Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              20     509
XP_005262424                                                           20     509
NP_006464                                                              18    1482
XP_005273771                                                           18    1482
NP_787069                                                              17    4312
NP_001263223                                                           17    4312
NP_001263222                                                           17    4312
NP_009115                                                              17    4312
NP_001875                                                              17    4312
NP_001258218                                                           16    5631
NP_001258217                                                           16    5631
NP_001258216                                                           16    5631
NP_001258247                                                           16    5631
NP_115810                                                              16    5631
NP_001258215                                                           16    5631
NP_006288                                                              16    5631
NP_776165                                                              16    5631
XP_006713311                                                           16    5631
XP_006713310                                                           16    5631
XP_005264819                                                           16    5631
XP_006713309                                                           16    5631
XP_005270397                                                           16    5631
NP_060763                                                              16    5631
NP_001155899                                                           16    7355
NP_000359                                                              16    7355
NP_001155898                                                           16    7355
NP_000143                                                              16    7355
NP_001073271                                                           16    7355
NP_001073272                                                           16    7355
NP_003941                                                              16    7355
NP_001230814                                                           16    7355
NP_001230806                                                           16    7355
NP_005740                                                              16    7355
NP_065873                                                              16    7355
NP_001258932                                                           16    7355
XP_005257251                                                           16    7355
XP_005257250                                                           16    7355
XP_006717335                                                           16    7355
XP_006717334                                                           16    7355
XP_005272268                                                           16    7355
XP_006717257                                                           16    7355
XP_006717256                                                           16    7355
XP_006710473                                                           16    7355
XP_006710472                                                           16    7355
XP_006710471                                                           16    7355
XP_006710470                                                           16    7355
XP_006710469                                                           16    7355
NP_001180264                                                           16    7355
NP_001400                                                              16    7355
NP_060150                                                              16    7355
NP_110418                                                              15    9605
NP_001157849                                                           15    9605
NP_689824                                                              15    9605
XP_006721347                                                           15    9605
XP_006716433                                                           15    9605
XP_005273633                                                           15    9605
XP_006716432                                                           15    9605
XP_005273632                                                           15    9605
XP_005244867                                                           15    9605
XP_006711056                                                           15    9605
NP_112561                                                              15    9605
NP_004239                                                              15    9605
NP_076983                                                              15    9605
NP_008914                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  KLYGLILM 9
          KLYGLILM
Sbjct: 9  KLYGLILM 16
>XP_005262424
          Length = 2875

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2  KLYGLILM 9
          KLYGLILM
Sbjct: 9  KLYGLILM 16
>NP_006464
          Length = 622

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKLYGLILM 9
           HK+YG IL+
Sbjct: 356 HKVYGAILV 364
>XP_005273771
          Length = 613

 Score = 18.1 bits (35), Expect =  1482
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKLYGLILM 9
           HK+YG IL+
Sbjct: 347 HKVYGAILV 355
>NP_787069
          Length = 549

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   HKLYGLIL 8
           H+L+GL+L
Sbjct: 325 HQLHGLLL 332
>NP_001263223
          Length = 515

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           HKLY L+
Sbjct: 374 HKLYSLV 380
>NP_001263222
          Length = 583

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           HKLY L+
Sbjct: 374 HKLYSLV 380
>NP_009115
          Length = 1504

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           HKLY L+
Sbjct: 374 HKLYSLV 380
>NP_001875
          Length = 354

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           HKLYG+
Sbjct: 342 HKLYGV 347
>NP_001258218
          Length = 462

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  HKLYG 5
          HKLYG
Sbjct: 44 HKLYG 48
>NP_001258217
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  HKLYG 5
          HKLYG
Sbjct: 44 HKLYG 48
>NP_001258216
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  HKLYG 5
          HKLYG
Sbjct: 44 HKLYG 48
>NP_001258247
          Length = 490

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1  HKLYG 5
          HKLYG
Sbjct: 44 HKLYG 48
>NP_115810
          Length = 567

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HKLYG 5
           HKLYG
Sbjct: 121 HKLYG 125
>NP_001258215
          Length = 538

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/5 (100%), Positives = 5/5 (100%)

Query: 1   HKLYG 5
           HKLYG
Sbjct: 120 HKLYG 124
>NP_006288
          Length = 633

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HKLYGLI 7
           H+LYG++
Sbjct: 624 HQLYGVV 630
>NP_776165
          Length = 226

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   YGLILM 9
           YGLILM
Sbjct: 154 YGLILM 159
>XP_006713311
          Length = 939

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H  YGLIL
Sbjct: 824 HTSYGLIL 831
>XP_006713310
          Length = 1038

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H  YGLIL
Sbjct: 923 HTSYGLIL 930
>XP_005264819
          Length = 1128

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HKLYGLIL 8
            H  YGLIL
Sbjct: 1036 HTSYGLIL 1043
>XP_006713309
          Length = 1151

