Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000213                                                              20     509
NP_001087241                                                           20     509
XP_005265799                                                           20     509
XP_005265798                                                           20     509
XP_005265797                                                           20     509
NP_000543                                                              17    3301
NP_064716                                                              17    3301
NP_066267                                                              17    4312
NP_940912                                                              17    4312
XP_006717852                                                           17    4312
XP_006717851                                                           17    4312
XP_006717850                                                           17    4312
XP_006717849                                                           17    4312
XP_006717848                                                           17    4312
XP_006717847                                                           17    4312
XP_006717846                                                           17    4312
XP_006717845                                                           17    4312
XP_005250953                                                           17    4312
XP_005250952                                                           17    4312
XP_005250951                                                           17    4312
NP_861452                                                              17    4312
NP_057006                                                              16    5631
NP_002438                                                              16    5631
NP_001123237                                                           16    5631
NP_694984                                                              16    5631
XP_006724887                                                           16    5631
XP_005262172                                                           16    5631
XP_005262170                                                           16    5631
XP_005265227                                                           16    5631
NP_002221                                                              16    7355
NP_068831                                                              16    7355
NP_689758                                                              16    7355
NP_003540                                                              16    7355
NP_001186958                                                           16    7355
NP_001186959                                                           16    7355
XP_006721941                                                           16    7355
XP_006721940                                                           16    7355
XP_006721939                                                           16    7355
XP_006721938                                                           16    7355
XP_006721937                                                           16    7355
XP_006721936                                                           16    7355
XP_006721935                                                           16    7355
XP_006721934                                                           16    7355
XP_005257370                                                           16    7355
XP_005262834                                                           16    7355
XP_006714175                                                           16    7355
XP_005262833                                                           16    7355
NP_776159                                                              16    7355
NP_065816                                                              15    9605
NP_073153                                                              15    9605
NP_001121182                                                           15    9605
NP_001121181                                                           15    9605
NP_001121180                                                           15    9605
NP_005798                                                              15    9605
XP_006726447                                                           15    9605
XP_005276263                                                           15    9605
XP_006726445                                                           15    9605
XP_006712754                                                           15    9605
XP_006712753                                                           15    9605
XP_005264736                                                           15    9605
XP_006712220                                                           15    9605
XP_005244879                                                           15    9605
XP_006711171                                                           15    9605
XP_006710573                                                           15    9605
XP_006710572                                                           15    9605
XP_006710571                                                           15    9605
XP_006710570                                                           15    9605
XP_006710569                                                           15    9605
XP_006710568                                                           15    9605
XP_006710567                                                           15    9605
XP_006710566                                                           15    9605
XP_005245859                                                           15    9605
>NP_000213
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSVRINYVG 9
           HSVRIN VG
Sbjct: 953 HSVRINSVG 961
>NP_001087241
          Length = 972

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSVRINYVG 9
           HSVRIN VG
Sbjct: 949 HSVRINSVG 957
>XP_005265799
          Length = 973

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSVRINYVG 9
           HSVRIN VG
Sbjct: 950 HSVRINSVG 958
>XP_005265798
          Length = 976

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSVRINYVG 9
           HSVRIN VG
Sbjct: 953 HSVRINSVG 961
>XP_005265797
          Length = 977

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSVRINYVG 9
           HSVRIN VG
Sbjct: 954 HSVRINSVG 962
>NP_000543
          Length = 2813

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2048 HEVRFNHLG 2056
>NP_064716
          Length = 578

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRINYVG 9
           +RINY+G
Sbjct: 166 IRINYLG 172
>NP_066267
          Length = 4377

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2876 HDVRENHIG 2884
>NP_940912
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   VRINYVG 9
           VR+NY+G
Sbjct: 477 VRLNYLG 483
>XP_006717852
          Length = 3508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2007 HDVRENHIG 2015
>XP_006717851
          Length = 3513

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2012 HDVRENHIG 2020
>XP_006717850
          Length = 4364

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2863 HDVRENHIG 2871
>XP_006717849
          Length = 4383

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2882 HDVRENHIG 2890
>XP_006717848
          Length = 4392

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2891 HDVRENHIG 2899
>XP_006717847
          Length = 4395

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2894 HDVRENHIG 2902
>XP_006717846
          Length = 4396

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2895 HDVRENHIG 2903
>XP_006717845
          Length = 4397

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSVRINYVG 9
            H VR N++G
Sbjct: 2896 HDVRENHIG 2904
>XP_005250953
          Length = 472

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSVRINY 7
           H V+INY
Sbjct: 437 HEVKINY 443
>XP_005250952
          Length = 618

