Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_064450                                                              22     134
XP_005273257                                                           22     134
NP_000421                                                              17    3301
NP_001172005                                                           17    3301
NP_001172010                                                           17    3301
NP_001172004                                                           17    3301
NP_002015                                                              17    3301
NP_001172011                                                           17    3301
NP_775102                                                              17    3301
NP_001177171                                                           17    3301
NP_001177170                                                           17    3301
NP_065851                                                              17    3301
XP_005257137                                                           17    3301
XP_005257136                                                           17    3301
XP_005257135                                                           17    3301
NP_056070                                                              17    4312
XP_005249023                                                           17    4312
XP_005249022                                                           17    4312
NP_004535                                                              16    5631
NP_689835                                                              16    5631
XP_005248505                                                           16    5631
XP_006712934                                                           16    5631
XP_006712933                                                           16    5631
XP_005247063                                                           16    5631
XP_006712606                                                           16    5631
NP_852118                                                              16    5631
NP_000375                                                              16    7355
NP_001138732                                                           16    7355
NP_005428                                                              16    7355
NP_001138735                                                           16    7355
NP_001138733                                                           16    7355
NP_001138734                                                           16    7355
NP_690856                                                              16    7355
NP_001180550                                                           16    7355
NP_055690                                                              16    7355
NP_001180551                                                           16    7355
NP_075447                                                              16    7355
NP_060212                                                              16    7355
XP_006723569                                                           16    7355
XP_005259486                                                           16    7355
XP_005258988                                                           16    7355
XP_006722557                                                           16    7355
XP_006722556                                                           16    7355
XP_005273605                                                           16    7355
NP_001073926                                                           16    7355
NP_061985                                                              15    9605
NP_001850                                                              15    9605
NP_001181966                                                           15    9605
NP_001071174                                                           15    9605
NP_689594                                                              15    9605
NP_006827                                                              15    9605
XP_006722681                                                           15    9605
XP_006722680                                                           15    9605
XP_006722679                                                           15    9605
XP_006715535                                                           15    9605
XP_006712319                                                           15    9605
NP_001186073                                                           15    9605
NP_001139669                                                           15    9605
>NP_064450
          Length = 1722

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEHSVTSAF 9
           HEHSV+SAF
Sbjct: 841 HEHSVSSAF 849
>XP_005273257
          Length = 1726

 Score = 21.6 bits (44), Expect =   134
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEHSVTSAF 9
           HEHSV+SAF
Sbjct: 845 HEHSVSSAF 853
>NP_000421
          Length = 410

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HEHSVTS 7
           HEH VTS
Sbjct: 379 HEHFVTS 385
>NP_001172005
          Length = 611

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEHSVTSAF 9
          HE S+T AF
Sbjct: 24 HEDSITVAF 32
>NP_001172010
          Length = 516

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEHSVTSAF 9
          HE S+T AF
Sbjct: 24 HEDSITVAF 32
>NP_001172004
          Length = 537

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEHSVTSAF 9
          HE S+T AF
Sbjct: 24 HEDSITVAF 32
>NP_002015
          Length = 632

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEHSVTSAF 9
          HE S+T AF
Sbjct: 24 HEDSITVAF 32
>NP_001172011
          Length = 586

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEHSVTSAF 9
          HE S+T AF
Sbjct: 24 HEDSITVAF 32
>NP_775102
          Length = 613

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HEHSVTSA 8
           H+H +TSA
Sbjct: 402 HDHVITSA 409
>NP_001177171
          Length = 640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  HEHSVTS 7
          HEH +TS
Sbjct: 91 HEHPITS 97
>NP_001177170
          Length = 640

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  HEHSVTS 7
          HEH +TS
Sbjct: 91 HEHPITS 97
>NP_065851
          Length = 777

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HEHSVTS 7
           HEH +TS
Sbjct: 228 HEHPITS 234
>XP_005257137
          Length = 614

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HEHSVTSA 8
           H+H +TSA
Sbjct: 403 HDHVITSA 410
>XP_005257136
          Length = 615

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HEHSVTSA 8
           H+H +TSA
Sbjct: 404 HDHVITSA 411
>XP_005257135
          Length = 616

 Score = 16.9 bits (32), Expect =  3301
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   HEHSVTSA 8
           H+H +TSA
Sbjct: 405 HDHVITSA 412
>NP_056070
          Length = 1755

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HEHSVT 6
            H+HSVT
Sbjct: 1729 HQHSVT 1734
>XP_005249023
          Length = 1052

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HEHSVT 6
            H+HSVT
Sbjct: 1026 HQHSVT 1031
>XP_005249022
          Length = 1755

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1    HEHSVT 6
            H+HSVT
Sbjct: 1729 HQHSVT 1734
>NP_004535
          Length = 355

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           HE  +TSA+
Sbjct: 225 HEMKITSAY 233
>NP_689835
          Length = 549

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HEHSVTSA 8
           H H +TSA
Sbjct: 507 HTHHITSA 514
>XP_005248505
          Length = 550

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HEHSVTSA 8
           H H +TSA
Sbjct: 508 HTHHITSA 515
>XP_006712934
          Length = 1583

