Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_001895                                                              20     299
NP_001091680                                                           20     299
NP_001091679                                                           20     299
XP_006713048                                                           20     299
XP_006713047                                                           20     299
XP_006713046                                                           20     299
XP_005264943                                                           20     299
XP_006718823                                                           18    1935
NP_006036                                                              17    3301
NP_002221                                                              17    4312
NP_068831                                                              17    4312
NP_079467                                                              17    4312
XP_006721941                                                           17    4312
XP_006721940                                                           17    4312
XP_006721939                                                           17    4312
XP_006721938                                                           17    4312
XP_006721937                                                           17    4312
XP_006721936                                                           17    4312
XP_006721935                                                           17    4312
XP_006721934                                                           17    4312
XP_005257370                                                           17    4312
XP_005245556                                                           17    4312
NP_002553                                                              16    5631
NP_056019                                                              16    5631
NP_778255                                                              16    5631
NP_001191449                                                           16    5631
NP_001191448                                                           16    5631
NP_002552                                                              16    5631
XP_006715725                                                           16    5631
XP_006715724                                                           16    5631
XP_006715723                                                           16    5631
XP_006715722                                                           16    5631
NP_001073870                                                           16    5631
NP_056342                                                              16    7355
NP_006328                                                              16    7355
NP_001164261                                                           16    7355
NP_997279                                                              16    7355
NP_116278                                                              16    7355
XP_006726477                                                           16    7355
XP_006726476                                                           16    7355
XP_003960392                                                           16    7355
XP_005269254                                                           16    7355
XP_005269255                                                           16    7355
XP_005268629                                                           16    7355
XP_006719020                                                           16    7355
XP_006719019                                                           16    7355
XP_006714494                                                           16    7355
XP_006714493                                                           16    7355
XP_373030                                                              16    7355
XP_006710701                                                           16    7355
XP_006710222                                                           16    7355
XP_006710221                                                           16    7355
XP_001717475                                                           16    7355
NP_001012300                                                           16    7355
NP_877426                                                              16    7355
NP_037372                                                              16    7355
NP_001139434                                                           15    9605
NP_001184226                                                           15    9605
NP_003866                                                              15    9605
NP_062547                                                              15    9605
NP_060259                                                              15    9605
NP_892021                                                              15    9605
NP_689648                                                              15    9605
NP_006169                                                              15    9605
XP_006725689                                                           15    9605
XP_006725339                                                           15    9605
XP_005260996                                                           15    9605
XP_005260995                                                           15    9605
XP_006721992                                                           15    9605
XP_005270837                                                           15    9605
XP_005270836                                                           15    9605
NP_002031                                                              15    9605
>NP_001895
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 208 VETARCTA 215
>NP_001091680
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 208 VETARCTA 215
>NP_001091679
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 208 VETARCTA 215
>XP_006713048
          Length = 720

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 208 VETARCTA 215
>XP_006713047
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 201 VETARCTA 208
>XP_006713046
          Length = 774

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 201 VETARCTA 208
>XP_005264943
          Length = 781

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/8 (100%), Positives = 8/8 (100%)

Query: 2   VETARCTA 9
           VETARCTA
Sbjct: 208 VETARCTA 215
>XP_006718823
          Length = 1011

 Score = 17.7 bits (34), Expect =  1935
 Identities = 6/7 (85%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           G ETARC
Sbjct: 121 GTETARC 127
>NP_006036
          Length = 1047

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VETARCTA 9
           +ETA CTA
Sbjct: 681 LETATCTA 688
>NP_002221
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>NP_068831
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>NP_079467
          Length = 932

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GVETARCTA 9
           G ET  CTA
Sbjct: 219 GTETDTCTA 227
>XP_006721941
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721940
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721939
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721938
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721937
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721936
          Length = 745

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 199 LDTARCT 205
>XP_006721935
          Length = 762

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 216 LDTARCT 222
>XP_006721934
          Length = 783

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 237 LDTARCT 243
>XP_005257370
          Length = 783

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 2   VETARCT 8
           ++TARCT
Sbjct: 237 LDTARCT 243
>XP_005245556
          Length = 933

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GVETARCTA 9
           G ET  CTA
Sbjct: 219 GTETDTCTA 227
>NP_002553
          Length = 595

 Score = 16.2 bits (30), Expect =  5631
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           G++T RC
Sbjct: 146 GIQTGRC 152
>NP_056019
          Length = 1657

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VETARCTA 9
            VET+RC +
Sbjct: 1013 VETSRCNS 1020
>NP_778255
          Length = 397

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           GV+T RC
Sbjct: 122 GVKTGRC 128
>NP_001191449
          Length = 398

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           GV+T RC
Sbjct: 122 GVKTGRC 128
>NP_001191448
          Length = 421

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           GV+T RC
Sbjct: 146 GVKTGRC 152
>NP_002552
          Length = 422

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 1   GVETARC 7
           GV+T RC
Sbjct: 146 GVKTGRC 152
>XP_006715725
          Length = 1516

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VETARCTA 9
            VET+RC +
Sbjct: 1013 VETSRCNS 1020
>XP_006715724
          Length = 1533

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VETARCTA 9
            VET+RC +
Sbjct: 1013 VETSRCNS 1020
>XP_006715723
          Length = 1559

