Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     175
NP_671714                                                              21     175
XP_006715890                                                           21     175
XP_005250160                                                           21     175
XP_005250159                                                           21     175
NP_689412                                                              17    3301
NP_689410                                                              17    3301
NP_006231                                                              17    3301
XP_006724563                                                           17    3301
XP_005274611                                                           17    3301
XP_005274610                                                           17    3301
XP_006715077                                                           17    3301
NP_001073379                                                           17    4312
NP_787048                                                              17    4312
NP_001239542                                                           17    4312
NP_001136336                                                           17    4312
NP_001239541                                                           17    4312
NP_001014972                                                           17    4312
NP_055312                                                              17    4312
XP_006721417                                                           17    4312
XP_006721416                                                           17    4312
XP_006719697                                                           17    4312
XP_006719696                                                           17    4312
XP_006719695                                                           17    4312
XP_005269238                                                           17    4312
XP_005264321                                                           17    4312
XP_006712053                                                           17    4312
XP_005264320                                                           17    4312
XP_006712052                                                           17    4312
XP_005264319                                                           17    4312
XP_005264318                                                           17    4312
XP_005270651                                                           17    4312
XP_006710487                                                           17    4312
NP_001002759                                                           16    5631
NP_660290                                                              16    5631
XP_005269581                                                           16    5631
XP_005269579                                                           16    5631
XP_005269578                                                           16    5631
NP_006230                                                              16    5631
NP_071418                                                              16    7355
XP_005247756                                                           16    7355
XP_005247755                                                           16    7355
NP_055558                                                              15    9605
NP_001094060                                                           15    9605
NP_001185524                                                           15    9605
NP_001185523                                                           15    9605
NP_758515                                                              15    9605
NP_006864                                                              15    9605
NP_001185522                                                           15    9605
NP_997203                                                              15    9605
NP_203754                                                              15    9605
NP_001002909                                                           15    9605
NP_000971                                                              15    9605
XP_006721846                                                           15    9605
XP_006721845                                                           15    9605
XP_006721844                                                           15    9605
XP_006718789                                                           15    9605
XP_006718788                                                           15    9605
XP_005274419                                                           15    9605
XP_005248098                                                           15    9605
XP_006713998                                                           15    9605
XP_006713997                                                           15    9605
>NP_005742
          Length = 3907

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HTMYRSRSD 9
            HT YRSRSD
Sbjct: 3828 HTTYRSRSD 3836
>NP_671714
          Length = 3899

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HTMYRSRSD 9
            HT YRSRSD
Sbjct: 3820 HTTYRSRSD 3828
>XP_006715890
          Length = 3860

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HTMYRSRSD 9
            HT YRSRSD
Sbjct: 3781 HTTYRSRSD 3789
>XP_005250160
          Length = 3939

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HTMYRSRSD 9
            HT YRSRSD
Sbjct: 3860 HTTYRSRSD 3868
>XP_005250159
          Length = 3952

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HTMYRSRSD 9
            HT YRSRSD
Sbjct: 3873 HTTYRSRSD 3881
>NP_689412
          Length = 591

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 501 TLYRYRSD 508
>NP_689410
          Length = 625

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 535 TLYRYRSD 542
>NP_006231
          Length = 653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 563 TLYRYRSD 570
>XP_006724563
          Length = 563

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 473 TLYRYRSD 480
>XP_005274611
          Length = 588

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 498 TLYRYRSD 505
>XP_005274610
          Length = 653

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   TMYRSRSD 9
           T+YR RSD
Sbjct: 563 TLYRYRSD 570
>XP_006715077
          Length = 140

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2  TMYRSRS 8
          T+YRSRS
Sbjct: 73 TLYRSRS 79
>NP_001073379
          Length = 1722

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT + SRS+
Sbjct: 1508 HTQFNSRSE 1516
>NP_787048
          Length = 546

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMYRSR 7
           TMYRSR
Sbjct: 430 TMYRSR 435
>NP_001239542
          Length = 1957

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 513 HYMYRPRS 520
>NP_001136336
          Length = 2521

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT YR+ +D
Sbjct: 1951 HTKYRAATD 1959
>NP_001239541
          Length = 1978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 513 HYMYRPRS 520
>NP_001014972
          Length = 1978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 513 HYMYRPRS 520
>NP_055312
          Length = 1978

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 513 HYMYRPRS 520
>XP_006721417
          Length = 2497

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT YR+ +D
Sbjct: 1927 HTKYRAATD 1935
>XP_006721416
          Length = 2504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT YR+ +D
Sbjct: 1934 HTKYRAATD 1942
>XP_006719697
          Length = 1658

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT + SRS+
Sbjct: 1444 HTQFNSRSE 1452
>XP_006719696
          Length = 1696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT + SRS+
Sbjct: 1444 HTQFNSRSE 1452
>XP_006719695
          Length = 1696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT + SRS+
Sbjct: 1444 HTQFNSRSE 1452
>XP_005269238
          Length = 1696

