Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_068838                                                              17    3301
NP_001138882                                                           17    3301
NP_001138880                                                           17    3301
XP_005262246                                                           17    3301
XP_005262245                                                           17    3301
XP_005262244                                                           17    3301
XP_006724750                                                           17    3301
XP_005262243                                                           17    3301
NP_031389                                                              17    3301
NP_001138881                                                           17    3301
NP_057646                                                              17    4312
NP_002717                                                              17    4312
NP_056505                                                              17    4312
NP_060385                                                              17    4312
NP_444251                                                              17    4312
NP_001230242                                                           17    4312
NP_001183980                                                           17    4312
XP_006719533                                                           17    4312
XP_005267101                                                           17    4312
XP_006712484                                                           17    4312
XP_006712483                                                           17    4312
XP_005246521                                                           17    4312
NP_009224                                                              16    5631
NP_001239133                                                           16    5631
NP_001002029                                                           16    5631
NP_490595                                                              16    5631
NP_001229752                                                           16    5631
XP_006721082                                                           16    5631
XP_005263887                                                           16    5631
NP_001232                                                              16    5631
NP_694940                                                              16    5631
NP_660213                                                              16    7355
NP_116162                                                              16    7355
NP_060487                                                              16    7355
NP_001073918                                                           16    7355
XP_005276388                                                           16    7355
XP_005269994                                                           16    7355
XP_006717743                                                           16    7355
XP_006713856                                                           16    7355
XP_005269424                                                           16    7355
XP_006713855                                                           16    7355
XP_005269422                                                           16    7355
XP_006713854                                                           16    7355
XP_005269420                                                           16    7355
XP_005269419                                                           16    7355
NP_036485                                                              16    7355
NP_001265853                                                           15    9605
NP_113584                                                              15    9605
NP_065145                                                              15    9605
NP_001121646                                                           15    9605
NP_002310                                                              15    9605
NP_001276863                                                           15    9605
XP_005262029                                                           15    9605
XP_005262028                                                           15    9605
XP_005262026                                                           15    9605
XP_006724637                                                           15    9605
XP_005262025                                                           15    9605
XP_005262024                                                           15    9605
XP_005262023                                                           15    9605
XP_005262022                                                           15    9605
XP_005250404                                                           15    9605
XP_005250403                                                           15    9605
XP_006714366                                                           15    9605
XP_006714365                                                           15    9605
NP_003351                                                              15    9605
NP_000929                                                              15    9605
>NP_068838
          Length = 761

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 408 HLMRKKYQC 416
>NP_001138882
          Length = 382

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  IRVKFAC 9
          +RV+FAC
Sbjct: 50 LRVRFAC 56
>NP_001138880
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IRVKFAC 9
           +RV+FAC
Sbjct: 139 LRVRFAC 145
>XP_005262246
          Length = 761

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 408 HLMRKKYQC 416
>XP_005262245
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 454 HLMRKKYQC 462
>XP_005262244
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 454 HLMRKKYQC 462
>XP_006724750
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 454 HLMRKKYQC 462
>XP_005262243
          Length = 807

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL+R K+ C
Sbjct: 454 HLMRKKYQC 462
>NP_031389
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IRVKFAC 9
           +RV+FAC
Sbjct: 139 LRVRFAC 145
>NP_001138881
          Length = 471

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IRVKFAC 9
           +RV+FAC
Sbjct: 139 LRVRFAC 145
>NP_057646
          Length = 1049

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 6/9 (66%)

Query: 1  HLIRVKFAC 9
          HL+ + F C
Sbjct: 90 HLVEIDFRC 98
>NP_002717
          Length = 710

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L RVKF+C
Sbjct: 168 LERVKFSC 175
>NP_056505
          Length = 1315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HLIRVKFAC 9
           HL++V ++C
Sbjct: 713 HLLKVLYSC 721
>NP_060385
          Length = 579

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR +FAC
Sbjct: 426 LIRSQFAC 433
>NP_444251
          Length = 570

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL++ K+ C
Sbjct: 336 HLLKKKYVC 344
>NP_001230242
          Length = 1294

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HLIRVKFAC 9
           HL++V ++C
Sbjct: 713 HLLKVLYSC 721
>NP_001183980
          Length = 569

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           HL++ K+ C
Sbjct: 335 HLLKKKYVC 343
>XP_006719533
          Length = 522

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR +FAC
Sbjct: 369 LIRSQFAC 376
>XP_005267101
          Length = 449

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L RVKF+C
Sbjct: 168 LERVKFSC 175
>XP_006712484
          Length = 851

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HLIRVKFAC 9
           HL++V ++C
Sbjct: 713 HLLKVLYSC 721
>XP_006712483
          Length = 1306

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HLIRVKFAC 9
           HL++V ++C
Sbjct: 704 HLLKVLYSC 712
>XP_005246521
          Length = 1315

