Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_055365                                                              20     509
NP_001139146                                                           17    4312
NP_066547                                                              17    4312
NP_001257700                                                           17    4312
NP_149091                                                              16    5631
NP_001165442                                                           16    5631
NP_001073121                                                           16    7355
NP_689957                                                              16    7355
NP_001367                                                              16    7355
NP_055591                                                              16    7355
NP_056190                                                              16    7355
NP_476511                                                              16    7355
NP_001128686                                                           16    7355
NP_001128685                                                           16    7355
NP_955749                                                              16    7355
NP_476510                                                              16    7355
NP_061724                                                              16    7355
NP_114065                                                              16    7355
NP_114066                                                              16    7355
XP_006719775                                                           16    7355
XP_006719774                                                           16    7355
XP_005254057                                                           16    7355
XP_006719772                                                           16    7355
XP_006719771                                                           16    7355
XP_006719770                                                           16    7355
XP_005254054                                                           16    7355
NP_787114                                                              16    7355
NP_919224                                                              15    9605
NP_001185617                                                           15    9605
NP_001003680                                                           15    9605
NP_001185616                                                           15    9605
NP_002294                                                              15    9605
NP_001003679                                                           15    9605
NP_001185618                                                           15    9605
NP_060773                                                              15    9605
NP_003296                                                              15    9605
NP_001124170                                                           15    9605
NP_001274418                                                           15    9605
NP_001177398                                                           15    9605
NP_116206                                                              15    9605
NP_001177397                                                           15    9605
NP_954701                                                              15    9605
NP_000505                                                              15    9605
NP_001265027                                                           15    9605
NP_115947                                                              15    9605
NP_922932                                                              15    9605
NP_085046                                                              15    9605
NP_060099                                                              15    9605
NP_065122                                                              15    9605
NP_001001851                                                           15    9605
NP_001161048                                                           15    9605
XP_005252334                                                           15    9605
XP_006715205                                                           15    9605
XP_006715204                                                           15    9605
XP_006714359                                                           15    9605
XP_006714358                                                           15    9605
XP_005264701                                                           15    9605
XP_005270636                                                           15    9605
XP_005270635                                                           15    9605
NP_001161049                                                           15    9605
>NP_055365
          Length = 1032

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           I IHVEVTE
Sbjct: 940 IVIHVEVTE 948
>NP_001139146
          Length = 1004

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAIHVEVT 8
           + IH+EVT
Sbjct: 481 VPIHIEVT 488
>NP_066547
          Length = 1100

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAIHVEVT 8
           + IH+EVT
Sbjct: 577 VPIHIEVT 584
>NP_001257700
          Length = 1200

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAIHVEVT 8
           + IH+EVT
Sbjct: 677 VPIHIEVT 684
>NP_149091
          Length = 859

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IHVEVTE 9
           +HV+VTE
Sbjct: 318 LHVQVTE 324
>NP_001165442
          Length = 745

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IHVEVTE 9
           +HV+VTE
Sbjct: 318 LHVQVTE 324
>NP_001073121
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAIHVEVT 8
           IA+H E+T
Sbjct: 125 IALHAELT 132
>NP_689957
          Length = 2213

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    IAIHVEVT 8
            IA+H E+T
Sbjct: 1638 IALHAELT 1645
>NP_001367
          Length = 4646

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1    IAIHVEVTE 9
            + +H E+TE
Sbjct: 1006 VGVHYELTE 1014
>NP_055591
          Length = 679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 596 IHVAVTE 602
>NP_056190
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AIHVEVT 8
           A HVEVT
Sbjct: 524 AYHVEVT 530
>NP_476511
          Length = 631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 548 IHVAVTE 554
>NP_001128686
          Length = 729

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 646 IHVAVTE 652
>NP_001128685
          Length = 681

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 598 IHVAVTE 604
>NP_955749
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   AIHVEVT 8
           A HVEVT
Sbjct: 524 AYHVEVT 530
>NP_476510
          Length = 759

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 676 IHVAVTE 682
>NP_061724
          Length = 948

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IHVEVTE 9
           IHV+VT+
Sbjct: 317 IHVDVTD 323
>NP_114065
          Length = 844

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IHVEVTE 9
           IHV+VT+
Sbjct: 317 IHVDVTD 323
>NP_114066
          Length = 685

