Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              21     175
NP_001091680                                                           21     175
NP_001091679                                                           21     175
XP_006713048                                                           21     175
XP_006713047                                                           21     175
XP_006713046                                                           21     175
XP_005264943                                                           21     175
NP_758424                                                              17    4312
NP_061142                                                              17    4312
NP_054735                                                              16    5631
NP_064450                                                              16    7355
XP_005273257                                                           16    7355
NP_000375                                                              15    9605
NP_858059                                                              15    9605
NP_858058                                                              15    9605
NP_001137499                                                           15    9605
NP_055249                                                              15    9605
NP_001137500                                                           15    9605
NP_001034                                                              15    9605
NP_001137498                                                           15    9605
NP_001135920                                                           15    9605
NP_001165972                                                           15    9605
NP_001165973                                                           15    9605
NP_001135921                                                           15    9605
NP_001165975                                                           15    9605
NP_001193762                                                           15    9605
NP_874369                                                              15    9605
NP_006379                                                              15    9605
NP_874368                                                              15    9605
NP_872344                                                              15    9605
NP_001431                                                              15    9605
XP_005262365                                                           15    9605
XP_006724777                                                           15    9605
XP_006721326                                                           15    9605
XP_006721159                                                           15    9605
XP_005255675                                                           15    9605
XP_006718484                                                           15    9605
XP_006717119                                                           15    9605
XP_005266123                                                           15    9605
XP_006716365                                                           15    9605
XP_006713086                                                           15    9605
NP_001135923                                                           15    9605
NP_114427                                                              15    9605
>NP_001895
          Length = 781

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 134 HAVVNLINY 142
>NP_001091680
          Length = 781

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 134 HAVVNLINY 142
>NP_001091679
          Length = 781

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 134 HAVVNLINY 142
>XP_006713048
          Length = 720

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 134 HAVVNLINY 142
>XP_006713047
          Length = 774

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 127 HAVVNLINY 135
>XP_006713046
          Length = 774

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 127 HAVVNLINY 135
>XP_005264943
          Length = 781

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HVVVNLINY 9
           H VVNLINY
Sbjct: 134 HAVVNLINY 142
>NP_758424
          Length = 1642

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H+V NL+ Y
Sbjct: 651 HIVWNLLKY 659
>NP_061142
          Length = 1642

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H+V NL+ Y
Sbjct: 651 HIVWNLLKY 659
>NP_054735
          Length = 587

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VVVNLIN 8
           V++NLIN
Sbjct: 303 VIINLIN 309
>NP_064450
          Length = 1722

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HVVVNLIN 8
            H VVNL N
Sbjct: 1384 HAVVNLDN 1391
>XP_005273257
          Length = 1726

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HVVVNLIN 8
            H VVNL N
Sbjct: 1388 HAVVNLDN 1395
>NP_000375
          Length = 4563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    HVVVNLI 7
            H V+NLI
Sbjct: 2319 HFVINLI 2325
>NP_858059
          Length = 1036

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H++VN+  Y
Sbjct: 624 HILVNMNGY 632
>NP_858058
          Length = 1046

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H++VN+  Y
Sbjct: 634 HILVNMNGY 642
>NP_001137499
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_055249
          Length = 597

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_001137500
          Length = 590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_001034
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VVVNLINY 9
           VVV++IN+
Sbjct: 533 VVVSIINF 540
>NP_001137498
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>NP_001135920
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VNLINY 9
          +NL+NY
Sbjct: 68 INLLNY 73
>NP_001165972
          Length = 617

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VVVNLINY 9
           VVV++IN+
Sbjct: 533 VVVSIINF 540
>NP_001165973
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VVVNLINY 9
           VVV++IN+
Sbjct: 428 VVVSIINF 435
>NP_001135921
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VNLINY 9
          +NL+NY
Sbjct: 68 INLLNY 73
>NP_001165975
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VVVNLINY 9
           VVV++IN+
Sbjct: 533 VVVSIINF 540
>NP_001193762
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NLINY
Sbjct: 443 LNLINY 448
>NP_874369
          Length = 546

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NLINY
Sbjct: 495 LNLINY 500
>NP_006379
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NLINY
Sbjct: 462 LNLINY 467
>NP_874368
          Length = 461

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NLINY
Sbjct: 410 LNLINY 415
>NP_872344
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VNLINY 9
          +NL+NY
Sbjct: 54 INLLNY 59
>NP_001431
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HVVVNL 6
           HV++NL
Sbjct: 273 HVIINL 278
>XP_005262365
          Length = 665

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H++VN+  Y
Sbjct: 253 HILVNMNGY 261
>XP_006724777
          Length = 1023

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HVVVNLINY 9
           H++VN+  Y
Sbjct: 611 HILVNMNGY 619
>XP_006721326
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   VVVNLINY 9
           VVV++IN+
Sbjct: 533 VVVSIINF 540
>XP_006721159
          Length = 521

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NL+NY
Sbjct: 113 INLLNY 118
>XP_005255675
          Length = 573

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NL+NY
Sbjct: 113 INLLNY 118
>XP_006718484
          Length = 522

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   VNLINY 9
           +NLINY
Sbjct: 471 LNLINY 476
>XP_006717119
          Length = 615

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>XP_005266123
          Length = 624

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  VVNLIN 8
          VVNLIN
Sbjct: 45 VVNLIN 50
>XP_006716365
          Length = 919

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HVVVNL 6
           HV++NL
Sbjct: 273 HVIINL 278
>XP_006713086
          Length = 1458

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    VVVNLINY 9
            +++NLI Y
Sbjct: 1277 ILINLIKY 1284
>NP_001135923
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VNLINY 9
          +NL+NY
Sbjct: 68 INLLNY 73
>NP_114427
          Length = 528

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4  VNLINY 9
          +NL+NY
Sbjct: 68 INLLNY 73
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.332    0.147    0.438 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 413,452
Number of extensions: 869
Number of successful extensions: 43
Number of sequences better than 10000.0: 43
Number of HSP's gapped: 43
Number of HSP's successfully gapped: 43
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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