Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_722576                                                              21     229
XP_005262424                                                           21     229
NP_008986                                                              20     299
XP_006717660                                                           20     299
NP_004091                                                              18    1482
NP_742103                                                              18    1482
NP_742101                                                              18    1482
XP_006715436                                                           18    1482
XP_005266910                                                           18    1482
XP_005266909                                                           18    1482
XP_005266908                                                           18    1482
XP_005266907                                                           18    1482
NP_835237                                                              17    2528
NP_115687                                                              17    2528
NP_001265586                                                           17    2528
NP_001005487                                                           17    3301
NP_659404                                                              17    4312
NP_001269536                                                           17    4312
NP_001271226                                                           17    4312
NP_001271227                                                           17    4312
XP_006724792                                                           17    4312
XP_005254507                                                           17    4312
XP_005254506                                                           17    4312
XP_005254505                                                           17    4312
XP_006720635                                                           17    4312
XP_006720634                                                           17    4312
NP_997290                                                              17    4312
NP_004564                                                              17    4312
NP_001092314                                                           16    5631
NP_001108603                                                           16    7355
NP_000056                                                              16    7355
NP_694984                                                              16    7355
NP_005119                                                              16    7355
NP_079111                                                              16    7355
XP_005276966                                                           16    7355
XP_006724701                                                           16    7355
XP_005262172                                                           16    7355
XP_005262170                                                           16    7355
XP_006724131                                                           16    7355
XP_005257746                                                           16    7355
XP_006714560                                                           16    7355
XP_005248414                                                           16    7355
XP_005248413                                                           16    7355
XP_006714559                                                           16    7355
XP_006712581                                                           16    7355
XP_005246132                                                           16    7355
NP_001073973                                                           16    7355
>NP_722576
          Length = 3080

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    GTRMTSNNT 9
            GTRMTS+NT
Sbjct: 1867 GTRMTSSNT 1875
>XP_005262424
          Length = 2875

 Score = 20.8 bits (42), Expect =   229
 Identities = 8/9 (88%), Positives = 9/9 (100%)

Query: 1    GTRMTSNNT 9
            GTRMTS+NT
Sbjct: 1662 GTRMTSSNT 1670
>NP_008986
          Length = 1390

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTRMTSNNT 9
            GTR TSNNT
Sbjct: 1243 GTRTTSNNT 1251
>XP_006717660
          Length = 1369

 Score = 20.4 bits (41), Expect =   299
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTRMTSNNT 9
            GTR TSNNT
Sbjct: 1222 GTRTTSNNT 1230
>NP_004091
          Length = 639

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 291 GAYMTSNNT 299
>NP_742103
          Length = 639

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 291 GAYMTSNNT 299
>NP_742101
          Length = 616

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 268 GAYMTSNNT 276
>XP_006715436
          Length = 585

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 237 GAYMTSNNT 245
>XP_005266910
          Length = 616

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 268 GAYMTSNNT 276
>XP_005266909
          Length = 620

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 291 GAYMTSNNT 299
>XP_005266908
          Length = 645

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 291 GAYMTSNNT 299
>XP_005266907
          Length = 645

 Score = 18.1 bits (35), Expect =  1482
 Identities = 7/9 (77%), Positives = 7/9 (77%)

Query: 1   GTRMTSNNT 9
           G  MTSNNT
Sbjct: 291 GAYMTSNNT 299
>NP_835237
          Length = 392

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GT+MT NN
Sbjct: 250 GTKMTVNN 257
>NP_115687
          Length = 421

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GT+MT NN
Sbjct: 279 GTKMTVNN 286
>NP_001265586
          Length = 438

 Score = 17.3 bits (33), Expect =  2528
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GT+MT NN
Sbjct: 296 GTKMTVNN 303
>NP_001005487
          Length = 307

 Score = 16.9 bits (32), Expect =  3301
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GTRMTSNNT 9
          GT +TS NT
Sbjct: 80 GTMLTSENT 88
>NP_659404
          Length = 547

