Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_443179                                                              20     509
XP_005266703                                                           20     509
NP_003156                                                              18    1135
NP_001027392                                                           18    1135
NP_001182156                                                           18    1482
NP_060106                                                              18    1482
XP_005259075                                                           18    1482
XP_005259074                                                           18    1482
XP_006723312                                                           18    1482
NP_001343                                                              17    3301
NP_851322                                                              16    5631
NP_065816                                                              16    7355
NP_998763                                                              16    7355
NP_001078823                                                           16    7355
NP_055778                                                              16    7355
NP_001093592                                                           16    7355
NP_078933                                                              16    7355
XP_006724755                                                           16    7355
XP_005262247                                                           16    7355
XP_005259577                                                           16    7355
XP_005259576                                                           16    7355
XP_006715622                                                           16    7355
XP_005267190                                                           16    7355
XP_005267189                                                           16    7355
XP_005267187                                                           16    7355
XP_005267185                                                           16    7355
XP_005267184                                                           16    7355
XP_006710573                                                           16    7355
XP_006710572                                                           16    7355
XP_006710571                                                           16    7355
XP_006710570                                                           16    7355
XP_006710569                                                           16    7355
XP_006710568                                                           16    7355
XP_006710567                                                           16    7355
XP_006710566                                                           16    7355
XP_005245859                                                           16    7355
NP_940686                                                              16    7355
NP_009055                                                              16    7355
NP_000242                                                              15    9605
NP_006531                                                              15    9605
NP_689703                                                              15    9605
NP_006337                                                              15    9605
NP_001073351                                                           15    9605
NP_001073350                                                           15    9605
NP_001073349                                                           15    9605
NP_057541                                                              15    9605
XP_005258773                                                           15    9605
XP_006719819                                                           15    9605
XP_005251190                                                           15    9605
XP_005251188                                                           15    9605
XP_005251189                                                           15    9605
XP_005251187                                                           15    9605
XP_005251186                                                           15    9605
XP_005251185                                                           15    9605
XP_005264389                                                           15    9605
XP_006711812                                                           15    9605
>NP_443179
          Length = 2170

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           HKENA LAQ
Sbjct: 698 HKENASLAQ 706
>XP_005266703
          Length = 1501

 Score = 19.6 bits (39), Expect =   509
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1  HKENALLAQ 9
          HKENA LAQ
Sbjct: 29 HKENASLAQ 37
>NP_003156
          Length = 603

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   HKENALLAQ 9
           +K+NALLAQ
Sbjct: 195 YKDNALLAQ 203
>NP_001027392
          Length = 594

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 9/9 (100%)

Query: 1   HKENALLAQ 9
           +K+NALLAQ
Sbjct: 195 YKDNALLAQ 203
>NP_001182156
          Length = 1069

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           HKEN LLA+
Sbjct: 983 HKENFLLAR 991
>NP_060106
          Length = 1214

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HKEN LLA+
Sbjct: 1128 HKENFLLAR 1136
>XP_005259075
          Length = 678

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           HKEN LLA+
Sbjct: 592 HKENFLLAR 600
>XP_005259074
          Length = 785

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           HKEN LLA+
Sbjct: 699 HKENFLLAR 707
>XP_006723312
          Length = 1129

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HKEN LLA+
Sbjct: 1043 HKENFLLAR 1051
>NP_001343
          Length = 325

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   KENALLAQ 9
           KENALL Q
Sbjct: 292 KENALLRQ 299
>NP_851322
          Length = 724

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   HKENALL 7
           HKENA++
Sbjct: 702 HKENAVV 708
>NP_065816
          Length = 5183

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2542 HKDQALLSK 2550
>NP_998763
          Length = 600

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KENALLAQ 9
           K+NALL Q
Sbjct: 209 KKNALLVQ 216
>NP_001078823
          Length = 900