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HKLYGLIL 8
            H  YGLIL
Sbjct: 1036 HTSYGLIL 1043
>XP_005270397
          Length = 193

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HKLYGLI 7
           HK++G+I
Sbjct: 171 HKIFGMI 177
>NP_060763
          Length = 581

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H  YGLIL
Sbjct: 489 HTSYGLIL 496
>NP_001155899
          Length = 1113

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 138 HRLYGM 143
>NP_000359
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 189 HRLYGM 194
>NP_001155898
          Length = 1163

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 189 HRLYGM 194
>NP_000143
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 572 HNLYGL 577
>NP_001073271
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 572 HNLYGL 577
>NP_001073272
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 572 HNLYGL 577
>NP_003941
          Length = 385

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3  LYGLILM 9
          LYGL+L+
Sbjct: 83 LYGLVLV 89
>NP_001230814
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  HKLYGL 6
          H LYGL
Sbjct: 88 HSLYGL 93
>NP_001230806
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 227 HSLYGL 232
>NP_005740
          Length = 345

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 227 HSLYGL 232
>NP_065873
          Length = 1235

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HKLYGLILM 9
           HK YG+ L+
Sbjct: 588 HKKYGVCLI 596
>NP_001258932
          Length = 1211

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HKLYGLILM 9
           HK YG+ L+
Sbjct: 543 HKKYGVCLI 551
>XP_005257251
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 572 HNLYGL 577
>XP_005257250
          Length = 952

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 572 HNLYGL 577
>XP_006717335
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 189 HRLYGM 194
>XP_006717334
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 189 HRLYGM 194
>XP_005272268
          Length = 1164

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1   HKLYGL 6
           H+LYG+
Sbjct: 189 HRLYGM 194
>XP_006717257
          Length = 1083

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HKLYGLILM 9
           HK YG+ L+
Sbjct: 415 HKKYGVCLI 423
>XP_006717256
          Length = 1172

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HKLYGLILM 9
           HK YG+ L+
Sbjct: 504 HKKYGVCLI 512
>XP_006710473
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 515 HRLYGACL 522
>XP_006710472
          Length = 1305

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 515 HRLYGACL 522
>XP_006710471
          Length = 1392

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 515 HRLYGACL 522
>XP_006710470
          Length = 1393

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 515 HRLYGACL 522
>XP_006710469
          Length = 1436

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 515 HRLYGACL 522
>NP_001180264
          Length = 242

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LYGLIL 8
           LYGLIL
Sbjct: 127 LYGLIL 132
>NP_001400
          Length = 1541

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HKLYGLIL 8
           H+LYG  L
Sbjct: 620 HRLYGACL 627
>NP_060150
          Length = 379

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 3   LYGLIL 8
           LYGLIL
Sbjct: 127 LYGLIL 132
>NP_110418
          Length = 441

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LYGLILM 9
           +YGLIL+
Sbjct: 232 IYGLILI 238
>NP_001157849
          Length = 289

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2   KLYGLIL 8
           +LYG++L
Sbjct: 195 RLYGIVL 201
>NP_689824
          Length = 740

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HKLYGL 6
           H LYGL
Sbjct: 636 HPLYGL 641
>XP_006721347
          Length = 519

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   HKLYGLIL 8
           H++ GL+L
Sbjct: 153 HRIVGLVL 160
>XP_006716433
          Length = 3069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1    HKLYG 5
            HK+YG
Sbjct: 1218 HKIYG 1222
>XP_005273633
          Length = 3069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1    HKLYG 5
            HK+YG
Sbjct: 1218 HKIYG 1222
>XP_006716432
          Length = 3172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1    HKLYG 5
            HK+YG
Sbjct: 1321 HKIYG 1325
>XP_005273632
          Length = 3172

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1    HKLYG 5
            HK+YG
Sbjct: 1321 HKIYG 1325
>XP_005244867
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           H+LYG +
Sbjct: 250 HRLYGCL 256
>XP_006711056
          Length = 389

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           H+LYG +
Sbjct: 250 HRLYGCL 256
>NP_112561
          Length = 2789

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/5 (80%), Positives = 5/5 (100%)

Query: 1   HKLYG 5
           HK+YG
Sbjct: 938 HKIYG 942
>NP_004239
          Length = 370

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HKLYGLILM 9
          H+L GLI++
Sbjct: 57 HQLKGLIVL 65
>NP_076983
          Length = 516

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2   KLYGLI 7
           KLYGL+
Sbjct: 329 KLYGLL 334
>NP_008914
          Length = 390

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HKLYGLI 7
           H+LYG +
Sbjct: 250 HRLYGCL 256
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.159    0.490 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 549,079
Number of extensions: 949
Number of successful extensions: 64
Number of sequences better than 10000.0: 64
Number of HSP's gapped: 64
Number of HSP's successfully gapped: 64
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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