Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005179                                                              20     390
NP_001005367                                                           17    4312
NP_001188390                                                           17    4312
NP_065710                                                              17    4312
NP_775899                                                              17    4312
XP_006726337                                                           17    4312
XP_006723359                                                           17    4312
XP_006722279                                                           17    4312
XP_006722278                                                           17    4312
XP_005257947                                                           17    4312
XP_005257945                                                           17    4312
XP_006722277                                                           17    4312
NP_001135780                                                           17    4312
NP_005624                                                              16    5631
NP_056261                                                              16    5631
NP_008870                                                              16    5631
NP_065810                                                              16    5631
XP_006720684                                                           16    5631
XP_005268078                                                           16    5631
XP_005264572                                                           16    5631
XP_006711822                                                           16    5631
XP_006711821                                                           16    5631
NP_001013421                                                           16    7355
NP_001185744                                                           16    7355
NP_001020280                                                           16    7355
NP_001764                                                              16    7355
NP_536721                                                              16    7355
XP_005275558                                                           16    7355
XP_005275391                                                           16    7355
XP_005275259                                                           16    7355
XP_005274965                                                           16    7355
XP_005272815                                                           16    7355
XP_005274885                                                           16    7355
XP_006723762                                                           16    7355
XP_005248836                                                           16    7355
NP_597702                                                              15    9605
NP_000821                                                              15    9605
NP_001438                                                              15    9605
NP_055947                                                              15    9605
NP_055797                                                              15    9605
NP_001171905                                                           15    9605
XP_005261001                                                           15    9605
XP_005267486                                                           15    9605
XP_006720145                                                           15    9605
XP_005267485                                                           15    9605
XP_005267483                                                           15    9605
XP_005267482                                                           15    9605
XP_005267481                                                           15    9605
XP_005267480                                                           15    9605
XP_005267479                                                           15    9605
XP_005267478                                                           15    9605
XP_005267477                                                           15    9605
XP_005268801                                                           15    9605
XP_005268800                                                           15    9605
XP_005268799                                                           15    9605
XP_005249731                                                           15    9605
XP_005249730                                                           15    9605
XP_005249729                                                           15    9605
XP_006714824                                                           15    9605
NP_114101                                                              15    9605
NP_005328                                                              15    9605
NP_056090                                                              15    9605
>NP_005179
          Length = 906

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   TTNVTEGS 9
           TTNVTEGS
Sbjct: 810 TTNVTEGS 817
>NP_001005367
          Length = 460

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           T NVTEG+
Sbjct: 353 TLNVTEGN 360
>NP_001188390
          Length = 451

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           T NVTEG+
Sbjct: 353 TLNVTEGN 360
>NP_065710
          Length = 450

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           T NVTEG+
Sbjct: 353 TLNVTEGN 360
>NP_775899
          Length = 4462

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   TNVTEG 8
           TNVTEG
Sbjct: 273 TNVTEG 278
>XP_006726337
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           T NVTEG+
Sbjct: 353 TLNVTEGN 360
>XP_006723359
          Length = 400

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           T NVTEG+
Sbjct: 353 TLNVTEGN 360
>XP_006722279
          Length = 1578

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTNVT G
Sbjct: 99  TTNVTRG 105
>XP_006722278
          Length = 1735

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTNVT G
Sbjct: 256 TTNVTRG 262
>XP_005257947
          Length = 1935

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTNVT G
Sbjct: 491 TTNVTRG 497
>XP_005257945
          Length = 1969

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTNVT G
Sbjct: 491 TTNVTRG 497
>XP_006722277
          Length = 1970

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTNVT G
Sbjct: 491 TTNVTRG 497
>NP_001135780
          Length = 2156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    HTTNVTEG 8
            HT N T+G
Sbjct: 1138 HTQNTTDG 1145
>NP_005624
          Length = 1333

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HTTNVT 6
           HTTN+T
Sbjct: 827 HTTNLT 832
>NP_056261
          Length = 2275

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TTNVTE 7
            TTNVTE
Sbjct: 1357 TTNVTE 1362
>NP_008870
          Length = 1332

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HTTNVT 6
           HTTN+T
Sbjct: 825 HTTNLT 830
>NP_065810
          Length = 4700

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HTTNVTEGS 9
            HT +++EGS
Sbjct: 3142 HTLDLSEGS 3150
>XP_006720684
          Length = 4713

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HTTNVTEGS 9
            HT +++EGS
Sbjct: 3155 HTLDLSEGS 3163
>XP_005268078
          Length = 1272

