Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006209                                                              21     229
XP_006713721                                                           21     229
NP_055569                                                              17    2528
NP_001277154                                                           17    2528
NP_898885                                                              17    2528
NP_003316                                                              17    3301
NP_775821                                                              17    3301
XP_005251455                                                           17    3301
XP_005251456                                                           17    3301
XP_005251454                                                           17    3301
NP_001018062                                                           17    4312
NP_001018060                                                           17    4312
NP_001136438                                                           17    4312
NP_689854                                                              17    4312
NP_003829                                                              17    4312
NP_001269813                                                           17    4312
NP_001269814                                                           17    4312
NP_612211                                                              17    4312
XP_006722611                                                           17    4312
XP_006722610                                                           17    4312
XP_006719336                                                           17    4312
XP_006719335                                                           17    4312
NP_002010                                                              16    5631
NP_001153392                                                           16    5631
NP_001153503                                                           16    5631
NP_001243592                                                           16    5631
NP_001153502                                                           16    5631
NP_001093116                                                           16    5631
NP_690872                                                              16    5631
NP_009187                                                              16    5631
NP_000822                                                              16    5631
XP_005256529                                                           16    5631
XP_006721516                                                           16    5631
XP_006718490                                                           16    5631
NP_001138684                                                           16    5631
NP_001138683                                                           16    5631
NP_001094859                                                           16    5631
NP_055483                                                              16    7355
NP_689707                                                              16    7355
NP_001153101                                                           16    7355
NP_003636                                                              16    7355
NP_001137159                                                           16    7355
NP_055760                                                              16    7355
NP_003387                                                              16    7355
XP_006725694                                                           16    7355
XP_005257694                                                           16    7355
XP_006714827                                                           16    7355
XP_005268453                                                           16    7355
XP_005268452                                                           16    7355
XP_005268451                                                           16    7355
XP_005268450                                                           16    7355
XP_005268449                                                           16    7355
XP_006714826                                                           16    7355
XP_005246254                                                           16    7355
XP_005246253                                                           16    7355
XP_005246252                                                           16    7355
XP_006711970                                                           16    7355
XP_006711969                                                           16    7355
XP_005246249                                                           16    7355
XP_006711968                                                           16    7355
XP_006711967                                                           16    7355
NP_112222                                                              16    7355
NP_006124                                                              15    9605
NP_683692                                                              15    9605
NP_115484                                                              15    9605
NP_060700                                                              15    9605
XP_005274287                                                           15    9605
XP_005248208                                                           15    9605
XP_005248207                                                           15    9605
XP_006714021                                                           15    9605
NP_940686                                                              15    9605
>NP_006209
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IGMLVCEFD 9
           IGM VCEFD
Sbjct: 121 IGMPVCEFD 129
>XP_006713721
          Length = 1068

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IGMLVCEFD 9
           IGM VCEFD
Sbjct: 121 IGMPVCEFD 129
>NP_055569
          Length = 473

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GM+VC F
Sbjct: 232 LGMVVCRF 239
>NP_001277154
          Length = 327

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  IGMLVCEF 8
          +GM+VC F
Sbjct: 86 LGMVVCRF 93
>NP_898885
          Length = 326

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GMLVCEFD 9
           G LVCEF+
Sbjct: 247 GPLVCEFN 254
>NP_003316
          Length = 1017

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGMLVCEFD 9
           +G+LVC  D
Sbjct: 341 LGILVCSMD 349
>NP_775821
          Length = 1326

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IGMLVC
Sbjct: 835 IGMLVC 840
>XP_005251455
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IGMLVC
Sbjct: 843 IGMLVC 848
>XP_005251456
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IGMLVC
Sbjct: 843 IGMLVC 848
>XP_005251454
          Length = 1334

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IGMLVC
Sbjct: 843 IGMLVC 848
>NP_001018062
          Length = 175

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IGMLVCEFD 9
          +G+ +C FD
Sbjct: 42 VGLCICLFD 50
>NP_001018060
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IGMLVCEFD 9
          +G+ +C FD
Sbjct: 42 VGLCICLFD 50
>NP_001136438
          Length = 1923

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1726 GLLICRFN 1733
>NP_689854
          Length = 1835

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GMLVCEF 8
           G+L+CE+
Sbjct: 388 GVLICEY 394
>NP_003829
          Length = 607

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IGMLVCEFD 9
           IG L CE D
Sbjct: 304 IGTLSCEID 312
>NP_001269813
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IGMLVCEFD 9
          +G+ +C FD
Sbjct: 42 VGLCICLFD 50
>NP_001269814
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IGMLVCEFD 9
          +G+ +C FD
Sbjct: 42 VGLCICLFD 50
>NP_612211
          Length = 204

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  IGMLVCEFD 9
          +G+ +C FD
Sbjct: 42 VGLCICLFD 50
>XP_006722611
          Length = 1034

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMLVCEFD 9
           G+L+C F+
Sbjct: 837 GLLICRFN 844
>XP_006722610
          Length = 1967

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1770 GLLICRFN 1777
>XP_006719336
          Length = 1779

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GMLVCEF 8
           G+L+CE+
Sbjct: 332 GVLICEY 338
>XP_006719335
          Length = 1793

