Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001010924                                                           18    1935
NP_065712                                                              17    2528
XP_005266263                                                           17    3301
XP_006720056                                                           17    3301
XP_005266261                                                           17    3301
XP_006720055                                                           17    3301
NP_001072113                                                           17    3301
NP_003894                                                              17    3301
NP_005088                                                              16    5631
NP_001093391                                                           16    5631
NP_001010872                                                           16    5631
NP_001034842                                                           16    5631
NP_060646                                                              16    5631
NP_665879                                                              16    5631
XP_005270329                                                           16    5631
XP_006715085                                                           16    5631
XP_006712080                                                           16    5631
XP_006712079                                                           16    5631
NP_057200                                                              16    5631
NP_071351                                                              16    7355
NP_001269836                                                           16    7355
NP_001269837                                                           16    7355
NP_006576                                                              16    7355
NP_037462                                                              16    7355
NP_062559                                                              16    7355
NP_932076                                                              16    7355
XP_006712712                                                           16    7355
XP_006712711                                                           16    7355
XP_006712710                                                           16    7355
XP_006712709                                                           16    7355
NP_000103                                                              15    9605
NP_620482                                                              15    9605
NP_000307                                                              15    9605
NP_001171673                                                           15    9605
NP_001077084                                                           15    9605
NP_001190189                                                           15    9605
NP_001243465                                                           15    9605
NP_001190190                                                           15    9605
NP_671488                                                              15    9605
NP_001190983                                                           15    9605
NP_001186492                                                           15    9605
NP_004540                                                              15    9605
NP_006381                                                              15    9605
NP_005779                                                              15    9605
NP_062828                                                              15    9605
NP_001138639                                                           15    9605
NP_001138638                                                           15    9605
NP_775899                                                              15    9605
NP_001193971                                                           15    9605
NP_938074                                                              15    9605
NP_001527                                                              15    9605
NP_009004                                                              15    9605
XP_006724177                                                           15    9605
XP_005258901                                                           15    9605
XP_005258899                                                           15    9605
XP_006719049                                                           15    9605
XP_006718184                                                           15    9605
XP_005252787                                                           15    9605
XP_005265401                                                           15    9605
XP_005265400                                                           15    9605
XP_005265399                                                           15    9605
XP_006713335                                                           15    9605
XP_006712362                                                           15    9605
NP_001177924                                                           15    9605
NP_001001667                                                           15    9605
>NP_001010924
          Length = 890

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1   GVHLEML 7
           GVHLEM+
Sbjct: 396 GVHLEMM 402
>NP_065712
          Length = 198

 Score = 17.3 bits (33), Expect =  2528
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1  GVHLEMLFI 9
          G H+E+LF+
Sbjct: 54 GCHVELLFL 62
>XP_005266263
          Length = 511

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 366 GCHLPMLYI 374
>XP_006720056
          Length = 526

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 272 GCHLPMLYI 280
>XP_005266261
          Length = 619

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 365 GCHLPMLYI 373
>XP_006720055
          Length = 619

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 365 GCHLPMLYI 373
>NP_001072113
          Length = 620

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 366 GCHLPMLYI 374
>NP_003894
          Length = 620

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ML+I
Sbjct: 366 GCHLPMLYI 374
>NP_005088
          Length = 557

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HLEMLFI 9
           HLE LFI
Sbjct: 116 HLEYLFI 122
>NP_001093391
          Length = 324

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HLEMLF 8
           HLEM+F
Sbjct: 161 HLEMIF 166
>NP_001010872
          Length = 1011

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GVHLEMLF 8
           G H+++LF
Sbjct: 118 GTHIDLLF 125
>NP_001034842
          Length = 1958

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GVHLEMLFI 9
            G HLE +F+
Sbjct: 1503 GGHLERIFV 1511
>NP_060646
          Length = 545

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HLEMLFI 9
           HLE LFI
Sbjct: 110 HLEYLFI 116
>NP_665879
          Length = 349

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GVHLEMLF 8
          G+HL +LF
Sbjct: 78 GLHLSVLF 85
>XP_005270329
          Length = 291

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 3   HLEMLFI 9
           HLE LFI
Sbjct: 116 HLEYLFI 122
>XP_006715085
          Length = 1011

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 1   GVHLEMLF 8
           G H+++LF
Sbjct: 118 GTHIDLLF 125
>XP_006712080
          Length = 924

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HLE +F+
Sbjct: 469 GGHLERIFV 477
>XP_006712079
          Length = 1683

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1    GVHLEMLFI 9
            G HLE +F+
Sbjct: 1228 GGHLERIFV 1236
>NP_057200
          Length = 426

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1  GVHLEMLF 8
          G+HL +LF
Sbjct: 78 GLHLSVLF 85
>NP_071351
          Length = 2752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1    GVHLEMLFI 9
            G+H  M FI
Sbjct: 2269 GIHFWMFFI 2277
>NP_001269836
          Length = 529

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  HLEMLFI 9
          HLE LF+
Sbjct: 40 HLEKLFV 46
>NP_001269837
          Length = 497

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  HLEMLFI 9
          HLE LF+
Sbjct: 8  HLEKLFV 14
>NP_006576
          Length = 548

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3  HLEMLFI 9
          HLE LF+
Sbjct: 59 HLEKLFV 65
>NP_037462
          Length = 376

