Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_444256                                                              18    1135
NP_444254                                                              18    1135
NP_444253                                                              18    1135
NP_444255                                                              18    1135
XP_005247551                                                           18    1135
XP_005247550                                                           18    1135
XP_006713712                                                           18    1135
XP_005247549                                                           18    1135
NP_005105                                                              17    4312
XP_005248278                                                           17    4312
NP_612422                                                              16    5631
NP_112506                                                              16    7355
NP_006453                                                              16    7355
NP_002010                                                              16    7355
NP_001153392                                                           16    7355
NP_001153502                                                           16    7355
NP_835226                                                              16    7355
NP_659429                                                              16    7355
NP_001268379                                                           16    7355
NP_001268380                                                           16    7355
XP_005260706                                                           16    7355
XP_005260703                                                           16    7355
XP_005260702                                                           16    7355
XP_006712420                                                           16    7355
XP_006712419                                                           16    7355
XP_005263954                                                           16    7355
NP_001027466                                                           15    9605
NP_000053                                                              15    9605
NP_001186738                                                           15    9605
NP_001186740                                                           15    9605
NP_056249                                                              15    9605
NP_001186741                                                           15    9605
NP_055426                                                              15    9605
NP_945345                                                              15    9605
NP_005388                                                              15    9605
NP_001018121                                                           15    9605
NP_003418                                                              15    9605
NP_060063                                                              15    9605
NP_942595                                                              15    9605
XP_006726599                                                           15    9605
XP_006719013                                                           15    9605
XP_005249698                                                           15    9605
XP_006715468                                                           15    9605
XP_005248756                                                           15    9605
XP_006715467                                                           15    9605
XP_005249427                                                           15    9605
XP_005249426                                                           15    9605
XP_005249421                                                           15    9605
XP_005263174                                                           15    9605
XP_001715329                                                           15    9605
NP_001129396                                                           15    9605
>NP_444256
          Length = 1794

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 116 QVTVELTV 123
>NP_444254
          Length = 1845

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 116 QVTVELTV 123
>NP_444253
          Length = 1914

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 116 QVTVELTV 123
>NP_444255
          Length = 1863

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 116 QVTVELTV 123
>XP_005247551
          Length = 1855

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 126 QVTVELTV 133
>XP_005247550
          Length = 1856

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 126 QVTVELTV 133
>XP_006713712
          Length = 1923

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 126 QVTVELTV 133
>XP_005247549
          Length = 1924

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           QVTVELTV
Sbjct: 126 QVTVELTV 133
>NP_005105
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HQVTVELT 8
           HQ+TVE T
Sbjct: 113 HQLTVEKT 120
>XP_005248278
          Length = 307

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HQVTVELT 8
           HQ+TVE T
Sbjct: 113 HQLTVEKT 120
>NP_612422
          Length = 327

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   QVTVELTV 9
           Q TVE+TV
Sbjct: 116 QATVEMTV 123
>NP_112506
          Length = 510

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HQVTVELTV 9
          H VT+ LTV
Sbjct: 67 HTVTIWLTV 75
>NP_006453
          Length = 468

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HQVTVELTV 9
          H VT+ LTV
Sbjct: 25 HTVTIWLTV 33
>NP_002010
          Length = 1338

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +T+ LT+
Sbjct: 615 HSITLNLTI 623
>NP_001153392
          Length = 687

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +T+ LT+
Sbjct: 615 HSITLNLTI 623
>NP_001153502
          Length = 733

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +T+ LT+
Sbjct: 615 HSITLNLTI 623
>NP_835226
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           HQ  ++LTV
Sbjct: 273 HQADIKLTV 281
>NP_659429
          Length = 1294

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           ++TVELTV
Sbjct: 210 KLTVELTV 217
>NP_001268379
          Length = 486

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           HQ  ++LTV
Sbjct: 272 HQADIKLTV 280
>NP_001268380
          Length = 487

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           HQ  ++LTV
Sbjct: 273 HQADIKLTV 281
>XP_005260706
          Length = 321

