Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
XP_005262424                                                           19     665
NP_788955                                                              18    1482
NP_919288                                                              17    3301
NP_001135916                                                           17    4312
NP_001135915                                                           17    4312
NP_079359                                                              17    4312
NP_073619                                                              16    5631
NP_001273208                                                           16    5631
NP_001073879                                                           16    5631
XP_006719255                                                           16    5631
XP_006719254                                                           16    5631
XP_006719253                                                           16    5631
XP_006719252                                                           16    5631
XP_006719251                                                           16    5631
XP_006719250                                                           16    5631
XP_005264215                                                           16    5631
XP_006712013                                                           16    5631
NP_001008219                                                           16    7355
NP_004029                                                              16    7355
NP_001008220                                                           16    7355
NP_001008222                                                           16    7355
NP_001137411                                                           16    7355
NP_001137410                                                           16    7355
NP_056190                                                              16    7355
NP_955749                                                              16    7355
NP_835470                                                              16    7355
NP_000690                                                              16    7355
NP_056025                                                              16    7355
NP_001274076                                                           16    7355
NP_066188                                                              16    7355
XP_006722383                                                           16    7355
XP_006722382                                                           16    7355
XP_006722381                                                           16    7355
XP_005258156                                                           16    7355
XP_005258155                                                           16    7355
XP_005250366                                                           16    7355
XP_006710644                                                           16    7355
XP_005270818                                                           16    7355
XP_006710643                                                           16    7355
XP_005270815                                                           16    7355
XP_006710642                                                           16    7355
XP_005270812                                                           16    7355
NP_001001389                                                           15    9605
NP_001001390                                                           15    9605
NP_000601                                                              15    9605
NP_001166282                                                           15    9605
NP_060034                                                              15    9605
NP_001166284                                                           15    9605
NP_001166286                                                           15    9605
NP_001166285                                                           15    9605
NP_776250                                                              15    9605
NP_758857                                                              15    9605
NP_061992                                                              15    9605
NP_002228                                                              15    9605
NP_055612                                                              15    9605
NP_872409                                                              15    9605
NP_114141                                                              15    9605
XP_006723848                                                           15    9605
XP_005274029                                                           15    9605
XP_005274028                                                           15    9605
XP_006718595                                                           15    9605
XP_005253297                                                           15    9605
XP_005253296                                                           15    9605
XP_005253295                                                           15    9605
XP_005253292                                                           15    9605
XP_005253291                                                           15    9605
XP_005253290                                                           15    9605
XP_006718452                                                           15    9605
XP_006718451                                                           15    9605
XP_005253289                                                           15    9605
XP_005253288                                                           15    9605
NP_997264                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSLTLQTRL 9
           HSLTL TRL
Sbjct: 505 HSLTLPTRL 513
>XP_005262424
          Length = 2875

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HSLTLQTRL 9
           HSLTL TRL
Sbjct: 300 HSLTLPTRL 308
>NP_788955
          Length = 250

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   HSLTLQTR 8
           HSLTLQ R
Sbjct: 242 HSLTLQAR 249
>NP_919288
          Length = 1005

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSLTLQTR 8
           HS TL+TR
Sbjct: 128 HSATLETR 135
>NP_001135916
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLTLQTRL 9
           H LTL+ RL
Sbjct: 297 HGLTLERRL 305
>NP_001135915
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLTLQTRL 9
           H LTL+ RL
Sbjct: 297 HGLTLERRL 305
>NP_079359
          Length = 508

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLTLQTRL 9
           H LTL+ RL
Sbjct: 297 HGLTLERRL 305
>NP_073619
          Length = 1183

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LTLQTRL 9
            +TLQTRL
Sbjct: 1142 ITLQTRL 1148
>NP_001273208
          Length = 439

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLTLQTRL 9
           HSL  +TRL
Sbjct: 431 HSLCFRTRL 439
>NP_001073879
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLTLQ
Sbjct: 615 HSLTLQ 620
>XP_006719255
          Length = 485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           +TLQTRL
Sbjct: 444 ITLQTRL 450
>XP_006719254
          Length = 810

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           +TLQTRL
Sbjct: 769 ITLQTRL 775
>XP_006719253
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           +TLQTRL
Sbjct: 990 ITLQTRL 996
>XP_006719252
          Length = 1031

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           +TLQTRL
Sbjct: 990 ITLQTRL 996
>XP_006719251
          Length = 1116

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LTLQTRL 9
            +TLQTRL
Sbjct: 1075 ITLQTRL 1081
>XP_006719250
          Length = 1141

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3    LTLQTRL 9
            +TLQTRL
Sbjct: 1100 ITLQTRL 1106
>XP_005264215
          Length = 481

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLTLQ
Sbjct: 221 HSLTLQ 226
>XP_006712013
          Length = 875

