Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001243398                                                           22     103
NP_036462                                                              22     103
NP_001243397                                                           22     103
XP_005269721                                                           22     103
NP_055623                                                              18    1935
NP_001258                                                              18    1935
XP_005247107                                                           18    1935
XP_005247106                                                           18    1935
NP_001121631                                                           17    3301
NP_064518                                                              17    3301
NP_060759                                                              17    3301
NP_001161707                                                           17    3301
XP_006721618                                                           17    3301
XP_005256772                                                           17    3301
XP_006715578                                                           17    3301
XP_005267112                                                           17    3301
XP_005267111                                                           17    3301
XP_005267110                                                           17    3301
XP_005267109                                                           17    3301
XP_006715576                                                           17    3301
XP_006715575                                                           17    3301
NP_060426                                                              17    3301
NP_001019993                                                           17    3301
XP_006714215                                                           17    4312
XP_006714214                                                           17    4312
XP_005262915                                                           17    4312
NP_055806                                                              17    4312
NP_001186692                                                           16    5631
NP_001230178                                                           16    5631
NP_002837                                                              16    5631
NP_001186693                                                           16    5631
NP_001230176                                                           16    5631
NP_001070818                                                           16    5631
NP_001230177                                                           16    5631
NP_003804                                                              16    7355
NP_055612                                                              16    7355
NP_060828                                                              16    7355
NP_001135389                                                           16    7355
NP_002213                                                              15    9605
NP_001093422                                                           15    9605
NP_001161744                                                           15    9605
NP_001121683                                                           15    9605
NP_219491                                                              15    9605
NP_116258                                                              15    9605
NP_620158                                                              15    9605
NP_001165108                                                           15    9605
NP_065810                                                              15    9605
XP_005260614                                                           15    9605
XP_006720684                                                           15    9605
XP_005268209                                                           15    9605
XP_005268208                                                           15    9605
XP_006713199                                                           15    9605
XP_006713198                                                           15    9605
XP_006713197                                                           15    9605
XP_005265167                                                           15    9605
XP_006713196                                                           15    9605
XP_006713195                                                           15    9605
XP_005265166                                                           15    9605
XP_006713194                                                           15    9605
XP_006712360                                                           15    9605
XP_006712359                                                           15    9605
XP_005246376                                                           15    9605
NP_003805                                                              15    9605
>NP_001243398
          Length = 1781

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IATTLQHIH 9
           IATTLQH+H
Sbjct: 646 IATTLQHLH 654
>NP_036462
          Length = 2073

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IATTLQHIH 9
           IATTLQH+H
Sbjct: 938 IATTLQHLH 946
>NP_001243397
          Length = 1890

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IATTLQHIH 9
           IATTLQH+H
Sbjct: 755 IATTLQHLH 763
>XP_005269721
          Length = 2073

 Score = 21.9 bits (45), Expect =   103
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IATTLQHIH 9
           IATTLQH+H
Sbjct: 938 IATTLQHLH 946
>NP_055623
          Length = 1054

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           + TTLQHI
Sbjct: 719 VTTTLQHI 726
>NP_001258
          Length = 359

 Score = 17.7 bits (34), Expect =  1935
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   TTLQHIH 9
           TTL+H+H
Sbjct: 268 TTLKHVH 274
>XP_005247107
          Length = 781

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           + TTLQHI
Sbjct: 719 VTTTLQHI 726
>XP_005247106
          Length = 1054

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           + TTLQHI
Sbjct: 719 VTTTLQHI 726
>NP_001121631
          Length = 832

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TTLQHIH 9
           TTL H+H
Sbjct: 147 TTLNHLH 153
>NP_064518
          Length = 378

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>NP_060759
          Length = 670

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TTLQHIH 9
           TTL H+H
Sbjct: 118 TTLNHLH 124
>NP_001161707
          Length = 2139

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    TLQHIH 9
            TLQH+H
Sbjct: 1089 TLQHLH 1094
>XP_006721618
          Length = 419

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TTLQHIH 9
           TTL H+H
Sbjct: 147 TTLNHLH 153
>XP_005256772
          Length = 803

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   TTLQHIH 9
           TTL H+H
Sbjct: 118 TTLNHLH 124
>XP_006715578
          Length = 232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>XP_005267112
          Length = 232

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>XP_005267111
          Length = 244

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IATTLQHI 8
          +AT+LQH+
Sbjct: 21 VATSLQHL 28
>XP_005267110
          Length = 244

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1  IATTLQHI 8
          +AT+LQH+
Sbjct: 21 VATSLQHL 28
>XP_005267109
          Length = 288

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>XP_006715576
          Length = 378

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>XP_006715575
          Length = 378

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IATTLQHI 8
           +AT+LQH+
Sbjct: 155 VATSLQHL 162
>NP_060426
          Length = 448