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IHVEVTE 9
           IHV+VT+
Sbjct: 317 IHVDVTD 323
>XP_006719775
          Length = 596

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 513 IHVAVTE 519
>XP_006719774
          Length = 626

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 543 IHVAVTE 549
>XP_005254057
          Length = 708

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 625 IHVAVTE 631
>XP_006719772
          Length = 709

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 626 IHVAVTE 632
>XP_006719771
          Length = 714

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 631 IHVAVTE 637
>XP_006719770
          Length = 744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 661 IHVAVTE 667
>XP_005254054
          Length = 758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   IHVEVTE 9
           IHV VTE
Sbjct: 675 IHVAVTE 681
>NP_787114
          Length = 446

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   IAIHVEVT 8
           I++H+E+T
Sbjct: 439 ISLHLEIT 446
>NP_919224
          Length = 1997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          HVEVT+
Sbjct: 93 HVEVTD 98
>NP_001185617
          Length = 906

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_001003680
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_001185616
          Length = 958

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_002294
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_001003679
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_001185618
          Length = 896

 Score = 15.4 bits (28), Expect =  9605
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   IAIHVEVTE 9
           + +H+E+T+
Sbjct: 241 LGLHMEITD 249
>NP_060773
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IAIHVEV 7
           IA+H EV
Sbjct: 807 IAVHAEV 813
>NP_003296
          Length = 848

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 86 HLEVTE 91
>NP_001124170
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVEVTE 9
           H+EVTE
Sbjct: 159 HLEVTE 164
>NP_001274418
          Length = 1997

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          HVEVT+
Sbjct: 93 HVEVTD 98
>NP_001177398
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIHVEVTE 9
           AIH+ VT+
Sbjct: 113 AIHLNVTD 120
>NP_116206
          Length = 728

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHVEVT 8
           +HVEVT
Sbjct: 312 LHVEVT 317
>NP_001177397
          Length = 228

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIHVEVTE 9
           AIH+ VT+
Sbjct: 139 AIHLNVTD 146
>NP_954701
          Length = 185

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIHVEVTE 9
           AIH+ VT+
Sbjct: 96  AIHLNVTD 103
>NP_000505
          Length = 211

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   AIHVEVTE 9
           AIH+ VT+
Sbjct: 122 AIHLNVTD 129
>NP_001265027
          Length = 159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  AIHVEVTE 9
          AIH+ VT+
Sbjct: 70 AIHLNVTD 77
>NP_115947
          Length = 506

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVEVTE 9
           HVE+TE
Sbjct: 405 HVELTE 410
>NP_922932
          Length = 1117

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   AIHVEVTE 9
           ++H+EV E
Sbjct: 742 SVHIEVRE 749
>NP_085046
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHVEVT 8
           +HVEVT
Sbjct: 526 LHVEVT 531
>NP_060099
          Length = 861

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIHVEVTE 9
           I +H E+TE
Sbjct: 391 IVVHNEMTE 399
>NP_065122
          Length = 862

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 90 HLEVTE 95
>NP_001001851
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   IHVEVT 8
           +HVEVT
Sbjct: 526 LHVEVT 531
>NP_001161048
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 90 HLEVTE 95
>XP_005252334
          Length = 337

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   HVEVTE 9
           HVE+TE
Sbjct: 236 HVELTE 241
>XP_006715205
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IAIHVEV 7
           IA+H EV
Sbjct: 807 IAVHAEV 813
>XP_006715204
          Length = 924

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   IAIHVEV 7
           IA+H EV
Sbjct: 807 IAVHAEV 813
>XP_006714359
          Length = 544

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 86 HLEVTE 91
>XP_006714358
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 86 HLEVTE 91
>XP_005264701
          Length = 1992

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          HVEVT+
Sbjct: 93 HVEVTD 98
>XP_005270636
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIHVEVTE 9
           I +H E+TE
Sbjct: 324 IVVHNEMTE 332
>XP_005270635
          Length = 794

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   IAIHVEVTE 9
           I +H E+TE
Sbjct: 324 IVVHNEMTE 332
>NP_001161049
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4  HVEVTE 9
          H+EVTE
Sbjct: 90 HLEVTE 95
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.319    0.133    0.339 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 529,927
Number of extensions: 596
Number of successful extensions: 60
Number of sequences better than 10000.0: 60
Number of HSP's gapped: 60
Number of HSP's successfully gapped: 60
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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