Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_005742                                                              21     229
NP_671714                                                              21     229
XP_006715890                                                           21     229
XP_005250160                                                           21     229
XP_005250159                                                           21     229
NP_031382                                                              17    2528
XP_005250289                                                           17    2528
NP_055429                                                              17    3301
NP_004597                                                              17    4312
NP_001273003                                                           17    4312
NP_620278                                                              17    4312
XP_005262357                                                           17    4312
XP_006724744                                                           17    4312
XP_005262354                                                           17    4312
XP_006724743                                                           17    4312
XP_005262353                                                           17    4312
XP_005262352                                                           17    4312
NP_722516                                                              17    4312
NP_064630                                                              16    5631
XP_005267114                                                           16    5631
NP_001231892                                                           16    7355
NP_005800                                                              16    7355
NP_001104488                                                           16    7355
NP_001104489                                                           16    7355
NP_660093                                                              16    7355
NP_892009                                                              16    7355
XP_006718432                                                           16    7355
XP_005253271                                                           16    7355
XP_006718431                                                           16    7355
XP_006718430                                                           16    7355
XP_006718429                                                           16    7355
XP_006718428                                                           16    7355
XP_006718427                                                           16    7355
NP_002565                                                              15    9605
NP_001189360                                                           15    9605
NP_859048                                                              15    9605
NP_859047                                                              15    9605
NP_003646                                                              15    9605
NP_000833                                                              15    9605
NP_009017                                                              15    9605
NP_001137303                                                           15    9605
XP_006720075                                                           15    9605
XP_006718893                                                           15    9605
XP_006718892                                                           15    9605
XP_006718891                                                           15    9605
XP_005263256                                                           15    9605
NP_001103447                                                           15    9605
>NP_005742
          Length = 3907

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GVITQLTAN 9
           G+ITQLTAN
Sbjct: 205 GIITQLTAN 213
>NP_671714
          Length = 3899

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GVITQLTAN 9
           G+ITQLTAN
Sbjct: 205 GIITQLTAN 213
>XP_006715890
          Length = 3860

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GVITQLTAN 9
           G+ITQLTAN
Sbjct: 205 GIITQLTAN 213
>XP_005250160
          Length = 3939

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GVITQLTAN 9
           G+ITQLTAN
Sbjct: 205 GIITQLTAN 213
>XP_005250159
          Length = 3952

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1   GVITQLTAN 9
           G+ITQLTAN
Sbjct: 205 GIITQLTAN 213
>NP_031382
          Length = 1761

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    ITQLTAN 9
            ITQLTAN
Sbjct: 1590 ITQLTAN 1596
>XP_005250289
          Length = 1761

 Score = 17.3 bits (33), Expect =  2528
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3    ITQLTAN 9
            ITQLTAN
Sbjct: 1590 ITQLTAN 1596
>NP_055429
          Length = 1843

 Score = 16.9 bits (32), Expect =  3301
 Identities = 7/8 (87%), Positives = 7/8 (87%)

Query: 2   VITQLTAN 9
           VITQLT N
Sbjct: 653 VITQLTMN 660
>NP_004597
          Length = 1893

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>NP_001273003
          Length = 1895

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>NP_620278
          Length = 1872

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_005262357
          Length = 999

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_006724744
          Length = 1851

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_005262354
          Length = 1906

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_006724743
          Length = 1924

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_005262353
          Length = 1926

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>XP_005262352
          Length = 1927

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 77 LITELTAN 84
>NP_722516
          Length = 1826

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2  VITQLTAN 9
          +IT+LTAN
Sbjct: 76 LITELTAN 83
>NP_064630
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GVITQLTA 8
            GV+TQL A
Sbjct: 1021 GVVTQLPA 1028
>XP_005267114
          Length = 1543

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1    GVITQLTA 8
            GV+TQL A
Sbjct: 1021 GVVTQLPA 1028
>NP_001231892
          Length = 2488

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1712 TQLTAN 1717
>NP_005800
          Length = 198

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVITQLTAN 9
           GV+ Q+T N
Sbjct: 136 GVLRQITVN 144
>NP_001104488
          Length = 2365

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1592 TQLTAN 1597
>NP_001104489
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TQLTAN 9
           TQLTAN
Sbjct: 720 TQLTAN 725
>NP_660093
          Length = 2429

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1656 TQLTAN 1661
>NP_892009
          Length = 2432

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1656 TQLTAN 1661
>XP_006718432
          Length = 1464

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TQLTAN 9
           TQLTAN
Sbjct: 688 TQLTAN 693
>XP_005253271
          Length = 1481

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TQLTAN 9
           TQLTAN
Sbjct: 705 TQLTAN 710
>XP_006718431
          Length = 1493

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TQLTAN 9
           TQLTAN
Sbjct: 720 TQLTAN 725
>XP_006718430
          Length = 1551

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   TQLTAN 9
           TQLTAN
Sbjct: 775 TQLTAN 780
>XP_006718429
          Length = 2416

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1640 TQLTAN 1645
>XP_006718428
          Length = 2455

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1679 TQLTAN 1684
>XP_006718427
          Length = 2465

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4    TQLTAN 9
            TQLTAN
Sbjct: 1689 TQLTAN 1694
>NP_002565
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GVITQLTAN 9
           G++ Q+T N
Sbjct: 137 GILRQITVN 145
>NP_001189360
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GVITQLTAN 9
           G++ Q+T N
Sbjct: 137 GILRQITVN 145
>NP_859048
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GVITQLTAN 9
           G++ Q+T N
Sbjct: 137 GILRQITVN 145
>NP_859047
          Length = 199

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1   GVITQLTAN 9
           G++ Q+T N
Sbjct: 137 GILRQITVN 145
>NP_003646
          Length = 560

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2   VITQLTAN 9
           +IT +TAN
Sbjct: 541 IITDVTAN 548
>NP_000833
          Length = 1180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VITQLTAN 9
            V+T+ TAN
Sbjct: 1032 VVTRFTAN 1039
>NP_009017
          Length = 1129

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GVITQLTAN 9
          G++T+ T N
Sbjct: 88 GILTRFTTN 96
>NP_001137303
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VITQLTAN 9
            V+T+ TAN
Sbjct: 1064 VVTRFTAN 1071
>XP_006720075
          Length = 1127

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 7/9 (77%)

Query: 1  GVITQLTAN 9
          G++T+ T N
Sbjct: 88 GILTRFTTN 96
>XP_006718893
          Length = 1180

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VITQLTAN 9
            V+T+ TAN
Sbjct: 1032 VVTRFTAN 1039
>XP_006718892
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VITQLTAN 9
            V+T+ TAN
Sbjct: 1064 VVTRFTAN 1071
>XP_006718891
          Length = 1212

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VITQLTAN 9
            V+T+ TAN
Sbjct: 1064 VVTRFTAN 1071
>XP_005263256
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVITQLTA 8
           G+ITQL +
Sbjct: 877 GIITQLAS 884
>NP_001103447
          Length = 1040

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVITQLTA 8
           G+ITQL +
Sbjct: 877 GIITQLAS 884
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.313    0.127    0.326 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 299,264
Number of extensions: 364
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.6 bits)
S2: 28 (15.4 bits)

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