Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001138390                                                           18    1135
NP_001138386                                                           18    1135
NP_001138387                                                           18    1135
NP_000132                                                              18    1135
NP_075259                                                              18    1135
NP_001138388                                                           18    1135
NP_001138391                                                           18    1135
NP_001138385                                                           18    1135
NP_075418                                                              18    1135
XP_006717776                                                           18    1135
XP_006717775                                                           18    1135
XP_006717774                                                           18    1135
XP_006717773                                                           18    1135
XP_006717772                                                           18    1135
XP_006717771                                                           18    1135
NP_003226                                                              17    2528
XP_005251095                                                           17    2528
XP_006716685                                                           17    2528
NP_001130008                                                           17    4312
NP_001164171                                                           17    4312
XP_006714077                                                           17    4312
NP_002200                                                              16    7355
NP_001107852                                                           16    7355
NP_001177087                                                           16    7355
NP_001135864                                                           16    7355
NP_001135863                                                           16    7355
NP_659461                                                              16    7355
NP_001273145                                                           16    7355
NP_060959                                                              16    7355
NP_061969                                                              16    7355
NP_062822                                                              16    7355
XP_005277970                                                           16    7355
XP_006724911                                                           16    7355
XP_006724910                                                           16    7355
XP_006721609                                                           16    7355
XP_006721107                                                           16    7355
XP_005255370                                                           16    7355
XP_006715187                                                           16    7355
XP_005245393                                                           16    7355
XP_006711515                                                           16    7355
XP_006711514                                                           16    7355
XP_006711513                                                           16    7355
NP_036525                                                              16    7355
NP_001137157                                                           16    7355
NP_001245143                                                           15    9605
NP_740754                                                              15    9605
NP_001245144                                                           15    9605
NP_001139280                                                           15    9605
NP_001550                                                              15    9605
NP_061336                                                              15    9605
NP_001012680                                                           15    9605
NP_001012682                                                           15    9605
NP_002385                                                              15    9605
NP_001013269                                                           15    9605
NP_000623                                                              15    9605
NP_079172                                                              15    9605
NP_000222                                                              15    9605
NP_060874                                                              15    9605
NP_001008238                                                           15    9605
XP_006722036                                                           15    9605
XP_005258068                                                           15    9605
XP_005258065                                                           15    9605
XP_005266562                                                           15    9605
XP_006719924                                                           15    9605
XP_006710680                                                           15    9605
XP_005270885                                                           15    9605
XP_005270884                                                           15    9605
XP_005270882                                                           15    9605
>NP_001138390
          Length = 704

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 263 IAIYCIGVF 271
>NP_001138386
          Length = 709

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 266 IAIYCIGVF 274
>NP_001138387
          Length = 707

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 289 IAIYCIGVF 297
>NP_000132
          Length = 821

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 378 IAIYCIGVF 386
>NP_075259
          Length = 822

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 379 IAIYCIGVF 387
>NP_001138388
          Length = 706

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 263 IAIYCIGVF 271
>NP_001138391
          Length = 680

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 290 IAIYCIGVF 298
>NP_001138385
          Length = 769

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 379 IAIYCIGVF 387
>NP_075418
          Length = 732

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 289 IAIYCIGVF 297
>XP_006717776
          Length = 806

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 397 IAIYCIGVF 405
>XP_006717775
          Length = 726

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 283 IAIYCIGVF 291
>XP_006717774
          Length = 752

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 309 IAIYCIGVF 317
>XP_006717773
          Length = 807

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 398 IAIYCIGVF 406
>XP_006717772
          Length = 838

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 397 IAIYCIGVF 405
>XP_006717771
          Length = 839

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           IAIY IGVF
Sbjct: 398 IAIYCIGVF 406
>NP_003226
          Length = 2768

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AIYRIGVF 9
            A YR+GVF
Sbjct: 2333 ASYRVGVF 2340
>XP_005251095
          Length = 2704

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AIYRIGVF 9
            A YR+GVF
Sbjct: 2269 ASYRVGVF 2276
>XP_006716685
          Length = 2747

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2    AIYRIGVF 9
            A YR+GVF
Sbjct: 2312 ASYRVGVF 2319
>NP_001130008
          Length = 616

 Score = 16.5 bits (31), Expect =  4312
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           + +Y++G+F
Sbjct: 122 VKVYKLGIF 130
>NP_001164171
          Length = 781

 Score = 16.5 bits (31), Expect =  4312
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           + +Y++G+F
Sbjct: 287 VKVYKLGIF 295
>XP_006714077
          Length = 906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIYRIGVF 9
           + +Y++G+F
Sbjct: 412 VKVYKLGIF 420
>NP_002200
          Length = 1170

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    IAIYRIGVF 9
            I +Y++G F
Sbjct: 1109 IVLYKVGFF 1117
>NP_001107852
          Length = 1086

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    IAIYRIGVF 9
            I +Y++G F
Sbjct: 1025 IVLYKVGFF 1033
>NP_001177087
          Length = 604

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+G+F
Sbjct: 204 YRLGIF 209
>NP_001135864
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 371 YRMGVF 376
>NP_001135863
          Length = 448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 342 YRMGVF 347
>NP_659461
          Length = 525

