Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_000332                                                              18    1482
NP_036565                                                              17    4312
NP_001139732                                                           17    4312
NP_001139731                                                           17    4312
NP_001139730                                                           17    4312
NP_079055                                                              17    4312
XP_006719667                                                           17    4312
XP_005269209                                                           17    4312
XP_005246485                                                           17    4312
NP_001029031                                                           16    5631
NP_001257377                                                           16    5631
NP_000009                                                              16    5631
NP_660160                                                              16    5631
NP_001257376                                                           16    5631
NP_848599                                                              16    5631
XP_006721579                                                           16    5631
XP_006713081                                                           16    5631
NP_071387                                                              16    5631
NP_620407                                                              16    7355
NP_002736                                                              16    7355
NP_075053                                                              16    7355
NP_055417                                                              16    7355
NP_066022                                                              16    7355
NP_922932                                                              16    7355
XP_006723369                                                           16    7355
XP_006721061                                                           16    7355
XP_006714735                                                           16    7355
XP_005248626                                                           16    7355
XP_006710064                                                           16    7355
NP_001265492                                                           16    7355
NP_597714                                                              16    7355
NP_004987                                                              15    9605
NP_005836                                                              15    9605
NP_000383                                                              15    9605
NP_055362                                                              15    9605
NP_001186704                                                           15    9605
NP_001264890                                                           15    9605
NP_001295                                                              15    9605
NP_001264891                                                           15    9605
NP_003777                                                              15    9605
NP_001229527                                                           15    9605
NP_005883                                                              15    9605
NP_001229588                                                           15    9605
NP_003147                                                              15    9605
XP_005257820                                                           15    9605
XP_006722133                                                           15    9605
XP_006722132                                                           15    9605
XP_006722131                                                           15    9605
XP_006722130                                                           15    9605
XP_006722129                                                           15    9605
XP_006722128                                                           15    9605
XP_006722127                                                           15    9605
XP_006722126                                                           15    9605
XP_006722125                                                           15    9605
XP_006720948                                                           15    9605
XP_006720947                                                           15    9605
XP_005255386                                                           15    9605
XP_005255385                                                           15    9605
XP_005255384                                                           15    9605
XP_006720542                                                           15    9605
XP_005254082                                                           15    9605
XP_006719977                                                           15    9605
XP_006717693                                                           15    9605
NP_036474                                                              15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IGMHDIIAA 9
            I MHDIIAA
Sbjct: 1301 IAMHDIIAA 1309
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IGMHDIIAA 9
            I MHDIIAA
Sbjct: 1301 IAMHDIIAA 1309
>NP_000332
          Length = 685

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +GMHDI+
Sbjct: 355 VGMHDIV 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IGMHDIIAA 9
           IGM +I+AA
Sbjct: 484 IGMGNIVAA 492
>NP_036565
          Length = 1304

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IGMHDIIA 8
            IG HD++A
Sbjct: 1088 IGPHDVLA 1095
>NP_001139732
          Length = 373

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 237 LGIHDII 243
>NP_001139731
          Length = 403

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 267 LGIHDII 273
>NP_001139730
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 285 LGIHDII 291
>NP_079055
          Length = 421

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 285 LGIHDII 291
>XP_006719667
          Length = 251

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 115 LGIHDII 121
>XP_005269209
          Length = 408

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +G+HDII
Sbjct: 272 LGIHDII 278
>XP_005246485
          Length = 1158

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGMHDIIA 8
           IG HD++A
Sbjct: 942 IGPHDVLA 949
>NP_001029031
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGMHDI 6
           +GMHD+
Sbjct: 145 VGMHDL 150
>NP_001257377
          Length = 579

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  IGMHDI 6
          +GMHD+
Sbjct: 91 VGMHDL 96
>NP_000009
          Length = 655

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGMHDI 6
           +GMHD+
Sbjct: 167 VGMHDL 172
>NP_660160
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  IGMHDIIA 8
          +GMH IIA
Sbjct: 66 LGMHVIIA 73
>NP_001257376
          Length = 678

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGMHDI 6
           +GMHD+
Sbjct: 190 VGMHDL 195
>NP_848599
          Length = 3092

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MHDIIAA 9
            +HD+IAA
Sbjct: 1080 VHDVIAA 1086
>XP_006721579
          Length = 708

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGMHDI 6
           +GMHD+
Sbjct: 213 VGMHDL 218
>XP_006713081
          Length = 3964

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MHDIIAA 9
            +HD+IAA
Sbjct: 1103 VHDVIAA 1109
>NP_071387
          Length = 704

