Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_008835                                                              20     509
NP_001075109                                                           20     509
NP_000375                                                              17    3301
XP_006716433                                                           17    4312
XP_005273633                                                           17    4312
XP_006716432                                                           17    4312
XP_005273632                                                           17    4312
NP_653229                                                              16    7355
NP_001276915                                                           16    7355
NP_060328                                                              16    7355
NP_001094058                                                           16    7355
NP_061323                                                              16    7355
XP_005260718                                                           16    7355
XP_006720657                                                           16    7355
XP_005254579                                                           16    7355
XP_005254578                                                           16    7355
XP_006720656                                                           16    7355
XP_003403748                                                           16    7355
NP_619635                                                              16    7355
NP_037393                                                              15    9605
NP_079033                                                              15    9605
NP_689742                                                              15    9605
NP_001028217                                                           15    9605
NP_001253979                                                           15    9605
NP_000043                                                              15    9605
NP_001253980                                                           15    9605
NP_001269153                                                           15    9605
NP_001275915                                                           15    9605
NP_001275914                                                           15    9605
NP_009099                                                              15    9605
NP_056052                                                              15    9605
NP_079467                                                              15    9605
NP_001153508                                                           15    9605
NP_060371                                                              15    9605
XP_005256997                                                           15    9605
XP_005256995                                                           15    9605
XP_006719528                                                           15    9605
XP_005253963                                                           15    9605
XP_005253962                                                           15    9605
XP_006717353                                                           15    9605
XP_006717352                                                           15    9605
XP_005266166                                                           15    9605
XP_005266167                                                           15    9605
XP_005266165                                                           15    9605
XP_005266164                                                           15    9605
XP_006717351                                                           15    9605
XP_005266163                                                           15    9605
XP_005266162                                                           15    9605
XP_006716378                                                           15    9605
XP_005248191                                                           15    9605
XP_005248189                                                           15    9605
XP_005248188                                                           15    9605
XP_005248187                                                           15    9605
XP_006712406                                                           15    9605
XP_005245556                                                           15    9605
NP_001153509                                                           15    9605
NP_001137291                                                           15    9605
NP_055993                                                              15    9605
YP_003024038                                                           15    9605
>NP_008835
          Length = 4128

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IANALNSEP 9
            IANAL+SEP
Sbjct: 3337 IANALSSEP 3345
>NP_001075109
          Length = 4097

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    IANALNSEP 9
            IANAL+SEP
Sbjct: 3337 IANALSSEP 3345
>NP_000375
          Length = 4563

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           IAN LNSE
Sbjct: 597 IANILNSE 604
>XP_006716433
          Length = 3069

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           + NALNSE
Sbjct: 221 LCNALNSE 228
>XP_005273633
          Length = 3069

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           + NALNSE
Sbjct: 221 LCNALNSE 228
>XP_006716432
          Length = 3172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           + NALNSE
Sbjct: 324 LCNALNSE 331
>XP_005273632
          Length = 3172

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           + NALNSE
Sbjct: 324 LCNALNSE 331
>NP_653229
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I  ALNS+P
Sbjct: 36 IHQALNSDP 44
>NP_001276915
          Length = 200

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 167 IANTLNEE 174
>NP_060328
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 268 IANTLNEE 275
>NP_001094058
          Length = 1191

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NALNSEP 9
           NA++SEP
Sbjct: 849 NAIDSEP 855
>NP_061323
          Length = 1064

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NALNSEP 9
           NA++SEP
Sbjct: 849 NAIDSEP 855
>XP_005260718
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I  ALNS+P
Sbjct: 36 IHQALNSDP 44
>XP_006720657
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 268 IANTLNEE 275
>XP_005254579
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 268 IANTLNEE 275
>XP_005254578
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 268 IANTLNEE 275
>XP_006720656
          Length = 301

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   IANALNSE 8
           IAN LN E
Sbjct: 268 IANTLNEE 275
>XP_003403748
          Length = 997

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           I  ALN+EP
Sbjct: 833 IHRALNTEP 841
>NP_619635
          Length = 1043

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           I  ALN+EP
Sbjct: 879 IHRALNTEP 887
>NP_037393
          Length = 798

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I+N  N+EP
Sbjct: 65 ISNQYNNEP 73
>NP_079033
          Length = 1298