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GTRMTSNN 8
           G RMTS N
Sbjct: 371 GNRMTSTN 378
>NP_001269536
          Length = 535

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GTRMTSNN 8
           G RMTS N
Sbjct: 359 GNRMTSTN 366
>NP_001271226
          Length = 1181

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 603 GTRMDSSN 610
>NP_001271227
          Length = 1170

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>XP_006724792
          Length = 411

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 6/8 (75%)

Query: 1   GTRMTSNN 8
           G RMTS N
Sbjct: 235 GNRMTSTN 242
>XP_005254507
          Length = 1070

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>XP_005254506
          Length = 1123

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>XP_005254505
          Length = 1124

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>XP_006720635
          Length = 1125

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>XP_006720634
          Length = 1184

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>NP_997290
          Length = 438

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           G RMTS+N
Sbjct: 187 GIRMTSSN 194
>NP_004564
          Length = 1185

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/8 (75%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           GTRM S+N
Sbjct: 607 GTRMDSSN 614
>NP_001092314
          Length = 351

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1  GTRMTSNNT 9
          GTR  S+NT
Sbjct: 37 GTRARSDNT 45
>NP_001108603
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 850 TRLSSNST 857
>NP_000056
          Length = 934

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 850 TRLSSNST 857
>NP_694984
          Length = 1802

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRMTSNN 8
           T+MT NN
Sbjct: 407 TKMTGNN 413
>NP_005119
          Length = 2298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GTRMTSNN 8
           G+R+TS+N
Sbjct: 947 GSRVTSHN 954
>NP_079111
          Length = 697

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTRMTSNNT 9
           G R TS NT
Sbjct: 559 GNRETSGNT 567
>XP_005276966
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTRMTSNNT 9
           G R TS NT
Sbjct: 561 GNRETSGNT 569
>XP_006724701
          Length = 1398

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2 TRMTSNN 8
         T+MT NN
Sbjct: 3 TKMTGNN 9
>XP_005262172
          Length = 1631

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRMTSNN 8
           T+MT NN
Sbjct: 236 TKMTGNN 242
>XP_005262170
          Length = 1752

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/7 (71%), Positives = 6/7 (85%)

Query: 2   TRMTSNN 8
           T+MT NN
Sbjct: 407 TKMTGNN 413
>XP_006724131
          Length = 2298

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 1   GTRMTSNN 8
           G+R+TS+N
Sbjct: 947 GSRVTSHN 954
>XP_005257746
          Length = 699

 Score = 15.8 bits (29), Expect =  7355
 Identities = 6/9 (66%), Positives = 6/9 (66%)

Query: 1   GTRMTSNNT 9
           G R TS NT
Sbjct: 561 GNRETSGNT 569
>XP_006714560
          Length = 814

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 730 TRLSSNST 737
>XP_005248414
          Length = 943

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 859 TRLSSNST 866
>XP_005248413
          Length = 953

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 869 TRLSSNST 876
>XP_006714559
          Length = 962

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 8/8 (100%)

Query: 2   TRMTSNNT 9
           TR++SN+T
Sbjct: 878 TRLSSNST 885
>XP_006712581
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           G R++SNN
Sbjct: 912 GNRISSNN 919
>XP_005246132
          Length = 1047

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           G R++SNN
Sbjct: 912 GNRISSNN 919
>NP_001073973
          Length = 1052

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/8 (62%), Positives = 7/8 (87%)

Query: 1   GTRMTSNN 8
           G R++SNN
Sbjct: 917 GNRISSNN 924
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.297    0.106    0.281 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 488,380
Number of extensions: 893
Number of successful extensions: 47
Number of sequences better than 10000.0: 47
Number of HSP's gapped: 47
Number of HSP's successfully gapped: 47
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 17 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (15.2 bits)
S2: 28 (15.4 bits)

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