Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              21     175
XP_006717989                                                           21     175
XP_006723595                                                           17    2528
NP_002448                                                              17    3301
NP_742066                                                              17    3301
XP_005264197                                                           17    3301
XP_006712004                                                           17    3301
NP_150375                                                              17    4312
NP_078886                                                              17    4312
NP_775185                                                              17    4312
XP_006726169                                                           17    4312
XP_006726075                                                           17    4312
XP_006725982                                                           17    4312
XP_006725773                                                           17    4312
XP_006725559                                                           17    4312
XP_006715227                                                           17    4312
XP_005247818                                                           17    4312
NP_078934                                                              16    5631
NP_085128                                                              16    5631
NP_001120680                                                           16    5631
NP_085139                                                              16    5631
XP_006714305                                                           16    5631
XP_005263139                                                           16    5631
NP_001155155                                                           16    7355
NP_733764                                                              16    7355
NP_653273                                                              16    7355
NP_683513                                                              16    7355
XP_005252487                                                           16    7355
XP_005248382                                                           16    7355
NP_055931                                                              15    9605
NP_001157683                                                           15    9605
NP_064716                                                              15    9605
NP_001157685                                                           15    9605
NP_001093869                                                           15    9605
NP_001093870                                                           15    9605
NP_008824                                                              15    9605
NP_006705                                                              15    9605
NP_001273067                                                           15    9605
NP_064450                                                              15    9605
XP_005251505                                                           15    9605
XP_005248794                                                           15    9605
XP_005248793                                                           15    9605
XP_005248792                                                           15    9605
XP_005266859                                                           15    9605
XP_005266858                                                           15    9605
XP_005266855                                                           15    9605
XP_005266854                                                           15    9605
XP_005262709                                                           15    9605
XP_005273257                                                           15    9605
XP_006711259                                                           15    9605
XP_005277566                                                           15    9605
NP_001010887                                                           15    9605
>NP_000305
          Length = 403

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ICSIKRADN 9
           ICSI+RADN
Sbjct: 303 ICSIERADN 311
>XP_006717989
          Length = 388

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   ICSIKRADN 9
           ICSI+RADN
Sbjct: 288 ICSIERADN 296
>XP_006723595
          Length = 678

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   ICSIKRADN 9
           +C +K ADN
Sbjct: 526 VCRVKPADN 534
>NP_002448
          Length = 5179

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2    CSIKRADN 9
            C IKR DN
Sbjct: 4995 CIIKRPDN 5002
>NP_742066
          Length = 1493

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           CSI R DN
Sbjct: 755 CSILRGDN 762
>XP_005264197
          Length = 786

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           CSI R DN
Sbjct: 755 CSILRGDN 762
>XP_006712004
          Length = 1488

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           CSI R DN
Sbjct: 750 CSILRGDN 757
>NP_150375
          Length = 1196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ICSIKRADN 9
           +CSI+RA +
Sbjct: 267 LCSIRRASS 275
>NP_078886
          Length = 488

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ICSIKRADN 9
           +C++K A+N
Sbjct: 292 VCALKTAEN 300
>NP_775185
          Length = 732

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   ICSIKRADN 9
           +CSI+RA +
Sbjct: 267 LCSIRRASS 275
>XP_006726169
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_006726075
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_006725982
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_006725773
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_006725559
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_006715227
          Length = 396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C +KRA N
Sbjct: 388 CDVKRAGN 395
>XP_005247818
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   ICSIKRADN 9
           +C++K A+N
Sbjct: 264 VCALKTAEN 272
>NP_078934
          Length = 1081

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1    ICSIKRADN 9
            ICS+  ADN
Sbjct: 1026 ICSLILADN 1034
>NP_085128
          Length = 2136

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ICSIKRADN 9
            +C++ R DN
Sbjct: 1685 VCTLTREDN 1693
>NP_001120680
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ICSIKRADN 9
            +C++ R DN
Sbjct: 1395 VCTLTREDN 1403
>NP_085139
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 2   CSIKRADN 9
           CS+++A+N
Sbjct: 271 CSVEKANN 278
>XP_006714305
          Length = 1902

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ICSIKRADN 9
            +C++ R DN
Sbjct: 1295 VCTLTREDN 1303
>XP_005263139
          Length = 2002

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    ICSIKRADN 9
            +C++ R DN
Sbjct: 1395 VCTLTREDN 1403
>NP_001155155
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS+KR D
Sbjct: 384 CSMKRKD 390
>NP_733764
          Length = 815

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS+KR D
Sbjct: 139 CSMKRKD 145
>NP_653273
          Length = 1139

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS+KR D
Sbjct: 463 CSMKRKD 469
>NP_683513
          Length = 127

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ICSIKRAD 8
          +C I+RAD
Sbjct: 48 MCRIQRAD 55
>XP_005252487
          Length = 919

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  ICSIKRAD 8
          IC  +RAD
Sbjct: 7  ICKTRRAD 14
>XP_005248382
          Length = 117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  ICSIKRAD 8
          +C I+RAD
Sbjct: 48 MCRIQRAD 55
>NP_055931
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C IK AD+
Sbjct: 292 CQIKTADS 299
>NP_001157683
          Length = 763

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C IK AD+
Sbjct: 292 CQIKTADS 299
>NP_064716
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ICSIKRAD 8
           IC++ R+D
Sbjct: 310 ICTVMRSD 317
>NP_001157685
          Length = 696

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   CSIKRADN 9
           C IK AD+
Sbjct: 292 CQIKTADS 299
>NP_001093869
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS K+AD
Sbjct: 581 CSCKQAD 587
>NP_001093870
          Length = 600

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS K+AD
Sbjct: 581 CSCKQAD 587
>NP_008824
          Length = 584

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           C +K+AD
Sbjct: 278 CRVKKAD 284
>NP_006705
          Length = 453

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 429 ICAIMNLDN 437
>NP_001273067
          Length = 322

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 298 ICAIMNLDN 306
>NP_064450
          Length = 1722

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    ICSIKR 6
            ICSI+R
Sbjct: 1464 ICSIRR 1469
>XP_005251505
          Length = 226

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           I  +KR DN
Sbjct: 114 IAELKRCDN 122
>XP_005248794
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ICSIKRAD 8
           IC++ R+D
Sbjct: 135 ICTVMRSD 142
>XP_005248793
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ICSIKRAD 8
           IC++ R+D
Sbjct: 135 ICTVMRSD 142
>XP_005248792
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   ICSIKRAD 8
           IC++ R+D
Sbjct: 135 ICTVMRSD 142
>XP_005266859
          Length = 233

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 209 ICAIMNLDN 217
>XP_005266858
          Length = 235

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 211 ICAIMNLDN 219
>XP_005266855
          Length = 364

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 340 ICAIMNLDN 348
>XP_005266854
          Length = 427

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           IC+I   DN
Sbjct: 403 ICAIMNLDN 411
>XP_005262709
          Length = 1337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           CS K+AD
Sbjct: 581 CSCKQAD 587
>XP_005273257
          Length = 1726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    ICSIKR 6
            ICSI+R
Sbjct: 1468 ICSIRR 1473
>XP_006711259
          Length = 434

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           C +K+AD
Sbjct: 128 CRVKKAD 134
>XP_005277566
          Length = 534

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 2   CSIKRAD 8
           C +K+AD
Sbjct: 278 CRVKKAD 284
>NP_001010887
          Length = 275

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   ICSIKRADN 9
           I  +KR DN
Sbjct: 163 IAELKRCDN 171
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.135    0.411 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 620,215
Number of extensions: 1438
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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