Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              19     665
NP_061836                                                              19     869
NP_387505                                                              19     869
XP_005261051                                                           19     869
NP_001135780                                                           18    1482
NP_079408                                                              18    1935
XP_006714089                                                           18    1935
XP_006714088                                                           18    1935
XP_005262715                                                           18    1935
NP_690605                                                              17    2528
NP_068769                                                              17    2528
NP_001009894                                                           17    4312
NP_060109                                                              16    7355
NP_001136089                                                           16    7355
NP_001185970                                                           16    7355
NP_001185971                                                           16    7355
NP_001185969                                                           16    7355
NP_001136091                                                           16    7355
NP_695014                                                              16    7355
NP_001276091                                                           16    7355
NP_001034656                                                           16    7355
XP_006721364                                                           16    7355
NP_001136090                                                           16    7355
NP_071764                                                              16    7355
NP_001276092                                                           16    7355
NP_115645                                                              16    7355
NP_001158234                                                           15    9605
NP_036597                                                              15    9605
NP_001070993                                                           15    9605
NP_848018                                                              15    9605
NP_001258604                                                           15    9605
NP_001158233                                                           15    9605
NP_787036                                                              15    9605
NP_787034                                                              15    9605
NP_787033                                                              15    9605
NP_001123562                                                           15    9605
NP_055642                                                              15    9605
NP_112584                                                              15    9605
NP_001257620                                                           15    9605
NP_002726                                                              15    9605
NP_001158230                                                           15    9605
NP_001158232                                                           15    9605
NP_001158231                                                           15    9605
NP_071930                                                              15    9605
XP_006723641                                                           15    9605
XP_006721648                                                           15    9605
XP_006721646                                                           15    9605
XP_005252581                                                           15    9605
XP_005252580                                                           15    9605
XP_005252577                                                           15    9605
XP_005252575                                                           15    9605
XP_005252574                                                           15    9605
XP_006717531                                                           15    9605
XP_005252563                                                           15    9605
XP_005252562                                                           15    9605
XP_006717530                                                           15    9605
XP_005252561                                                           15    9605
XP_005252559                                                           15    9605
XP_006717529                                                           15    9605
XP_005252558                                                           15    9605
XP_005252557                                                           15    9605
XP_005249866                                                           15    9605
XP_005265457                                                           15    9605
XP_006711736                                                           15    9605
XP_005245701                                                           15    9605
XP_005245700                                                           15    9605
NP_001070994                                                           15    9605
NP_777568                                                              15    9605
>NP_722576
          Length = 3080

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           HFLK ESSE
Sbjct: 162 HFLKNESSE 170
>NP_061836
          Length = 2320

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    FLKIESSE 9
            FLKIESSE
Sbjct: 1750 FLKIESSE 1757
>NP_387505
          Length = 2269

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    FLKIESSE 9
            FLKIESSE
Sbjct: 1750 FLKIESSE 1757
>XP_005261051
          Length = 2242

 Score = 18.9 bits (37), Expect =   869
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2    FLKIESSE 9
            FLKIESSE
Sbjct: 1672 FLKIESSE 1679
>NP_001135780
          Length = 2156

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           H+L IESSE
Sbjct: 910 HYLYIESSE 918
>NP_079408
          Length = 1342

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    HFLKIESSE 9
            HFLK  SSE
Sbjct: 1042 HFLKCPSSE 1050
>XP_006714089
          Length = 1281

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    HFLKIESSE 9
            HFLK  SSE
Sbjct: 1042 HFLKCPSSE 1050
>XP_006714088
          Length = 1283

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           HFLK  SSE
Sbjct: 983 HFLKCPSSE 991
>XP_005262715
          Length = 1320

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1    HFLKIESSE 9
            HFLK  SSE
Sbjct: 1020 HFLKCPSSE 1028
>NP_690605
          Length = 297

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLKIES 7
           HFLK+ES
Sbjct: 145 HFLKMES 151
>NP_068769
          Length = 297

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HFLKIES 7
           HFLK+ES
Sbjct: 145 HFLKMES 151
>NP_001009894
          Length = 325

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           HFLKI++ +
Sbjct: 306 HFLKIDNQK 314
>NP_060109
          Length = 2916

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HFLKIESSE 9
           HF K+E  E
Sbjct: 265 HFKKVERDE 273
>NP_001136089
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 568 NFLKIEVSQ 576
>NP_001185970
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 583 NFLKIEVSQ 591
>NP_001185971
          Length = 706

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 607 NFLKIEVSQ 615
>NP_001185969
          Length = 704