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLTLQ
Sbjct: 615 HSLTLQ 620
>NP_001008219
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_004029
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_001008220
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_001008222
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_001137411
          Length = 674

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           H LTLQ  L
Sbjct: 122 HGLTLQLHL 130
>NP_001137410
          Length = 661

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           H LTLQ  L
Sbjct: 109 HGLTLQLHL 117
>NP_056190
          Length = 929

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           LTL+TRL
Sbjct: 749 LTLETRL 755
>NP_955749
          Length = 884

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LTLQTRL 9
           LTL+TRL
Sbjct: 749 LTLETRL 755
>NP_835470
          Length = 341

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HSLTLQTR 8
           H LTLQ R
Sbjct: 205 HCLTLQKR 212
>NP_000690
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_056025
          Length = 1586

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 797 HSLRLQT 803
>NP_001274076
          Length = 281

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HSLTLQTR 8
           H LTLQ R
Sbjct: 205 HCLTLQKR 212
>NP_066188
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_006722383
          Length = 981

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 127 HSLRLQT 133
>XP_006722382
          Length = 1644

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 818 HSLRLQT 824
>XP_006722381
          Length = 1672

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 818 HSLRLQT 824
>XP_005258156
          Length = 1905

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    HSLTLQT 7
            HSL LQT
Sbjct: 1116 HSLRLQT 1122
>XP_005258155
          Length = 1970

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    HSLTLQT 7
            HSL LQT
Sbjct: 1116 HSLRLQT 1122
>XP_005250366
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HSLTLQTR 8
           H LTLQ R
Sbjct: 205 HCLTLQKR 212
>XP_006710644
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_005270818
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_006710643
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_005270815
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_006710642
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>XP_005270812
          Length = 511

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   SLTLQTRL 9
           SLTLQT L
Sbjct: 452 SLTLQTGL 459
>NP_001001389
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 434 HSITLQ 439
>NP_001001390
          Length = 493

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 228 HSITLQ 233
>NP_000601
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 477 HSITLQ 482
>NP_001166282
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLT+Q
Sbjct: 296 HSLTIQ 301
>NP_060034
          Length = 2551

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TLQTRL 9
            TLQTRL
Sbjct: 2396 TLQTRL 2401
>NP_001166284
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLT+Q
Sbjct: 296 HSLTIQ 301
>NP_001166286
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLT+Q
Sbjct: 296 HSLTIQ 301
>NP_001166285
          Length = 320

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLT+Q
Sbjct: 296 HSLTIQ 301
>NP_776250
          Length = 369

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HSLT+Q
Sbjct: 345 HSLTIQ 350
>NP_758857
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 353 HSLGLQT 359
>NP_061992
          Length = 797

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 435 HSITLQ 440
>NP_002228
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 359 HSLGLQT 365
>NP_055612
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSLTLQTRL 9
           HSL + TR+
Sbjct: 335 HSLQVHTRM 343
>NP_872409
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           HS TLQ  L
Sbjct: 110 HSFTLQIML 118
>NP_114141
          Length = 5635

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1    HSLTLQTR 8
            HSLTL+ +
Sbjct: 1657 HSLTLECK 1664
>XP_006723848
          Length = 513

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HSLTLQT 7
           HSL LQT
Sbjct: 359 HSLGLQT 365
>XP_005274029
          Length = 198

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           HS TLQ  L
Sbjct: 138 HSFTLQIML 146
>XP_005274028
          Length = 230

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           HS TLQ  L
Sbjct: 138 HSFTLQIML 146
>XP_006718595
          Length = 505

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HSLTLQTRL 9
           HS TLQ  L
Sbjct: 110 HSFTLQIML 118
>XP_005253297
          Length = 535

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 270 HSITLQ 275
>XP_005253296
          Length = 578

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 313 HSITLQ 318
>XP_005253295
          Length = 580

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 315 HSITLQ 320
>XP_005253292
          Length = 700

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 435 HSITLQ 440
>XP_005253291
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 437 HSITLQ 442
>XP_005253290
          Length = 703

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 438 HSITLQ 443
>XP_006718452
          Length = 735

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 470 HSITLQ 475
>XP_006718451
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 476 HSITLQ 481
>XP_005253289
          Length = 742

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 477 HSITLQ 482
>XP_005253288
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HSLTLQ 6
           HS+TLQ
Sbjct: 478 HSITLQ 483
>NP_997264
          Length = 292

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4  TLQTRL 9
          TLQTRL
Sbjct: 39 TLQTRL 44
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.128    0.343 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 379,850
Number of extensions: 590
Number of successful extensions: 73
Number of sequences better than 10000.0: 73
Number of HSP's gapped: 73
Number of HSP's successfully gapped: 73
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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