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HQVTVELTV 9
          H VT+ LTV
Sbjct: 84 HTVTIWLTV 92
>XP_005260703
          Length = 461

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HQVTVELTV 9
          H VT+ LTV
Sbjct: 84 HTVTIWLTV 92
>XP_005260702
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HQVTVELTV 9
          H VT+ LTV
Sbjct: 84 HTVTIWLTV 92
>XP_006712420
          Length = 1162

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  QVTVELTV 9
          ++TVELTV
Sbjct: 60 KLTVELTV 67
>XP_006712419
          Length = 1308

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           ++TVELTV
Sbjct: 210 KLTVELTV 217
>XP_005263954
          Length = 1312

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           ++TVELTV
Sbjct: 210 KLTVELTV 217
>NP_001027466
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HQVTVELT 8
           HQ  +ELT
Sbjct: 443 HQTVLELT 450
>NP_000053
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HQVTVELT 8
           HQ  +ELT
Sbjct: 443 HQTVLELT 450
>NP_001186738
          Length = 913

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +TVE +V
Sbjct: 853 HNITVESSV 861
>NP_001186740
          Length = 948

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +TVE +V
Sbjct: 888 HNITVESSV 896
>NP_056249
          Length = 962

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +TVE +V
Sbjct: 902 HNITVESSV 910
>NP_001186741
          Length = 942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HQVTVELTV 9
           H +TVE +V
Sbjct: 882 HNITVESSV 890
>NP_055426
          Length = 5596

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HQVTVE 6
            H+VTVE
Sbjct: 1929 HEVTVE 1934
>NP_945345
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   VTVELTV 9
           VTVE+TV
Sbjct: 622 VTVEVTV 628
>NP_005388
          Length = 526

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HQVTVELT 8
           H VT +LT
Sbjct: 164 HSVTTDLT 171
>NP_001018121
          Length = 558

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HQVTVELT 8
           H VT +LT
Sbjct: 164 HSVTTDLT 171
>NP_003418
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVTV+
Sbjct: 45 HQVTVQ 50
>NP_060063
          Length = 662

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVT+E
Sbjct: 49 HQVTLE 54
>NP_942595
          Length = 1161

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVT+E
Sbjct: 49 HQVTLE 54
>XP_006726599
          Length = 949

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QVTVELTV 9
           Q TV+LT+
Sbjct: 481 QTTVQLTI 488
>XP_006719013
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QVTVELTV 9
           Q TV+LT+
Sbjct: 426 QTTVQLTI 433
>XP_005249698
          Length = 1044

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   QVTVELTV 9
           +VT+E+TV
Sbjct: 625 RVTIEVTV 632
>XP_006715468
          Length = 3744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          H+VTVE
Sbjct: 77 HEVTVE 82
>XP_005248756
          Length = 3905

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HQVTVE 6
           H+VTVE
Sbjct: 238 HEVTVE 243
>XP_006715467
          Length = 5550

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HQVTVE 6
            H+VTVE
Sbjct: 1929 HEVTVE 1934
>XP_005249427
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVTV+
Sbjct: 45 HQVTVQ 50
>XP_005249426
          Length = 515

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVTV+
Sbjct: 45 HQVTVQ 50
>XP_005249421
          Length = 570

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVTV+
Sbjct: 45 HQVTVQ 50
>XP_005263174
          Length = 1124

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HQVTVE 6
          HQVT+E
Sbjct: 49 HQVTLE 54
>XP_001715329
          Length = 894

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   QVTVELTV 9
           Q TV+LT+
Sbjct: 426 QTTVQLTI 433
>NP_001129396
          Length = 1590

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2    QVTVELTV 9
            +VT+E+TV
Sbjct: 1171 RVTIEVTV 1178
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.318    0.126    0.327 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 378,615
Number of extensions: 737
Number of successful extensions: 51
Number of sequences better than 10000.0: 51
Number of HSP's gapped: 51
Number of HSP's successfully gapped: 51
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.8 bits)
S2: 28 (15.4 bits)

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