Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
XP_005266703                                                           20     509
NP_001269889                                                           18    1482
NP_001269888                                                           18    1482
NP_060707                                                              18    1482
NP_001129706                                                           18    1935
NP_001129705                                                           18    1935
XP_006726467                                                           17    2528
XP_006712970                                                           17    2528
XP_006710209                                                           17    2528
NP_004534                                                              16    5631
NP_001258137                                                           16    5631
NP_002099                                                              16    5631
NP_001245263                                                           16    5631
NP_001157980                                                           16    5631
NP_001157979                                                           16    5631
NP_064504                                                              16    5631
NP_001245262                                                           16    5631
NP_078901                                                              16    5631
XP_005268878                                                           16    5631
XP_005250558                                                           16    5631
XP_005246674                                                           16    5631
XP_005246673                                                           16    5631
XP_005246672                                                           16    5631
XP_005246670                                                           16    5631
XP_005246669                                                           16    5631
XP_005246668                                                           16    5631
XP_005246667                                                           16    5631
XP_005246665                                                           16    5631
XP_006712605                                                           16    5631
XP_006712604                                                           16    5631
XP_005246663                                                           16    5631
XP_005246660                                                           16    5631
XP_005246661                                                           16    5631
XP_005246659                                                           16    5631
XP_005246658                                                           16    5631
XP_005246657                                                           16    5631
XP_005246656                                                           16    5631
XP_005246655                                                           16    5631
XP_005246654                                                           16    5631
XP_005246653                                                           16    5631
XP_005246652                                                           16    5631
XP_005246649                                                           16    5631
XP_005246651                                                           16    5631
XP_005246650                                                           16    5631
XP_005246648                                                           16    5631
XP_005246647                                                           16    5631
NP_001248311                                                           16    7355
NP_001248313                                                           16    7355
NP_001035787                                                           16    7355
NP_000246                                                              16    7355
XP_006718318                                                           16    7355
XP_005249200                                                           16    7355
NP_001273135                                                           15    9605
NP_055710                                                              15    9605
NP_056078                                                              15    9605
NP_958505                                                              15    9605
NP_001167587                                                           15    9605
NP_001167588                                                           15    9605
NP_002716                                                              15    9605
XP_005254315                                                           15    9605
XP_005254314                                                           15    9605
XP_006720509                                                           15    9605
XP_005254313                                                           15    9605
XP_005254312                                                           15    9605
XP_006715629                                                           15    9605
XP_005248735                                                           15    9605
XP_006715443                                                           15    9605
XP_005248732                                                           15    9605
XP_005248731                                                           15    9605
NP_078970                                                              15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IETLAKGYK 9
            I TLAKGYK
Sbjct: 2093 IATLAKGYK 2101
>XP_005266703
          Length = 1501

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    IETLAKGYK 9
            I TLAKGYK
Sbjct: 1424 IATLAKGYK 1432
>NP_001269889
          Length = 1135

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETLAKGYK 9
           ETL++GYK
Sbjct: 572 ETLSRGYK 579
>NP_001269888
          Length = 1135

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETLAKGYK 9
           ETL++GYK
Sbjct: 572 ETLSRGYK 579
>NP_060707
          Length = 1150

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   ETLAKGYK 9
           ETL++GYK
Sbjct: 587 ETLSRGYK 594
>NP_001129706
          Length = 887

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IETLAKGYK 9
           +E LAKGY+
Sbjct: 308 VEKLAKGYQ 316
>NP_001129705
          Length = 817

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IETLAKGYK 9
           +E LAKGY+
Sbjct: 308 VEKLAKGYQ 316
>XP_006726467
          Length = 430

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLAKGYK 9
           TLA+GYK
Sbjct: 350 TLARGYK 356
>XP_006712970
          Length = 430

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLAKGYK 9
           TLA+GYK
Sbjct: 350 TLARGYK 356
>XP_006710209
          Length = 413

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   TLAKGYK 9
           TLA+GYK
Sbjct: 333 TLARGYK 339
>NP_004534
          Length = 6669

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>NP_001258137
          Length = 8560

