Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           18    1135
NP_000242                                                              18    1135
XP_005264389                                                           18    1135
NP_852478                                                              17    2528
NP_665803                                                              17    3301
NP_444284                                                              16    5631
XP_006718716                                                           16    5631
NP_003923                                                              16    7355
NP_001265518                                                           16    7355
NP_001268232                                                           15    9605
NP_006406                                                              15    9605
NP_570853                                                              15    9605
NP_002327                                                              15    9605
NP_570854                                                              15    9605
NP_000453                                                              15    9605
NP_004456                                                              15    9605
NP_683710                                                              15    9605
NP_001166251                                                           15    9605
NP_001166250                                                           15    9605
NP_001107604                                                           15    9605
NP_006575                                                              15    9605
NP_001180459                                                           15    9605
NP_001180458                                                           15    9605
XP_006721704                                                           15    9605
XP_005268328                                                           15    9605
XP_006720739                                                           15    9605
XP_005268327                                                           15    9605
XP_005268326                                                           15    9605
XP_005268324                                                           15    9605
XP_005268325                                                           15    9605
XP_006720738                                                           15    9605
XP_006720737                                                           15    9605
XP_006720736                                                           15    9605
XP_006719141                                                           15    9605
XP_006716207                                                           15    9605
XP_006716206                                                           15    9605
XP_005248321                                                           15    9605
XP_005247190                                                           15    9605
XP_006713571                                                           15    9605
XP_005246845                                                           15    9605
XP_006712765                                                           15    9605
XP_006712764                                                           15    9605
XP_005246844                                                           15    9605
XP_006712763                                                           15    9605
XP_006712762                                                           15    9605
XP_006712761                                                           15    9605
NP_683711                                                              15    9605
>NP_001245210
          Length = 868

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           IAAV+ALNL
Sbjct: 238 IAAVRALNL 246
>NP_000242
          Length = 934

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           IAAV+ALNL
Sbjct: 304 IAAVRALNL 312
>XP_005264389
          Length = 921

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           IAAV+ALNL
Sbjct: 304 IAAVRALNL 312
>NP_852478
          Length = 1179

 Score = 17.3 bits (33), Expect =  2528
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   IAAVKALNL 9
           IAAVK LNL
Sbjct: 575 IAAVKDLNL 583
>NP_665803
          Length = 1025

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           +AAVKAL+L
Sbjct: 176 LAAVKALSL 184
>NP_444284
          Length = 295

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IAAVKALNL 9
           +AAV+ LNL
Sbjct: 209 VAAVQGLNL 217
>XP_006718716
          Length = 303

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   IAAVKALNL 9
           +AAV+ LNL
Sbjct: 217 VAAVQGLNL 225
>NP_003923
          Length = 369

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IAAVKALN 8
           +AA++ALN
Sbjct: 119 VAAIEALN 126
>NP_001265518
          Length = 359

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   IAAVKALN 8
           +AA++ALN
Sbjct: 109 VAAIEALN 116
>NP_001268232
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AAVKALNL 9
           AA++ALN+
Sbjct: 348 AAIEALNI 355
>NP_006406
          Length = 473

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   AAVKALNL 9
           AA++ALN+
Sbjct: 348 AAIEALNI 355
>NP_570853
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>NP_002327
          Length = 1613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IAAVKALNL 9
            I AVK LNL
Sbjct: 1191 IHAVKELNL 1199
>NP_570854
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 65 AAIKALEL 72
>NP_000453
          Length = 875

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 68 AAIKALEL 75
>NP_004456
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAAVKALN 8
           + AVKA+N
Sbjct: 120 VVAVKAIN 127
>NP_683710
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           +AA++A+N+
Sbjct: 181 VAAMRAINI 189
>NP_001166251
          Length = 361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVKALNL 9
           A+KA+NL
Sbjct: 236 AIKAINL 242
>NP_001166250
          Length = 464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVKALNL 9
           A+KA+NL
Sbjct: 236 AIKAINL 242
>NP_001107604
          Length = 2694

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2231 AAVEALNV 2238
>NP_006575
          Length = 530

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 IAAVKALN 8
         +AA+KA+N
Sbjct: 1 MAAIKAVN 8
>NP_001180459
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 IAAVKALN 8
         +AA+KA+N
Sbjct: 1 MAAIKAVN 8
>NP_001180458
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 IAAVKALN 8
         +AA+KA+N
Sbjct: 1 MAAIKAVN 8
>XP_006721704
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1 IAAVKALN 8
         +AA+KA+N
Sbjct: 1 MAAIKAVN 8
>XP_005268328
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_006720739
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_005268327
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_005268326
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_005268324
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_005268325
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_006720738
          Length = 852

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 45 AAIKALEL 52
>XP_006720737
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 65 AAIKALEL 72
>XP_006720736
          Length = 872

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  AAVKALNL 9
          AA+KAL L
Sbjct: 65 AAIKALEL 72
>XP_006719141
          Length = 1613

 Score = 15.4 bits (28), Expect =  9605
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    IAAVKALNL 9
            I AVK LNL
Sbjct: 1191 IHAVKELNL 1199
>XP_006716207
          Length = 202

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1  IAAVKALNL 9
          +AA++A+N+
Sbjct: 68 VAAMRAINI 76
>XP_006716206
          Length = 216

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           +AA++A+N+
Sbjct: 181 VAAMRAINI 189
>XP_005248321
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   IAAVKALN 8
           + AVKA+N
Sbjct: 120 VVAVKAIN 127
>XP_005247190
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVKALNL 9
           A+KA+NL
Sbjct: 175 AIKAINL 181
>XP_006713571
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AVKALNL 9
           A+KA+NL
Sbjct: 218 AIKAINL 224
>XP_005246845
          Length = 1624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 1148 AAVEALNV 1155
>XP_006712765
          Length = 2679

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2203 AAVEALNV 2210
>XP_006712764
          Length = 2697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2260 AAVEALNV 2267
>XP_005246844
          Length = 2707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2231 AAVEALNV 2238
>XP_006712763
          Length = 2716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2260 AAVEALNV 2267
>XP_006712762
          Length = 2723

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2260 AAVEALNV 2267
>XP_006712761
          Length = 2736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    AAVKALNL 9
            AAV+ALN+
Sbjct: 2260 AAVEALNV 2267
>NP_683711
          Length = 308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 9/9 (100%)

Query: 1   IAAVKALNL 9
           +AA++A+N+
Sbjct: 174 VAAMRAINI 182
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.132    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 220,028
Number of extensions: 392
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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