Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001245210                                                           20     299
NP_000242                                                              20     299
XP_005264389                                                           20     299
NP_001094809                                                           17    2528
NP_001127948                                                           17    2528
NP_056165                                                              17    2528
XP_005270761                                                           17    2528
XP_005270760                                                           17    2528
XP_005270759                                                           17    2528
XP_006710604                                                           17    2528
XP_005270758                                                           17    2528
NP_001005493                                                           17    4312
NP_000171                                                              16    5631
NP_004027                                                              16    5631
NP_940912                                                              16    5631
NP_055325                                                              16    5631
NP_149015                                                              16    5631
NP_001513                                                              16    5631
XP_006715989                                                           16    5631
XP_006711990                                                           16    5631
XP_005264162                                                           16    5631
XP_005264161                                                           16    5631
XP_005264159                                                           16    5631
XP_006711989                                                           16    5631
XP_006711988                                                           16    5631
NP_005192                                                              16    5631
NP_001121371                                                           16    7355
NP_001269092                                                           16    7355
NP_001121370                                                           16    7355
NP_000075                                                              16    7355
NP_037438                                                              16    7355
NP_055087                                                              15    9605
NP_001247421                                                           15    9605
NP_001247423                                                           15    9605
NP_203747                                                              15    9605
NP_001247422                                                           15    9605
NP_002897                                                              15    9605
NP_001269058                                                           15    9605
NP_001247424                                                           15    9605
NP_940865                                                              15    9605
NP_940870                                                              15    9605
XP_006722213                                                           15    9605
XP_005258117                                                           15    9605
XP_006722212                                                           15    9605
XP_005258116                                                           15    9605
XP_005258115                                                           15    9605
XP_005254195                                                           15    9605
XP_005254194                                                           15    9605
XP_005250863                                                           15    9605
XP_006715495                                                           15    9605
XP_006715494                                                           15    9605
XP_006715493                                                           15    9605
XP_005264988                                                           15    9605
XP_005264986                                                           15    9605
XP_005264985                                                           15    9605
XP_006713076                                                           15    9605
NP_001004475                                                           15    9605
NP_659400                                                              15    9605
>NP_001245210
          Length = 868

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAELANF 8
           HVAELANF
Sbjct: 763 HVAELANF 770
>NP_000242
          Length = 934

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAELANF 8
           HVAELANF
Sbjct: 829 HVAELANF 836
>XP_005264389
          Length = 921

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1   HVAELANF 8
           HVAELANF
Sbjct: 829 HVAELANF 836
>NP_001094809
          Length = 145

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HVAELANFT 9
          H+A L N+T
Sbjct: 35 HIARLTNYT 43
>NP_001127948
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>NP_056165
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>XP_005270761
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>XP_005270760
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>XP_005270759
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>XP_006710604
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>XP_005270758
          Length = 803

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL+N T
Sbjct: 743 HVGELSNLT 751
>NP_001005493
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV EL +FT
Sbjct: 191 HVLELMSFT 199
>NP_000171
          Length = 1103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           H AE+AN +
Sbjct: 945 HAAEIANMS 953
>NP_004027
          Length = 1144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1012 HLADLADF 1019
>NP_940912
          Length = 1313

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HVAELANFT 9
          H+A ++NFT
Sbjct: 77 HLAFISNFT 85
>NP_055325
          Length = 4935

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV E ANF
Sbjct: 600 HVPEKANF 607
>NP_149015
          Length = 5142

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV E ANF
Sbjct: 600 HVPEKANF 607
>NP_001513
          Length = 1108

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           H AE+AN +
Sbjct: 949 HAAEIANMS 957
>XP_006715989
          Length = 5148

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV E ANF
Sbjct: 600 HVPEKANF 607
>XP_006711990
          Length = 1131

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1035 HLADLADF 1042
>XP_005264162
          Length = 1144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1012 HLADLADF 1019
>XP_005264161
          Length = 1145

