Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              20     299
NP_671714                                                              20     299
XP_006715890                                                           20     299
XP_005250160                                                           20     299
XP_005250159                                                           20     299
NP_001186130                                                           18    1482
XP_005247836                                                           18    1482
XP_006713810                                                           18    1482
XP_005247834                                                           18    1482
NP_003556                                                              17    3301
NP_001096654                                                           17    4312
NP_061836                                                              17    4312
NP_001264242                                                           17    4312
NP_065810                                                              17    4312
NP_387505                                                              17    4312
XP_005261051                                                           17    4312
XP_006720684                                                           17    4312
NP_060510                                                              16    7355
NP_004362                                                              16    7355
NP_001091868                                                           16    7355
NP_001161437                                                           16    7355
NP_689711                                                              16    7355
NP_001182760                                                           16    7355
NP_055665                                                              16    7355
NP_001035519                                                           16    7355
NP_001028289                                                           16    7355
XP_005266415                                                           16    7355
XP_005266414                                                           16    7355
XP_006713496                                                           16    7355
XP_005265679                                                           16    7355
XP_005273233                                                           16    7355
XP_005273232                                                           16    7355
XP_005273231                                                           16    7355
XP_006710447                                                           16    7355
XP_006710446                                                           16    7355
XP_006710445                                                           16    7355
XP_005270577                                                           16    7355
NP_075561                                                              15    9605
NP_001230175                                                           15    9605
NP_071751                                                              15    9605
NP_001139761                                                           15    9605
NP_036553                                                              15    9605
NP_005112                                                              15    9605
XP_006714554                                                           15    9605
XP_005248410                                                           15    9605
XP_006714553                                                           15    9605
XP_005248407                                                           15    9605
XP_005248406                                                           15    9605
XP_005248404                                                           15    9605
XP_005248403                                                           15    9605
XP_006714552                                                           15    9605
XP_005248402                                                           15    9605
XP_006710654                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSLSEQADS 9
            HSLSE+ADS
Sbjct: 2375 HSLSEEADS 2383
>NP_671714
          Length = 3899

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSLSEQADS 9
            HSLSE+ADS
Sbjct: 2367 HSLSEEADS 2375
>XP_006715890
          Length = 3860

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSLSEQADS 9
            HSLSE+ADS
Sbjct: 2328 HSLSEEADS 2336
>XP_005250160
          Length = 3939

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSLSEQADS 9
            HSLSE+ADS
Sbjct: 2407 HSLSEEADS 2415
>XP_005250159
          Length = 3952

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    HSLSEQADS 9
            HSLSE+ADS
Sbjct: 2420 HSLSEEADS 2428
>NP_001186130
          Length = 839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HSLSEQADS 9
           HSLSE AD+
Sbjct: 635 HSLSEYADN 643
>XP_005247836
          Length = 627

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HSLSEQADS 9
           HSLSE AD+
Sbjct: 423 HSLSEYADN 431
>XP_006713810
          Length = 838

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HSLSEQADS 9
           HSLSE AD+
Sbjct: 634 HSLSEYADN 642
>XP_005247834
          Length = 839

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HSLSEQADS 9
           HSLSE AD+
Sbjct: 635 HSLSEYADN 643
>NP_003556
          Length = 1050

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    HSLSEQAD 8
            H LS+QAD
Sbjct: 1019 HMLSDQAD 1026
>NP_001096654
          Length = 1196

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSLSEQAD 8
           HSL+EQ D
Sbjct: 461 HSLTEQDD 468
>NP_061836
          Length = 2320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLSEQADS 9
            S+SE+ADS
Sbjct: 1786 SISEEADS 1793
>NP_001264242
          Length = 1419

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HSLSEQAD 8
           HSL+EQ D
Sbjct: 684 HSLTEQDD 691
>NP_065810
          Length = 4700

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    SLSEQADS 9
            S SEQADS
Sbjct: 1313 SYSEQADS 1320
>NP_387505
          Length = 2269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLSEQADS 9
            S+SE+ADS
Sbjct: 1786 SISEEADS 1793
>XP_005261051
          Length = 2242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2    SLSEQADS 9
            S+SE+ADS
Sbjct: 1708 SISEEADS 1715
>XP_006720684
          Length = 4713