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HTTNVT 6
           HTTN+T
Sbjct: 765 HTTNLT 770
>XP_005264572
          Length = 1318

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HTTNVT 6
           HTTN+T
Sbjct: 827 HTTNLT 832
>XP_006711822
          Length = 2266

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TTNVTE 7
            TTNVTE
Sbjct: 1348 TTNVTE 1353
>XP_006711821
          Length = 2301

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2    TTNVTE 7
            TTNVTE
Sbjct: 1383 TTNVTE 1388
>NP_001013421
          Length = 361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2  TTNVTEGS 9
          TTN T GS
Sbjct: 19 TTNQTNGS 26
>NP_001185744
          Length = 1773

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 826 TTDSTEGS 833
>NP_001020280
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  TTNVTE 7
          TTN+TE
Sbjct: 83 TTNITE 88
>NP_001764
          Length = 328

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  TTNVTE 7
          TTN+TE
Sbjct: 83 TTNITE 88
>NP_536721
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HTTNVT 6
           HTTN T
Sbjct: 247 HTTNTT 252
>XP_005275558
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_005275391
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_005275259
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_005274965
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_005272815
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_005274885
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>XP_006723762
          Length = 397

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HTTNVT 6
           HTTN T
Sbjct: 247 HTTNTT 252
>XP_005248836
          Length = 1776

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TTNVTEGS 9
           TT+ TEGS
Sbjct: 829 TTDSTEGS 836
>NP_597702
          Length = 1115

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TTNVTEG 8
           TTN+T G
Sbjct: 424 TTNLTSG 430
>NP_000821
          Length = 918

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           H TN T G+
Sbjct: 883 HPTNSTSGT 891
>NP_001438
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    HTTNVTEG 8
            +TT+++EG
Sbjct: 2277 YTTSISEG 2284
>NP_055947
          Length = 957

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HTTNVTEG 8
           H TN T+G
Sbjct: 429 HQTNQTKG 436
>NP_055797
          Length = 2341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2071 SNVTQGS 2077
>NP_001171905
          Length = 1077

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HTTNVTE 7
           HT NVT+
Sbjct: 336 HTENVTK 342
>XP_005261001
          Length = 903

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           H TN T G+
Sbjct: 868 HPTNSTSGT 876
>XP_005267486
          Length = 1421

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 1151 SNVTQGS 1157
>XP_006720145
          Length = 1423

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 1153 SNVTQGS 1159
>XP_005267485
          Length = 1459

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 1189 SNVTQGS 1195
>XP_005267483
          Length = 2230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 1960 SNVTQGS 1966
>XP_005267482
          Length = 2243

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 1973 SNVTQGS 1979
>XP_005267481
          Length = 2293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2023 SNVTQGS 2029
>XP_005267480
          Length = 2336

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2066 SNVTQGS 2072
>XP_005267479
          Length = 2344

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2074 SNVTQGS 2080
>XP_005267478
          Length = 2348

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2078 SNVTQGS 2084
>XP_005267477
          Length = 2349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    TNVTEGS 9
            +NVT+GS
Sbjct: 2079 SNVTQGS 2085
>XP_005268801
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           HT N  EG+
Sbjct: 792 HTRNSAEGT 800
>XP_005268800
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           HT N  EG+
Sbjct: 793 HTRNSAEGT 801
>XP_005268799
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           HT N  EG+
Sbjct: 981 HTRNSAEGT 989
>XP_005249731
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HTTNVTEG 8
           H TN T+G
Sbjct: 429 HQTNQTKG 436
>XP_005249730
          Length = 539

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HTTNVTEG 8
           H TN T+G
Sbjct: 429 HQTNQTKG 436
>XP_005249729
          Length = 968

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HTTNVTEG 8
           H TN T+G
Sbjct: 429 HQTNQTKG 436
>XP_006714824
          Length = 4349

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1    HTTNVTEG 8
            +TT+++EG
Sbjct: 2277 YTTSISEG 2284
>NP_114101
          Length = 425

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HTTNVTEG 8
          +TTN+T G
Sbjct: 53 NTTNLTAG 60
>NP_005328
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HTTNVTE 7
           HT NVT+
Sbjct: 386 HTENVTK 392
>NP_056090
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTTNVTEGS 9
           HT N  EG+
Sbjct: 980 HTRNSAEGT 988
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.292    0.108    0.291 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 606,995
Number of extensions: 1422
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.0 bits)
S2: 28 (15.4 bits)

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