Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245200                                                           21     229
NP_000240                                                              21     229
NP_001161089                                                           21     229
XP_005265218                                                           21     229
NP_569733                                                              17    3301
NP_904324                                                              17    3301
XP_006719745                                                           17    3301
XP_006719744                                                           17    3301
XP_005254044                                                           17    3301
NP_002300                                                              17    4312
NP_001171953                                                           17    4312
XP_006724303                                                           17    4312
XP_005261658                                                           17    4312
XP_006724302                                                           17    4312
NP_037505                                                              17    4312
NP_001120867                                                           16    5631
NP_660323                                                              16    5631
NP_003970                                                              16    5631
XP_005246398                                                           16    5631
XP_005246397                                                           16    5631
XP_006712392                                                           16    5631
XP_005246396                                                           16    5631
XP_006712391                                                           16    5631
XP_006712390                                                           16    5631
XP_005246395                                                           16    5631
XP_005246394                                                           16    5631
XP_005246393                                                           16    5631
NP_001004750                                                           16    5631
NP_055782                                                              16    7355
NP_060501                                                              16    7355
NP_003732                                                              16    7355
NP_872393                                                              16    7355
XP_006725604                                                           16    7355
XP_006725603                                                           16    7355
XP_006725602                                                           16    7355
XP_006725601                                                           16    7355
XP_006725600                                                           16    7355
XP_005254293                                                           16    7355
XP_005254289                                                           16    7355
XP_005254292                                                           16    7355
XP_005254291                                                           16    7355
XP_005254290                                                           16    7355
XP_005247908                                                           16    7355
XP_005247907                                                           16    7355
XP_005247906                                                           16    7355
XP_005247905                                                           16    7355
XP_005264894                                                           16    7355
XP_006712515                                                           16    7355
XP_006712514                                                           16    7355
XP_006712513                                                           16    7355
XP_006712512                                                           16    7355
XP_006712511                                                           16    7355
XP_006712510                                                           16    7355
XP_006712509                                                           16    7355
XP_005246533                                                           16    7355
XP_006712508                                                           16    7355
NP_115893                                                              16    7355
NP_001180251                                                           15    9605
NP_001180250                                                           15    9605
NP_054721                                                              15    9605
NP_003666                                                              15    9605
NP_055061                                                              15    9605
NP_001127949                                                           15    9605
NP_002573                                                              15    9605
NP_001229921                                                           15    9605
XP_006724446                                                           15    9605
XP_005252949                                                           15    9605
XP_005252948                                                           15    9605
XP_005252693                                                           15    9605
XP_005252691                                                           15    9605
XP_006711704                                                           15    9605
XP_005273413                                                           15    9605
NP_848632                                                              15    9605
NP_001004730                                                           15    9605
>NP_001245200
          Length = 687

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAHVTIT 8
           HVAHVTIT
Sbjct: 109 HVAHVTIT 116
>NP_000240
          Length = 756

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAHVTIT 8
           HVAHVTIT
Sbjct: 109 HVAHVTIT 116
>NP_001161089
          Length = 658

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1  HVAHVTIT 8
          HVAHVTIT
Sbjct: 11 HVAHVTIT 18
>XP_005265218
          Length = 687

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAHVTIT 8
           HVAHVTIT
Sbjct: 109 HVAHVTIT 116
>NP_569733
          Length = 1068

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAHVTI 7
           HV H+TI
Sbjct: 679 HVTHITI 685
>NP_904324
          Length = 1068

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAHVTI 7
           HV H+TI
Sbjct: 679 HVTHITI 685
>XP_006719745
          Length = 1043

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAHVTI 7
           HV H+TI
Sbjct: 679 HVTHITI 685
>XP_006719744
          Length = 1044

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAHVTI 7
           HV H+TI
Sbjct: 679 HVTHITI 685
>XP_005254044
          Length = 1068

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAHVTI 7
           HV H+TI
Sbjct: 679 HVTHITI 685
>NP_002300
          Length = 202

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAHVTIT 8
           HV HV +T
Sbjct: 160 HVGHVDVT 167
>NP_001171953
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AHVTITM 9
           AH TITM
Sbjct: 181 AHTTITM 187
>XP_006724303
          Length = 202

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAHVTIT 8
           HV HV +T
Sbjct: 160 HVGHVDVT 167
>XP_005261658
          Length = 206

