Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_071325                                                              18    1135
NP_998778                                                              18    1135
XP_006713920                                                           18    1135
XP_006713919                                                           18    1135
NP_001030022                                                           18    1935
NP_733751                                                              18    1935
NP_061873                                                              18    1935
XP_006716142                                                           18    1935
XP_005250088                                                           18    1935
XP_006716141                                                           18    1935
XP_005250085                                                           18    1935
XP_006716140                                                           18    1935
XP_005250084                                                           18    1935
XP_005250083                                                           18    1935
XP_005250082                                                           18    1935
XP_005248369                                                           18    1935
NP_000103                                                              17    3301
NP_149078                                                              17    3301
NP_001129586                                                           16    5631
NP_001129585                                                           16    5631
NP_001070833                                                           16    5631
NP_009102                                                              16    5631
NP_001070834                                                           16    5631
NP_612154                                                              16    5631
NP_060876                                                              16    5631
NP_004523                                                              16    5631
NP_001193555                                                           16    5631
XP_006716995                                                           16    5631
XP_005272216                                                           16    5631
XP_005272215                                                           16    5631
XP_005272213                                                           16    5631
NP_892006                                                              16    7355
NP_149062                                                              16    7355
XP_006715488                                                           16    7355
XP_006715487                                                           16    7355
XP_006715486                                                           16    7355
XP_006715485                                                           16    7355
XP_006715484                                                           16    7355
XP_006715483                                                           16    7355
XP_006715482                                                           16    7355
XP_006715481                                                           16    7355
XP_006715480                                                           16    7355
XP_006715479                                                           16    7355
XP_006715478                                                           16    7355
XP_006715477                                                           16    7355
XP_006715476                                                           16    7355
XP_006715475                                                           16    7355
XP_006715474                                                           16    7355
XP_006715473                                                           16    7355
XP_006715472                                                           16    7355
XP_006715471                                                           16    7355
XP_006715470                                                           16    7355
NP_004095                                                              15    9605
NP_612396                                                              15    9605
NP_006090                                                              15    9605
XP_006722242                                                           15    9605
XP_006713675                                                           15    9605
XP_005247475                                                           15    9605
XP_005247474                                                           15    9605
>NP_071325
          Length = 701

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HCIAESAAL 9
           HC A SAAL
Sbjct: 391 HCFATSAAL 399
>NP_998778
          Length = 701

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HCIAESAAL 9
           HC A SAAL
Sbjct: 391 HCFATSAAL 399
>XP_006713920
          Length = 701

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HCIAESAAL 9
           HC A SAAL
Sbjct: 391 HCFATSAAL 399
>XP_006713919
          Length = 701

 Score = 18.5 bits (36), Expect =  1135
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   HCIAESAAL 9
           HC A SAAL
Sbjct: 391 HCFATSAAL 399
>NP_001030022
          Length = 497

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1   HCIAES 6
           HCIAES
Sbjct: 169 HCIAES 174
>NP_733751
          Length = 4911

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4185 HGIAESAAL 4193
>NP_061873
          Length = 356

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  HCIAES 6
          HCIAES
Sbjct: 28 HCIAES 33
>XP_006716142
          Length = 4927

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4201 HGIAESAAL 4209
>XP_005250088
          Length = 4928

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4202 HGIAESAAL 4210
>XP_006716141
          Length = 4959

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4233 HGIAESAAL 4241
>XP_005250085
          Length = 4979

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4257 HGIAESAAL 4265
>XP_006716140
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4256 HGIAESAAL 4264
>XP_005250084
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4256 HGIAESAAL 4264
>XP_005250083
          Length = 4982

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4256 HGIAESAAL 4264
>XP_005250082
          Length = 4983

 Score = 17.7 bits (34), Expect =  1935
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    HCIAESAAL 9
            H IAESAAL
Sbjct: 4257 HGIAESAAL 4265
>XP_005248369
          Length = 375