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    SLSEQADS 9
            S SEQADS
Sbjct: 1326 SYSEQADS 1333
>NP_060510
          Length = 528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSLSEQADS 9
          H LSE +DS
Sbjct: 86 HCLSEGSDS 94
>NP_004362
          Length = 1224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H L E+A+S
Sbjct: 765 HGLDEEAES 773
>NP_001091868
          Length = 1233

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H L E+A+S
Sbjct: 774 HGLDEEAES 782
>NP_001161437
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>NP_689711
          Length = 698

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>NP_001182760
          Length = 1283

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>NP_055665
          Length = 1099

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SLSEQADS 9
           SLS++ADS
Sbjct: 810 SLSQKADS 817
>NP_001035519
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H  S+QADS
Sbjct: 892 HGDSDQADS 900
>NP_001028289
          Length = 1075

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SLSEQADS 9
           SLS++ADS
Sbjct: 786 SLSQKADS 793
>XP_005266415
          Length = 1158

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H  S+QADS
Sbjct: 891 HGDSDQADS 899
>XP_005266414
          Length = 1159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H  S+QADS
Sbjct: 892 HGDSDQADS 900
>XP_006713496
          Length = 591

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SLSEQADS 9
           SLS++ADS
Sbjct: 302 SLSQKADS 309
>XP_005265679
          Length = 858

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   SLSEQADS 9
           SLS++ADS
Sbjct: 810 SLSQKADS 817
>XP_005273233
          Length = 376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSLSEQADS 9
          H LSE +DS
Sbjct: 86 HCLSEGSDS 94
>XP_005273232
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSLSEQADS 9
          H LSE +DS
Sbjct: 86 HCLSEGSDS 94
>XP_005273231
          Length = 418

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HSLSEQADS 9
          H LSE +DS
Sbjct: 86 HCLSEGSDS 94
>XP_006710447
          Length = 1192

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>XP_006710446
          Length = 1239

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 565 HTLKEIADS 573
>XP_006710445
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>XP_005270577
          Length = 1250

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L E ADS
Sbjct: 576 HTLKEIADS 584
>NP_075561
          Length = 3197

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2435 HNLFEQGDA 2443
>NP_001230175
          Length = 804

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSLSEQAD 8
           HSLSE+ +
Sbjct: 130 HSLSEEME 137
>NP_071751
          Length = 736

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSLSEQAD 8
           HSLSE+ +
Sbjct: 130 HSLSEEME 137
>NP_001139761
          Length = 697

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HSLSEQAD 8
           HSLSE+ +
Sbjct: 130 HSLSEEME 137
>NP_036553
          Length = 1914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HSLSEQA 7
           HSL++QA
Sbjct: 641 HSLNDQA 647
>NP_005112
          Length = 2174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HSLSEQAD 8
           H LSE+ D
Sbjct: 97  HDLSEEED 104
>XP_006714554
          Length = 1442

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HSLSEQADS 9
           H+L EQ D+
Sbjct: 626 HNLFEQGDA 634
>XP_005248410
          Length = 2132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 1316 HNLFEQGDA 1324
>XP_006714553
          Length = 2792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2435 HNLFEQGDA 2443
>XP_005248407
          Length = 3208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2392 HNLFEQGDA 2400
>XP_005248406
          Length = 3214

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2434 HNLFEQGDA 2442
>XP_005248404
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2434 HNLFEQGDA 2442
>XP_005248403
          Length = 3250

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2434 HNLFEQGDA 2442
>XP_006714552
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2435 HNLFEQGDA 2443
>XP_005248402
          Length = 3251

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    HSLSEQADS 9
            H+L EQ D+
Sbjct: 2435 HNLFEQGDA 2443
>XP_006710654
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   SEQADS 9
           SEQADS
Sbjct: 346 SEQADS 351
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.287    0.101    0.241 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 455,967
Number of extensions: 964
Number of successful extensions: 53
Number of sequences better than 10000.0: 53
Number of HSP's gapped: 53
Number of HSP's successfully gapped: 53
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (14.9 bits)
S2: 28 (15.4 bits)

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