Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_006715                                                              21     229
NP_005913                                                              21     229
XP_005267046                                                           21     229
XP_005267045                                                           21     229
NP_998765                                                              17    2528
XP_005254329                                                           17    2528
NP_055490                                                              17    3301
XP_006724409                                                           17    3301
XP_005261851                                                           17    3301
XP_005261850                                                           17    3301
XP_006711121                                                           17    3301
XP_006711120                                                           17    3301
XP_006711119                                                           17    3301
NP_001138678                                                           17    3301
NP_056195                                                              17    4312
NP_620158                                                              17    4312
NP_001264242                                                           17    4312
XP_006726232                                                           17    4312
XP_006726230                                                           17    4312
XP_006726308                                                           17    4312
XP_006726307                                                           17    4312
XP_006726306                                                           17    4312
XP_006726303                                                           17    4312
XP_006726301                                                           17    4312
XP_006726300                                                           17    4312
XP_006712361                                                           17    4312
XP_005246377                                                           17    4312
XP_006712360                                                           17    4312
XP_006712359                                                           17    4312
XP_005246376                                                           17    4312
NP_112241                                                              16    5631
NP_958815                                                              16    7355
NP_004949                                                              16    7355
NP_004512                                                              16    7355
NP_005947                                                              16    7355
NP_001010903                                                           16    7355
NP_001185734                                                           16    7355
NP_001185736                                                           16    7355
NP_001185735                                                           16    7355
NP_443070                                                              16    7355
NP_542386                                                              16    7355
NP_001185741                                                           16    7355
XP_005255486                                                           16    7355
XP_005255485                                                           16    7355
XP_005255484                                                           16    7355
XP_006720966                                                           16    7355
XP_005263496                                                           16    7355
XP_005263495                                                           16    7355
NP_001138362                                                           16    7355
NP_001229285                                                           15    9605
NP_001229286                                                           15    9605
NP_004820                                                              15    9605
NP_001138929                                                           15    9605
NP_001138930                                                           15    9605
NP_060623                                                              15    9605
NP_115584                                                              15    9605
NP_444262                                                              15    9605
NP_006286                                                              15    9605
NP_005698                                                              15    9605
NP_775899                                                              15    9605
XP_005275347                                                           15    9605
XP_005275078                                                           15    9605
XP_005272926                                                           15    9605
XP_005274943                                                           15    9605
XP_005248773                                                           15    9605
XP_005249419                                                           15    9605
NP_940970                                                              15    9605
>NP_006715
          Length = 1558

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEARERASR 9
           HEARERAS+
Sbjct: 806 HEARERASK 814
>NP_005913
          Length = 1608

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEARERASR 9
           HEARERAS+
Sbjct: 806 HEARERASK 814
>XP_005267046
          Length = 1554

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEARERASR 9
           HEARERAS+
Sbjct: 806 HEARERASK 814
>XP_005267045
          Length = 1604

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   HEARERASR 9
           HEARERAS+
Sbjct: 806 HEARERASK 814
>NP_998765
          Length = 849

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HEARERA 7
           H+ARERA
Sbjct: 841 HQARERA 847
>XP_005254329
          Length = 481

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   HEARERA 7
           H+ARERA
Sbjct: 473 HQARERA 479
>NP_055490
          Length = 2017

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EARERASR 9
            EARERA R
Sbjct: 1973 EARERAHR 1980
>XP_006724409
          Length = 1806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    HEARER 6
            HEARER
Sbjct: 1426 HEARER 1431
>XP_005261851
          Length = 1806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    HEARER 6
            HEARER
Sbjct: 1426 HEARER 1431
>XP_005261850
          Length = 1806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    HEARER 6
            HEARER
Sbjct: 1426 HEARER 1431
>XP_006711121
          Length = 1945

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EARERASR 9
            EARERA R
Sbjct: 1901 EARERAHR 1908
>XP_006711120
          Length = 1972

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EARERASR 9
            EARERA R
Sbjct: 1935 EARERAHR 1942
>XP_006711119
          Length = 1979

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2    EARERASR 9
            EARERA R
Sbjct: 1935 EARERAHR 1942
>NP_001138678
          Length = 1806

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1    HEARER 6
            HEARER
Sbjct: 1426 HEARER 1431
>NP_056195
          Length = 469

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  HEARERASR 9
          HEARE+  R
Sbjct: 84 HEAREKLLR 92
>NP_620158
          Length = 591

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 481 HEDKERARR 489
>NP_001264242
          Length = 1419

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   HEARERASR 9
           HE RE+++R
Sbjct: 665 HEEREKSNR 673
>XP_006726232
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726230
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726308
          Length = 415

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726307
          Length = 479

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726306
          Length = 518

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726303
          Length = 550

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726301
          Length = 637

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006726300
          Length = 638

