Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000360                                                              20     299
XP_005268094                                                           20     299
NP_000224                                                              18    1482
NP_852111                                                              18    1482
NP_000136                                                              18    1482
XP_005264366                                                           18    1482
XP_006712078                                                           18    1482
NP_000543                                                              17    3301
NP_060051                                                              17    3301
NP_001154915                                                           17    4312
NP_003966                                                              17    4312
NP_001154913                                                           17    4312
NP_001154914                                                           17    4312
NP_001128663                                                           17    4312
NP_066919                                                              17    4312
NP_003878                                                              17    4312
NP_001003406                                                           17    4312
NP_001154916                                                           17    4312
XP_006711965                                                           17    4312
XP_006711964                                                           17    4312
XP_006711963                                                           17    4312
XP_006711962                                                           17    4312
XP_006711961                                                           17    4312
XP_006711678                                                           17    4312
NP_003652                                                              16    5631
NP_001130012                                                           16    5631
NP_663318                                                              16    5631
NP_001130013                                                           16    5631
NP_001157745                                                           16    5631
NP_001074010                                                           16    5631
XP_005261853                                                           16    5631
XP_005261852                                                           16    5631
XP_005258050                                                           16    5631
XP_005254310                                                           16    5631
XP_005254309                                                           16    5631
XP_005254306                                                           16    5631
XP_005254305                                                           16    5631
XP_005254304                                                           16    5631
XP_005254303                                                           16    5631
XP_006720506                                                           16    5631
XP_005254302                                                           16    5631
XP_005254301                                                           16    5631
XP_006720505                                                           16    5631
XP_005254300                                                           16    5631
NP_060029                                                              16    5631
NP_001269939                                                           16    7355
NP_001257903                                                           16    7355
NP_001269938                                                           16    7355
NP_116575                                                              16    7355
NP_057518                                                              16    7355
NP_079032                                                              16    7355
NP_078997                                                              16    7355
NP_060417                                                              16    7355
NP_659416                                                              16    7355
NP_001264100                                                           16    7355
NP_001264102                                                           16    7355
XP_006721269                                                           16    7355
XP_005270210                                                           16    7355
XP_006718033                                                           16    7355
XP_006714183                                                           16    7355
XP_006714182                                                           16    7355
NP_079104                                                              15    9605
NP_002554                                                              15    9605
NP_001036038                                                           15    9605
XP_006726485                                                           15    9605
XP_006722770                                                           15    9605
XP_006722769                                                           15    9605
XP_006722768                                                           15    9605
XP_005272521                                                           15    9605
XP_006722082                                                           15    9605
XP_006717983                                                           15    9605
XP_005270036                                                           15    9605
XP_005270035                                                           15    9605
XP_005251638                                                           15    9605
XP_005249571                                                           15    9605
NP_001094386                                                           15    9605
NP_942090                                                              15    9605
>NP_000360
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISFYAL
Sbjct: 637 MAPISFYAL 645
>XP_005268094
          Length = 764

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISFYAL
Sbjct: 637 MAPISFYAL 645
>NP_000224
          Length = 699

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISF+A+
Sbjct: 582 MAPISFFAI 590
>NP_852111
          Length = 669

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISF+A+
Sbjct: 559 MAPISFFAI 567
>NP_000136
          Length = 695

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISF+A+
Sbjct: 585 MAPISFFAI 593
>XP_005264366
          Length = 380

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISF+A+
Sbjct: 263 MAPISFFAI 271
>XP_006712078
          Length = 389

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 9/9 (100%)

Query: 1   IAPISFYAL 9
           +APISF+A+
Sbjct: 272 MAPISFFAI 280
>NP_000543
          Length = 2813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    IAPISFYAL 9
            +AP +FYA+
Sbjct: 2154 LAPATFYAI 2162
>NP_060051
          Length = 479

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SFY
Sbjct: 254 LAPLSFY 260
>NP_001154915
          Length = 361

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 258 PIAFYAM 264
>NP_003966
          Length = 389

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 286 PIAFYAM 292
>NP_001154913
          Length = 399

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 296 PIAFYAM 302
>NP_001154914
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 268 PIAFYAM 274
>NP_001128663
          Length = 961

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 720 PISFYQL 726
>NP_066919
          Length = 2223

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IAPISFYAL 9
          +API+F+ L
Sbjct: 54 LAPIAFFCL 62
>NP_003878
          Length = 1006

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 720 PISFYQL 726
>NP_001003406
          Length = 2188

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  IAPISFYAL 9
          +API+F+ L
Sbjct: 54 LAPIAFFCL 62
>NP_001154916
          Length = 389

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 286 PIAFYAM 292
>XP_006711965
          Length = 964

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 723 PISFYQL 729
>XP_006711964
          Length = 970

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 684 PISFYQL 690
>XP_006711963
          Length = 978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 692 PISFYQL 698
>XP_006711962
          Length = 984

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 698 PISFYQL 704
>XP_006711961
          Length = 1009