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+G+F
Sbjct: 175 YRLGIF 180
>NP_001273145
          Length = 514

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIYRIGV 8
          A+Y+IGV
Sbjct: 12 AVYQIGV 18
>NP_060959
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    IYRIGVF 9
            +YRIG++
Sbjct: 2234 VYRIGLY 2240
>NP_061969
          Length = 602

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   AIYRIGV 8
           A+Y+IGV
Sbjct: 100 AVYQIGV 106
>NP_062822
          Length = 477

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 371 YRMGVF 376
>XP_005277970
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 426 YRMGVF 431
>XP_006724911
          Length = 541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 435 YRMGVF 440
>XP_006724910
          Length = 570

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+GVF
Sbjct: 464 YRMGVF 469
>XP_006721609
          Length = 947

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IYRIGV 8
           +YRIGV
Sbjct: 456 VYRIGV 461
>XP_006721107
          Length = 1087

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    IAIYRIGVF 9
            I +Y++G F
Sbjct: 1026 IVLYKVGFF 1034
>XP_005255370
          Length = 1169

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    IAIYRIGVF 9
            I +Y++G F
Sbjct: 1108 IVLYKVGFF 1116
>XP_006715187
          Length = 554

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2  AIYRIGV 8
          A+Y+IGV
Sbjct: 52 AVYQIGV 58
>XP_005245393
          Length = 2663

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    IYRIGVF 9
            +YRIG++
Sbjct: 2234 VYRIGLY 2240
>XP_006711515
          Length = 2904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    IYRIGVF 9
            +YRIG++
Sbjct: 2174 VYRIGLY 2180
>XP_006711514
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    IYRIGVF 9
            +YRIG++
Sbjct: 2234 VYRIGLY 2240
>XP_006711513
          Length = 2964

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3    IYRIGVF 9
            +YRIG++
Sbjct: 2234 VYRIGLY 2240
>NP_036525
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IYRIGV 8
           +YRIGV
Sbjct: 456 VYRIGV 461
>NP_001137157
          Length = 575

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   YRIGVF 9
           YR+G+F
Sbjct: 175 YRLGIF 180
>NP_001245143
          Length = 659

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 633 IAIIMVGIF 641
>NP_740754
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   IAIYRIGV 8
           IAI RIGV
Sbjct: 311 IAIDRIGV 318
>NP_001245144
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 547 IAIIMVGIF 555
>NP_001139280
          Length = 1153

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    AIYRIGVF 9
            A+Y++G F
Sbjct: 1127 ALYKLGFF 1134
>NP_001550
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 633 IAIIMVGIF 641
>NP_061336
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   IAIYRIGV 8
           IAI RIGV
Sbjct: 311 IAIDRIGV 318
>NP_001012680
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AIYRIG 7
           A+YRIG
Sbjct: 224 ALYRIG 229
>NP_001012682
          Length = 568

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AIYRIG 7
           A+YRIG
Sbjct: 161 ALYRIG 166
>NP_002385
          Length = 630

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AIYRIG 7
           A+YRIG
Sbjct: 223 ALYRIG 228
>NP_001013269
          Length = 529

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   AIYRIG 7
           A+YRIG
Sbjct: 122 ALYRIG 127
>NP_000623
          Length = 1152

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    AIYRIGVF 9
            A+Y++G F
Sbjct: 1126 ALYKLGFF 1133
>NP_079172
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IA Y +G+F
Sbjct: 581 IAFYLLGMF 589
>NP_000222
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  IYRIGVF 9
          +Y+IG++
Sbjct: 23 VYKIGIY 29
>NP_060874
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  AIYRIGVF 9
          A Y++G+F
Sbjct: 36 ASYKLGIF 43
>NP_001008238
          Length = 151

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           + +YR+G F
Sbjct: 100 LILYRLGYF 108
>XP_006722036
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  AIYRIGVF 9
          A Y++G+F
Sbjct: 36 ASYKLGIF 43
>XP_005258068
          Length = 366

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  AIYRIGVF 9
          A Y++G+F
Sbjct: 36 ASYKLGIF 43
>XP_005258065
          Length = 387

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  AIYRIGVF 9
          A Y++G+F
Sbjct: 36 ASYKLGIF 43
>XP_005266562
          Length = 291

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  IYRIGVF 9
          +Y+IG++
Sbjct: 23 VYKIGIY 29
>XP_006719924
          Length = 309

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/7 (42%), Positives = 7/7 (100%)

Query: 3  IYRIGVF 9
          +Y+IG++
Sbjct: 41 VYKIGIY 47
>XP_006710680
          Length = 776

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 547 IAIIMVGIF 555
>XP_005270885
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 633 IAIIMVGIF 641
>XP_005270884
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 633 IAIIMVGIF 641
>XP_005270882
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIYRIGVF 9
           IAI  +G+F
Sbjct: 633 IAIIMVGIF 641
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.170    0.510 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 387,073
Number of extensions: 531
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.8 bits)
S2: 28 (15.4 bits)

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