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  HEARERASR 9
          HE ++RAS+
Sbjct: 5  HEKKDRASK 13
>XP_006712361
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 335 HEDKERARR 343
>XP_005246377
          Length = 445

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 335 HEDKERARR 343
>XP_006712360
          Length = 505

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 395 HEDKERARR 403
>XP_006712359
          Length = 577

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 467 HEDKERARR 475
>XP_005246376
          Length = 612

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           HE +ERA R
Sbjct: 502 HEDKERARR 510
>NP_112241
          Length = 631

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   HEARERA 7
           HEA ERA
Sbjct: 148 HEAAERA 154
>NP_958815
          Length = 371

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           +RERASR
Sbjct: 327 SRERASR 333
>NP_004949
          Length = 2549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    HEARERASR 9
            HE  E ASR
Sbjct: 2028 HEGLEEASR 2036
>NP_004512
          Length = 963

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EARERASR 9
           EA+E ASR
Sbjct: 883 EAKENASR 890
>NP_005947
          Length = 935

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   EARERAS 8
           EA+ERAS
Sbjct: 260 EAKERAS 266
>NP_001010903
          Length = 652

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   EARERASR 9
           E RE+ASR
Sbjct: 114 EPREKASR 121
>NP_001185734
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HEARERASR 9
          HE RE+  R
Sbjct: 87 HERREKVKR 95
>NP_001185736
          Length = 159

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HEARERASR 9
          HE RE+  R
Sbjct: 87 HERREKVKR 95
>NP_001185735
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HEARERASR 9
          HE RE+  R
Sbjct: 87 HERREKVKR 95
>NP_443070
          Length = 414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           AR+RASR
Sbjct: 349 ARDRASR 355
>NP_542386
          Length = 275

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HEARERASR 9
          HE RE+  R
Sbjct: 87 HERREKVKR 95
>NP_001185741
          Length = 454

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1  HEARERASR 9
          HE RE+  R
Sbjct: 87 HERREKVKR 95
>XP_005255486
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           +RERASR
Sbjct: 241 SRERASR 247
>XP_005255485
          Length = 285

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           +RERASR
Sbjct: 241 SRERASR 247
>XP_005255484
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           +RERASR
Sbjct: 274 SRERASR 280
>XP_006720966
          Length = 318

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   ARERASR 9
           +RERASR
Sbjct: 274 SRERASR 280
>XP_005263496
          Length = 2322

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    HEARERASR 9
            HE  E ASR
Sbjct: 1801 HEGLEEASR 1809
>XP_005263495
          Length = 2549

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    HEARERASR 9
            HE  E ASR
Sbjct: 2028 HEGLEEASR 2036
>NP_001138362
          Length = 618

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HEARERAS 8
           H AR RAS
Sbjct: 142 HRARARAS 149
>NP_001229285
          Length = 209

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RERASR 9
           RERASR
Sbjct: 189 RERASR 194
>NP_001229286
          Length = 192

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RERASR 9
           RERASR
Sbjct: 172 RERASR 177
>NP_004820
          Length = 304

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RERASR 9
           RERASR
Sbjct: 284 RERASR 289
>NP_001138929
          Length = 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RERASR 9
           RERASR
Sbjct: 283 RERASR 288
>NP_001138930
          Length = 287

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   RERASR 9
           RERASR
Sbjct: 267 RERASR 272
>NP_060623
          Length = 333

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HEARERAS 8
           HE  ERAS
Sbjct: 121 HEGFERAS 128
>NP_115584
          Length = 564

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HEARERAS 8
           HE  ERAS
Sbjct: 121 HEGFERAS 128
>NP_444262
          Length = 368

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HEARERAS 8
           HE  ERAS
Sbjct: 121 HEGFERAS 128
>NP_006286
          Length = 1264

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 762 EAREKAAK 769
>NP_005698
          Length = 485

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   HEARERASR 9
           +EA ERA R
Sbjct: 366 YEAEERALR 374
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    HEARERASR 9
            HE RER  R
Sbjct: 1212 HEFRERFRR 1220
>XP_005275347
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 763 EAREKAAK 770
>XP_005275078
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 763 EAREKAAK 770
>XP_005272926
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 763 EAREKAAK 770
>XP_005274943
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 763 EAREKAAK 770
>XP_005248773
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HEARERASR 9
           HE RE+  R
Sbjct: 98  HEGREKRHR 106
>XP_005249419
          Length = 1265

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   EARERASR 9
           EARE+A++
Sbjct: 763 EAREKAAK 770
>NP_940970
          Length = 223

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HEARERASR 9
           HE RE+  R
Sbjct: 98  HEGREKRHR 106
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.312    0.115    0.302 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 420,227
Number of extensions: 564
Number of successful extensions: 67
Number of sequences better than 10000.0: 67
Number of HSP's gapped: 67
Number of HSP's successfully gapped: 67
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.7 bits)
S2: 28 (15.4 bits)

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