Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

XP_005249641                                                           17    2528
NP_066939                                                              17    2528
NP_000027                                                              17    3301
NP_001166097                                                           17    3301
NP_077010                                                              17    4312
NP_690621                                                              17    4312
NP_690620                                                              17    4312
NP_690619                                                              17    4312
NP_006081                                                              17    4312
NP_001007795                                                           17    4312
NP_002812                                                              17    4312
NP_001257327                                                           17    4312
NP_061060                                                              17    4312
NP_150377                                                              17    4312
XP_005266060                                                           17    4312
XP_006710349                                                           17    4312
XP_005270410                                                           17    4312
XP_006710348                                                           17    4312
NP_705898                                                              16    5631
NP_036214                                                              16    5631
NP_150229                                                              16    5631
XP_005250907                                                           16    5631
NP_001005197                                                           16    5631
NP_004657                                                              16    7355
NP_001273516                                                           16    7355
NP_057192                                                              16    7355
NP_001273517                                                           16    7355
NP_001273518                                                           16    7355
NP_001025230                                                           16    7355
XP_006717751                                                           16    7355
XP_006717749                                                           16    7355
XP_006717748                                                           16    7355
XP_005267067                                                           16    7355
NP_001398                                                              15    9605
NP_444282                                                              15    9605
NP_001273283                                                           15    9605
NP_683766                                                              15    9605
NP_001273284                                                           15    9605
NP_056379                                                              15    9605
NP_001438                                                              15    9605
NP_660358                                                              15    9605
NP_116182                                                              15    9605
NP_001265544                                                           15    9605
NP_001129965                                                           15    9605
NP_001274738                                                           15    9605
NP_115796                                                              15    9605
NP_001265542                                                           15    9605
NP_002578                                                              15    9605
XP_005255896                                                           15    9605
XP_005255895                                                           15    9605
XP_005273812                                                           15    9605
XP_005266942                                                           15    9605
XP_005268513                                                           15    9605
XP_005268512                                                           15    9605
XP_005268511                                                           15    9605
XP_005268510                                                           15    9605
XP_005268509                                                           15    9605
XP_006714824                                                           15    9605
XP_005246419                                                           15    9605
XP_005271342                                                           15    9605
NP_001073961                                                           15    9605
NP_006574                                                              15    9605
NP_001073941                                                           15    9605
NP_803237                                                              15    9605
>XP_005249641
          Length = 979

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAVLMFYCA 9
           +A+L+F CA
Sbjct: 789 VAILLFSCA 797
>NP_066939
          Length = 1119

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAVLMFYCA 9
           +A+L+F CA
Sbjct: 789 VAILLFSCA 797
>NP_000027
          Length = 780

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMFYCA 9
          L+FYCA
Sbjct: 19 LLFYCA 24
>NP_001166097
          Length = 776

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  LMFYCA 9
          L+FYCA
Sbjct: 19 LLFYCA 24
>NP_077010
          Length = 488

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 140 LMFYC 144
>NP_690621
          Length = 1014

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 666 LMFYC 670
>NP_690620
          Length = 940

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 592 LMFYC 596
>NP_690619
          Length = 1030

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 682 LMFYC 686
>NP_006081
          Length = 416

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   MFYCA 9
           MFYCA
Sbjct: 192 MFYCA 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           +L+FYC
Sbjct: 102 LLVFYC 107
>NP_001007795
          Length = 416

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   MFYCA 9
           MFYCA
Sbjct: 192 MFYCA 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           +L+FYC
Sbjct: 102 LLVFYC 107
>NP_002812
          Length = 1070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 722 LMFYC 726
>NP_001257327
          Length = 1078

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           LMFYC
Sbjct: 730 LMFYC 734
>NP_061060
          Length = 542

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           VLMF+C
Sbjct: 361 VLMFFC 366
>NP_150377
          Length = 918

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           + +LM+YC
Sbjct: 716 VLMLMYYC 723
>XP_005266060
          Length = 955

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           + +LM+YC
Sbjct: 716 VLMLMYYC 723
>XP_006710349
          Length = 219

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   MFYCA 9
           MFYCA
Sbjct: 192 MFYCA 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           +L+FYC
Sbjct: 102 LLVFYC 107
>XP_005270410
          Length = 268

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   MFYCA 9
           MFYCA
Sbjct: 192 MFYCA 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           +L+FYC
Sbjct: 102 LLVFYC 107
>XP_006710348
          Length = 416

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 5   MFYCA 9
           MFYCA
Sbjct: 192 MFYCA 196

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 3   VLMFYC 8
           +L+FYC
Sbjct: 102 LLVFYC 107
>NP_705898
          Length = 564

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   AVLMFYCA 9
           AVLM +CA
Sbjct: 159 AVLMQFCA 166
>NP_036214
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AVLMFYCA 9
           A LM+YC+
Sbjct: 267 AHLMYYCS 274
>NP_150229
          Length = 1359

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAVLMFYCA 9
           I +LM +CA
Sbjct: 244 IPILMVFCA 252
>XP_005250907
          Length = 1082