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           ++EN LLAQ
Sbjct: 198 NRENDLLAQ 206
>NP_055778
          Length = 1366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HKENAL 6
           HK+NAL
Sbjct: 978 HKQNAL 983
>NP_001093592
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HKENAL 6
           HK+NAL
Sbjct: 921 HKQNAL 926
>NP_078933
          Length = 937

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           ++EN LLAQ
Sbjct: 198 NRENDLLAQ 206
>XP_006724755
          Length = 532

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           ++EN LLAQ
Sbjct: 198 NRENDLLAQ 206
>XP_005262247
          Length = 845

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           ++EN LLAQ
Sbjct: 106 NRENDLLAQ 114
>XP_005259577
          Length = 1366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HKENAL 6
           HK+NAL
Sbjct: 978 HKQNAL 983
>XP_005259576
          Length = 1366

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HKENAL 6
           HK+NAL
Sbjct: 978 HKQNAL 983
>XP_006715622
          Length = 2499

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 1540 HRENAL 1545
>XP_005267190
          Length = 3424

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2465 HRENAL 2470
>XP_005267189
          Length = 3425

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2479 HRENAL 2484
>XP_005267187
          Length = 3433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2474 HRENAL 2479
>XP_005267185
          Length = 3437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2478 HRENAL 2483
>XP_005267184
          Length = 3438

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2479 HRENAL 2484
>XP_006710573
          Length = 5177

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2543 HKDQALLSK 2551
>XP_006710572
          Length = 5188

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>XP_006710571
          Length = 5194

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>XP_006710570
          Length = 5195

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>XP_006710569
          Length = 5212

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2543 HKDQALLSK 2551
>XP_006710568
          Length = 5221

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>XP_006710567
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>XP_006710566
          Length = 5222

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2553 HKDQALLSK 2561
>XP_005245859
          Length = 5223

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HKENALLAQ 9
            HK+ ALL++
Sbjct: 2554 HKDQALLSK 2562
>NP_940686
          Length = 259

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   KENALLAQ 9
           +EN LLAQ
Sbjct: 105 RENQLLAQ 112
>NP_009055
          Length = 3433

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HKENAL 6
            H+ENAL
Sbjct: 2474 HRENAL 2479
>NP_000242
          Length = 934

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  HKENALLA 8
          H E+ALLA
Sbjct: 46 HGEDALLA 53
>NP_006531
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>NP_689703
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           H+E+ALL +
Sbjct: 304 HEEDALLKE 312
>NP_006337
          Length = 757

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HKENALL 7
           H EN+LL
Sbjct: 699 HSENSLL 705
>NP_001073351
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKENALLA 8
           H ENAL A
Sbjct: 197 HSENALHA 204
>NP_001073350
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKENALLA 8
           H ENAL A
Sbjct: 354 HSENALHA 361
>NP_001073349
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKENALLA 8
           H ENAL A
Sbjct: 354 HSENALHA 361
>NP_057541
          Length = 878

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKENALLA 8
           H ENAL A
Sbjct: 354 HSENALHA 361
>XP_005258773
          Length = 721

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HKENALLA 8
           H ENAL A
Sbjct: 197 HSENALHA 204
>XP_006719819
          Length = 332

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HKENALL 7
           H EN+LL
Sbjct: 274 HSENSLL 280
>XP_005251190
          Length = 1395

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005251188
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005251189
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005251187
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005251186
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005251185
          Length = 1464

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   KENALL 7
           KENALL
Sbjct: 740 KENALL 745
>XP_005264389
          Length = 921

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  HKENALLA 8
          H E+ALLA
Sbjct: 46 HGEDALLA 53
>XP_006711812
          Length = 586

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HKENALLAQ 9
           H+E+ALL +
Sbjct: 304 HEEDALLKE 312
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.309    0.119    0.310 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 473,244
Number of extensions: 704
Number of successful extensions: 56
Number of sequences better than 10000.0: 56
Number of HSP's gapped: 56
Number of HSP's successfully gapped: 56
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.5 bits)
S2: 28 (15.4 bits)

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