Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000258                                                              21     175
NP_001035957                                                           21     175
XP_006721991                                                           21     175
XP_006721990                                                           21     175
XP_006721989                                                           21     175
XP_005258041                                                           21     175
XP_006721988                                                           21     175
XP_006721987                                                           21     175
XP_006721986                                                           21     175
XP_005258040                                                           21     175
XP_006721985                                                           21     175
NP_001244935                                                           17    2528
NP_057213                                                              17    2528
XP_006714215                                                           17    3301
XP_006714214                                                           17    3301
XP_005262915                                                           17    3301
NP_055806                                                              17    3301
NP_001274426                                                           17    4312
NP_071929                                                              17    4312
NP_998814                                                              17    4312
XP_005269584                                                           17    4312
XP_005269583                                                           17    4312
XP_006717688                                                           17    4312
XP_005269582                                                           17    4312
XP_005250584                                                           17    4312
NP_001444                                                              16    7355
NP_950252                                                              16    7355
NP_001124146                                                           16    7355
NP_001210                                                              16    7355
NP_001186602                                                           16    7355
NP_001186601                                                           16    7355
NP_001186600                                                           16    7355
NP_004668                                                              16    7355
XP_006716114                                                           16    7355
XP_005245180                                                           16    7355
XP_005245177                                                           16    7355
XP_005245176                                                           16    7355
XP_005245175                                                           16    7355
XP_005245174                                                           16    7355
NP_001008405                                                           16    7355
NP_001002906                                                           16    7355
NP_149080                                                              16    7355
NP_001558                                                              15    9605
NP_085139                                                              15    9605
XP_006725418                                                           15    9605
XP_006725417                                                           15    9605
XP_006725414                                                           15    9605
XP_005261298                                                           15    9605
XP_005261296                                                           15    9605
XP_005261295                                                           15    9605
XP_005257754                                                           15    9605
XP_005257753                                                           15    9605
XP_006722170                                                           15    9605
XP_006718600                                                           15    9605
XP_006718599                                                           15    9605
XP_006718598                                                           15    9605
XP_006718597                                                           15    9605
XP_005274036                                                           15    9605
XP_005274035                                                           15    9605
NP_036497                                                              15    9605
NP_001001659                                                           15    9605
>NP_000258
          Length = 2818

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1143 HCTVLAMS 1150
>NP_001035957
          Length = 2839

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1143 HCTVLAMS 1150
>XP_006721991
          Length = 1632

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>XP_006721990
          Length = 2823

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>XP_006721989
          Length = 2823

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>XP_005258041
          Length = 2836

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1143 HCTVLAMS 1150
>XP_006721988
          Length = 2846

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>XP_006721987
          Length = 2849

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>XP_006721986
          Length = 2854

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1140 HCTVLAMS 1147
>XP_005258040
          Length = 2857

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1143 HCTVLAMS 1150
>XP_006721985
          Length = 2867

 Score = 21.2 bits (43), Expect =   175
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    HCTVLAMS 8
            HCTVLAMS
Sbjct: 1153 HCTVLAMS 1160
>NP_001244935
          Length = 352

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HCTVLA 6
           HCT+LA
Sbjct: 231 HCTILA 236
>NP_057213
          Length = 406

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 1   HCTVLA 6
           HCT+LA
Sbjct: 231 HCTILA 236
>XP_006714215
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HCTVLAM 7
           HC+++AM
Sbjct: 495 HCSIIAM 501
>XP_006714214
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HCTVLAM 7
           HC+++AM
Sbjct: 495 HCSIIAM 501
>XP_005262915
          Length = 3544

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HCTVLAM 7
           HC+++AM
Sbjct: 495 HCSIIAM 501
>NP_055806
          Length = 3526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1   HCTVLAM 7
           HC+++AM
Sbjct: 477 HCSIIAM 483
>NP_001274426
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HCTVLAMSK 9
          HC  LAM++
Sbjct: 11 HCLYLAMTR 19
>NP_071929
          Length = 697

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HCTVLAMSK 9
          HC  LAM++
Sbjct: 11 HCLYLAMTR 19
>NP_998814
          Length = 337

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   CTVLAM 7
           CTVLAM
Sbjct: 291 CTVLAM 296
>XP_005269584
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   CTVLAM 7
           CTVLAM
Sbjct: 175 CTVLAM 180
>XP_005269583
          Length = 221

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   CTVLAM 7
           CTVLAM
Sbjct: 175 CTVLAM 180
>XP_006717688
          Length = 314

