Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_003477                                                              18    1482
XP_006721350                                                           18    1482
XP_006721349                                                           18    1482
NP_079141                                                              17    2528
NP_004981                                                              17    2528
XP_005253541                                                           17    2528
NP_001124396                                                           17    3301
NP_001010866                                                           17    3301
NP_000298                                                              17    3301
NP_005595                                                              17    3301
NP_054890                                                              17    3301
NP_001272916                                                           17    3301
NP_002692                                                              17    3301
NP_976034                                                              17    3301
NP_001167002                                                           17    3301
NP_036298                                                              17    3301
XP_005251496                                                           17    3301
XP_006710481                                                           17    3301
XP_006710480                                                           17    3301
NP_006227                                                              17    3301
NP_002690                                                              17    3301
NP_000278                                                              16    5631
NP_644813                                                              16    5631
XP_005249237                                                           16    5631
NP_689549                                                              16    7355
NP_001193907                                                           16    7355
NP_001193908                                                           16    7355
NP_001193906                                                           16    7355
NP_001193921                                                           16    7355
NP_001193922                                                           16    7355
NP_005114                                                              16    7355
NP_001171474                                                           16    7355
NP_653269                                                              16    7355
NP_001138663                                                           16    7355
NP_002967                                                              16    7355
NP_115665                                                              16    7355
XP_006719782                                                           16    7355
XP_006714864                                                           16    7355
XP_006713184                                                           16    7355
XP_006712745                                                           16    7355
XP_006712744                                                           16    7355
XP_006712743                                                           16    7355
NP_000830                                                              16    7355
NP_001129396                                                           16    7355
NP_950252                                                              15    9605
NP_000780                                                              15    9605
NP_079128                                                              15    9605
NP_060445                                                              15    9605
NP_001274750                                                           15    9605
NP_683699                                                              15    9605
NP_001274751                                                           15    9605
NP_001274752                                                           15    9605
NP_004186                                                              15    9605
NP_683700                                                              15    9605
NP_001186681                                                           15    9605
NP_001129524                                                           15    9605
NP_689572                                                              15    9605
NP_001186682                                                           15    9605
NP_071373                                                              15    9605
NP_803171                                                              15    9605
XP_006723073                                                           15    9605
XP_006723072                                                           15    9605
XP_005258564                                                           15    9605
XP_005258563                                                           15    9605
XP_005258562                                                           15    9605
XP_005250256                                                           15    9605
XP_005266015                                                           15    9605
XP_005245177                                                           15    9605
XP_005245176                                                           15    9605
XP_005245175                                                           15    9605
XP_005245174                                                           15    9605
XP_005270633                                                           15    9605
XP_006710467                                                           15    9605
XP_005270632                                                           15    9605
NP_659802                                                              15    9605
>NP_003477
          Length = 507

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IFSTTRLCR 9
           IFSTT LC+
Sbjct: 489 IFSTTVLCQ 497
>XP_006721350
          Length = 241

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IFSTTRLCR 9
           IFSTT LC+
Sbjct: 223 IFSTTVLCQ 231
>XP_006721349
          Length = 334

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IFSTTRLCR 9
           IFSTT LC+
Sbjct: 316 IFSTTVLCQ 324
>NP_079141
          Length = 305

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IFSTTRLC 8
           +FS+T+LC
Sbjct: 101 VFSSTQLC 108
>NP_004981
          Length = 900

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IFSTTRLCR 9
          +FST+ +CR
Sbjct: 59 LFSTSAICR 67
>XP_005253541
          Length = 289

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IFSTTRLC 8
           +FS+T+LC
Sbjct: 101 VFSSTQLC 108
>NP_001124396
          Length = 666

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           FSTT LC
Sbjct: 357 FSTTSLC 363
>NP_001010866
          Length = 392

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           FSTT LC
Sbjct: 357 FSTTSLC 363
>NP_000298
          Length = 361

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           +FS T +CR
Sbjct: 226 VFSQTTICR 234
>NP_005595
          Length = 443

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           +FS T +CR
Sbjct: 302 VFSQTTICR 310
>NP_054890
          Length = 101

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  FSTTRLCR 9
          FST R+C+
Sbjct: 55 FSTCRICK 62
>NP_001272916
          Length = 265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IFSTTRLCR 9
          +FS T +CR
Sbjct: 83 VFSQTTICR 91
>NP_002692
          Length = 360

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           +FS T +CR
Sbjct: 178 VFSQTTICR 186
>NP_976034
          Length = 190

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IFSTTRLCR 9
          +FS T +CR
Sbjct: 8  VFSQTTICR 16
>NP_001167002
          Length = 190

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IFSTTRLCR 9
          +FS T +CR
Sbjct: 8  VFSQTTICR 16
>NP_036298
          Length = 956

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   STTRLC 8
           STTRLC
Sbjct: 175 STTRLC 180
>XP_005251496
          Length = 653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   STTRLC 8
           STTRLC
Sbjct: 175 STTRLC 180
>XP_006710481
          Length = 542

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           FSTT LC
Sbjct: 357 FSTTSLC 363
>XP_006710480
          Length = 642

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           FSTT LC
Sbjct: 357 FSTTSLC 363
>NP_006227
          Length = 500

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           +FS T +CR
Sbjct: 354 VFSQTTICR 362
>NP_002690
          Length = 451

