Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001155973                                                           18    1135
NP_055903                                                              18    1135
NP_067018                                                              18    1482
NP_001298                                                              17    2528
NP_001171952                                                           17    2528
NP_001171951                                                           17    2528
NP_065854                                                              17    3301
NP_008915                                                              17    3301
NP_064517                                                              17    3301
NP_001153572                                                           17    3301
XP_006724095                                                           17    3301
XP_006724093                                                           17    3301
XP_006724092                                                           17    3301
XP_005261217                                                           17    3301
XP_005261216                                                           17    3301
XP_005263210                                                           17    3301
NP_955360                                                              17    3301
NP_878268                                                              17    3301
NP_001032642                                                           17    3301
NP_001191676                                                           17    4312
NP_002904                                                              17    4312
NP_004432                                                              17    4312
NP_057710                                                              16    5631
XP_005260503                                                           16    5631
XP_005260502                                                           16    5631
NP_003042                                                              16    7355
NP_001159968                                                           16    7355
NP_001092007                                                           16    7355
NP_689499                                                              16    7355
NP_005089                                                              16    7355
NP_001138471                                                           16    7355
NP_115622                                                              16    7355
NP_002201                                                              16    7355
NP_001138472                                                           16    7355
XP_005266139                                                           16    7355
XP_005266136                                                           16    7355
XP_006717167                                                           16    7355
XP_006717166                                                           16    7355
XP_006717165                                                           16    7355
XP_006712576                                                           16    7355
XP_005246593                                                           16    7355
NP_001167621                                                           15    9605
NP_878899                                                              15    9605
NP_071896                                                              15    9605
NP_060829                                                              15    9605
NP_001167589                                                           15    9605
NP_976049                                                              15    9605
XP_005270105                                                           15    9605
XP_006713597                                                           15    9605
XP_006713596                                                           15    9605
XP_006713595                                                           15    9605
XP_006713594                                                           15    9605
>NP_001155973
          Length = 1833

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           GV FVVSGR
Sbjct: 354 GVNFVVSGR 362
>NP_055903
          Length = 1723

 Score = 18.5 bits (36), Expect =  1135
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           GV FVVSGR
Sbjct: 354 GVNFVVSGR 362
>NP_067018
          Length = 220

 Score = 18.1 bits (35), Expect =  1482
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G++FV+SG
Sbjct: 122 GIVFVISG 129
>NP_001298
          Length = 211

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IF+V+G
Sbjct: 123 GIIFIVAG 130
>NP_001171952
          Length = 145

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IF+V+G
Sbjct: 123 GIIFIVAG 130
>NP_001171951
          Length = 211

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IF+V+G
Sbjct: 123 GIIFIVAG 130
>NP_065854
          Length = 620

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVIFVVSGR 9
           GV+F V GR
Sbjct: 318 GVLFCVGGR 326
>NP_008915
          Length = 228

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G++F++SG
Sbjct: 121 GIVFILSG 128
>NP_064517
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>NP_001153572
          Length = 207

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G++F++SG
Sbjct: 100 GIVFILSG 107
>XP_006724095
          Length = 265

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>XP_006724093
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>XP_006724092
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>XP_005261217
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>XP_005261216
          Length = 463

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           G +FVVSG
Sbjct: 105 GFVFVVSG 112
>XP_005263210
          Length = 437

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVIFVVSGR 9
           GV+F V GR
Sbjct: 135 GVLFCVGGR 143
>NP_955360
          Length = 225

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IF+++G
Sbjct: 123 GIIFIITG 130
>NP_878268
          Length = 226

 Score = 16.9 bits (32), Expect =  3301
 Identities = 4/8 (50%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G++F++SG
Sbjct: 119 GIVFILSG 126
>NP_001032642
          Length = 376

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G +FVVSG
Sbjct: 18 GFVFVVSG 25
>NP_001191676
          Length = 1148

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IFV++G
Sbjct: 409 GLIFVITG 416
>NP_002904
          Length = 1147

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GVIFVVSG 8
           G+IFV++G
Sbjct: 409 GLIFVITG 416
>NP_004432
          Length = 984

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GVIFVVS 7
           GV+FVVS
Sbjct: 549 GVVFVVS 555
>NP_057710
          Length = 659

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   IFVVSGR 9
           IFVV+GR
Sbjct: 276 IFVVTGR 282
>XP_005260503
          Length = 153

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G+IFV+ G
Sbjct: 80 GIIFVLEG 87
>XP_005260502
          Length = 271

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GVIFVVSG 8
          G+IFV+ G
Sbjct: 80 GIIFVLEG 87
>NP_003042
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           GV+ ++SG
Sbjct: 427 GVVLIISG 434
>NP_001159968
          Length = 500

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           GV+ ++SG
Sbjct: 427 GVVLIISG 434
>NP_001092007
          Length = 1342

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 521 ILFVVSG 527
>NP_689499
          Length = 1317

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 496 ILFVVSG 502
>NP_005089
          Length = 206

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 4   FVVSGR 9
           FVVSGR
Sbjct: 182 FVVSGR 187
>NP_001138471
          Length = 1002

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           G++++ +GR
Sbjct: 355 GIVYIFNGR 363
>NP_115622
          Length = 569

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   IFVVSGR 9
           +FVV+GR
Sbjct: 110 VFVVTGR 116
>NP_002201
          Length = 1048

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           G++++ +GR
Sbjct: 401 GIVYIFNGR 409
>NP_001138472
          Length = 1012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           G++++ +GR
Sbjct: 365 GIVYIFNGR 373
>XP_005266139
          Length = 741

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 522 ILFVVSG 528
>XP_005266136
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 522 ILFVVSG 528
>XP_006717167
          Length = 1309

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 488 ILFVVSG 494
>XP_006717166
          Length = 1316

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 495 ILFVVSG 501
>XP_006717165
          Length = 1343

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VIFVVSG 8
           ++FVVSG
Sbjct: 522 ILFVVSG 528
>XP_006712576
          Length = 901

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           G++++ +GR
Sbjct: 254 GIVYIFNGR 262
>XP_005246593
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 3/9 (33%), Positives = 8/9 (88%)

Query: 1   GVIFVVSGR 9
           G++++ +GR
Sbjct: 400 GIVYIFNGR 408
>NP_001167621
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 91 GVIFVV 96
>NP_878899
          Length = 428

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 91 GVIFVV 96
>NP_071896
          Length = 800

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           GVI V+SG
Sbjct: 400 GVIKVISG 407
>NP_060829
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           G+I+VV G
Sbjct: 276 GMIYVVQG 283
>NP_001167589
          Length = 666

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IFVVSGR 9
           +F+V+GR
Sbjct: 223 VFIVTGR 229
>NP_976049
          Length = 651

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 3   IFVVSGR 9
           +F+V+GR
Sbjct: 223 VFIVTGR 229
>XP_005270105
          Length = 500

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GVIFVVSG 8
           GVI V+SG
Sbjct: 400 GVIKVISG 407
>XP_006713597
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 66 GVIFVV 71
>XP_006713596
          Length = 403

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 66 GVIFVV 71
>XP_006713595
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 76 GVIFVV 81
>XP_006713594
          Length = 413

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 1  GVIFVV 6
          GVIFVV
Sbjct: 76 GVIFVV 81
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.336    0.157    0.451 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 454,065
Number of extensions: 992
Number of successful extensions: 52
Number of sequences better than 10000.0: 52
Number of HSP's gapped: 52
Number of HSP's successfully gapped: 52
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.2 bits)
S2: 28 (15.4 bits)

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