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IATTLQHIH 9
           IAT LQ +H
Sbjct: 403 IATLLQQVH 411
>NP_001019993
          Length = 147

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  IATTLQHIH 9
          + +TL+H+H
Sbjct: 23 VMSTLEHLH 31
>XP_006714215
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IATTLQHI 8
            +ATTLQ++
Sbjct: 1419 VATTLQYV 1426
>XP_006714214
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IATTLQHI 8
            +ATTLQ++
Sbjct: 1419 VATTLQYV 1426
>XP_005262915
          Length = 3544

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IATTLQHI 8
            +ATTLQ++
Sbjct: 1419 VATTLQYV 1426
>NP_055806
          Length = 3526

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IATTLQHI 8
            +ATTLQ++
Sbjct: 1401 VATTLQYV 1408
>NP_001186692
          Length = 950

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           IA TL+H+
Sbjct: 909 IAATLEHV 916
>NP_001230178
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IATTLQH 7
           IAT LQH
Sbjct: 124 IATVLQH 130
>NP_002837
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           IA TL+H+
Sbjct: 938 IAATLEHV 945
>NP_001186693
          Length = 889

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           IA TL+H+
Sbjct: 848 IAATLEHV 855
>NP_001230176
          Length = 491

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1  IATTLQH 7
          IAT LQH
Sbjct: 71 IATVLQH 77
>NP_001070818
          Length = 569

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IATTLQH 7
           IAT LQH
Sbjct: 149 IATVLQH 155
>NP_001230177
          Length = 544

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   IATTLQH 7
           IAT LQH
Sbjct: 124 IATVLQH 130
>NP_003804
          Length = 722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TLQHIH 9
           TLQH H
Sbjct: 579 TLQHTH 584
>NP_055612
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   TLQHIH 9
           TL+H+H
Sbjct: 644 TLEHLH 649
>NP_060828
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IATTLQHIH 9
           IAT + H+H
Sbjct: 390 IATDIIHLH 398
>NP_001135389
          Length = 1335

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IATTLQHIH 9
           + TTL+H H
Sbjct: 773 LETTLRHKH 781
>NP_002213
          Length = 2695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1256 AVTMQHI 1262
>NP_001093422
          Length = 2710

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1271 AVTMQHI 1277
>NP_001161744
          Length = 2743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1265 AVTMQHI 1271
>NP_001121683
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  TLQHIH 9
          TL+H+H
Sbjct: 23 TLEHMH 28
>NP_219491
          Length = 246

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IATTLQHI 8
           +ATTLQ +
Sbjct: 155 LATTLQEV 162
>NP_116258
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  TLQHIH 9
          TL+H+H
Sbjct: 52 TLEHMH 57
>NP_620158
          Length = 591

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TLQHIH 9
           TLQH H
Sbjct: 144 TLQHSH 149
>NP_001165108
          Length = 299

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TLQHIH 9
          TLQH H
Sbjct: 58 TLQHSH 63
>NP_065810
          Length = 4700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            ATTL H+
Sbjct: 1470 ATTLTHV 1476
>XP_005260614
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   TTLQHI 8
           TT+QHI
Sbjct: 428 TTVQHI 433
>XP_006720684
          Length = 4713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            ATTL H+
Sbjct: 1483 ATTLTHV 1489
>XP_005268209
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ATTLQH 7
           ATT+QH
Sbjct: 277 ATTVQH 282
>XP_005268208
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ATTLQH 7
           ATT+QH
Sbjct: 277 ATTVQH 282
>XP_006713199
          Length = 2695

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1280 AVTMQHI 1286
>XP_006713198
          Length = 2699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1280 AVTMQHI 1286
>XP_006713197
          Length = 2712

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1256 AVTMQHI 1262
>XP_005265167
          Length = 2719

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1280 AVTMQHI 1286
>XP_006713196
          Length = 2721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1265 AVTMQHI 1271
>XP_006713195
          Length = 2727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1271 AVTMQHI 1277
>XP_005265166
          Length = 2735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1280 AVTMQHI 1286
>XP_006713194
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2    ATTLQHI 8
            A T+QHI
Sbjct: 1280 AVTMQHI 1286
>XP_006712360
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4  TLQHIH 9
          TLQH H
Sbjct: 58 TLQHSH 63
>XP_006712359
          Length = 577

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TLQHIH 9
           TLQH H
Sbjct: 130 TLQHSH 135
>XP_005246376
          Length = 612

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 4   TLQHIH 9
           TLQH H
Sbjct: 165 TLQHSH 170
>NP_003805
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   ATTLQH 7
           ATT+QH
Sbjct: 277 ATTVQH 282
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.132    0.396 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 558,152
Number of extensions: 544
Number of successful extensions: 63
Number of sequences better than 10000.0: 63
Number of HSP's gapped: 63
Number of HSP's successfully gapped: 63
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.3 bits)
S2: 28 (15.4 bits)

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