Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              19     665
NP_671714                                                              19     665
XP_006715890                                                           19     665
XP_005250160                                                           19     665
XP_005250159                                                           19     665
XP_005275817                                                           16    5631
NP_001035089                                                           16    7355
NP_001193937                                                           16    7355
NP_001919                                                              16    7355
NP_149977                                                              16    7355
XP_005262012                                                           16    7355
XP_006715557                                                           16    7355
XP_006715556                                                           16    7355
XP_006715555                                                           16    7355
XP_006715554                                                           16    7355
XP_006715553                                                           16    7355
XP_006715552                                                           16    7355
XP_005267054                                                           16    7355
XP_005267053                                                           16    7355
XP_006715551                                                           16    7355
XP_006715550                                                           16    7355
XP_006715549                                                           16    7355
XP_006715548                                                           16    7355
XP_006715547                                                           16    7355
XP_006715546                                                           16    7355
NP_612567                                                              15    9605
NP_003257                                                              15    9605
NP_612564                                                              15    9605
NP_079031                                                              15    9605
NP_001013865                                                           15    9605
NP_001005205                                                           15    9605
XP_005254726                                                           15    9605
XP_006720752                                                           15    9605
XP_006720751                                                           15    9605
XP_006720750                                                           15    9605
XP_006720749                                                           15    9605
XP_006720748                                                           15    9605
NP_001004064                                                           15    9605
>NP_005742
          Length = 3907

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    GVVTMTSR 8
            GVVTMTSR
Sbjct: 1022 GVVTMTSR 1029
>NP_671714
          Length = 3899

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    GVVTMTSR 8
            GVVTMTSR
Sbjct: 1022 GVVTMTSR 1029
>XP_006715890
          Length = 3860

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    GVVTMTSR 8
            GVVTMTSR
Sbjct: 1022 GVVTMTSR 1029
>XP_005250160
          Length = 3939

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    GVVTMTSR 8
            GVVTMTSR
Sbjct: 1022 GVVTMTSR 1029
>XP_005250159
          Length = 3952

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 1    GVVTMTSR 8
            GVVTMTSR
Sbjct: 1022 GVVTMTSR 1029
>XP_005275817
          Length = 254

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1  GVVTMTSRV 9
          GVV +TSR+
Sbjct: 49 GVVWVTSRI 57
>NP_001035089
          Length = 1651

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 457 GVVTVTPR 464
>NP_001193937
          Length = 1743

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 441 GVVTVTPR 448
>NP_001919
          Length = 253

 Score = 15.8 bits (29), Expect =  7355
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GVVTMTSRV 9
           GVVT  SRV
Sbjct: 220 GVVTSGSRV 228
>NP_149977
          Length = 707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVV +TSR
Sbjct: 183 GVVKLTSR 190
>XP_005262012
          Length = 682

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVV +TSR
Sbjct: 158 GVVKLTSR 165
>XP_006715557
          Length = 1744

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 441 GVVTVTPR 448
>XP_006715556
          Length = 1051

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_006715555
          Length = 1638

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_006715554
          Length = 1768

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_006715553
          Length = 1808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 441 GVVTVTPR 448
>XP_006715552
          Length = 1817

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 443 GVVTVTPR 450
>XP_005267054
          Length = 1823

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_005267053
          Length = 1824

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 457 GVVTVTPR 464
>XP_006715551
          Length = 1825

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_006715550
          Length = 1830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>XP_006715549
          Length = 1830

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 456 GVVTVTPR 463
>XP_006715548
          Length = 1831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 457 GVVTVTPR 464
>XP_006715547
          Length = 1831

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 457 GVVTVTPR 464
>XP_006715546
          Length = 1832

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVVTMTSR 8
           GVVT+T R
Sbjct: 458 GVVTVTPR 465
>NP_612567
          Length = 639

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           GV+TM+S
Sbjct: 210 GVITMSS 216
>NP_003257
          Length = 799

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           GV+TM+S
Sbjct: 370 GVITMSS 376
>NP_612564
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           GV+TM+S
Sbjct: 410 GVITMSS 416
>NP_079031
          Length = 1034

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 428 GIVTMSS 434
>NP_001013865
          Length = 1016

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 410 GIVTMSS 416
>NP_001005205
          Length = 316

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  GVVTMTS 7
          G++T+TS
Sbjct: 44 GIITLTS 50
>XP_005254726
          Length = 932

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 563 GIVTMSS 569
>XP_006720752
          Length = 981

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 375 GIVTMSS 381
>XP_006720751
          Length = 1068

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 462 GIVTMSS 468
>XP_006720750
          Length = 1069

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 463 GIVTMSS 469
>XP_006720749
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 481 GIVTMSS 487
>XP_006720748
          Length = 1150

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVVTMTS 7
           G+VTM+S
Sbjct: 544 GIVTMSS 550
>NP_001004064
          Length = 315

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 1  GVVTMTS 7
          G++T+TS
Sbjct: 44 GIITLTS 50
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.126    0.320 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 269,545
Number of extensions: 374
Number of successful extensions: 38
Number of sequences better than 10000.0: 38
Number of HSP's gapped: 38
Number of HSP's successfully gapped: 38
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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