 Score = 16.5 bits (31), Expect =  4312
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1   HLIRVKFAC 9
           HL++V ++C
Sbjct: 713 HLLKVLYSC 721
>NP_009224
          Length = 1744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RVKFAC 9
            R+KFAC
Sbjct: 1613 RMKFAC 1618
>NP_001239133
          Length = 1698

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RVKFAC 9
            R+KFAC
Sbjct: 1567 RMKFAC 1572
>NP_001002029
          Length = 1744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RVKFAC 9
            R+KFAC
Sbjct: 1613 RMKFAC 1618
>NP_490595
          Length = 730

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           H+I+V  AC
Sbjct: 102 HVIKVAHAC 110
>NP_001229752
          Length = 1744

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4    RVKFAC 9
            R+KFAC
Sbjct: 1613 RMKFAC 1618
>XP_006721082
          Length = 287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  HLIRVKFAC 9
          H++R+K +C
Sbjct: 10 HIVRLKPSC 18
>XP_005263887
          Length = 709

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           H+I+V  AC
Sbjct: 102 HVIKVAHAC 110
>NP_001232
          Length = 663

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HLIRVKFAC 9
           H+I+V  AC
Sbjct: 102 HVIKVAHAC 110
>NP_694940
          Length = 287

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  HLIRVKFAC 9
          H++R+K +C
Sbjct: 10 HIVRLKPSC 18
>NP_660213
          Length = 161

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HLIRVK 6
           HLIR+K
Sbjct: 115 HLIRIK 120
>NP_116162
          Length = 712

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>NP_060487
          Length = 898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   HLIRVKFA 8
           H+I+VK+A
Sbjct: 388 HVIKVKWA 395
>NP_001073918
          Length = 1060

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ +AC
Sbjct: 661 LVRILYAC 668
>XP_005276388
          Length = 215

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 7/9 (77%)

Query: 1  HLIRVKFAC 9
          H+++V + C
Sbjct: 29 HIVQVSYIC 37
>XP_005269994
          Length = 898

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   HLIRVKFA 8
           H+I+VK+A
Sbjct: 388 HVIKVKWA 395
>XP_006717743
          Length = 1090

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ +AC
Sbjct: 691 LVRILYAC 698
>XP_006713856
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_005269424
          Length = 743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_006713855
          Length = 753

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_005269422
          Length = 767

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_006713854
          Length = 777

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_005269420
          Length = 779

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>XP_005269419
          Length = 803

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           LIR+ F+C
Sbjct: 220 LIRLDFSC 227
>NP_036485
          Length = 314

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HLIRVKFAC 9
          HL+ V F C
Sbjct: 25 HLLSVLFLC 33
>NP_001265853
          Length = 276

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HLIRVK 6
           HL+RVK
Sbjct: 193 HLLRVK 198
>NP_113584
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>NP_065145
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  HLIRVKFA 8
          HL  +KFA
Sbjct: 7  HLFNLKFA 14
>NP_001121646
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HLIRVKFA 8
           HL+ VK+A
Sbjct: 149 HLLGVKYA 156
>NP_002310
          Length = 683

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ F+C
Sbjct: 206 LVRLDFSC 213
>NP_001276863
          Length = 652

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ F+C
Sbjct: 206 LVRLDFSC 213
>XP_005262029
          Length = 4240

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005262028
          Length = 4341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005262026
          Length = 4359

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_006724637
          Length = 4365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1142 HLMLQKFLC 1150
>XP_005262025
          Length = 4373

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005262024
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005262023
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005262022
          Length = 4374

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    HLIRVKFAC 9
            HL+  KF C
Sbjct: 1151 HLMLQKFLC 1159
>XP_005250404
          Length = 621

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ F+C
Sbjct: 206 LVRLDFSC 213
>XP_005250403
          Length = 644

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   LIRVKFAC 9
           L+R+ F+C
Sbjct: 206 LVRLDFSC 213
>XP_006714366
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HLIRVKFA 8
           HL+ VK+A
Sbjct: 149 HLLGVKYA 156
>XP_006714365
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HLIRVKFA 8
           HL+ VK+A
Sbjct: 149 HLLGVKYA 156
>NP_003351
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HLIRVKFA 8
           HL+ VK+A
Sbjct: 149 HLLGVKYA 156
>NP_000929
          Length = 1174

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2    LIRVKFAC 9
            L+R+ +AC
Sbjct: 1148 LVRMPYAC 1155
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.352    0.152    0.550 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 460,508
Number of extensions: 1014
Number of successful extensions: 66
Number of sequences better than 10000.0: 66
Number of HSP's gapped: 66
Number of HSP's successfully gapped: 66
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 14 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (17.0 bits)
S2: 28 (15.4 bits)

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