Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_000305                                                              20     390
XP_006717989                                                           20     390
NP_006222                                                              19     869
NP_078945                                                              18    1935
XP_006714754                                                           18    1935
XP_005248656                                                           18    1935
NP_001138727                                                           17    2528
NP_001093326                                                           17    2528
NP_001093327                                                           17    2528
NP_003630                                                              17    2528
XP_005274821                                                           17    2528
XP_005274820                                                           17    2528
XP_006724916                                                           17    2528
XP_005274817                                                           17    2528
NP_004463                                                              17    4312
NP_001123633                                                           16    5631
NP_005611                                                              16    5631
XP_005257603                                                           16    5631
XP_006722058                                                           16    5631
XP_005257602                                                           16    5631
XP_006717757                                                           16    5631
XP_006717756                                                           16    5631
NP_001123631                                                           16    5631
NP_689922                                                              16    5631
NP_055950                                                              16    7355
NP_002204                                                              16    7355
NP_001107604                                                           16    7355
XP_005250292                                                           16    7355
XP_005247493                                                           16    7355
XP_006712765                                                           16    7355
XP_006712764                                                           16    7355
XP_005246844                                                           16    7355
XP_006712763                                                           16    7355
XP_006712762                                                           16    7355
XP_006712761                                                           16    7355
NP_689620                                                              16    7355
NP_001167535                                                           15    9605
NP_001167534                                                           15    9605
NP_001167536                                                           15    9605
NP_001167537                                                           15    9605
NP_001138389                                                           15    9605
NP_001138390                                                           15    9605
NP_001138386                                                           15    9605
NP_001138387                                                           15    9605
NP_000132                                                              15    9605
NP_075259                                                              15    9605
NP_001138388                                                           15    9605
NP_056934                                                              15    9605
NP_075598                                                              15    9605
NP_075594                                                              15    9605
NP_075593                                                              15    9605
NP_001138391                                                           15    9605
NP_001138385                                                           15    9605
NP_075418                                                              15    9605
NP_001167538                                                           15    9605
NP_036221                                                              15    9605
NP_001254513                                                           15    9605
NP_055763                                                              15    9605
NP_955447                                                              15    9605
XP_006717776                                                           15    9605
XP_006717775                                                           15    9605
XP_006717774                                                           15    9605
XP_006717773                                                           15    9605
XP_006717772                                                           15    9605
XP_006717771                                                           15    9605
XP_006716377                                                           15    9605
XP_006716376                                                           15    9605
XP_006716375                                                           15    9605
XP_006716374                                                           15    9605
XP_006716373                                                           15    9605
XP_006716372                                                           15    9605
XP_006716371                                                           15    9605
XP_006716370                                                           15    9605
XP_006716369                                                           15    9605
XP_006716368                                                           15    9605
XP_006716367                                                           15    9605
XP_006716366                                                           15    9605
>NP_000305
          Length = 403

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GVAIPSQRR 9
           GV IPSQRR
Sbjct: 165 GVTIPSQRR 173
>XP_006717989
          Length = 388

 Score = 20.0 bits (40), Expect =   390
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1   GVAIPSQRR 9
           GV IPSQRR
Sbjct: 150 GVTIPSQRR 158
>NP_006222
          Length = 2286

 Score = 18.9 bits (37), Expect =   869
 Identities = 7/9 (77%), Positives = 8/9 (88%)

Query: 1    GVAIPSQRR 9
            G+ IPSQRR
Sbjct: 1501 GIFIPSQRR 1509
>NP_078945
          Length = 614

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPSQRR
Sbjct: 589 AIPSQRR 595
>XP_006714754
          Length = 452

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPSQRR
Sbjct: 427 AIPSQRR 433
>XP_005248656
          Length = 491

 Score = 17.7 bits (34), Expect =  1935
 Identities = 7/7 (100%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPSQRR
Sbjct: 466 AIPSQRR 472
>NP_001138727
          Length = 320

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 280 LALPSQRR 287
>NP_001093326
          Length = 487

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 447 LALPSQRR 454
>NP_001093327
          Length = 419

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 379 LALPSQRR 386
>NP_003630
          Length = 419

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 379 LALPSQRR 386
>XP_005274821
          Length = 418

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 378 LALPSQRR 385
>XP_005274820
          Length = 419

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 379 LALPSQRR 386
>XP_006724916
          Length = 461

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 421 LALPSQRR 428
>XP_005274817
          Length = 486

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 8/8 (100%)

Query: 2   VAIPSQRR 9
           +A+PSQRR
Sbjct: 446 LALPSQRR 453
>NP_004463
          Length = 465

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2  VAIPSQRR 9
          +A+P+QRR
Sbjct: 46 LAVPAQRR 53
>NP_001123633
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVAIPSQ 7
           G+AIPS+
Sbjct: 155 GIAIPSE 161
>NP_005611
          Length = 105

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+PSQ+R
Sbjct: 98  AVPSQKR 104
>XP_005257603
          Length = 5256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPS+RR
Sbjct: 111 AIPSKRR 117
>XP_006722058
          Length = 5256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPS+RR
Sbjct: 111 AIPSKRR 117
>XP_005257602
          Length = 5256