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   GMLVCEF 8
           G+L+CE+
Sbjct: 388 GVLICEY 394
>NP_002010
          Length = 1338

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IGMLVCE 7
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001153392
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IGMLVCE 7
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001153503
          Length = 541

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IGMLVCE 7
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001243592
          Length = 580

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IGMLVCEF 8
           +GML C F
Sbjct: 450 LGMLACVF 457
>NP_001153502
          Length = 733

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IGMLVCE 7
           IG+L CE
Sbjct: 202 IGLLTCE 208
>NP_001093116
          Length = 566

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IGMLVCEF 8
           +GML C F
Sbjct: 436 LGMLACVF 443
>NP_690872
          Length = 602

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IGMLVCEF 8
           +GML C F
Sbjct: 472 LGMLACVF 479
>NP_009187
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GML+C F
Sbjct: 448 LGMLLCLF 455
>NP_000822
          Length = 919

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2  GMLVCEF 8
          G+LVC F
Sbjct: 18 GLLVCAF 24
>XP_005256529
          Length = 517

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IGMLVCEF 8
           +GML C F
Sbjct: 387 LGMLACVF 394
>XP_006721516
          Length = 552

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IGMLVCEF 8
           +GML C F
Sbjct: 422 LGMLACVF 429
>XP_006718490
          Length = 635

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GML+C F
Sbjct: 448 LGMLLCLF 455
>NP_001138684
          Length = 565

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GML+C F
Sbjct: 304 LGMLLCLF 311
>NP_001138683
          Length = 687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GML+C F
Sbjct: 426 LGMLLCLF 433
>NP_001094859
          Length = 229

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +G+L+C F
Sbjct: 93  LGLLLCSF 100
>NP_055483
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1753 GLLLCRFN 1760
>NP_689707
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IG+LVC
Sbjct: 558 IGLLVC 563
>NP_001153101
          Length = 567

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGMLVCE 7
           +G+LVC+
Sbjct: 369 VGLLVCK 375
>NP_003636
          Length = 620

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGMLVCE 7
           +G+LVC+
Sbjct: 422 VGLLVCK 428
>NP_001137159
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   IGMLVC 6
           IG+LVC
Sbjct: 533 IGLLVC 538
>NP_055760
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 659 GMTISEFD 666
>NP_003387
          Length = 357

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  IGMLVCEF 8
          +G+L C+F
Sbjct: 84 LGLLECQF 91
>XP_006725694
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  IGMLVCEF 8
          +G+L C+F
Sbjct: 84 LGLLECQF 91
>XP_005257694
          Length = 329

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  IGMLVCEF 8
          +G+L C+F
Sbjct: 84 LGLLECQF 91
>XP_006714827
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 548 GMTISEFD 555
>XP_005268453
          Length = 572

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 548 GMTISEFD 555
>XP_005268452
          Length = 588

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 564 GMTISEFD 571
>XP_005268451
          Length = 621

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 597 GMTISEFD 604
>XP_005268450
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 610 GMTISEFD 617
>XP_005268449
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 626 GMTISEFD 633
>XP_006714826
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMLVCEFD 9
           GM + EFD
Sbjct: 659 GMTISEFD 666
>XP_005246254
          Length = 947

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMLVCEFD 9
           G+L+C F+
Sbjct: 751 GLLLCRFN 758
>XP_005246253
          Length = 1038

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMLVCEFD 9
           G+L+C F+
Sbjct: 842 GLLLCRFN 849
>XP_005246252
          Length = 1850

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1654 GLLLCRFN 1661
>XP_006711970
          Length = 1948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1752 GLLLCRFN 1759
>XP_006711969
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1753 GLLLCRFN 1760
>XP_005246249
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1753 GLLLCRFN 1760
>XP_006711968
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1753 GLLLCRFN 1760
>XP_006711967
          Length = 1949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    GMLVCEFD 9
            G+L+C F+
Sbjct: 1753 GLLLCRFN 1760
>NP_112222
          Length = 294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           IG+++C F
Sbjct: 225 IGVIICVF 232
>NP_006124
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GM+VC +
Sbjct: 136 LGMVVCNW 143
>NP_683692
          Length = 3051

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    GMLVCE 7
            G+L+CE
Sbjct: 1895 GVLICE 1900
>NP_115484
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 2   GMLVCEFD 9
           G  VC FD
Sbjct: 333 GSAVCAFD 340
>NP_060700
          Length = 1156

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    IGMLVCE 7
            IG+ +CE
Sbjct: 1032 IGLYICE 1038
>XP_005274287
          Length = 1042

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IGMLVCEF 8
           +GM+VC +
Sbjct: 136 LGMVVCNW 143
>XP_005248208
          Length = 3097

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    GMLVCE 7
            G+L+CE
Sbjct: 1895 GVLICE 1900
>XP_005248207
          Length = 3098

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    GMLVCE 7
            G+L+CE
Sbjct: 1895 GVLICE 1900
>XP_006714021
          Length = 3112

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2    GMLVCE 7
            G+L+CE
Sbjct: 1895 GVLICE 1900
>NP_940686
          Length = 259

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 6/8 (75%)

Query: 2  GMLVCEFD 9
          G ++C FD
Sbjct: 65 GKILCPFD 72
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.159    0.537 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 656,827
Number of extensions: 1100
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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