN 344
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.303    0.117    0.299 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 579,508
Number of extensions: 1283
Number of successful extensions: 65
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 65
Number of HSP's successfully gapped: 65
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.3 bits)
S2: 28 (15.4 bits)

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