Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443187                                                              17    2528
NP_056525                                                              17    3301
NP_001269346                                                           17    4312
NP_001035915                                                           17    4312
NP_689564                                                              17    4312
NP_001257578                                                           17    4312
NP_001257577                                                           17    4312
XP_006721514                                                           17    4312
XP_005256514                                                           17    4312
XP_005249902                                                           16    5631
NP_076972                                                              16    5631
NP_055828                                                              16    7355
NP_001009999                                                           16    7355
NP_003669                                                              16    7355
NP_001002878                                                           16    7355
NP_001002879                                                           16    7355
NP_001002877                                                           16    7355
NP_000258                                                              16    7355
NP_001035957                                                           16    7355
NP_061060                                                              16    7355
XP_005261858                                                           16    7355
XP_005261857                                                           16    7355
XP_005261856                                                           16    7355
XP_006724410                                                           16    7355
XP_005261855                                                           16    7355
XP_005261854                                                           16    7355
XP_006721990                                                           16    7355
XP_006721989                                                           16    7355
XP_005258041                                                           16    7355
XP_006721988                                                           16    7355
XP_006721987                                                           16    7355
XP_006721986                                                           16    7355
XP_005258040                                                           16    7355
XP_006721985                                                           16    7355
XP_006721513                                                           16    7355
XP_006710537                                                           16    7355
XP_006710536                                                           16    7355
XP_006710535                                                           16    7355
XP_005245843                                                           16    7355
NP_000855                                                              16    7355
NP_006327                                                              15    9605
NP_848635                                                              15    9605
NP_076982                                                              15    9605
NP_001269619                                                           15    9605
NP_001269617                                                           15    9605
NP_001244965                                                           15    9605
NP_060589                                                              15    9605
NP_001244962                                                           15    9605
XP_006726676                                                           15    9605
XP_005276555                                                           15    9605
XP_006721126                                                           15    9605
XP_005252255                                                           15    9605
XP_005252253                                                           15    9605
XP_005252252                                                           15    9605
XP_005252250                                                           15    9605
XP_005251703                                                           15    9605
XP_005251702                                                           15    9605
>NP_443187
          Length = 710

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   DVYLSSEI 9
           DVYL SEI
Sbjct: 149 DVYLPSEI 156
>NP_056525
          Length = 478

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           IDV LSSE+
Sbjct: 416 IDVQLSSEL 424
>NP_001269346
          Length = 566

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IDVYLSSEI 9
          + +Y+SSEI
Sbjct: 53 VPIYISSEI 61
>NP_001035915
          Length = 596

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>NP_689564
          Length = 612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>NP_001257578
          Length = 560

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>NP_001257577
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>XP_006721514
          Length = 596

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>XP_005256514
          Length = 633

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSEI
Sbjct: 109 VPIYISSEI 117
>XP_005249902
          Length = 589

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IDVYLSSEI 9
          +D+Y SS++
Sbjct: 24 LDIYFSSQL 32
>NP_076972
          Length = 449

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IDVYLSSEI 9
          +D+Y SS++
Sbjct: 24 LDIYFSSQL 32
>NP_055828
          Length = 852

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 518 DVYLSS 523
>NP_001009999
          Length = 876

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 542 DVYLSS 547
>NP_003669
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002878
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002879
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_001002877
          Length = 683

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 633 LDVYLETE 640
>NP_000258
          Length = 2818

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1760 DIYYASEI 1767
>NP_001035957
          Length = 2839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1781 DIYYASEI 1788
>NP_061060
          Length = 542

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +D+Y S+E
Sbjct: 368 VDIYFSAE 375
>XP_005261858
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 294 LDVYLETE 301
>XP_005261857
          Length = 410

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 360 LDVYLETE 367
>XP_005261856
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_006724410
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_005261855
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_005261854
          Length = 694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IDVYLSSE 8
           +DVYL +E
Sbjct: 644 LDVYLETE 651
>XP_006721990
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1791 DIYYASEI 1798
>XP_006721989
          Length = 2823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1791 DIYYASEI 1798
>XP_005258041
          Length = 2836

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1760 DIYYASEI 1767
>XP_006721988
          Length = 2846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1770 DIYYASEI 1777
>XP_006721987
          Length = 2849

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1791 DIYYASEI 1798
>XP_006721986
          Length = 2854

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1778 DIYYASEI 1785
>XP_005258040
          Length = 2857

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1781 DIYYASEI 1788
>XP_006721985
          Length = 2867

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    DVYLSSEI 9
            D+Y +SEI
Sbjct: 1791 DIYYASEI 1798
>XP_006721513
          Length = 598

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDVYLSSEI 9
           + +Y+SSE+
Sbjct: 109 VPIYISSEL 117
>XP_006710537
          Length = 878

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 544 DVYLSS 549
>XP_006710536
          Length = 828

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 544 DVYLSS 549
>XP_006710535
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 524 DVYLSS 529
>XP_005245843
          Length = 872

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   DVYLSS 7
           DVYLSS
Sbjct: 538 DVYLSS 543
>NP_000855
          Length = 377

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   DVYLSSEI 9
           D++LSS+I
Sbjct: 112 DIWLSSDI 119
>NP_006327
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVYLSSEI 9
          D++L SEI
Sbjct: 39 DIFLPSEI 46
>NP_848635
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   DVYLSSE 8
           D Y+SSE
Sbjct: 278 DAYMSSE 284
>NP_076982
          Length = 854

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 80 YLSSEI 85
>NP_001269619
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 12 YLSSEI 17
>NP_001269617
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 80 YLSSEI 85
>NP_001244965
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>NP_060589
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>NP_001244962
          Length = 687

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>XP_006726676
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>XP_005276555
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>XP_006721126
          Length = 708

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IDVYLSSEI 9
          IDVYL+  +
Sbjct: 13 IDVYLAKSL 21
>XP_005252255
          Length = 786

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 12 YLSSEI 17
>XP_005252253
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 80 YLSSEI 85
>XP_005252252
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 80 YLSSEI 85
>XP_005252250
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  YLSSEI 9
          YLSSEI
Sbjct: 80 YLSSEI 85
>XP_005251703
          Length = 764

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVYLSSEI 9
          D++L SEI
Sbjct: 39 DIFLPSEI 46
>XP_005251702
          Length = 766

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  DVYLSSEI 9
          D++L SEI
Sbjct: 39 DIFLPSEI 46
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.316    0.139    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 421,355
Number of extensions: 510
Number of successful extensions: 57
Number of sequences better than 10000.0: 57
Number of HSP's gapped: 57
Number of HSP's successfully gapped: 57
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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