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VETARCTA 9
            VET+RC +
Sbjct: 1013 VETSRCNS 1020
>XP_006715722
          Length = 1614

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 2    VETARCTA 9
            VET+RC +
Sbjct: 1013 VETSRCNS 1020
>NP_001073870
          Length = 430

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 2   VETARCTA 9
           VET  CTA
Sbjct: 158 VETGGCTA 165
>NP_056342
          Length = 808

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GVETARCTA 9
           GVET+R  A
Sbjct: 119 GVETSRALA 127
>NP_006328
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GVETARCT 8
          GVE  RC+
Sbjct: 78 GVEPGRCS 85
>NP_001164261
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVETARCTA 9
           G+E +RC A
Sbjct: 125 GLELSRCRA 133
>NP_997279
          Length = 634

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GVETARC 7
          GVE  RC
Sbjct: 92 GVEAVRC 98
>NP_116278
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GVETARCTA 9
          G+E +RC A
Sbjct: 18 GLELSRCRA 26
>XP_006726477
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_006726476
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_003960392
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 56 GIQTPRC 62
>XP_005269254
          Length = 557

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVETARCTA 9
           G+E +RC A
Sbjct: 125 GLELSRCRA 133
>XP_005269255
          Length = 450

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GVETARCTA 9
          G+E +RC A
Sbjct: 18 GLELSRCRA 26
>XP_005268629
          Length = 462

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GVETARCT 8
          GVE  RC+
Sbjct: 78 GVEPGRCS 85
>XP_006719020
          Length = 150

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GVETARCTA 9
          GV+T +C A
Sbjct: 58 GVKTDKCNA 66
>XP_006719019
          Length = 330

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1  GVETARCTA 9
          GV+T +C A
Sbjct: 58 GVKTDKCNA 66
>XP_006714494
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_006714493
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_373030
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 56 GIQTPRC 62
>XP_006710701
          Length = 656

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GVETARC 7
          GVE  RC
Sbjct: 92 GVEAVRC 98
>XP_006710222
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_006710221
          Length = 1793

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 23 GIQTPRC 29
>XP_001717475
          Length = 1826

 Score = 15.8 bits (29), Expect =  7355
 Identities = 4/7 (57%), Positives = 6/7 (85%)

Query: 1  GVETARC 7
          G++T RC
Sbjct: 56 GIQTPRC 62
>NP_001012300
          Length = 475

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 1  GVETARCT 8
          GVE  RC+
Sbjct: 91 GVEPGRCS 98
>NP_877426
          Length = 186

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  VETARC 7
          +ETARC
Sbjct: 87 LETARC 92
>NP_037372
          Length = 214

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 2  VETARC 7
          +ETARC
Sbjct: 87 LETARC 92
>NP_001139434
          Length = 1087

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 5/7 (71%)

Query: 1  GVETARC 7
          G E ARC
Sbjct: 29 GAEPARC 35
>NP_001184226
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GVETARCT 8
          G E A CT
Sbjct: 16 GTEKAECT 23
>NP_003866
          Length = 693

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVETARCTA 9
           GV++  CTA
Sbjct: 246 GVDSTVCTA 254
>NP_062547
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GVETARCTA 9
           G ET+ C A
Sbjct: 759 GAETSTCQA 767
>NP_060259
          Length = 833

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VETARCTA 9
           V T+RC A
Sbjct: 521 VNTSRCVA 528
>NP_892021
          Length = 582

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VETARCTA 9
           VET  C+A
Sbjct: 402 VETVHCSA 409
>NP_689648
          Length = 426

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 4   TARCTA 9
           TARC+A
Sbjct: 297 TARCSA 302
>NP_006169
          Length = 744

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETARCTA 9
           ETA+C A
Sbjct: 578 ETAKCQA 584
>XP_006725689
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETARCTA 9
           ETA+C A
Sbjct: 578 ETAKCQA 584
>XP_006725339
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETARCTA 9
           ETA+C A
Sbjct: 578 ETAKCQA 584
>XP_005260996
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GVETARCT 8
          G E A CT
Sbjct: 16 GTEKAECT 23
>XP_005260995
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GVETARCT 8
          G E A CT
Sbjct: 16 GTEKAECT 23
>XP_006721992
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 3   ETARCTA 9
           ETA+C A
Sbjct: 578 ETAKCQA 584
>XP_005270837
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VETARCTA 9
           VET  C+A
Sbjct: 196 VETVHCSA 203
>XP_005270836
          Length = 376

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 6/8 (75%)

Query: 2   VETARCTA 9
           VET  C+A
Sbjct: 196 VETVHCSA 203
>NP_002031
          Length = 454

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/8 (62%), Positives = 5/8 (62%)

Query: 1  GVETARCT 8
          G E A CT
Sbjct: 16 GTEKAECT 23
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.317    0.123    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 559,227
Number of extensions: 832
Number of successful extensions: 72
Number of sequences better than 10000.0: 72
Number of HSP's gapped: 72
Number of HSP's successfully gapped: 72
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

CANCERTOPE    |     Raghava's Group    |     IMTECH    |     CSIR    |     CRDD    |     GPSR Package