Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001268421                                                           19     869
NP_000170                                                              19     869
NP_001268422                                                           19     869
NP_001268423                                                           19     869
XP_005264328                                                           19     869
NP_689540                                                              17    2528
XP_006720086                                                           17    2528
XP_006720085                                                           17    2528
XP_006720084                                                           17    2528
NP_059127                                                              17    3301
NP_001025162                                                           17    3301
NP_073571                                                              17    3301
NP_758952                                                              17    3301
NP_001020368                                                           17    3301
XP_006720300                                                           17    3301
XP_006720299                                                           17    3301
XP_006720298                                                           17    3301
NP_003991                                                              17    3301
NP_001020370                                                           17    3301
NP_000383                                                              17    4312
NP_036558                                                              17    4312
XP_006717694                                                           17    4312
XP_006717693                                                           17    4312
NP_002363                                                              16    5631
NP_001032203                                                           16    5631
NP_068579                                                              16    5631
XP_006726589                                                           16    5631
XP_005254968                                                           16    5631
XP_005254967                                                           16    5631
XP_006720570                                                           16    5631
XP_006718462                                                           16    5631
XP_005250580                                                           16    5631
XP_006714679                                                           16    5631
XP_006710010                                                           16    5631
NP_006113                                                              16    5631
NP_002431                                                              16    7355
NP_001273760                                                           16    7355
NP_001273759                                                           16    7355
NP_001259                                                              16    7355
NP_001138505                                                           16    7355
XP_005266301                                                           16    7355
XP_005266299                                                           16    7355
XP_006719822                                                           16    7355
XP_006719821                                                           16    7355
NP_001275500                                                           15    9605
NP_001159530                                                           15    9605
NP_057097                                                              15    9605
NP_057540                                                              15    9605
NP_001275499                                                           15    9605
NP_001275497                                                           15    9605
NP_001275496                                                           15    9605
NP_001275495                                                           15    9605
NP_001275494                                                           15    9605
NP_001275493                                                           15    9605
NP_001001998                                                           15    9605
NP_892014                                                              15    9605
NP_570718                                                              15    9605
NP_001275498                                                           15    9605
NP_001257310                                                           15    9605
XP_006720621                                                           15    9605
XP_006720620                                                           15    9605
XP_006720619                                                           15    9605
XP_006720618                                                           15    9605
XP_006718498                                                           15    9605
XP_005273831                                                           15    9605
XP_005273830                                                           15    9605
XP_005273828                                                           15    9605
XP_005273827                                                           15    9605
XP_005273826                                                           15    9605
XP_005273824                                                           15    9605
XP_005273823                                                           15    9605
XP_005273822                                                           15    9605
XP_005263532                                                           15    9605
NP_002676                                                              15    9605
>NP_001268421
          Length = 1230

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HFLVLVDEL 9
            H LVLVDEL
Sbjct: 1077 HSLVLVDEL 1085
>NP_000170
          Length = 1360

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HFLVLVDEL 9
            H LVLVDEL
Sbjct: 1207 HSLVLVDEL 1215
>NP_001268422
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HFLVLVDEL 9
           H LVLVDEL
Sbjct: 905 HSLVLVDEL 913
>NP_001268423
          Length = 1058

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HFLVLVDEL 9
           H LVLVDEL
Sbjct: 905 HSLVLVDEL 913
>XP_005264328
          Length = 1261

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HFLVLVDEL 9
            H LVLVDEL
Sbjct: 1108 HSLVLVDEL 1116
>NP_689540
          Length = 723

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HFLVLVDE 8
           H+LV VDE
Sbjct: 273 HYLVAVDE 280
>XP_006720086
          Length = 703

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HFLVLVDE 8
           H+LV VDE
Sbjct: 246 HYLVAVDE 253
>XP_006720085
          Length = 704

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HFLVLVDE 8
           H+LV VDE
Sbjct: 273 HYLVAVDE 280
>XP_006720084
          Length = 730

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   HFLVLVDE 8
           H+LV VDE
Sbjct: 273 HYLVAVDE 280
>NP_059127
          Length = 489

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 1   HFLVLVDE 8
           H LVLVDE
Sbjct: 453 HRLVLVDE 460
>NP_001025162
          Length = 478

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLVLVD 7
           HFLVLV+
Sbjct: 290 HFLVLVE 296
>NP_073571
          Length = 456

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLVLVD 7
           HFLVLV+
Sbjct: 290 HFLVLVE 296
>NP_758952
          Length = 1137

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLVLVDEL 9
           HF +LV+EL
Sbjct: 357 HFKLLVEEL 365
>NP_001020368
          Length = 380

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF VL+ EL
Sbjct: 144 HFTVLIHEL 152
>XP_006720300
          Length = 320

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLVLVD 7
           HFLVLV+
Sbjct: 132 HFLVLVE 138
>XP_006720299
          Length = 320

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLVLVD 7
           HFLVLV+
Sbjct: 132 HFLVLVE 138
>XP_006720298
          Length = 447

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLVLVD 7
           HFLVLV+
Sbjct: 290 HFLVLVE 296
>NP_003991
          Length = 390