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           AIPS+RR
Sbjct: 111 AIPSKRR 117
>XP_006717757
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GVAIPSQ 7
          G+AIPS+
Sbjct: 45 GIAIPSE 51
>XP_006717756
          Length = 879

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1  GVAIPSQ 7
          G+AIPS+
Sbjct: 45 GIAIPSE 51
>NP_001123631
          Length = 227

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVAIPSQ 7
           G+AIPS+
Sbjct: 155 GIAIPSE 161
>NP_689922
          Length = 989

 Score = 16.2 bits (30), Expect =  5631
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GVAIPSQ 7
           G+AIPS+
Sbjct: 155 GIAIPSE 161
>NP_055950
          Length = 2012

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           V IPSQR+
Sbjct: 676 VRIPSQRQ 683
>NP_002204
          Length = 799

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVAIPSQRR 9
           GV+ P QR+
Sbjct: 404 GVSYPGQRK 412
>NP_001107604
          Length = 2694

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_005250292
          Length = 1654

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           V IPSQR+
Sbjct: 318 VRIPSQRQ 325
>XP_005247493
          Length = 769

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVAIPSQRR 9
           GV+ P QR+
Sbjct: 374 GVSYPGQRK 382
>XP_006712765
          Length = 2679

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_006712764
          Length = 2697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_005246844
          Length = 2707

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_006712763
          Length = 2716

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_006712762
          Length = 2723

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>XP_006712761
          Length = 2736

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 3   AIPSQRR 9
           A+P+QRR
Sbjct: 308 ALPNQRR 314
>NP_689620
          Length = 225

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           VA+ SQRR
Sbjct: 217 VAVESQRR 224
>NP_001167535
          Length = 812

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 729 AVPSQR 734
>NP_001167534
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>NP_001167536
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>NP_001167537
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 650 AVPSQR 655
>NP_001138389
          Length = 705

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 626 AVPSQR 631
>NP_001138390
          Length = 704

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 625 AVPSQR 630
>NP_001138386
          Length = 709

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 630 AVPSQR 635
>NP_001138387
          Length = 707

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 653 AVPSQR 658
>NP_000132
          Length = 821

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 742 AVPSQR 747
>NP_075259
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 743 AVPSQR 748
>NP_001138388
          Length = 706

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 627 AVPSQR 632
>NP_056934
          Length = 820

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>NP_075598
          Length = 822

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 739 AVPSQR 744
>NP_075594
          Length = 731

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 648 AVPSQR 653
>NP_075593
          Length = 733

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 650 AVPSQR 655
>NP_001138391
          Length = 680

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 654 AVPSQR 659
>NP_001138385
          Length = 769

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 743 AVPSQR 748
>NP_075418
          Length = 732

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 653 AVPSQR 658
>NP_001167538
          Length = 853

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 770 AVPSQR 775
>NP_036221
          Length = 738

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/9 (55%), Positives = 7/9 (77%)

Query: 1   GVAIPSQRR 9
           G+A P +RR
Sbjct: 162 GLAYPERRR 170
>NP_001254513
          Length = 512

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           + +PSQ+R
Sbjct: 357 IVLPSQKR 364
>NP_055763
          Length = 541

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           + +PSQ+R
Sbjct: 357 IVLPSQKR 364
>NP_955447
          Length = 487

 Score = 15.4 bits (28), Expect =  9605
 Identities = 4/8 (50%), Positives = 7/8 (87%)

Query: 2   VAIPSQRR 9
           + +PSQ+R
Sbjct: 357 IVLPSQKR 364
>XP_006717776
          Length = 806

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 761 AVPSQR 766
>XP_006717775
          Length = 726

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 647 AVPSQR 652
>XP_006717774
          Length = 752

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 673 AVPSQR 678
>XP_006717773
          Length = 807

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 762 AVPSQR 767
>XP_006717772
          Length = 838

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 759 AVPSQR 764
>XP_006717771
          Length = 839

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 760 AVPSQR 765
>XP_006716377
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 648 AVPSQR 653
>XP_006716376
          Length = 741

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 648 AVPSQR 653
>XP_006716375
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 650 AVPSQR 655
>XP_006716374
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 650 AVPSQR 655
>XP_006716373
          Length = 743

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 650 AVPSQR 655
>XP_006716372
          Length = 824

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 731 AVPSQR 736
>XP_006716371
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>XP_006716370
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>XP_006716369
          Length = 830

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 737 AVPSQR 742
>XP_006716368
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 739 AVPSQR 744
>XP_006716367
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 739 AVPSQR 744
>XP_006716366
          Length = 832

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/6 (83%), Positives = 6/6 (100%)

Query: 3   AIPSQR 8
           A+PSQR
Sbjct: 739 AVPSQR 744
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.322    0.135    0.384 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 685,498
Number of extensions: 1026
Number of successful extensions: 77
Number of sequences better than 10000.0: 77
Number of HSP's gapped: 77
Number of HSP's successfully gapped: 77
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.9 bits)
S2: 28 (15.4 bits)

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