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1027 NAVDSEP 1033
>NP_689742
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IANALNSEP 9
           IAN   SEP
Sbjct: 610 IANTSTSEP 618
>NP_001028217
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IANALNSEP 9
           IAN   SEP
Sbjct: 610 IANTSTSEP 618
>NP_001253979
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IANALNSEP 9
           IAN   SEP
Sbjct: 610 IANTSTSEP 618
>NP_000043
          Length = 1500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IANALNSE 8
            I+NALN++
Sbjct: 1169 ISNALNAQ 1176
>NP_001253980
          Length = 842

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IANALNSEP 9
           IAN   SEP
Sbjct: 582 IANTSTSEP 590
>NP_001269153
          Length = 1422

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    IANALNSE 8
            I+NALN++
Sbjct: 1091 ISNALNAQ 1098
>NP_001275915
          Length = 1616

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ANALNS 7
            ANALNS
Sbjct: 1261 ANALNS 1266
>NP_001275914
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ANALNS 7
            ANALNS
Sbjct: 1266 ANALNS 1271
>NP_009099
          Length = 1581

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ANALNS 7
            ANALNS
Sbjct: 1226 ANALNS 1231
>NP_056052
          Length = 1354

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NALNSEP 9
           N+LNS P
Sbjct: 662 NSLNSNP 668
>NP_079467
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NALNSEP 9
           N+LNS P
Sbjct: 838 NSLNSHP 844
>NP_001153508
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           +AN LN+E
Sbjct: 486 VANILNNE 493
>NP_060371
          Length = 816

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +A ALN EP
Sbjct: 523 LALALNMEP 531
>XP_005256997
          Length = 1560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ANALNS 7
            ANALNS
Sbjct: 1205 ANALNS 1210
>XP_005256995
          Length = 1621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    ANALNS 7
            ANALNS
Sbjct: 1266 ANALNS 1271
>XP_006719528
          Length = 641

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +A ALN EP
Sbjct: 595 LALALNMEP 603
>XP_005253963
          Length = 748

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +A ALN EP
Sbjct: 455 LALALNMEP 463
>XP_005253962
          Length = 870

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +A ALN EP
Sbjct: 577 LALALNMEP 585
>XP_006717353
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NALNSEP 9
           NA++SEP
Sbjct: 972 NAVDSEP 978
>XP_006717352
          Length = 1250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   NALNSEP 9
           NA++SEP
Sbjct: 979 NAVDSEP 985
>XP_005266166
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 996  NAVDSEP 1002
>XP_005266167
          Length = 1267

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 996  NAVDSEP 1002
>XP_005266165
          Length = 1272

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1001 NAVDSEP 1007
>XP_005266164
          Length = 1291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1020 NAVDSEP 1026
>XP_006717351
          Length = 1292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1021 NAVDSEP 1027
>XP_005266163
          Length = 1294

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1023 NAVDSEP 1029
>XP_005266162
          Length = 1295

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    NALNSEP 9
            NA++SEP
Sbjct: 1024 NAVDSEP 1030
>XP_006716378
          Length = 749

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           +AN LN+E
Sbjct: 486 VANILNNE 493
>XP_005248191
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I+N  N+EP
Sbjct: 70 ISNQYNNEP 78
>XP_005248189
          Length = 795

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I+N  N+EP
Sbjct: 62 ISNQYNNEP 70
>XP_005248188
          Length = 802

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I+N  N+EP
Sbjct: 69 ISNQYNNEP 77
>XP_005248187
          Length = 803

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  IANALNSEP 9
          I+N  N+EP
Sbjct: 70 ISNQYNNEP 78
>XP_006712406
          Length = 785

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   IANALNSEP 9
           IAN   SEP
Sbjct: 610 IANTSTSEP 618
>XP_005245556
          Length = 933

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   NALNSEP 9
           N+LNS P
Sbjct: 839 NSLNSHP 845
>NP_001153509
          Length = 734

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           +AN LN+E
Sbjct: 471 VANILNNE 478
>NP_001137291
          Length = 888

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +A ALN EP
Sbjct: 595 LALALNMEP 603
>NP_055993
          Length = 727

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IANALNSE 8
           +AN LN+E
Sbjct: 464 VANILNNE 471
>YP_003024038
          Length = 380

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IANALNSEP 9
           +AN LN+ P
Sbjct: 258 LANPLNTPP 266
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.298    0.117    0.302 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 493,011
Number of extensions: 607
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.1 bits)
S2: 28 (15.4 bits)

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