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAHVTIT 8
           HV HV +T
Sbjct: 164 HVGHVDVT 171
>XP_006724302
          Length = 778

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AHVTITM 9
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_037505
          Length = 765

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AHVTITM 9
           AH TITM
Sbjct: 181 AHTTITM 187
>NP_001120867
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>NP_660323
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>NP_003970
          Length = 357

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVAHVTITM 9
           H AH+ +TM
Sbjct: 209 HGAHIYLTM 217
>XP_005246398
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246397
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712392
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_005246396
          Length = 218

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3  AHVTIT 8
          AHVTIT
Sbjct: 88 AHVTIT 93
>XP_006712391
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHVTIT 8
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_006712390
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHVTIT 8
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246395
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHVTIT 8
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246394
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHVTIT 8
           AHVTIT
Sbjct: 106 AHVTIT 111
>XP_005246393
          Length = 236

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   AHVTIT 8
           AHVTIT
Sbjct: 106 AHVTIT 111
>NP_001004750
          Length = 312

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HV H+T++
Sbjct: 268 HVVHITMS 275
>NP_055782
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>NP_060501
          Length = 1151

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1    HVAHVT 6
            H AHVT
Sbjct: 1074 HAAHVT 1079
>NP_003732
          Length = 955

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HVA VT+T
Sbjct: 255 HVALVTLT 262
>NP_872393
          Length = 3234

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006725604
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725603
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725602
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725601
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_006725600
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254293
          Length = 904

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254289
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254292
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254291
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005254290
          Length = 1017

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           V HVTIT
Sbjct: 777 VKHVTIT 783
>XP_005247908
          Length = 894

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HVA VT+T
Sbjct: 255 HVALVTLT 262
>XP_005247907
          Length = 954

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HVA VT+T
Sbjct: 255 HVALVTLT 262
>XP_005247906
          Length = 981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HVA VT+T
Sbjct: 255 HVALVTLT 262
>XP_005247905
          Length = 982

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HVAHVTIT 8
           HVA VT+T
Sbjct: 255 HVALVTLT 262
>XP_005264894
          Length = 1070

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H AHVT
Sbjct: 993 HAAHVT 998
>XP_006712515
          Length = 3232

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712514
          Length = 2496

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712513
          Length = 3220

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712512
          Length = 3237

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712511
          Length = 3256

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712510
          Length = 3305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712509
          Length = 3319

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_005246533
          Length = 3323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>XP_006712508
          Length = 3324

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>NP_115893
          Length = 3258

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAHVTITM 9
          HV H T T+
Sbjct: 84 HVLHCTATL 92
>NP_001180251
          Length = 657

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H+AH T
Sbjct: 369 HIAHTT 374
>NP_001180250
          Length = 631

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H+AH T
Sbjct: 284 HIAHTT 289
>NP_054721
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H+AH T
Sbjct: 369 HIAHTT 374
>NP_003666
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 301 HVAHV 305
>NP_055061
          Length = 3014

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAHVTITM 9
           H AHV I +
Sbjct: 771 HTAHVLINV 779
>NP_001127949
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           HV HVT
Sbjct: 385 HVLHVT 390
>NP_002573
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           HV HVT
Sbjct: 446 HVLHVT 451
>NP_001229921
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           HV HVT
Sbjct: 400 HVLHVT 405
>XP_006724446
          Length = 3019

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAHVTITM 9
           H AHV I +
Sbjct: 771 HTAHVLINV 779
>XP_005252949
          Length = 1001

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 292 HVAHV 296
>XP_005252948
          Length = 1007

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 260 HVAHV 264
>XP_005252693
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 263 HVAHV 267
>XP_005252691
          Length = 351

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 310 HVAHV 314
>XP_006711704
          Length = 646

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H+AH T
Sbjct: 369 HIAHTT 374
>XP_005273413
          Length = 716

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 5/6 (83%)

Query: 1   HVAHVT 6
           H+AH T
Sbjct: 369 HIAHTT 374
>NP_848632
          Length = 1039

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HVAHV 5
           HVAHV
Sbjct: 292 HVAHV 296
>NP_001004730
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VAHVTIT 8
           VAH T+T
Sbjct: 157 VAHTTLT 163
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.335    0.127    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 526,128
Number of extensions: 859
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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