Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001275701                                                           20     299
NP_004561                                                              20     299
NP_001275703                                                           20     299
XP_005253450                                                           20     299
XP_006719151                                                           20     299
NP_001274324                                                           17    2528
XP_006712547                                                           17    2528
NP_001026885                                                           17    3301
NP_001271278                                                           17    3301
NP_001271276                                                           17    3301
NP_001271277                                                           17    3301
XP_006722199                                                           17    3301
XP_005257785                                                           17    3301
NP_115510                                                              17    3301
NP_001265584                                                           17    4312
XP_006723743                                                           17    4312
NP_001154803                                                           16    5631
NP_001154802                                                           16    5631
NP_061857                                                              16    5631
NP_003990                                                              16    5631
NP_059988                                                              16    5631
XP_005269041                                                           16    5631
XP_006714572                                                           16    5631
XP_005248442                                                           16    5631
XP_005248441                                                           16    5631
NP_775859                                                              16    7355
NP_005564                                                              16    7355
NP_001124427                                                           16    7355
NP_056133                                                              16    7355
NP_219479                                                              16    7355
XP_006722772                                                           16    7355
XP_006722771                                                           16    7355
XP_005272522                                                           16    7355
XP_006722770                                                           16    7355
XP_006722769                                                           16    7355
XP_006722768                                                           16    7355
XP_005272521                                                           16    7355
XP_005248705                                                           16    7355
XP_006715387                                                           16    7355
XP_006715386                                                           16    7355
NP_001004488                                                           16    7355
NP_000383                                                              15    9605
NP_001257457                                                           15    9605
NP_060080                                                              15    9605
NP_001257458                                                           15    9605
NP_001257459                                                           15    9605
NP_878910                                                              15    9605
NP_006335                                                              15    9605
NP_004993                                                              15    9605
NP_055592                                                              15    9605
NP_056504                                                              15    9605
XP_005256469                                                           15    9605
XP_005256468                                                           15    9605
XP_006720643                                                           15    9605
XP_006720642                                                           15    9605
XP_005254536                                                           15    9605
XP_006720641                                                           15    9605
XP_006720640                                                           15    9605
XP_005254533                                                           15    9605
XP_005254532                                                           15    9605
XP_006720639                                                           15    9605
XP_005254530                                                           15    9605
XP_006720638                                                           15    9605
XP_006717693                                                           15    9605
XP_005250036                                                           15    9605
XP_005250035                                                           15    9605
XP_005250034                                                           15    9605
XP_005250033                                                           15    9605
XP_005273417                                                           15    9605
>NP_001275701
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSQMLLNLL 9
            HSQ+LLNLL
Sbjct: 1150 HSQLLLNLL 1158
>NP_004561
          Length = 1445

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSQMLLNLL 9
            HSQ+LLNLL
Sbjct: 1109 HSQLLLNLL 1117
>NP_001275703
          Length = 1264

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HSQMLLNLL 9
           HSQ+LLNLL
Sbjct: 928 HSQLLLNLL 936
>XP_005253450
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSQMLLNLL 9
            HSQ+LLNLL
Sbjct: 1150 HSQLLLNLL 1158
>XP_006719151
          Length = 1486

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSQMLLNLL 9
            HSQ+LLNLL
Sbjct: 1150 HSQLLLNLL 1158
>NP_001274324
          Length = 1688

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           H Q+LLNL+
Sbjct: 794 HPQLLLNLV 802
>XP_006712547
          Length = 1674

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           H Q+LLNL+
Sbjct: 791 HPQLLLNLV 799
>NP_001026885
          Length = 1027

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           H QML+NL
Sbjct: 351 HVQMLINL 358
>NP_001271278
          Length = 305

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           H QML+NL
Sbjct: 178 HVQMLINL 185
>NP_001271276
          Length = 684

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           H QML+NL
Sbjct: 99  HVQMLINL 106
>NP_001271277
          Length = 621

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           H QML+NL
Sbjct: 103 HVQMLINL 110
>XP_006722199
          Length = 641

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   HSQMLLNL 8
           HS+ML+N+
Sbjct: 419 HSKMLMNI 426
>XP_005257785
          Length = 1887

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HSQMLLNL 8
            HS+ML+N+
Sbjct: 1665 HSKMLMNI 1672
>NP_115510
          Length = 1663

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1    HSQMLLNL 8
            HS+ML+N+
Sbjct: 1499 HSKMLMNI 1506
>NP_001265584
          Length = 113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          HS +LLN++
Sbjct: 10 HSHILLNII 18
>XP_006723743
          Length = 113

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          HS +LLN++
Sbjct: 10 HSHILLNII 18
>NP_001154803
          Length = 703

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          H Q+++NLL
Sbjct: 88 HLQVMINLL 96
>NP_001154802
          Length = 692

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          H Q+++NLL
Sbjct: 77 HLQVMINLL 85
>NP_061857
          Length = 1049