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HEHSVTSA 8
            HEH  TSA
Sbjct: 1177 HEHLKTSA 1184
>XP_006712933
          Length = 1687

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HEHSVTSA 8
            HEH  TSA
Sbjct: 1281 HEHLKTSA 1288
>XP_005247063
          Length = 361

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           HE  +TSA+
Sbjct: 225 HEMKITSAY 233
>XP_006712606
          Length = 375

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           HE  +TSA+
Sbjct: 225 HEMKITSAY 233
>NP_852118
          Length = 1684

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1    HEHSVTSA 8
            HEH  TSA
Sbjct: 1278 HEHLKTSA 1285
>NP_000375
          Length = 4563

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HEHSVTS 7
            H HS+T+
Sbjct: 3182 HRHSITN 3188
>NP_001138732
          Length = 650

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           + HS TS+F
Sbjct: 289 NSHSTTSSF 297
>NP_005428
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           + HS TS+F
Sbjct: 273 NSHSTTSSF 281
>NP_001138735
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           + HS TS+F
Sbjct: 273 NSHSTTSSF 281
>NP_001138733
          Length = 630

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           + HS TS+F
Sbjct: 289 NSHSTTSSF 297
>NP_001138734
          Length = 614

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   HEHSVTSAF 9
           + HS TS+F
Sbjct: 273 NSHSTTSSF 281
>NP_690856
          Length = 802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HEHSVTSA 8
           H HSVT A
Sbjct: 147 HIHSVTRA 154
>NP_001180550
          Length = 228

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   EHSVTSAF 9
           +H VTS+F
Sbjct: 117 DHMVTSSF 124
>NP_055690
          Length = 1648

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HEHSVTS 7
           H+H +TS
Sbjct: 591 HDHRITS 597
>NP_001180551
          Length = 116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EHSVTSAF 9
          +H VTS+F
Sbjct: 5  DHMVTSSF 12
>NP_075447
          Length = 1437

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HEHSVTSAF 9
            HE+SVT+ +
Sbjct: 1192 HENSVTNFY 1200
>NP_060212
          Length = 1178

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EHSVTSA 8
           EH VTSA
Sbjct: 554 EHCVTSA 560
>XP_006723569
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HEHSVTSAF 9
           H H V +AF
Sbjct: 662 HHHYVAAAF 670
>XP_005259486
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HEHSVTSAF 9
           H H V +AF
Sbjct: 662 HHHYVAAAF 670
>XP_005258988
          Length = 116

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2  EHSVTSAF 9
          +H VTS+F
Sbjct: 5  DHMVTSSF 12
>XP_006722557
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EHSVTSA 8
           EH VTSA
Sbjct: 452 EHCVTSA 458
>XP_006722556
          Length = 1100

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   EHSVTSA 8
           EH VTSA
Sbjct: 476 EHCVTSA 482
>XP_005273605
          Length = 1388

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1    HEHSVTSAF 9
            HE+SVT+ +
Sbjct: 1143 HENSVTNFY 1151
>NP_001073926
          Length = 713

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HEHSVTSAF 9
           H H V +AF
Sbjct: 662 HHHYVAAAF 670
>NP_061985
          Length = 2146

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HEHSVTS 7
            H HS+T+
Sbjct: 1506 HAHSITT 1512
>NP_001850
          Length = 190

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  HEHSVTSA 8
          H H  TSA
Sbjct: 22 HHHPTTSA 29
>NP_001181966
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HEHSVT 6
           +EHSVT
Sbjct: 316 YEHSVT 321
>NP_001071174
          Length = 904

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HEHSVT 6
           +EHSVT
Sbjct: 316 YEHSVT 321
>NP_689594
          Length = 3549

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EHSVTSA 8
           +HSVTS+
Sbjct: 430 DHSVTSS 436
>NP_006827
          Length = 2671

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HEHSVTS 7
           H H++TS
Sbjct: 955 HTHTITS 961
>XP_006722681
          Length = 1365

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   HEHSVTS 7
           H HS+T+
Sbjct: 725 HAHSITT 731
>XP_006722680
          Length = 1636

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HEHSVTS 7
            H HS+T+
Sbjct: 1506 HAHSITT 1512
>XP_006722679
          Length = 2128

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1    HEHSVTS 7
            H HS+T+
Sbjct: 1506 HAHSITT 1512
>XP_006715535
          Length = 946

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HEHSVT 6
           +EHSVT
Sbjct: 316 YEHSVT 321
>XP_006712319
          Length = 3308

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EHSVTSA 8
           +HSVTS+
Sbjct: 189 DHSVTSS 195
>NP_001186073
          Length = 3327

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   EHSVTSA 8
           +HSVTS+
Sbjct: 208 DHSVTSS 214
>NP_001139669
          Length = 7081

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1    HEHSVTS 7
            HE S+TS
Sbjct: 1796 HEDSITS 1802
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.315    0.115    0.338 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 530,441
Number of extensions: 537
Number of successful extensions: 58
Number of sequences better than 10000.0: 58
Number of HSP's gapped: 58
Number of HSP's successfully gapped: 58
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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