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VHLEMLFI 9
          +HLE LFI
Sbjct: 55 LHLEDLFI 62
>NP_062559
          Length = 344

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3  HLEMLF 8
          H+EMLF
Sbjct: 56 HVEMLF 61
>NP_932076
          Length = 340

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2  VHLEMLFI 9
          +HLE LFI
Sbjct: 19 LHLEDLFI 26
>XP_006712712
          Length = 1414

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           VH EMLF
Sbjct: 161 VHEEMLF 167
>XP_006712711
          Length = 1448

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           VH EMLF
Sbjct: 195 VHEEMLF 201
>XP_006712710
          Length = 1528

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           VH EMLF
Sbjct: 326 VHEEMLF 332
>XP_006712709
          Length = 1579

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           VH EMLF
Sbjct: 326 VHEEMLF 332
>NP_000103
          Length = 739

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/6 (66%), Positives = 6/6 (100%)

Query: 1  GVHLEM 6
          G+HLE+
Sbjct: 26 GIHLEL 31
>NP_620482
          Length = 1341

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GVHLEMLFI 9
           GVH ++LF+
Sbjct: 295 GVHGKVLFL 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVHLEMLF 8
           G +LEM+F
Sbjct: 493 GKYLEMMF 500
>NP_000307
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 441 MHYEMLF 447
>NP_001171673
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 441 MHYEMLF 447
>NP_001077084
          Length = 1314

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GVHLEMLFI 9
           GVH ++LF+
Sbjct: 295 GVHGKVLFL 303

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVHLEMLF 8
           G +LEM+F
Sbjct: 493 GKYLEMMF 500
>NP_001190189
          Length = 134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  GVHLEMLFI 9
          G+H ++L+I
Sbjct: 56 GLHRQLLYI 64
>NP_001243465
          Length = 385

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 75 GIHEEML 81
>NP_001190190
          Length = 114

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  GVHLEMLFI 9
          G+H ++L+I
Sbjct: 56 GLHRQLLYI 64
>NP_671488
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VHLEMLFI 9
          +HL M+F+
Sbjct: 62 LHLHMIFL 69
>NP_001190983
          Length = 88

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  GVHLEMLFI 9
          G+H ++L+I
Sbjct: 56 GLHRQLLYI 64
>NP_001186492
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VHLEMLFI 9
          +HL M+F+
Sbjct: 62 LHLHMIFL 69
>NP_004540
          Length = 119

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/9 (44%), Positives = 8/9 (88%)

Query: 1  GVHLEMLFI 9
          G+H ++L+I
Sbjct: 56 GLHRQLLYI 64
>NP_006381
          Length = 1037

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HLEMLF 8
           HLE+LF
Sbjct: 714 HLEILF 719
>NP_005779
          Length = 531

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVHLEML 7
           G+H EML
Sbjct: 228 GIHEEML 234
>NP_062828
          Length = 394

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 84 GIHEEML 90
>NP_001138639
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVHLEML 7
           G+H EML
Sbjct: 151 GIHEEML 157
>NP_001138638
          Length = 469

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVHLEML 7
           G+H EML
Sbjct: 166 GIHEEML 172
>NP_775899
          Length = 4462

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3    HLEMLFI 9
            HLE +FI
Sbjct: 1498 HLESIFI 1504
>NP_001193971
          Length = 285

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 43 GIHEEML 49
>NP_938074
          Length = 353

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 43 GIHEEML 49
>NP_001527
          Length = 371

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 61 GIHEEML 67
>NP_009004
          Length = 360

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2  VHLEMLFI 9
          +HL M+F+
Sbjct: 62 LHLHMIFL 69
>XP_006724177
          Length = 383

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/7 (57%), Positives = 7/7 (100%)

Query: 2  VHLEMLF 8
          +HL++LF
Sbjct: 14 IHLQILF 20
>XP_005258901
          Length = 293

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 37 GIHEEML 43
>XP_005258899
          Length = 342

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 32 GIHEEML 38
>XP_006719049
          Length = 257

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 24 GIHEEML 30
>XP_006718184
          Length = 367

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1  GVHLEML 7
          G+H EML
Sbjct: 64 GIHEEML 70
>XP_005252787
          Length = 498

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVHLEML 7
           G+H EML
Sbjct: 195 GIHEEML 201
>XP_005265401
          Length = 562

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 410 MHYEMLF 416
>XP_005265400
          Length = 575

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 423 MHYEMLF 429
>XP_005265399
          Length = 593

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 441 MHYEMLF 447
>XP_006713335
          Length = 606

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   VHLEMLF 8
           +H EMLF
Sbjct: 454 MHYEMLF 460
>XP_006712362
          Length = 1350

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GVHLEMLFI 9
           GVH ++LF+
Sbjct: 304 GVHGKVLFL 312

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GVHLEMLF 8
           G +LEM+F
Sbjct: 502 GKYLEMMF 509
>NP_001177924
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   HLEMLF 8
           HLE+LF
Sbjct: 509 HLEILF 514
>NP_001001667
          Length = 313

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVHLEMLFI 9
           G HL ++FI
Sbjct: 240 GSHLTLVFI 248
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.343    0.161    0.488 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 583,271
Number of extensions: 802
Number of successful extensions: 68
Number of sequences better than 10000.0: 65
Number of HSP's gapped: 68
Number of HSP's successfully gapped: 68
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 15 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.5 bits)
S2: 28 (15.4 bits)

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