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  HCIAES 6
          HCIAES
Sbjct: 47 HCIAES 52
>NP_000103
          Length = 739

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC   SAAL
Sbjct: 432 HCFTTSAAL 440
>NP_149078
          Length = 416

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC AES  L
Sbjct: 58 HCFAESREL 66
>NP_001129586
          Length = 608

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC A  AAL
Sbjct: 13 HCAAMGAAL 21
>NP_001129585
          Length = 725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC A  AAL
Sbjct: 130 HCAAMGAAL 138
>NP_001070833
          Length = 725

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC A  AAL
Sbjct: 130 HCAAMGAAL 138
>NP_009102
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC A  AAL
Sbjct: 130 HCAAMGAAL 138
>NP_001070834
          Length = 671

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC A  AAL
Sbjct: 76 HCAAMGAAL 84
>NP_612154
          Length = 1125

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC AES  L
Sbjct: 748 HCNAESQCL 756
>NP_060876
          Length = 5412

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1    HCIAESAAL 9
            HC AES  L
Sbjct: 5035 HCNAESQCL 5043
>NP_004523
          Length = 1176

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC AES  L
Sbjct: 799 HCNAESQCL 807
>NP_001193555
          Length = 452

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   HCIAESAA 8
           HC  ESAA
Sbjct: 126 HCPIESAA 133
>XP_006716995
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC A  AAL
Sbjct: 13 HCAAMGAAL 21
>XP_005272216
          Length = 630

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC A  AAL
Sbjct: 13 HCAAMGAAL 21
>XP_005272215
          Length = 693

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1  HCIAESAAL 9
          HC A  AAL
Sbjct: 76 HCAAMGAAL 84
>XP_005272213
          Length = 747

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC A  AAL
Sbjct: 130 HCAAMGAAL 138
>NP_892006
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1625 CVQEAAAL 1632
>NP_149062
          Length = 8749

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715488
          Length = 8721

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715487
          Length = 8744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715486
          Length = 8758

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715485
          Length = 8793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1579 CVQEAAAL 1586
>XP_006715484
          Length = 8794

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715483
          Length = 8795

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715482
          Length = 8797

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1625 CVQEAAAL 1632
>XP_006715481
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1585 CVQEAAAL 1592
>XP_006715480
          Length = 8799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715479
          Length = 8804

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715478
          Length = 8809

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715477
          Length = 8822

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1608 CVQEAAAL 1615
>XP_006715476
          Length = 8823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715475
          Length = 8827

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715474
          Length = 8829

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1615 CVQEAAAL 1622
>XP_006715473
          Length = 8832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715472
          Length = 8839

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1625 CVQEAAAL 1632
>XP_006715471
          Length = 8842

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>XP_006715470
          Length = 8846

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C+ E+AAL
Sbjct: 1632 CVQEAAAL 1639
>NP_004095
          Length = 2511

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    CIAESAAL 9
            C++E AAL
Sbjct: 1127 CLSERAAL 1134
>NP_612396
          Length = 346

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC+   AAL
Sbjct: 114 HCMITGAAL 122
>NP_006090
          Length = 628

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC   SAA+
Sbjct: 467 HCSVTSAAI 475
>XP_006722242
          Length = 195

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   HCIAESAAL 9
           HC+   AAL
Sbjct: 114 HCMITGAAL 122
>XP_006713675
          Length = 681

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2 CIAESA 7
         C+AESA
Sbjct: 3 CLAESA 8
>XP_005247475
          Length = 699

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2 CIAESA 7
         C+AESA
Sbjct: 3 CLAESA 8
>XP_005247474
          Length = 702

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2 CIAESA 7
         C+AESA
Sbjct: 3 CLAESA 8
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.325    0.123    0.380 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 398,319
Number of extensions: 481
Number of successful extensions: 59
Number of sequences better than 10000.0: 59
Number of HSP's gapped: 59
Number of HSP's successfully gapped: 59
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.1 bits)
S2: 28 (15.4 bits)

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