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1013 HLADLADF 1020
>XP_005264159
          Length = 1166

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1034 HLADLADF 1041
>XP_006711989
          Length = 1167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1035 HLADLADF 1042
>XP_006711988
          Length = 1167

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HVAELANF 8
            H+A+LA+F
Sbjct: 1035 HLADLADF 1042
>NP_005192
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV E+ +FT
Sbjct: 283 HVTEIISFT 291
>NP_001121371
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           H+A++AN
Sbjct: 801 HIAQMAN 807
>NP_001269092
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           H+A++AN
Sbjct: 751 HIAQMAN 757
>NP_001121370
          Length = 816

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           H+A++AN
Sbjct: 801 HIAQMAN 807
>NP_000075
          Length = 746

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           H+A++AN
Sbjct: 731 HIAQMAN 737
>NP_037438
          Length = 342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   HVAELA 6
           HVAELA
Sbjct: 230 HVAELA 235
>NP_055087
          Length = 1686

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAELANF 8
           VAE ANF
Sbjct: 730 VAEAANF 736
>NP_001247421
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AELANFT 9
           AELA FT
Sbjct: 419 AELAEFT 425
>NP_001247423
          Length = 447

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AELANFT 9
           AELA FT
Sbjct: 283 AELAEFT 289
>NP_203747
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 581 HVPEMAN 587
>NP_001247422
          Length = 604

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AELANFT 9
           AELA FT
Sbjct: 419 AELAEFT 425
>NP_002897
          Length = 583

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   AELANFT 9
           AELA FT
Sbjct: 419 AELAEFT 425
>NP_001269058
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 608 HVPEMAN 614
>NP_001247424
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3  AELANFT 9
          AELA FT
Sbjct: 72 AELAEFT 78
>NP_940865
          Length = 563

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HVAELANFT 9
          HV +L N T
Sbjct: 86 HVTQLLNMT 94
>NP_940870
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV +L NF
Sbjct: 550 HVLDLLNF 557
>XP_006722213
          Length = 1030

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 188 HVPEMAN 194
>XP_005258117
          Length = 984

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 142 HVPEMAN 148
>XP_006722212
          Length = 1401

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 559 HVPEMAN 565
>XP_005258116
          Length = 1430

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 588 HVPEMAN 594
>XP_005258115
          Length = 1450

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HVAELAN 7
           HV E+AN
Sbjct: 608 HVPEMAN 614
>XP_005254195
          Length = 1155

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAELANF 8
           VAE ANF
Sbjct: 196 VAEAANF 202
>XP_005254194
          Length = 1689

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VAELANF 8
           VAE ANF
Sbjct: 730 VAEAANF 736
>XP_005250863
          Length = 436

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           +VAELAN
Sbjct: 267 NVAELAN 273
>XP_006715495
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV +L NF
Sbjct: 550 HVLDLLNF 557
>XP_006715494
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV +L NF
Sbjct: 324 HVLDLLNF 331
>XP_006715493
          Length = 1243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HVAELANF 8
           HV +L NF
Sbjct: 550 HVLDLLNF 557
>XP_005264988
          Length = 746

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAELANFT 9
           HV +L N T
Sbjct: 211 HVTQLLNMT 219
>XP_005264986
          Length = 801

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAELANFT 9
           HV +L N T
Sbjct: 211 HVTQLLNMT 219
>XP_005264985
          Length = 813

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAELANFT 9
           HV +L N T
Sbjct: 211 HVTQLLNMT 219
>XP_006713076
          Length = 814

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HVAELANFT 9
           HV +L N T
Sbjct: 211 HVTQLLNMT 219
>NP_001004475
          Length = 314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HVAELANFT 9
           HV ELA F+
Sbjct: 194 HVKELALFS 202
>NP_659400
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HVAELAN 7
           +VAELAN
Sbjct: 267 NVAELAN 273
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.127    0.362 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 421,011
Number of extensions: 625
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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