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   CTVLAM 7
           CTVLAM
Sbjct: 291 CTVLAM 296
>XP_005269582
          Length = 328

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   CTVLAM 7
           CTVLAM
Sbjct: 282 CTVLAM 287
>XP_005250584
          Length = 430

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  HCTVLAMSK 9
          HC  LAM++
Sbjct: 11 HCLYLAMTR 19
>NP_001444
          Length = 553

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1   HCTVLAMS 8
           HC + AMS
Sbjct: 394 HCNLQAMS 401
>NP_950252
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>NP_001124146
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTVLAMSK 9
          CT  A+SK
Sbjct: 13 CTAFALSK 20
>NP_001210
          Length = 315

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTVLAMSK 9
          CT  A+SK
Sbjct: 13 CTAFALSK 20
>NP_001186602
          Length = 224

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTVLAMSK 9
          CT  A+SK
Sbjct: 13 CTAFALSK 20
>NP_001186601
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTVLAMSK 9
          CT  A+SK
Sbjct: 21 CTAFALSK 28
>NP_001186600
          Length = 323

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2  CTVLAMSK 9
          CT  A+SK
Sbjct: 21 CTAFALSK 28
>NP_004668
          Length = 117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  HCTVLAM 7
          HC +LA+
Sbjct: 22 HCNILAI 28
>XP_006716114
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTVLAMSK 9
           C V+A+SK
Sbjct: 312 CIVMALSK 319
>XP_005245180
          Length = 395

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>XP_005245177
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>XP_005245176
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>XP_005245175
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>XP_005245174
          Length = 766

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  HCTVLAMS 8
          HC VLA++
Sbjct: 26 HCWVLAVA 33
>NP_001008405
          Length = 348

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   CTVLAMSK 9
           C V+A+SK
Sbjct: 312 CIVMALSK 319
>NP_001002906
          Length = 117

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  HCTVLAM 7
          HC +LA+
Sbjct: 22 HCNILAI 28
>NP_149080
          Length = 403

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   HCTVLAM 7
           HC VLA+
Sbjct: 276 HCDVLAV 282
>NP_001558
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1121 CSVLQMAK 1128
>NP_085139
          Length = 569

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HCTVLA 6
           HC VLA
Sbjct: 531 HCPVLA 536
>XP_006725418
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  HCTVLA 6
          HC VLA
Sbjct: 31 HCQVLA 36
>XP_006725417
          Length = 725

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  HCTVLA 6
          HC VLA
Sbjct: 31 HCQVLA 36
>XP_006725414
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HCTVLA 6
           HC VLA
Sbjct: 340 HCQVLA 345
>XP_005261298
          Length = 399

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTVLAMS 8
           CT+LA S
Sbjct: 383 CTILARS 389
>XP_005261296
          Length = 416

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTVLAMS 8
           CT+LA S
Sbjct: 400 CTILARS 406
>XP_005261295
          Length = 435

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   CTVLAMS 8
           CT+LA S
Sbjct: 419 CTILARS 425
>XP_005257754
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  HCTVLA 6
          HC VLA
Sbjct: 31 HCQVLA 36
>XP_005257753
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1  HCTVLA 6
          HC VLA
Sbjct: 31 HCQVLA 36
>XP_006722170
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 5/6 (83%)

Query: 1   HCTVLA 6
           HC VLA
Sbjct: 340 HCQVLA 345
>XP_006718600
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1022 CSVLQMAK 1029
>XP_006718599
          Length = 1159

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1022 CSVLQMAK 1029
>XP_006718598
          Length = 1206

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1143 CSVLQMAK 1150
>XP_006718597
          Length = 1258

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1121 CSVLQMAK 1128
>XP_005274036
          Length = 1280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1143 CSVLQMAK 1150
>XP_005274035
          Length = 1280

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CTVLAMSK 9
            C+VL M+K
Sbjct: 1143 CSVLQMAK 1150
>NP_036497
          Length = 311

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CTVLAMS 8
           CTVLA++
Sbjct: 141 CTVLAVT 147
>NP_001001659
          Length = 310

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   CTVLAMS 8
           CTVLA++
Sbjct: 140 CTVLAVA 146
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.331    0.123    0.399 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 386,974
Number of extensions: 383
Number of successful extensions: 61
Number of sequences better than 10000.0: 61
Number of HSP's gapped: 61
Number of HSP's successfully gapped: 61
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.4 bits)
S2: 28 (15.4 bits)

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