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>NP_002099
          Length = 657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           I  LAKGY
Sbjct: 215 INVLAKGY 222
>NP_001245263
          Length = 591

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           I  LAKGY
Sbjct: 215 INVLAKGY 222
>NP_001157980
          Length = 8525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>NP_001157979
          Length = 8525

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>NP_064504
          Length = 902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IETLAKGY 8
           +ET+ KGY
Sbjct: 552 METIEKGY 559
>NP_001245262
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1  IETLAKGY 8
          I  LAKGY
Sbjct: 7  INVLAKGY 14
>NP_078901
          Length = 699

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IETLAKGY 8
           +ET+ KGY
Sbjct: 552 METIEKGY 559
>XP_005268878
          Length = 556

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           I  LAKGY
Sbjct: 215 INVLAKGY 222
>XP_005250558
          Length = 1024

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IETLAKGY 8
           +ET+ KGY
Sbjct: 674 METIEKGY 681
>XP_005246674
          Length = 7553

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246673
          Length = 8018

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246672
          Length = 8277

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246670
          Length = 8282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246669
          Length = 8282

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246668
          Length = 8308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246667
          Length = 8308

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246665
          Length = 8339

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_006712605
          Length = 8370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_006712604
          Length = 8370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246663
          Length = 8370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246660
          Length = 8370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246661
          Length = 8370

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246659
          Length = 8401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246658
          Length = 8401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246657
          Length = 8432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246656
          Length = 8432

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246655
          Length = 8463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246654
          Length = 8463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246653
          Length = 8463

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246652
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246649
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246651
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246650
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246648
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>XP_005246647
          Length = 8494

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2    ETLAKGY 8
            +T+AKGY
Sbjct: 1546 KTIAKGY 1552
>NP_001248311
          Length = 449

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           +  LAKGY
Sbjct: 389 VSALAKGY 396
>NP_001248313
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           +  LAKGY
Sbjct: 281 VSALAKGY 288
>NP_001035787
          Length = 471

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           +  LAKGY
Sbjct: 411 VSALAKGY 418
>NP_000246
          Length = 750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IETLAKGYK 9
           I TLA G+K
Sbjct: 671 ISTLAAGHK 679
>XP_006718318
          Length = 248

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           +  LAKGY
Sbjct: 188 VSALAKGY 195
>XP_005249200
          Length = 750

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IETLAKGYK 9
           I TLA G+K
Sbjct: 671 ISTLAAGHK 679
>NP_001273135
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 638 ETLLQGYQ 645
>NP_055710
          Length = 1403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 714 ETLLQGYQ 721
>NP_056078
          Length = 3036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>NP_958505
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           IET+  GY
Sbjct: 254 IETIPNGY 261
>NP_001167587
          Length = 3037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>NP_001167588
          Length = 2400

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 1419 LRTLATGYE 1427
>NP_002716
          Length = 382

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IETLAKGY 8
           IET+  GY
Sbjct: 254 IETIPNGY 261
>XP_005254315
          Length = 2576

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>XP_005254314
          Length = 2605

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>XP_006720509
          Length = 2646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>XP_005254313
          Length = 3057

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>XP_005254312
          Length = 3058

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            + TLA GY+
Sbjct: 2055 LRTLATGYE 2063
>XP_006715629
          Length = 1667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            +ET A+G K
Sbjct: 1439 VETAARGVK 1447
>XP_005248735
          Length = 760

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 714 ETLLQGYQ 721
>XP_006715443
          Length = 1327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 638 ETLLQGYQ 645
>XP_005248732
          Length = 1330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 714 ETLLQGYQ 721
>XP_005248731
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   ETLAKGYK 9
           ETL +GY+
Sbjct: 676 ETLLQGYQ 683
>NP_078970
          Length = 1667

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    IETLAKGYK 9
            +ET A+G K
Sbjct: 1439 VETAARGVK 1447
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.311    0.133    0.353 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 454,671
Number of extensions: 469
Number of successful extensions: 71
Number of sequences better than 10000.0: 71
Number of HSP's gapped: 71
Number of HSP's successfully gapped: 71
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.4 bits)
S2: 28 (15.4 bits)

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