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           +FS T +CR
Sbjct: 287 VFSQTTICR 295
>NP_000278
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IFSTTRLCR 9
           IFS  R CR
Sbjct: 514 IFSRARRCR 522
>NP_644813
          Length = 537

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   STTRLCR 9
           STT LCR
Sbjct: 341 STTLLCR 347
>XP_005249237
          Length = 892

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IFSTTRLCR 9
           IFS  R CR
Sbjct: 426 IFSRARRCR 434
>NP_689549
          Length = 1066

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FSTT+ C
Sbjct: 194 LFSTTQNC 201
>NP_001193907
          Length = 425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 185 VTSTTKSCR 193
>NP_001193908
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 236 VTSTTKSCR 244
>NP_001193906
          Length = 476

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 236 VTSTTKSCR 244
>NP_001193921
          Length = 482

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 242 VTSTTKSCR 250
>NP_001193922
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 246 VTSTTKSCR 254
>NP_005114
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 232 VTSTTKSCR 240
>NP_001171474
          Length = 941

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   STTRLCR 9
           +TT++CR
Sbjct: 825 ATTKMCR 831
>NP_653269
          Length = 1149

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   STTRLCR 9
           +TT++CR
Sbjct: 825 ATTKMCR 831
>NP_001138663
          Length = 657

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           F+TT LC
Sbjct: 605 FTTTSLC 611
>NP_002967
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IFSTTRLC 8
            IFS T LC
Sbjct: 1323 IFSITGLC 1330
>NP_115665
          Length = 771

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTRLCR 9
           TTRLC+
Sbjct: 651 TTRLCQ 656
>XP_006719782
          Length = 284

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IFSTTRLCR 9
           + STT+ CR
Sbjct: 246 VTSTTKSCR 254
>XP_006714864
          Length = 772

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TTRLCR 9
           TTRLC+
Sbjct: 652 TTRLCQ 657
>XP_006713184
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTRLC 8
           +TTRLC
Sbjct: 402 NTTRLC 407
>XP_006712745
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IFSTTRLC 8
            IFS T LC
Sbjct: 1323 IFSITGLC 1330
>XP_006712744
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IFSTTRLC 8
            IFS T LC
Sbjct: 1323 IFSITGLC 1330
>XP_006712743
          Length = 1682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    IFSTTRLC 8
            IFS T LC
Sbjct: 1323 IFSITGLC 1330
>NP_000830
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   STTRLC 8
           +TTRLC
Sbjct: 402 NTTRLC 407
>NP_001129396
          Length = 1590

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FSTT+ C
Sbjct: 119 LFSTTKDC 126
>NP_950252
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           + TT+LC
Sbjct: 759 YDTTKLC 765
>NP_000780
          Length = 1306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           I+ST ++C
Sbjct: 150 IYSTAKVC 157
>NP_079128
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSTTRLCR 9
           F+T R CR
Sbjct: 457 FATQRQCR 464
>NP_060445
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FS T++C
Sbjct: 488 LFSLTQIC 495
>NP_001274750
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FS T++C
Sbjct: 374 LFSLTQIC 381
>NP_683699
          Length = 255

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TTRLCR 9
          TTR CR
Sbjct: 54 TTRCCR 59
>NP_001274751
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FS T++C
Sbjct: 374 LFSLTQIC 381
>NP_001274752
          Length = 477

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IFSTTRLC 8
           +FS T++C
Sbjct: 374 LFSLTQIC 381
>NP_004186
          Length = 241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TTRLCR 9
          TTR CR
Sbjct: 54 TTRCCR 59
>NP_683700
          Length = 234

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TTRLCR 9
          TTR CR
Sbjct: 54 TTRCCR 59
>NP_001186681
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>NP_001129524
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 299 IFNTTRI 305
>NP_689572
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>NP_001186682
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>NP_071373
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           F+TT LC
Sbjct: 538 FATTYLC 544
>NP_803171
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSTTRLCR 9
           F+T R CR
Sbjct: 223 FATQRQCR 230
>XP_006723073
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>XP_006723072
          Length = 674

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 181 IFNTTRI 187
>XP_005258564
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>XP_005258563
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>XP_005258562
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IFSTTRL 7
           IF+TTR+
Sbjct: 310 IFNTTRI 316
>XP_005250256
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           F+TT LC
Sbjct: 520 FTTTYLC 526
>XP_005266015
          Length = 594

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           F+TT LC
Sbjct: 538 FATTYLC 544
>XP_005245177
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           + TT+LC
Sbjct: 759 YDTTKLC 765
>XP_005245176
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           + TT+LC
Sbjct: 759 YDTTKLC 765
>XP_005245175
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           + TT+LC
Sbjct: 759 YDTTKLC 765
>XP_005245174
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           + TT+LC
Sbjct: 759 YDTTKLC 765
>XP_005270633
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSTTRLCR 9
           F+T R CR
Sbjct: 182 FATQRQCR 189
>XP_006710467
          Length = 626

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSTTRLCR 9
           F+T R CR
Sbjct: 223 FATQRQCR 230
>XP_005270632
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   FSTTRLCR 9
           F+T R CR
Sbjct: 457 FATQRQCR 464
>NP_659802
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   FSTTRLC 8
           F+TT LC
Sbjct: 520 FTTTYLC 526
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.347    0.143    0.475 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,110
Number of extensions: 615
Number of successful extensions: 75
Number of sequences better than 10000.0: 75
Number of HSP's gapped: 75
Number of HSP's successfully gapped: 75
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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