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSVRINY 7
           H V+INY
Sbjct: 583 HEVKINY 589
>XP_005250951
          Length = 660

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSVRINY 7
           H V+INY
Sbjct: 625 HEVKINY 631
>NP_861452
          Length = 723

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSVRINY 7
           H V+INY
Sbjct: 688 HEVKINY 694
>NP_057006
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 119 RVNYIG 124
>NP_002438
          Length = 1400

 Score = 16.2 bits (30), Expect =  5631
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H+++  Y+G
Sbjct: 878 HAIKFEYIG 886
>NP_001123237
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 119 RVNYIG 124
>NP_694984
          Length = 1802

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H +RI Y+G
Sbjct: 340 HVIRIYYLG 348
>XP_006724887
          Length = 373

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 119 RVNYIG 124
>XP_005262172
          Length = 1631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H +RI Y+G
Sbjct: 169 HVIRIYYLG 177
>XP_005262170
          Length = 1752

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H +RI Y+G
Sbjct: 340 HVIRIYYLG 348
>XP_005265227
          Length = 1401

 Score = 16.2 bits (30), Expect =  5631
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H+++  Y+G
Sbjct: 879 HAIKFEYIG 887
>NP_002221
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>NP_068831
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>NP_689758
          Length = 473

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 220 RLNYIG 225
>NP_003540
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HSVRINYVG 9
           HS+  NY G
Sbjct: 210 HSMASNYTG 218
>NP_001186958
          Length = 417

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HSVRINYVG 9
           HS+  NY G
Sbjct: 210 HSMASNYTG 218
>NP_001186959
          Length = 387

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HSVRINYVG 9
           HS+  NY G
Sbjct: 210 HSMASNYTG 218
>XP_006721941
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721940
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721939
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721938
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721937
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721936
          Length = 745

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 474 NSVRLNY 480
>XP_006721935
          Length = 762

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 491 NSVRLNY 497
>XP_006721934
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 512 NSVRLNY 518
>XP_005257370
          Length = 783

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSVRINY 7
           +SVR+NY
Sbjct: 512 NSVRLNY 518
>XP_005262834
          Length = 431

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 178 RLNYIG 183
>XP_006714175
          Length = 432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 179 RLNYIG 184
>XP_005262833
          Length = 472

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 4   RINYVG 9
           R+NY+G
Sbjct: 219 RLNYIG 224
>NP_776159
          Length = 402

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HSVRINYVG 9
           H++R +Y G
Sbjct: 343 HTIRCSYCG 351
>NP_065816
          Length = 5183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>NP_073153
          Length = 1944

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1    HSVRINYV 8
            H VR+N V
Sbjct: 1045 HPVRVNVV 1052
>NP_001121182
          Length = 1270

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1180 HTIRIQY 1186
>NP_001121181
          Length = 1311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1221 HTIRIQY 1227
>NP_001121180
          Length = 1363

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1273 HTIRIQY 1279
>NP_005798
          Length = 1404

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1314 HTIRIQY 1320
>XP_006726447
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  HSVRINYV 8
          H VR+N V
Sbjct: 30 HPVRVNVV 37
>XP_005276263
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  HSVRINYV 8
          H VR+N V
Sbjct: 30 HPVRVNVV 37
>XP_006726445
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSVRINYV 8
           H VR+N V
Sbjct: 308 HPVRVNVV 315
>XP_006712754
          Length = 1784

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSVRINYV 8
           H VR+N V
Sbjct: 885 HPVRVNVV 892
>XP_006712753
          Length = 1846

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSVRINYV 8
           H VR+N V
Sbjct: 947 HPVRVNVV 954
>XP_005264736
          Length = 671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSVRINYV 8
           H VR+N V
Sbjct: 333 HPVRVNVV 340
>XP_006712220
          Length = 338

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSVRINYV 8
           H VR+N V
Sbjct: 308 HPVRVNVV 315
>XP_005244879
          Length = 1361

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1271 HTIRIQY 1277
>XP_006711171
          Length = 1381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HSVRINY 7
            H++RI Y
Sbjct: 1291 HTIRIQY 1297
>XP_006710573
          Length = 5177

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710572
          Length = 5188

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710571
          Length = 5194

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710570
          Length = 5195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710569
          Length = 5212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710568
          Length = 5221

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710567
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_006710566
          Length = 5222

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
>XP_005245859
          Length = 5223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    SVRINYVG 9
            +VR+NY G
Sbjct: 1872 NVRMNYSG 1879
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.326    0.142    0.434 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 456,745
Number of extensions: 974
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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