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HTMYRSRSD 9
            HT + SRS+
Sbjct: 1444 HTQFNSRSE 1452
>XP_005264321
          Length = 1206

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 619 HYMYRPRS 626
>XP_006712053
          Length = 1467

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1 HTMYRSRS 8
         H MYR RS
Sbjct: 2 HYMYRPRS 9
>XP_005264320
          Length = 1467

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1 HTMYRSRS 8
         H MYR RS
Sbjct: 2 HYMYRPRS 9
>XP_006712052
          Length = 1467

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1 HTMYRSRS 8
         H MYR RS
Sbjct: 2 HYMYRPRS 9
>XP_005264319
          Length = 2049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 619 HYMYRPRS 626
>XP_005264318
          Length = 2084

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           H MYR RS
Sbjct: 619 HYMYRPRS 626
>XP_005270651
          Length = 371

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMYRSR 7
           TMYRSR
Sbjct: 255 TMYRSR 260
>XP_006710487
          Length = 464

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMYRSR 7
           TMYRSR
Sbjct: 430 TMYRSR 435
>NP_001002759
          Length = 245

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRS++D
Sbjct: 178 MYRSKND 184
>NP_660290
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRS++D
Sbjct: 165 MYRSKND 171
>XP_005269581
          Length = 232

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRS++D
Sbjct: 165 MYRSKND 171
>XP_005269579
          Length = 254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRS++D
Sbjct: 187 MYRSKND 193
>XP_005269578
          Length = 307

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRS++D
Sbjct: 240 MYRSKND 246
>NP_006230
          Length = 753

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TMYRSRSD 9
           T+YR+RS+
Sbjct: 649 TLYRNRSN 656
>NP_071418
          Length = 364

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTMYRSRSD 9
           H +YR R D
Sbjct: 94  HLVYRLRED 102
>XP_005247756
          Length = 360

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTMYRSRSD 9
           H +YR R D
Sbjct: 94  HLVYRLRED 102
>XP_005247755
          Length = 368

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTMYRSRSD 9
           H +YR R D
Sbjct: 94  HLVYRLRED 102
>NP_055558
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMYRSRSD 9
           T YR+R D
Sbjct: 422 TTYRNRQD 429
>NP_001094060
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMYRSRSD 9
           T YR+R D
Sbjct: 422 TTYRNRQD 429
>NP_001185524
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HTMYRSR 7
           HT++RS+
Sbjct: 265 HTLFRSQ 271
>NP_001185523
          Length = 1135

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HTMYRSR 7
           HT++RS+
Sbjct: 265 HTLFRSQ 271
>NP_758515
          Length = 1182

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HTMYRSR 7
           HT++RS+
Sbjct: 265 HTLFRSQ 271
>NP_006864
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HTMYRSR 7
           HT++RS+
Sbjct: 265 HTLFRSQ 271
>NP_001185522
          Length = 1158

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HTMYRSR 7
           HT++RS+
Sbjct: 265 HTLFRSQ 271
>NP_997203
          Length = 288

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HTMYRSRSD 9
           H MYR+  D
Sbjct: 151 HCMYRAIQD 159
>NP_203754
          Length = 1729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MYRSRSD 9
            MYRSR++
Sbjct: 1570 MYRSRAN 1576
>NP_001002909
          Length = 1502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           HT  RSRS
Sbjct: 949 HTRERSRS 956
>NP_000971
          Length = 176

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 5/9 (55%)

Query: 1  HTMYRSRSD 9
          H MYR   D
Sbjct: 91 HNMYREYRD 99
>XP_006721846
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           HT  RSRS
Sbjct: 871 HTRERSRS 878
>XP_006721845
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           HT  RSRS
Sbjct: 871 HTRERSRS 878
>XP_006721844
          Length = 1424

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HTMYRSRS 8
           HT  RSRS
Sbjct: 871 HTRERSRS 878
>XP_006718789
          Length = 1053

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   MYRSRSD 9
           MYRSR++
Sbjct: 894 MYRSRAN 900
>XP_006718788
          Length = 1729

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MYRSRSD 9
            MYRSR++
Sbjct: 1570 MYRSRAN 1576
>XP_005274419
          Length = 1808

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3    MYRSRSD 9
            MYRSR++
Sbjct: 1649 MYRSRAN 1655
>XP_005248098
          Length = 1310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMYRSRSD 9
           T YR+R D
Sbjct: 313 TTYRNRQD 320
>XP_006713998
          Length = 1332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMYRSRSD 9
           T YR+R D
Sbjct: 422 TTYRNRQD 429
>XP_006713997
          Length = 1419

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   TMYRSRSD 9
           T YR+R D
Sbjct: 422 TTYRNRQD 429
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.321    0.121    0.361 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 489,859
Number of extensions: 707
Number of successful extensions: 62
Number of sequences better than 10000.0: 62
Number of HSP's gapped: 62
Number of HSP's successfully gapped: 62
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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