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          H Q+++NLL
Sbjct: 77 HLQVMINLL 85
>NP_003990
          Length = 979

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           HS ML+++L
Sbjct: 737 HSSMLIHIL 745
>NP_059988
          Length = 368

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           H QMLLN
Sbjct: 183 HLQMLLN 189
>XP_005269041
          Length = 1049

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HSQMLLNLL 9
          H Q+++NLL
Sbjct: 77 HLQVMINLL 85
>XP_006714572
          Length = 647

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           HS ML+++L
Sbjct: 405 HSSMLIHIL 413
>XP_005248442
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           HS ML+++L
Sbjct: 738 HSSMLIHIL 746
>XP_005248441
          Length = 980

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           HS ML+++L
Sbjct: 738 HSSMLIHIL 746
>NP_775859
          Length = 1326

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    HSQMLLN 7
            HSQ L+N
Sbjct: 1057 HSQFLIN 1063
>NP_005564
          Length = 586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           H Q+LLN
Sbjct: 114 HDQLLLN 120
>NP_001124427
          Length = 1173

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 808 SQLLLNL 814
>NP_056133
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 650 SQLLLNL 656
>NP_219479
          Length = 292

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           H Q+LLN
Sbjct: 97  HQQLLLN 103
>XP_006722772
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 650 SQLLLNL 656
>XP_006722771
          Length = 1015

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 650 SQLLLNL 656
>XP_005272522
          Length = 1088

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 723 SQLLLNL 729
>XP_006722770
          Length = 1345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   SQMLLNL 8
           SQ+LLNL
Sbjct: 980 SQLLLNL 986
>XP_006722769
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SQMLLNL 8
            SQ+LLNL
Sbjct: 996  SQLLLNL 1002
>XP_006722768
          Length = 1361

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SQMLLNL 8
            SQ+LLNL
Sbjct: 996  SQLLLNL 1002
>XP_005272521
          Length = 1426

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2    SQMLLNL 8
            SQ+LLNL
Sbjct: 1061 SQLLLNL 1067
>XP_005248705
          Length = 217

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  HSQMLLN 7
          H Q+LLN
Sbjct: 22 HQQLLLN 28
>XP_006715387
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  HSQMLLN 7
          H Q+LLN
Sbjct: 31 HQQLLLN 37
>XP_006715386
          Length = 226

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  HSQMLLN 7
          H Q+LLN
Sbjct: 31 HQQLLLN 37
>NP_001004488
          Length = 310

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3  QMLLNLL 9
          QML+NLL
Sbjct: 79 QMLVNLL 85
>NP_000383
          Length = 1545

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSQMLLNLL 9
            H Q+L N+L
Sbjct: 1057 HKQLLNNIL 1065
>NP_001257457
          Length = 995

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>NP_060080
          Length = 986

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>NP_001257458
          Length = 985

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>NP_001257459
          Length = 994

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>NP_878910
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HS+MLL +
Sbjct: 146 HSEMLLRV 153
>NP_006335
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HS+MLL +
Sbjct: 119 HSEMLLRV 126
>NP_004993
          Length = 377

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HSQMLLNLL 9
           HS +++NL+
Sbjct: 122 HSNVVINLI 130
>NP_055592
          Length = 1524

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSQMLLNLL 9
          HS+ L NLL
Sbjct: 79 HSRKLQNLL 87
>NP_056504
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HSQ L+N+
Sbjct: 532 HSQRLVNV 539
>XP_005256469
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HS+MLL +
Sbjct: 119 HSEMLLRV 126
>XP_005256468
          Length = 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HS+MLL +
Sbjct: 146 HSEMLLRV 153
>XP_006720643
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>XP_006720642
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>XP_005254536
          Length = 1003

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 165 HSQTILN 171
>XP_006720641
          Length = 1008

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_006720640
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_005254533
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_005254532
          Length = 1017

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_006720639
          Length = 1018

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_005254530
          Length = 1025

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_006720638
          Length = 1026

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HSQMLLN 7
           HSQ +LN
Sbjct: 188 HSQTILN 194
>XP_006717693
          Length = 1313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSQMLLNLL 9
           H Q+L N+L
Sbjct: 825 HKQLLNNIL 833
>XP_005250036
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HSQ L+N+
Sbjct: 532 HSQRLVNV 539
>XP_005250035
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HSQ L+N+
Sbjct: 532 HSQRLVNV 539
>XP_005250034
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HSQ L+N+
Sbjct: 532 HSQRLVNV 539
>XP_005250033
          Length = 1009

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSQMLLNL 8
           HSQ L+N+
Sbjct: 532 HSQRLVNV 539
>XP_005273417
          Length = 1487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSQMLLNLL 9
          HS+ L NLL
Sbjct: 79 HSRKLQNLL 87
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.138    0.371 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 419,140
Number of extensions: 842
Number of successful extensions: 69
Number of sequences better than 10000.0: 69
Number of HSP's gapped: 69
Number of HSP's successfully gapped: 69
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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