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AVLMFYCA 9
           A LM+YC+
Sbjct: 198 AHLMYYCS 205
>NP_001005197
          Length = 314

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   AVLMFY 7
           AVLMFY
Sbjct: 247 AVLMFY 252
>NP_004657
          Length = 513

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  IAVLMFY 7
          +A+L+FY
Sbjct: 9  VAILLFY 15
>NP_001273516
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1 IAVLMFYCA 9
         +A+L+ YC+
Sbjct: 1 MAILLSYCS 9
>NP_057192
          Length = 238

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IAVLMFYCA 9
          +A+L+ YC+
Sbjct: 11 MAILLSYCS 19
>NP_001273517
          Length = 134

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IAVLMFYCA 9
          +A+L+ YC+
Sbjct: 11 MAILLSYCS 19
>NP_001273518
          Length = 137

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IAVLMFYCA 9
          +A+L+ YC+
Sbjct: 11 MAILLSYCS 19
>NP_001025230
          Length = 271

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AVLMFYCA 9
           A+L  YCA
Sbjct: 182 AILPLYCA 189
>XP_006717751
          Length = 150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  AVLMFYCA 9
          A+L  YCA
Sbjct: 61 AILPLYCA 68
>XP_006717749
          Length = 222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AVLMFYCA 9
           A+L  YCA
Sbjct: 182 AILPLYCA 189
>XP_006717748
          Length = 258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   AVLMFYCA 9
           A+L  YCA
Sbjct: 169 AILPLYCA 176
>XP_005267067
          Length = 245

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IAVLMFYCA 9
          +A+L+ YC+
Sbjct: 11 MAILLSYCS 19
>NP_001398
          Length = 3312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1    IAVLMFYC 8
            +AVL+ +C
Sbjct: 2765 LAVLLLFC 2772
>NP_444282
          Length = 780

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           I +LMF C
Sbjct: 586 ILILMFTC 593
>NP_001273283
          Length = 751

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           IA+L F C
Sbjct: 584 IAILAFIC 591
>NP_683766
          Length = 926

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           IA+L F C
Sbjct: 759 IAILAFIC 766
>NP_001273284
          Length = 855

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           IA+L F C
Sbjct: 688 IAILAFIC 695
>NP_056379
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4  LMFYC 8
          L+FYC
Sbjct: 43 LLFYC 47
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4    LMFYC 8
            L+FYC
Sbjct: 4066 LLFYC 4070
>NP_660358
          Length = 481

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           IAVL  YC
Sbjct: 265 IAVLKEYC 272
>NP_116182
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           L+FYC
Sbjct: 148 LLFYC 152
>NP_001265544
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 491 LAVLVRYC 498
>NP_001129965
          Length = 543

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           L+FYC
Sbjct: 161 LLFYC 165
>NP_001274738
          Length = 491

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           L+FYC
Sbjct: 111 LLFYC 115
>NP_115796
          Length = 1237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 870 LAVLVRYC 877
>NP_001265542
          Length = 1076

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 886 LAVLVRYC 893
>NP_002578
          Length = 1060

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 870 LAVLVRYC 877
>XP_005255896
          Length = 296

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VLMFYCA 9
           VL+F+C+
Sbjct: 288 VLVFFCS 294
>XP_005255895
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VLMFYCA 9
           VL+F+C+
Sbjct: 387 VLVFFCS 393
>XP_005273812
          Length = 649

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           I +LMF C
Sbjct: 455 ILILMFTC 462
>XP_005266942
          Length = 448

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           IAVL  YC
Sbjct: 232 IAVLKEYC 239
>XP_005268513
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 491 LAVLVRYC 498
>XP_005268512
          Length = 858

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 491 LAVLVRYC 498
>XP_005268511
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 914 LAVLVRYC 921
>XP_005268510
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 848 LAVLVRYC 855
>XP_005268509
          Length = 1281

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAVLMFYC 8
           +AVL+ YC
Sbjct: 914 LAVLVRYC 921
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4    LMFYC 8
            L+FYC
Sbjct: 4066 LLFYC 4070
>XP_005246419
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AVLMFYC 8
           AVL+ YC
Sbjct: 289 AVLLCYC 295
>XP_005271342
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           L+FYC
Sbjct: 146 LLFYC 150
>NP_001073961
          Length = 395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   VLMFYCA 9
           VL+F+C+
Sbjct: 387 VLVFFCS 393
>NP_006574
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 4   LMFYC 8
           +MFYC
Sbjct: 204 VMFYC 208
>NP_001073941
          Length = 262

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IAVLMFYC 8
           I VLMF C
Sbjct: 201 IWVLMFLC 208
>NP_803237
          Length = 826

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   AVLMFYC 8
           AVL+ YC
Sbjct: 372 AVLLCYC 378
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.357    0.151    0.530 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 426,344
Number of extensions: 547
Number of successful extensions: 69
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.2 bits)
S2: 28 (15.4 bits)

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