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1  IGMHDIIA 8
          +G HD+I+
Sbjct: 77 LGQHDVIS 84
>NP_620407
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  IGMHDIIAA 9
          IG++DII A
Sbjct: 84 IGINDIIRA 92
>NP_002736
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  IGMHDIIAA 9
          IG++DII A
Sbjct: 84 IGINDIIRA 92
>NP_075053
          Length = 765

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GMHDIIA 8
           G HD++A
Sbjct: 741 GFHDVLA 747
>NP_055417
          Length = 1358

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    IGMHDII 7
            +G HDII
Sbjct: 1326 VGHHDII 1332
>NP_066022
          Length = 2564

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IGMHDII 7
           +G HDI+
Sbjct: 140 VGSHDIV 146
>NP_922932
          Length = 1117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IGMHDIIA 8
           +G+H +IA
Sbjct: 152 VGLHGVIA 159
>XP_006723369
          Length = 2394

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IGMHDII 7
           +G HDI+
Sbjct: 140 VGSHDIV 146
>XP_006721061
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GMHDII 7
           G+HDI+
Sbjct: 676 GLHDIV 681
>XP_006714735
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GMHDIIA 8
           G HD++A
Sbjct: 698 GFHDVLA 704
>XP_005248626
          Length = 724

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   GMHDIIA 8
           G HD++A
Sbjct: 700 GFHDVLA 706
>XP_006710064
          Length = 688

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 2   GMHDII 7
           G+HDI+
Sbjct: 676 GLHDIV 681
>NP_001265492
          Length = 441

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IGMHDIIAA 9
           IG+HD +A+
Sbjct: 385 IGIHDPLAS 393
>NP_597714
          Length = 439

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IGMHDIIAA 9
           IG+HD +A+
Sbjct: 383 IGIHDPLAS 391
>NP_004987
          Length = 1531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1361 IGLHDL 1366
>NP_005836
          Length = 1325

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1108 IGLHDL 1113
>NP_000383
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1368 IGLHDL 1373
>NP_055362
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +GMH++I
Sbjct: 138 LGMHNLI 144
>NP_001186704
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GMHDIIA 8
            G+H+IIA
Sbjct: 1008 GVHNIIA 1014
>NP_001264890
          Length = 791

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMHDIIAA 9
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>NP_001295
          Length = 1380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    GMHDIIA 8
            G+H+IIA
Sbjct: 1255 GVHNIIA 1261
>NP_001264891
          Length = 540

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMHDIIAA 9
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>NP_003777
          Length = 1527

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1357 IGLHDL 1362
>NP_001229527
          Length = 150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IGMHDIIAA 9
          IG+H I+A+
Sbjct: 68 IGVHYIVAS 76
>NP_005883
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 284 GGHDIILA 291
>NP_001229588
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           GM DI+ A
Sbjct: 179 GMQDIVVA 186
>NP_003147
          Length = 685

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   GMHDIIAA 9
           G+H ++AA
Sbjct: 446 GIHSLVAA 453
>XP_005257820
          Length = 1463

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1293 IGLHDL 1298
>XP_006722133
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722132
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722131
          Length = 1100

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722130
          Length = 1106

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722129
          Length = 1110

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006722128
          Length = 1148

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 274 GGHDIILA 281
>XP_006722127
          Length = 1154

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 280 GGHDIILA 287
>XP_006722126
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 284 GGHDIILA 291
>XP_006722125
          Length = 1164

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GMHDIIAA 9
           G HDII A
Sbjct: 290 GGHDIILA 297
>XP_006720948
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1231 IGLHDL 1236
>XP_006720947
          Length = 1466

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1361 IGLHDL 1366
>XP_005255386
          Length = 1472

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1302 IGLHDL 1307
>XP_005255385
          Length = 1485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1315 IGLHDL 1320
>XP_005255384
          Length = 1489

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1319 IGLHDL 1324
>XP_006720542
          Length = 352

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGMHDII 7
           +GMH++I
Sbjct: 138 LGMHNLI 144
>XP_005254082
          Length = 1282

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1065 IGLHDL 1070
>XP_006719977
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1078 IGLHDL 1083
>XP_006717693
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1    IGMHDI 6
            IG+HD+
Sbjct: 1136 IGLHDL 1141
>NP_036474
          Length = 260

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 2   GMHDIIA 8
           G+HD+++
Sbjct: 108 GLHDVLS 114
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.148    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 459,648
Number of extensions: 624
Number of successful extensions: 67
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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