Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000042                                                              20     390
XP_006718908                                                           20     390
XP_005271621                                                           20     390
XP_006718907                                                           20     390
XP_006718906                                                           20     390
XP_005271619                                                           20     390
XP_005271618                                                           20     390
NP_066933                                                              17    3301
NP_542376                                                              17    3301
NP_004361                                                              17    3301
XP_005251116                                                           17    3301
XP_006716714                                                           17    3301
XP_006715397                                                           17    3301
XP_005249698                                                           17    4312
NP_001129396                                                           17    4312
NP_000050                                                              16    5631
NP_536724                                                              16    5631
NP_005397                                                              16    7355
NP_003592                                                              16    7355
NP_001127958                                                           16    7355
NP_443174                                                              16    7355
NP_001265874                                                           16    7355
NP_060962                                                              16    7355
NP_001161693                                                           16    7355
XP_006716431                                                           16    7355
XP_005246404                                                           16    7355
NP_005530                                                              16    7355
NP_001078956                                                           15    9605
NP_663788                                                              15    9605
NP_001106984                                                           15    9605
NP_001106983                                                           15    9605
NP_060517                                                              15    9605
XP_006720023                                                           15    9605
XP_005254148                                                           15    9605
XP_005254146                                                           15    9605
XP_006720020                                                           15    9605
XP_005254144                                                           15    9605
XP_006720019                                                           15    9605
XP_005254143                                                           15    9605
XP_005254142                                                           15    9605
XP_005268536                                                           15    9605
XP_006710377                                                           15    9605
>NP_000042
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2998 IDQSFNKV 3005
>XP_006718908
          Length = 1708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 1650 IDQSFNKV 1657
>XP_005271621
          Length = 2708

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2650 IDQSFNKV 2657
>XP_006718907
          Length = 3050

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2992 IDQSFNKV 2999
>XP_006718906
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2998 IDQSFNKV 3005
>XP_005271619
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2998 IDQSFNKV 3005
>XP_005271618
          Length = 3056

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    IDQSFNKV 8
            IDQSFNKV
Sbjct: 2998 IDQSFNKV 3005
>NP_066933
          Length = 1796

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DQSFNKVV 9
            D++FNK++
Sbjct: 1045 DENFNKII 1052
>NP_542376
          Length = 1899

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DQSFNKVV 9
            D +FNKVV
Sbjct: 1172 DDNFNKVV 1179
>NP_004361
          Length = 3063

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DQSFNKVV 9
            D +FNKVV
Sbjct: 2336 DDNFNKVV 2343
>XP_005251116
          Length = 1780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DQSFNKVV 9
            D++FNK++
Sbjct: 1045 DENFNKII 1052
>XP_006716714
          Length = 1796

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2    DQSFNKVV 9
            D++FNK++
Sbjct: 1045 DENFNKII 1052
>XP_006715397
          Length = 2972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DQSFNKVV 9
            D +FNKVV
Sbjct: 2245 DDNFNKVV 2252
>XP_005249698
          Length = 1044

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  IDQSFNKVV 9
          IDQ+FN  V
Sbjct: 38 IDQNFNNYV 46
>NP_001129396
          Length = 1590

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IDQSFNKVV 9
           IDQ+FN  V
Sbjct: 584 IDQNFNNYV 592
>NP_000050
          Length = 3418

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    QSFNKVV 9
            +SFNK+V
Sbjct: 1441 ESFNKIV 1447
>NP_536724
          Length = 435

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   QSFNKVV 9
           Q FNKVV
Sbjct: 100 QDFNKVV 106
>NP_005397
          Length = 1354

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    DQSFNKVV 9
            +QSF KVV
Sbjct: 1339 NQSFRKVV 1346
>NP_003592
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IDQSFNKV 8
           +DQ+ NK+
Sbjct: 638 VDQNLNKI 645
>NP_001127958
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IDQSFNK 7
           +DQSF K
Sbjct: 374 VDQSFQK 380
>NP_443174
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IDQSFNK 7
           +DQSF K
Sbjct: 374 VDQSFQK 380
>NP_001265874
          Length = 333

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDQSFNKVV 9
           +D+S+ KV+
Sbjct: 297 LDESYQKVI 305
>NP_060962
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDQSFNKVV 9
           +D+S+ KV+
Sbjct: 286 LDESYQKVI 294
>NP_001161693
          Length = 1820

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    QSFNKVV 9
            +SFNK+V
Sbjct: 1686 KSFNKIV 1692
>XP_006716431
          Length = 322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   IDQSFNKVV 9
           +D+S+ KV+
Sbjct: 286 LDESYQKVI 294
>XP_005246404
          Length = 1821

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    QSFNKVV 9
            +SFNK+V
Sbjct: 1687 KSFNKIV 1693
>NP_005530
          Length = 412

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IDQSFNKV 8
           IDQ F KV
Sbjct: 218 IDQRFEKV 225
>NP_001078956
          Length = 828

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DQSFNKVV 9
           DQ FN+++
Sbjct: 313 DQKFNELI 320
>NP_663788
          Length = 782

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>NP_001106984
          Length = 753

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QSFNKVV 9
          Q+FNKV+
Sbjct: 66 QNFNKVL 72
>NP_001106983
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 116 QNFNKVL 122
>NP_060517
          Length = 420

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DQSFNKVV 9
           ++SFNK++
Sbjct: 285 EKSFNKLI 292
>XP_006720023
          Length = 679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>XP_005254148
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QSFNKVV 9
          Q+FNKV+
Sbjct: 13 QNFNKVL 19
>XP_005254146
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QSFNKVV 9
          Q+FNKV+
Sbjct: 13 QNFNKVL 19
>XP_006720020
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  QSFNKVV 9
          Q+FNKV+
Sbjct: 19 QNFNKVL 25
>XP_005254144
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>XP_006720019
          Length = 815

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>XP_005254143
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>XP_005254142
          Length = 874

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   QSFNKVV 9
           Q+FNKV+
Sbjct: 95  QNFNKVL 101
>XP_005268536
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   DQSFNKVV 9
           ++SFNK++
Sbjct: 404 EKSFNKLI 411
>XP_006710377
          Length = 827

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   DQSFNKVV 9
           DQ FN+++
Sbjct: 313 DQKFNELI 320
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.136    0.354 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 476,050
Number of extensions: 700
Number of successful extensions: 42
Number of sequences better than 10000.0: 42
Number of HSP's gapped: 42
Number of HSP's successfully gapped: 42
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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