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF VL+ EL
Sbjct: 154 HFTVLIHEL 162
>NP_001020370
          Length = 311

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HFLVLVDEL 9
          HF VL+ EL
Sbjct: 75 HFTVLIHEL 83
>NP_000383
          Length = 1545

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HFL  VDE+
Sbjct: 823 HFLPQVDEI 831
>NP_036558
          Length = 1217

 Score = 16.5 bits (31), Expect =  4312
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   LVLVDEL 9
           LVLVDEL
Sbjct: 395 LVLVDEL 401
>XP_006717694
          Length = 895

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HFL  VDE+
Sbjct: 823 HFLPQVDEI 831
>XP_006717693
          Length = 1313

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HFL  VDE+
Sbjct: 591 HFLPQVDEI 599
>NP_002363
          Length = 1144

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>NP_001032203
          Length = 473

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVLVDEL 9
           LVL+DEL
Sbjct: 190 LVLIDEL 196
>NP_068579
          Length = 974

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVLVDEL 9
           LVL+DEL
Sbjct: 190 LVLIDEL 196
>XP_006726589
          Length = 931

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLVLVD 7
           HF VLVD
Sbjct: 244 HFRVLVD 250
>XP_005254968
          Length = 1156

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>XP_005254967
          Length = 1175

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>XP_006720570
          Length = 1181

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>XP_006718462
          Length = 4966

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1    HFLVLVD 7
            HF VLVD
Sbjct: 4269 HFRVLVD 4275
>XP_005250580
          Length = 485

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   LVLVDEL 9
           LVL+DEL
Sbjct: 190 LVLIDEL 196
>XP_006714679
          Length = 662

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>XP_006710010
          Length = 1103

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLVLVD 7
           HF VLVD
Sbjct: 465 HFRVLVD 471
>NP_006113
          Length = 1150

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           H+  L+D+L
Sbjct: 259 HYFALIDQL 267
>NP_002431
          Length = 936

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LVLVDEL 9
           L+L+DEL
Sbjct: 755 LILIDEL 761
>NP_001273760
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 244 HTLVLTDE 251
>NP_001273759
          Length = 556

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 273 HTLVLTDE 280
>NP_001259
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 268 HTLVLTDE 275
>NP_001138505
          Length = 122

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  HFLVLVDE 8
          HF+ L DE
Sbjct: 21 HFVCLADE 28
>XP_005266301
          Length = 527

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 244 HTLVLTDE 251
>XP_005266299
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 268 HTLVLTDE 275
>XP_006719822
          Length = 551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 268 HTLVLTDE 275
>XP_006719821
          Length = 561

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           H LVL DE
Sbjct: 278 HTLVLTDE 285
>NP_001275500
          Length = 208

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 133 FLMLVDPL 140
>NP_001159530
          Length = 730

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  HFLVLVD 7
          HF+VL++
Sbjct: 23 HFIVLIN 29
>NP_057097
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF +L DE+
Sbjct: 93  HFRLLKDEI 101
>NP_057540
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001275499
          Length = 186

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 111 FLMLVDPL 118
>NP_001275497
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001275496
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001275495
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001275494
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001275493
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001001998
          Length = 885

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF+  +DEL
Sbjct: 289 HFISSLDEL 297
>NP_892014
          Length = 792

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 773 HFLEFMDE 780
>NP_570718
          Length = 754

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  HFLVLVD 7
          HF+VL++
Sbjct: 23 HFIVLIN 29
>NP_001275498
          Length = 183

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   FLVLVDEL 9
           FL+LVD L
Sbjct: 108 FLMLVDPL 115
>NP_001257310
          Length = 517

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 498 HFLEFMDE 505
>XP_006720621
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF +L DE+
Sbjct: 93  HFRLLKDEI 101
>XP_006720620
          Length = 261

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF +L DE+
Sbjct: 93  HFRLLKDEI 101
>XP_006720619
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF +L DE+
Sbjct: 93  HFRLLKDEI 101
>XP_006720618
          Length = 327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF +L DE+
Sbjct: 93  HFRLLKDEI 101
>XP_006718498
          Length = 388

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 369 HFLEFMDE 376
>XP_005273831
          Length = 415

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 396 HFLEFMDE 403
>XP_005273830
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 540 HFLEFMDE 547
>XP_005273828
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 540 HFLEFMDE 547
>XP_005273827
          Length = 559

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 540 HFLEFMDE 547
>XP_005273826
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 669 HFLEFMDE 676
>XP_005273824
          Length = 713

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 694 HFLEFMDE 701
>XP_005273823
          Length = 758

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 739 HFLEFMDE 746
>XP_005273822
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HFLVLVDE 8
           HFL  +DE
Sbjct: 781 HFLEFMDE 788
>XP_005263532
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF+  +DEL
Sbjct: 313 HFISSLDEL 321
>NP_002676
          Length = 860

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLVLVDEL 9
           HF+  +DEL
Sbjct: 289 HFISSLDEL 297
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.340    0.159    0.465 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 522,699
Number of extensions: 960
Number of successful extensions: 74
Number of sequences better than 10000.0: 74
Number of HSP's gapped: 74
Number of HSP's successfully gapped: 74
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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