Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     299
NP_001075109                                                           20     299
NP_060800                                                              18    1935
NP_001120683                                                           18    1935
NP_001245228                                                           18    1935
XP_005270059                                                           18    1935
XP_006717994                                                           18    1935
NP_116316                                                              17    3301
XP_006713991                                                           17    3301
XP_005248091                                                           17    3301
XP_005248090                                                           17    3301
NP_005236                                                              17    4312
NP_077321                                                              17    4312
NP_064576                                                              17    4312
NP_001273739                                                           17    4312
XP_005251635                                                           17    4312
XP_005251634                                                           17    4312
XP_006714202                                                           17    4312
XP_005262892                                                           17    4312
XP_005262891                                                           17    4312
XP_006713766                                                           17    4312
XP_005247697                                                           17    4312
NP_000303                                                              16    5631
NP_056028                                                              16    5631
NP_001230183                                                           16    5631
NP_001919                                                              16    5631
XP_006718232                                                           16    5631
XP_005252889                                                           16    5631
XP_006712696                                                           16    5631
XP_005263774                                                           16    5631
XP_005263773                                                           16    5631
XP_005263772                                                           16    5631
NP_001171600                                                           16    7355
NP_001018098                                                           16    7355
NP_060154                                                              16    7355
NP_060550                                                              16    7355
NP_065872                                                              16    7355
NP_036563                                                              16    7355
XP_006716250                                                           16    7355
NP_001188413                                                           15    9605
NP_116023                                                              15    9605
NP_690577                                                              15    9605
NP_001186020                                                           15    9605
NP_001186014                                                           15    9605
NP_775804                                                              15    9605
NP_001186018                                                           15    9605
NP_055938                                                              15    9605
NP_001194005                                                           15    9605
NP_597707                                                              15    9605
NP_543024                                                              15    9605
NP_001161946                                                           15    9605
NP_065904                                                              15    9605
NP_065878                                                              15    9605
NP_060337                                                              15    9605
NP_079161                                                              15    9605
NP_001099046                                                           15    9605
NP_001229858                                                           15    9605
XP_005260352                                                           15    9605
XP_006720908                                                           15    9605
XP_005253507                                                           15    9605
XP_005251676                                                           15    9605
XP_006714343                                                           15    9605
XP_005263211                                                           15    9605
XP_006713126                                                           15    9605
XP_005264779                                                           15    9605
XP_005264778                                                           15    9605
XP_005264777                                                           15    9605
XP_005244992                                                           15    9605
XP_006711258                                                           15    9605
XP_005244991                                                           15    9605
>NP_008835
          Length = 4128

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            IGEYDVLR
Sbjct: 2933 IGEYDVLR 2940
>NP_001075109
          Length = 4097

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            IGEYDVLR
Sbjct: 2933 IGEYDVLR 2940
>NP_060800
          Length = 456

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IGEYDVLRA 9
          IGEY+ LRA
Sbjct: 21 IGEYEDLRA 29
>NP_001120683
          Length = 631

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IGEYDVLRA 9
          IGEY+ LRA
Sbjct: 21 IGEYEDLRA 29
>NP_001245228
          Length = 558

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IGEYDVLRA 9
          IGEY+ LRA
Sbjct: 21 IGEYEDLRA 29
>XP_005270059
          Length = 573

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IGEYDVLRA 9
          IGEY+ LRA
Sbjct: 21 IGEYEDLRA 29
>XP_006717994
          Length = 617

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1  IGEYDVLRA 9
          IGEY+ LRA
Sbjct: 21 IGEYEDLRA 29
>NP_116316
          Length = 141

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  IGEYDV 6
          IGEYDV
Sbjct: 85 IGEYDV 90
>XP_006713991
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IGEYDV
Sbjct: 109 IGEYDV 114
>XP_005248091
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IGEYDV
Sbjct: 109 IGEYDV 114
>XP_005248090
          Length = 165

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IGEYDV
Sbjct: 109 IGEYDV 114
>NP_005236
          Length = 4588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    GEYDVL 7
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>NP_077321
          Length = 559

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G Y +LRA
Sbjct: 336 VGSYPILRA 344
>NP_064576
          Length = 360

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEYDVLRA 9
           G+YD+LR+
Sbjct: 257 GKYDLLRS 264
>NP_001273739
          Length = 386

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G Y +LRA
Sbjct: 163 VGSYPILRA 171
>XP_005251635
          Length = 493

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G Y +LRA
Sbjct: 270 VGSYPILRA 278
>XP_005251634
          Length = 522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G Y +LRA
Sbjct: 336 VGSYPILRA 344
>XP_006714202
          Length = 4588

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    GEYDVL 7
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_005262892
          Length = 4600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    GEYDVL 7
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_005262891
          Length = 4600

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2    GEYDVL 7
            GEYD+L
Sbjct: 1318 GEYDIL 1323
>XP_006713766
          Length = 342

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEYDVLRA 9
           G+YD+LR+
Sbjct: 239 GKYDLLRS 246
>XP_005247697
          Length = 359

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   GEYDVLRA 9
           G+YD+LR+
Sbjct: 256 GKYDLLRS 263
>NP_000303
          Length = 461