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 605 NFLKIEVSQ 613
>NP_001136091
          Length = 658

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 559 NFLKIEVSQ 567
>NP_695014
          Length = 405

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           HFL +ES +
Sbjct: 296 HFLPLESCQ 304
>NP_001276091
          Length = 874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLKIES 7
           HFL IES
Sbjct: 334 HFLGIES 340
>NP_001034656
          Length = 263

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1  HFLKIE 6
          HFLKI+
Sbjct: 68 HFLKID 73
>XP_006721364
          Length = 831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLKIES 7
           HFL IES
Sbjct: 334 HFLGIES 340
>NP_001136090
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 568 NFLKIEVSQ 576
>NP_071764
          Length = 667

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLKIE S+
Sbjct: 568 NFLKIEVSQ 576
>NP_001276092
          Length = 809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLKIES 7
           HFL IES
Sbjct: 269 HFLGIES 275
>NP_115645
          Length = 874

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HFLKIES 7
           HFL IES
Sbjct: 334 HFLGIES 340
>NP_001158234
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_036597
          Length = 1015

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           +FLK+E+ E
Sbjct: 277 NFLKMEAGE 285
>NP_001070993
          Length = 650

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FLKIESSE 9
          FL+ ESSE
Sbjct: 91 FLEYESSE 98
>NP_848018
          Length = 482

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLKIESS 8
           HF K ESS
Sbjct: 467 HFSKSESS 474
>NP_001258604
          Length = 805

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKIESSE 9
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_001158233
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_787036
          Length = 532

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLKIESSE 9
           +LK+ES E
Sbjct: 201 YLKVESCE 208
>NP_787034
          Length = 502

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLKIESSE 9
           +LK+ES E
Sbjct: 201 YLKVESCE 208
>NP_787033
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLKIESSE 9
           +LK+ES E
Sbjct: 201 YLKVESCE 208
>NP_001123562
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           H LKI++ E
Sbjct: 461 HLLKIDNRE 469
>NP_055642
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKIESSE 9
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_112584
          Length = 523

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           H LKI++ E
Sbjct: 461 HLLKIDNRE 469
>NP_001257620
          Length = 585

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLKIESSE 9
           +LK+ES E
Sbjct: 201 YLKVESCE 208
>NP_002726
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_001158230
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_001158232
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_001158231
          Length = 381

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>NP_071930
          Length = 538

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FLKIESSE 9
          FL+ ESSE
Sbjct: 91 FLEYESSE 98
>XP_006723641
          Length = 555

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   FLKIESSE 9
           +LK+ES E
Sbjct: 201 YLKVESCE 208
>XP_006721648
          Length = 446

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           H LKI++ E
Sbjct: 384 HLLKIDNRE 392
>XP_006721646
          Length = 542

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HFLKIESSE 9
           H LKI++ E
Sbjct: 480 HLLKIDNRE 488
>XP_005252581
          Length = 1175

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252580
          Length = 1241

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252577
          Length = 1371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252575
          Length = 1411

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252574
          Length = 1449

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_006717531
          Length = 1902

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HFLKIESSE 9
          + +KIESS+
Sbjct: 56 YLMKIESSQ 64
>XP_005252563
          Length = 1930

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252562
          Length = 1935

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_006717530
          Length = 1942

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252561
          Length = 1947

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252559
          Length = 1970

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_006717529
          Length = 1971

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252558
          Length = 1981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005252557
          Length = 1982

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HFLKIESSE 9
           + +KIESS+
Sbjct: 136 YLMKIESSQ 144
>XP_005249866
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HFLKIESSE 9
          HF K+E  E
Sbjct: 53 HFEKLEKEE 61
>XP_005265457
          Length = 625

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FLKIESSE 9
          FL+ ESSE
Sbjct: 91 FLEYESSE 98
>XP_006711736
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKIESSE 9
           +K+ESSE
Sbjct: 139 MKVESSE 145
>XP_005245701
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKIESSE 9
           +K+ESSE
Sbjct: 139 MKVESSE 145
>XP_005245700
          Length = 810

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   LKIESSE 9
           +K+ESSE
Sbjct: 139 MKVESSE 145
>NP_001070994
          Length = 598

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  FLKIESSE 9
          FL+ ESSE
Sbjct: 91 FLEYESSE 98
>NP_777568
          Length = 306

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HFLKIESS 8
           HF K ESS
Sbjct: 291 HFSKSESS 298
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.128    0.333 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 369,451
Number of extensions: 393
Number of successful extensions: 68
Number of sequences better than 10000.0: 68
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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