Cancertope

In silico Platform for designing genome-based
Personalized immunotherapy or Vaccine against Cancer

Blast-Search of mutated query peptide against human proteome

BLAST Search Results
BLASTP 2.2.15 [Oct-15-2006]


Reference:
Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schäffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= User_input
         (9 letters)

Database: HUMAN_PROTEOME_FASTA 
           71,491 sequences; 45,948,801 total letters

Searching..................................................done



                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

NP_733751                                                              19     665
XP_006716142                                                           19     665
XP_005250088                                                           19     665
XP_006716141                                                           19     665
XP_005250085                                                           19     665
XP_006716140                                                           19     665
XP_005250084                                                           19     665
XP_005250083                                                           19     665
XP_005250082                                                           19     665
NP_001129490                                                           17    4312
NP_001278092                                                           17    4312
NP_000111                                                              17    4312
NP_061836                                                              17    4312
NP_387505                                                              17    4312
XP_005261051                                                           17    4312
NP_001135780                                                           17    4312
NP_055449                                                              16    5631
NP_001073918                                                           16    5631
XP_006717743                                                           16    5631
NP_001273768                                                           16    7355
NP_005757                                                              16    7355
XP_006719976                                                           16    7355
NP_001171601                                                           15    9605
NP_001954                                                              15    9605
NP_001171602                                                           15    9605
NP_689725                                                              15    9605
XP_006724216                                                           15    9605
XP_006724215                                                           15    9605
XP_006724214                                                           15    9605
XP_006724213                                                           15    9605
XP_006724212                                                           15    9605
XP_005262859                                                           15    9605
XP_005262858                                                           15    9605
XP_005262857                                                           15    9605
XP_005262856                                                           15    9605
XP_006714188                                                           15    9605
XP_006714187                                                           15    9605
XP_005262855                                                           15    9605
XP_005262854                                                           15    9605
XP_005262853                                                           15    9605
>NP_733751
          Length = 4911

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2490 GTMPSQERF 2498
>XP_006716142
          Length = 4927

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_005250088
          Length = 4928

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_006716141
          Length = 4959

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_005250085
          Length = 4979

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_006716140
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_005250084
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>XP_005250083
          Length = 4982

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2506 GTMPSQERF 2514
>XP_005250082
          Length = 4983

 Score = 19.2 bits (38), Expect =   665
 Identities = 8/9 (88%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GTM SQERF
Sbjct: 2507 GTMPSQERF 2515
>NP_001129490
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GTMLSQERF 9
           GT++S +RF
Sbjct: 365 GTIISSQRF 373
>NP_001278092
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GTMLSQERF 9
           GT++S +RF
Sbjct: 365 GTIISSQRF 373
>NP_000111
          Length = 455

 Score = 16.5 bits (31), Expect =  4312
 Identities = 5/9 (55%), Positives = 8/9 (88%)

Query: 1   GTMLSQERF 9
           GT++S +RF
Sbjct: 365 GTIISSQRF 373
>NP_061836
          Length = 2320

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GT+LSQE +
Sbjct: 1084 GTVLSQEPY 1092
>NP_387505
          Length = 2269

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GT+LSQE +
Sbjct: 1084 GTVLSQEPY 1092
>XP_005261051
          Length = 2242

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 8/9 (88%)

Query: 1    GTMLSQERF 9
            GT+LSQE +
Sbjct: 1006 GTVLSQEPY 1014
>NP_001135780
          Length = 2156

 Score = 16.5 bits (31), Expect =  4312
 Identities = 6/9 (66%), Positives = 7/9 (77%)

Query: 1   GTMLSQERF 9
           GT+LSQ  F
Sbjct: 406 GTLLSQRSF 414
>NP_055449
          Length = 454

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 1  GTMLSQE 7
          GT+LSQE
Sbjct: 46 GTVLSQE 52
>NP_001073918
          Length = 1060

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TMLSQER 8
           T+LSQER
Sbjct: 318 TLLSQER 324
>XP_006717743
          Length = 1090

 Score = 16.2 bits (30), Expect =  5631
 Identities = 6/7 (85%), Positives = 7/7 (100%)

Query: 2   TMLSQER 8
           T+LSQER
Sbjct: 348 TLLSQER 354
>NP_001273768
          Length = 1076

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GTMLSQERF 9
           GTM+  E F
Sbjct: 729 GTMIKMENF 737
>NP_005757
          Length = 1045

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GTMLSQERF 9
           GTM+  E F
Sbjct: 729 GTMIKMENF 737
>XP_006719976
          Length = 1045

 Score = 15.8 bits (29), Expect =  7355
 Identities = 5/9 (55%), Positives = 6/9 (66%)

Query: 1   GTMLSQERF 9
           GTM+  E F
Sbjct: 729 GTMIKMENF 737
>NP_001171601
          Length = 1166

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>NP_001954
          Length = 1207

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>NP_001171602
          Length = 1165

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 462 GTLLSQQ 468
>NP_689725
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMLSQE 7
           TMLSQE
Sbjct: 219 TMLSQE 224
>XP_006724216
          Length = 278

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMLSQE 7
           TMLSQE
Sbjct: 219 TMLSQE 224
>XP_006724215
          Length = 476

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2  TMLSQE 7
          TMLSQE
Sbjct: 88 TMLSQE 93
>XP_006724214
          Length = 494

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMLSQE 7
           TMLSQE
Sbjct: 106 TMLSQE 111
>XP_006724213
          Length = 554

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMLSQE 7
           TMLSQE
Sbjct: 166 TMLSQE 171
>XP_006724212
          Length = 607

 Score = 15.4 bits (28), Expect =  9605
 Identities = 6/6 (100%), Positives = 6/6 (100%)

Query: 2   TMLSQE 7
           TMLSQE
Sbjct: 219 TMLSQE 224
>XP_005262859
          Length = 688

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_005262858
          Length = 914

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_005262857
          Length = 1052

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_005262856
          Length = 1061

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_006714188
          Length = 1132

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 421 GTLLSQQ 427
>XP_006714187
          Length = 1133

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_005262855
          Length = 1134

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
>XP_005262854
          Length = 1173

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 462 GTLLSQQ 468
>XP_005262853
          Length = 1215

 Score = 15.4 bits (28), Expect =  9605
 Identities = 5/7 (71%), Positives = 7/7 (100%)

Query: 1   GTMLSQE 7
           GT+LSQ+
Sbjct: 504 GTLLSQQ 510
  Database: HUMAN_PROTEOME_FASTA
    Posted date:  May 26, 2014 10:46 AM
  Number of letters in database: 45,948,801
  Number of sequences in database:  71,491
  
Lambda     K      H
   0.323    0.132    0.357 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Sequences: 71491
Number of Hits to DB: 412,128
Number of extensions: 678
Number of successful extensions: 40
Number of sequences better than 10000.0: 40
Number of HSP's gapped: 40
Number of HSP's successfully gapped: 40
Length of query: 9
Length of database: 45,948,801
Length adjustment: 0
Effective length of query: 9
Effective length of database: 45,948,801
Effective search space: 413539209
Effective search space used: 413539209
Neighboring words threshold: 11
Window for multiple hits: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 28 (16.0 bits)
S2: 28 (15.4 bits)

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