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGEYDVLR 8
           +GEYD+ R
Sbjct: 265 LGEYDLRR 272
>NP_056028
          Length = 1287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EYDVLRA 9
           EYDVL A
Sbjct: 160 EYDVLHA 166
>NP_001230183
          Length = 1241

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EYDVLRA 9
           EYDVL A
Sbjct: 160 EYDVLHA 166
>NP_001919
          Length = 253

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YDVLRA 9
           YDVLRA
Sbjct: 95  YDVLRA 100
>XP_006718232
          Length = 1263

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EYDVLRA 9
           EYDVL A
Sbjct: 136 EYDVLHA 142
>XP_005252889
          Length = 1307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   EYDVLRA 9
           EYDVL A
Sbjct: 160 EYDVLHA 166
>XP_006712696
          Length = 469

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGEYDVLR 8
           +GEYD+ R
Sbjct: 273 LGEYDLRR 280
>XP_005263774
          Length = 482

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGEYDVLR 8
           +GEYD+ R
Sbjct: 286 LGEYDLRR 293
>XP_005263773
          Length = 516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGEYDVLR 8
           +GEYD+ R
Sbjct: 320 LGEYDLRR 327
>XP_005263772
          Length = 522

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IGEYDVLR 8
           +GEYD+ R
Sbjct: 326 LGEYDLRR 333
>NP_001171600
          Length = 715

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GEYDVL 7
           G+YDVL
Sbjct: 386 GQYDVL 391
>NP_001018098
          Length = 3628

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            +GE+D+L+
Sbjct: 3028 VGEHDLLK 3035
>NP_060154
          Length = 3710

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            +GE+D+L+
Sbjct: 2985 VGEHDLLK 2992
>NP_060550
          Length = 3585

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            +GE+D+L+
Sbjct: 2985 VGEHDLLK 2992
>NP_065872
          Length = 3753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    IGEYDVLR 8
            +GE+D+L+
Sbjct: 3028 VGEHDLLK 3035
>NP_036563
          Length = 775

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GEYDVL 7
           G+YDVL
Sbjct: 446 GQYDVL 451
>XP_006716250
          Length = 583

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   GEYDVL 7
           G+YDVL
Sbjct: 446 GQYDVL 451
>NP_001188413
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GEYDVLRA 9
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_116023
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GEYDVLRA 9
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_690577
          Length = 672

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GEYDVLRA 9
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>NP_001186020
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>NP_001186014
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>NP_775804
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>NP_001186018
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>NP_055938
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IG+YD+
Sbjct: 279 IGQYDI 284
>NP_001194005
          Length = 423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GEYDVLRA 9
           GE DVL A
Sbjct: 188 GEMDVLHA 195
>NP_597707
          Length = 656

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IGEYDVLR 8
          IG+Y+V++
Sbjct: 45 IGQYEVVK 52
>NP_543024
          Length = 572

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GEYDVLRA 9
           GE DVL A
Sbjct: 188 GEMDVLHA 195
>NP_001161946
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EYDVLR 8
           EYD+LR
Sbjct: 231 EYDMLR 236
>NP_065904
          Length = 622

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  IGEYDVL 7
          +GEYD L
Sbjct: 19 LGEYDPL 25
>NP_065878
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G+Y  LRA
Sbjct: 484 LGQYSPLRA 492
>NP_060337
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  IGEYDVL 7
          +G YD+L
Sbjct: 81 VGPYDIL 87
>NP_079161
          Length = 462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   EYDVLR 8
           EYD+LR
Sbjct: 317 EYDMLR 322
>NP_001099046
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   GEYDVLR 8
           G Y+VLR
Sbjct: 124 GRYEVLR 130
>NP_001229858
          Length = 549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IGEYDVLR 8
          IG+Y+V++
Sbjct: 45 IGQYEVVK 52
>XP_005260352
          Length = 576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   GEYDVLRA 9
           GE DVL A
Sbjct: 188 GEMDVLHA 195
>XP_006720908
          Length = 429

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1  IGEYDVLR 8
          IG+Y+V++
Sbjct: 45 IGQYEVVK 52
>XP_005253507
          Length = 440

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  IGEYDVL 7
          +GEYD L
Sbjct: 19 LGEYDPL 25
>XP_005251676
          Length = 1089

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   GEYDVLRA 9
           GE+DVL A
Sbjct: 222 GEWDVLIA 229
>XP_006714343
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G+Y  LRA
Sbjct: 151 LGQYSPLRA 159
>XP_005263211
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IGEYDVLRA 9
           +G+Y  LRA
Sbjct: 484 LGQYSPLRA 492
>XP_006713126
          Length = 980

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IG+YD+
Sbjct: 225 IGQYDI 230
>XP_005264779
          Length = 989

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IG+YD+
Sbjct: 234 IGQYDI 239
>XP_005264778
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IG+YD+
Sbjct: 246 IGQYDI 251
>XP_005264777
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   IGEYDV 6
           IG+YD+
Sbjct: 248 IGQYDI 253
>XP_005244992
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>XP_006711258
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
>XP_005244991
          Length = 1035

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IGEYDVL 7
           +GEY+V+
Sbjct: 320 LGEYEVI 326
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.324    0.150    0.421 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 498,840
Number of extensions: 754
Number of successful extensions: 70
Number of sequences better than 10000.0: 70
Number of HSP's gapped: 70
Number of HSP's successfully gapped: 70
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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