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY L
Sbjct: 723 PISFYQL 729
>XP_006711678
          Length = 395

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   PISFYAL 9
           PI+FYA+
Sbjct: 292 PIAFYAM 298
>NP_003652
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 338 VAPVSFF 344
>NP_001130012
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 338 VAPVSFF 344
>NP_663318
          Length = 414

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 354 VAPVSFF 360
>NP_001130013
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 320 VAPVSFF 326
>NP_001157745
          Length = 3065

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>NP_001074010
          Length = 2856

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005261853
          Length = 380

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 320 VAPVSFF 326
>XP_005261852
          Length = 396

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   IAPISFY 7
           +AP+SF+
Sbjct: 336 VAPVSFF 342
>XP_005258050
          Length = 330

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 206 PVSFYQL 212
>XP_005254310
          Length = 2906

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254309
          Length = 2956

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254306
          Length = 3066

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254305
          Length = 3114

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254304
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254303
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_006720506
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254302
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254301
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_006720505
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>XP_005254300
          Length = 3115

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 173 PVSFYKL 179
>NP_060029
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY L
Sbjct: 206 PVSFYQL 212
>NP_001269939
          Length = 996

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAPISFYAL 9
           +AP+S +AL
Sbjct: 259 LAPVSSFAL 267
>NP_001257903
          Length = 5121

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PISFYAL 9
            PI FY+L
Sbjct: 1856 PIEFYSL 1862
>NP_001269938
          Length = 1300

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAPISFYAL 9
           +AP+S +AL
Sbjct: 482 LAPVSSFAL 490
>NP_116575
          Length = 1243

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAPISFYAL 9
           +AP+S +AL
Sbjct: 506 LAPVSSFAL 514
>NP_057518
          Length = 1219

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   IAPISFYAL 9
           +AP+S +AL
Sbjct: 482 LAPVSSFAL 490
>NP_079032
          Length = 949

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   APISFYA 8
           +P++FYA
Sbjct: 824 SPVAFYA 830
>NP_078997
          Length = 3616

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   APISFY 7
           AP+SFY
Sbjct: 183 APMSFY 188
>NP_060417
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           PISFY +
Sbjct: 259 PISFYKI 265
>NP_659416
          Length = 533

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           + PIS Y+L
Sbjct: 378 LTPISMYSL 386
>NP_001264100
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           + PIS Y+L
Sbjct: 378 LTPISMYSL 386
>NP_001264102
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           + PIS Y+L
Sbjct: 378 LTPISMYSL 386
>XP_006721269
          Length = 5138

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    PISFYAL 9
            PI FY+L
Sbjct: 1873 PIEFYSL 1879
>XP_005270210
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   APISFYA 8
           +P++FYA
Sbjct: 763 SPVAFYA 769
>XP_006718033
          Length = 888

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   APISFYA 8
           +P++FYA
Sbjct: 763 SPVAFYA 769
>XP_006714183
          Length = 470

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           + PIS Y+L
Sbjct: 378 LTPISMYSL 386
>XP_006714182
          Length = 485

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           + PIS Y+L
Sbjct: 378 LTPISMYSL 386
>NP_079104
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IAPISFY 7
           + P+SFY
Sbjct: 133 LKPVSFY 139
>NP_002554
          Length = 373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAPISFYA 8
           I+PI FY+
Sbjct: 183 ISPILFYS 190
>NP_001036038
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  PISFY 7
          PISFY
Sbjct: 82 PISFY 86
>XP_006726485
          Length = 330

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   APISFY 7
           APISF+
Sbjct: 322 APISFF 327
>XP_006722770
          Length = 1345

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY +
Sbjct: 141 PVSFYEI 147
>XP_006722769
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY +
Sbjct: 157 PVSFYEI 163
>XP_006722768
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY +
Sbjct: 157 PVSFYEI 163
>XP_005272521
          Length = 1426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 3   PISFYAL 9
           P+SFY +
Sbjct: 222 PVSFYEI 228
>XP_006722082
          Length = 384

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  PISFY 7
          PISFY
Sbjct: 82 PISFY 86
>XP_006717983
          Length = 1104

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           I+P  FYAL
Sbjct: 950 ISPNLFYAL 958
>XP_005270036
          Length = 1113

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           I+P  FYAL
Sbjct: 950 ISPNLFYAL 958
>XP_005270035
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           I+P  FYAL
Sbjct: 950 ISPNLFYAL 958
>XP_005251638
          Length = 237

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   IAPISFY 7
           + P+SFY
Sbjct: 133 LKPVSFY 139
>XP_005249571
          Length = 566

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   APISFY 7
           APISF+
Sbjct: 558 APISFF 563
>NP_001094386
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 3  PISFY 7
          PISFY
Sbjct: 11 PISFY 15
>NP_942090
          Length = 1189

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IAPISFYAL 9
           I+P  FYAL
Sbjct: 950 ISPNLFYAL 958
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.337    0.149    0.443 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 551,042
Number of extensions: 758
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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